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Title: SITE-DIRECTED MUTAGENESIS STUDY OF VITREOSCILLA HEMOGLOBIN-THE ROLE OF TYROSINE (B10) AND PROLINE (E8) IN THE STRUCTURE OF THE LIGAND-BINDING SITE
Creator: Zhang, Yifan
Date: 2015, 2015-05
Description: Vitreoscilla is a genus of Gram-negative aerobic bacterium which has the capability to synthesis a soluble, homodimertic hemoglobin,...
Show moreVitreoscilla is a genus of Gram-negative aerobic bacterium which has the capability to synthesis a soluble, homodimertic hemoglobin, Vitreoscilla hemoglobin (VHb). The Vitreoscilla hemoglobin was the first bacterial hemoglobin discovered, and has a wide range of biological and biotechnological applications. The distal site is one of the hot spots in VHb studies because of its unique structure. The Tyrosine residue at B10 and its hydrogen bonded Proline at E8 were considered as the ligand binding functional sites in distal space of VHb according to the previous study. In this study, two single mutated and one double mutated Vitreoscilla hemoglobin at position B10 and E8 were constructed and purified. In the two single mutants, the Tyr at B10 and the Pro at E8 were mutated to Ala. In the double mutant, both of the sites were mutated to Ala. The CO di↵erence spectrum data of the mutants indicate that the ligand binding ability of the Vitreoscilla hemoglobin was not neutralized by the mutations at ProE8 and TyrB10. Circular dichroism spectrum data of the mutants is similar to the wild type Vitreoscilla hemoglobin, which means the globin secondary structure is conserved. However the micro-environment in the distal sites is changed: the IR spectrum of the carbonyl stretch bond red-shifted in the CO bound VHb double mutant. A molecular dynamic simulation was introduced in the study to o↵er some guidance for future research plans. The simulation results showed that the B10 and E8 residue mutated to Ala might reduce the flexibility of the D-region, because of the more completed C and E helix. The volume of cavity where the heme group inserts changes significantly in various mutant models, which may provide a rough explanation of the change in carbonyl stretch bond IR spectrum. Additionally, an interesting conformation of Gln E7 was found in the simulation of double mutant model.
M.S. in Biology, May 2015
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Title: Combating Underage Drinking and Driving (Semester Unknown) IPRO 351: CombatingUnderageDrinkingandDrivingIPRO351AbstractF10
Creator: Hajakian, Melene, Cartabiano, Vincent, Abbasi, Rawan, Salem, Stephanie, Macon, Briana, Graham, Stuart, Kurenty, Edinam, Mazur, Mikayla, Menezes, Sandra, Nealy, Kimberly, Svaldi, Jared, Szalko, Alex, Wong, Claire
Date: 2010, 2010-12
Description: A. The team purpose is to combat underage drinking and driving B. Application/Testing Design:  To develop i-phone applications New/Existing...
Show moreA. The team purpose is to combat underage drinking and driving B. Application/Testing Design:  To develop i-phone applications New/Existing Tech:  Develop a comparable device that will be competitive in the market Behavior and Survey:  Gather data to find out what people want (validation) or would be interested in --- our target market Finance/Marketing:  Compile details/info to create a business plan – opportunity assessment
Deliverables
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Title: The Michael Reese Campus: An Interprofessional Urban Development Problem (Semester Unknown) IPRO 356: TheMichaelReeseCampusIPRO356MidTermPresentationSp11
Creator: Abro, Anam, Anderson, Brieg, Bobak, Tadeusz, Brenner, Kevin, Brown, Damon, Cretiu, Peter, Cuevas, Jose, Ferrari, Howard, Jarosz, Michelle, Jeong, Hye Sun, Muyco, Michael, Spencer, Samantha
Date: 2011, 2011-05
Description: IPRO 356 is a team of students from multiple disciplines tasked with the goal of designing a second anchor for the Michael Reese to accompany...
Show moreIPRO 356 is a team of students from multiple disciplines tasked with the goal of designing a second anchor for the Michael Reese to accompany the planned continued care community designed by the previous semester’s IPRO. The anchor will help meet the needs of the community as well as improve the economic condition of the current surrounding area by bringing jobs, people, and revenue to the Michael Reese site. The team will help in a revitalization of Chicago’s south side.
Sponsorship: CB Richard Ellis, Jones Lang LaSalle, City of Chicago and other stakeholders
Deliverables
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Title: Nonlinear time series models for multivariable dynamic processes
Creator: Cinar, A.
Date: 1995-11
Publisher: ELSEVIER SCIENCE BV
Description: Several paradigms are available for developing nonlinear dynamic input-output models of processes. Polynomial models, threshold models, models...
Show moreSeveral paradigms are available for developing nonlinear dynamic input-output models of processes. Polynomial models, threshold models, models based on spline functions, and polynomial models with exponential and trigonometric functions can describe various types of nonlinearities and pathological behavior observed in many physical processes. A unified nonlinear model development framework is not available, and the search of the appropriate nonlinear structure is part of the model development effort. Various artificial neural network structures and nonlinear time series model structures are presented and illustrated by developing a model from data sets generated by a series of example systems. The use of a nonlinear model development paradigm which is not compatible with the types of nonlinearities that exist in the data can have a significant effect on model development effort and model accuracy.
Endnote format citation
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Title: Synthetic Biology: Engineering a Novel Organism (semester?), IPRO 302
Creator: Allam, Emad, Bridgeman, Bryan, Chen, Hoa, Hussain, Faraz, Hutchinson, Daniel, King, Heather, Le, Thien, Lim, Soo, Liu, Lily, Mahmud, Saba, Maltby, Edward, Patel, Sid, Ramirez, Hazel, Ross, Trillian
Date: 2006-05, 2006-05
Description: Our objectives are fairly straightforward. If the genetic code can be called its own language, then we want to become fluent in it. The...
Show moreOur objectives are fairly straightforward. If the genetic code can be called its own language, then we want to become fluent in it. The current technology does not allow us the ability to “write our own novel” (i.e. make a new organism from scratch), but what we can do is write our own pamphlet. This semester, we are trying to complete our test case, which is to create a colony of Escherichia coli that flash different colors all in unison. Once we complete this task, we hope to export this system into higher organisms, such as Zebrafish (Danio rerio). We are also seeking to move forward conceptually by planning long term goals for the Ipro, such as the development of not just test cases, but new, useful organisms.
Deliverables for IPRO 302: Synthetic Biology: Engineering a Novel Organism for the Spring 2006 semester
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Title: Elevator Control System
Creator: Schwarz, Ernst L.
Date: 1942-03-31
Description: Sponsorship: Armour Research Foundation
United States Patent

Title: Method for Efficient Heat Treatment of Steel
Creator: Nash, Philip, Sista, Vivekanand, Sahay, Satyam
Date: 2012-03-20, 2011-11-29
Description: A method for heat treatment of steel and a system thereof is provided. First the steel is austenitized at a suitable temperature and then the...
Show moreA method for heat treatment of steel and a system thereof is provided. First the steel is austenitized at a suitable temperature and then the temperature is rapidly brought down to the austempering temperature. Here the cyclic austempering is carried out between two austempering temperatures by modulating the temperature with controlled heating and cooling and the controlled temperature modulation is obtained by controlling the temperature-time profile in a batch furnace or by controlling the zone temperatures in a continuous furnace. This method of cyclic austempering reduces the austempering time, reduces the energy consumption and emissions, enhances the productivity and reduces the process cost.
Sponsorship: Tata Consultancy Services, Ltd. and Illinois Institute of Technology
United States Patent
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Title: Research Web (Semester Unknown) IPRO 321: ResearchWebIPRO321FinalPresentationF09
Creator: Abhay, Anandha, Cornelius, Zachary, Corsus, Tom, De Courten-myers, Maximilian, Eberlin, Adam, Kapaldo, James, Nicholson, Bethany, Sizyuk, Yuriy, Sundberg, Stephen
Date: 2009, 2009-12
Description: The focus of our IPRO project was ResearchWeb, an IIT-centered interactive website allowing students and faculty to share research data,...
Show moreThe focus of our IPRO project was ResearchWeb, an IIT-centered interactive website allowing students and faculty to share research data, discuss their research findings, and find research opportunities. Our team brought together undergraduate students from several different departments, about half of whom were programmers. This report summarizes our goals and purpose, our team organization, our research findings, and our conclusions regarding the project’s future.
Deliverables
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Title: Means for Recording
Creator: Camras, Marvin
Date: 1958-08-19
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

Title: BUOY (Semester Unknown) IPRO 310: BUOYIPRO310PosterSu09
Creator: Baar, Coleman, Dykeman, Kimberly, Hotz, Thomas, Kruse, Kevin, Kwiatkowski, Lisa, Lane, Brendan, Lopez, Roman, Reilly, Jeffrey, Sarkar, Smita, Sowiak, Joanna, Stelcel, Carl, Winston, Nithin, Zhou, Raymond
Date: 2009, 2009-07
Description: Our mission is to develop, test, and implement assistive technology with the community that promotes safety and improves independence of blind...
Show moreOur mission is to develop, test, and implement assistive technology with the community that promotes safety and improves independence of blind and visually impaired (BVI) swimmers.
Deliverables
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Title: MATHEMATICAL-MODELS OF COCURRENT SPRAY-DRYING
Creator: Negiz, A., Lagergren, E. S., Cinar, A.
Date: 1995-10
Publisher: AMER CHEMICAL SOC
Description: A steady state mathematical model for a cocurrent spray dryer-is developed. The model includes the mass, momentum, and energy balances for a...
Show moreA steady state mathematical model for a cocurrent spray dryer-is developed. The model includes the mass, momentum, and energy balances for a single drying droplet as well as the total energy and mass balances of the drying medium. A log normal droplet size distribution is assumed to hold at the exit of the twin-fluid atomizer located at the top of the drying chamber. The discretization of this log normal distribution with a certain number of bins yields a system of nonlinear coupled first-order differential equations as a function of the axial distance of the drying chamber. This system of equations is used to compute the axial changes in droplet diameter, density, velocity, moisture, and temperature for the droplets at each representative bin. Furthermore, the distributions of important process parameters such as droplet moisture content, diameter, density, and temperature are also obtainable along the length of the chamber. On the basis of the developed model, a constrained nonlinear optimization problem is solved, where the exit particle moisture content is minimized with respect to the process inputs subjected to a fixed mean particle diameter at the chamber exit. Response surface studies based on empirical models are also performed to illustrate the effectiveness of these techniques in achieving the optimal solution when an a priori model is not available. The structure of empirical models obtained from the model is shown to be in agreement with the structure of the empirical models obtained from the experimental studies.
Endnote format citation
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Title: Automatic Insulin Pumps Using Recursive Multivariable Models and Adaptive Control Algorithms
Creator: Cinar, Ali, Oruklu, Meriyan
Date: 2014-04-09, 2014-04-08
Description: A method and device for monitoring or treating patient glucose levels. The device includes a glucose sensor for measuring a glucose level of a...
Show moreA method and device for monitoring or treating patient glucose levels. The device includes a glucose sensor for measuring a glucose level of a patient, a physiological status monitoring system for measuring at least one physical or metabolic variable of the patient, and an automatic controller in communication with the glucose sensor and the physiological status monitoring system. The controller includes a prediction module for automatically predicting a future glucose level using data measured by the glucose sensor and the physiological sensor.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Thermally Regenerative Galvanic Cell Employing the Fluorides of Arsenic, Cerium and Uranium
Creator: Mccully, Charles R.
Date: 4/23/2009, 1967-05-09
Description: Sponsorship: IIT Research Institute
United States Patent

Title: Tests on the gravity cell
Creator: Evans, P. W., Linderberg, W. A.
Date: 2009, 1912
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/testsongravityce00evan
Thesis (B.S.)--Armour Institute of Technology

Title: Planning for Human Implantation of a Cortical Visual Prosthesis (sequence unknown), IPRO 334 - Deliverables: IPRO 334 Final Report F09
Creator: Bern, David, Chen, Shanyl, Deroo, Mary, Gorski, David, Kelly, Thomas, Leasenby, Alex, Li, Zhi, Pyrkh, Hanna, Subhani, Maham, Taneja, Aanchal
Date: 2009-12
Description: The Intracortical Visual Prosthesis is based upon that concept that by implanting a large number of subminiature electrodes within the human...
Show moreThe Intracortical Visual Prosthesis is based upon that concept that by implanting a large number of subminiature electrodes within the human visual cortex, coordinated temporal-spatial image information can be artificially communicated to the human visual cortex in the form of electrical currents, acting as a sensory substitute for normal vision.
Sponsorship: IIT Laboratory of Neural Prosthetic Research
Deliverables for IPRO 334: Planning for Human Implantation of a Cortical Visual Prosthesis for the fall 2009 semester
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Title: Small-Scale Desalination (Semester Unknown) EnPRO 354: Small-ScaleDesalinationEnPRO354MidTermPresentationtSp10
Creator: Adamczyk, Paul, Au, Bonnie, Bijonowski, Brent, Fanelli, Daniel, Hoxha, Edlira, Krauszowska, Monika, Pham, Nga, Rauf, Aamir, Schlessinger, Hannah, Wolber, Brian
Date: 2010, 2010-05
Description: Freshwater is one of Earth’s most precious resources and is now increasing in scarcity. Global warming induced climate change is now changing...
Show moreFreshwater is one of Earth’s most precious resources and is now increasing in scarcity. Global warming induced climate change is now changing rain patterns and causing record drought, growing global populations are increasing demand, and the individual demand per person is increasing and human populations urbanize and adopt modern plumbing. The biggest contributor to increasing demand for water is mismanagement and pollution. However for this project we will be focusing on water quantity rather than quality.
Deliverables
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Title: Magnetic Head Assembly
Creator: Camras, Marvin
Date: 1956-09-04
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

Title: ECONOMIC BASED CONTROL SYSTEM DESIGN
Creator: Omell, Benjamin Peter
Date: 2013, 2013-12
Description: EMPC differs from traditional MPC by directly utilizing a profit based function as the objective as opposed to a quadratic function that...
Show moreEMPC differs from traditional MPC by directly utilizing a profit based function as the objective as opposed to a quadratic function that minimizes the distance from a set point that is predetermined. However, implementation of EMPC can result in unexpected and at times pathological closed-loop behavior, including inventory creep, bang-bang actuation and instability. To address these issues, an infinite-horizon version of EMPC is developed and shown to avoid many of the performance issues observed in the finite-horizon version. First, modifications to the EMPC problem will be used for the conceptual development of the Economic Linear Optimal Controller (ELOC), which is a statistically constrained linear feedback controller. Then, pointwise- in-time constraints can be reintroduced using one of two methods; Constrained ELOC or Infinite-Horizon EMPC (IH-EMPC). We also investigate the impact of problem formulation modifications on the ELOC. The first issue is that of disturbance modeling and the second is the impact of controller sample-time. The third topic concerns incorporation of computational delay in the feedback-loop, using both full and partial state information structures. Finally an illustration of the impact of plant-model mismatch is presented. The Constrained ELOC formulation is further modified to allow for market responsive smart grid applications. In particular an Integrated Gasification Combined Cycle (IGCC) process with hydrogen storage will be used to demonstrate the Constrained ELOC for such applications. The ELOC will be used as a vehicle to exploit dispatch capabilities by pursuing directly the objective of maximizing revenue. The idea being that process modifications to enable dispatch capabilities will allow for a time-shift of power production away from periods of low energy value to periods of high value. An in depth discussion is provided on how energy value forecasts are incorporated into the design of the constrained ELOC. Finally, an extension of the ix ELOC to the controller embedded equipment design is provided. The work concludes with a discussion of the computational aspects of solving the ELOC problem. In particular, the impact of reverse-convex constraints inherent to the ELOC problem are discussed along with existing solution methods. The main contribution of this final chapter is a novel application of the Generalized Bender’s Decomposition (GBD) algorithm to the ELOC problem. This new approach is shown to retain global optimality, reduce computational effort (by orders of magnitude) and expand the class of problems one can solve.
PH.D in Chemical Engineering, December 2013
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Title: Video Playback System with Flutter Tolerant Clamping
Creator: Camras, Marvin
Date: 2009-05-04, 1975-03-04
Description: A magnetic reproducing system for association with a color broadcast television receiver wherein a substantial degree of flutter in the tape...
Show moreA magnetic reproducing system for association with a color broadcast television receiver wherein a substantial degree of flutter in the tape drive is tolerated by the receiver circuitry and a special flutter tolerant clamping circuit is utilized for transmitting the reproduced video signal to the receiver.
Sponsorship: IIT Research Institute
United States Patent
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Title: Devices that Assist Blind & Visually-Impaired Individuals in Swimming and Other Exercise Activities (sequence unknown), IPRO 310 - Deliverables
Creator: Dykeman, Kimberly, Healton, Michaela, Lipman, Timothy, Ludwig, Ross, Park, Jay, Reilly, Jeffrey, Sarkar, Smita, Sirk, Phillip, Toro, Branden
Date: 2009-12
Description: The objective is to develop, test, and implement assistive technology with the community that promotes safety and improves independence of...
Show moreThe objective is to develop, test, and implement assistive technology with the community that promotes safety and improves independence of blind and visually impaired (BVI) swimmers.
Sponsorship: Chicago Lighthouse for the Blind & Visually-Impaired. Notre Dame University
Deliverables for IPRO 310:Devices that Assist Blind & Visually-Impaired Individuals in Swimming and Other Exercise Activities for the fall 2009 semester.
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