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Title: MEMBRANE-DRUG INTERACTION MECHANISMS OF PEPTOID-BASED ANTIMICROBIAL AGENTS
Creator: Andreev, Konstantin
Date: 2017, 2017-05
Description: Nature is a major source of inspiration for drug design. Bacteria are developing resistance towards conventional antibiotics. Utilizing...
Show moreNature is a major source of inspiration for drug design. Bacteria are developing resistance towards conventional antibiotics. Utilizing antimicrobial peptides (AMPs) – an essential component of innate immune system, as therapeutic agents, may be a viable alternative. Unfortunately, there are a number of serious hurdles on the way towards clinical application of AMPs, including their low bioavailability, costly manufacturing process and toxicity against host cells. To address this issues, current research is focused on the design of synthetic compounds mimicking natural peptides, among which oligo(Nsubstituted glycines), or peptoids, have shown great promise. Antimicrobial drug efficacy is defined by how it interacts with the membrane of invading pathogen. The physicochemical characteristics of peptoid molecule play a crucial role in these interactions, yet their detailed structure-activity relationships remain obscure. Herein, we have demonstrated that conformational flexibility, cationic charge or hydrophobicity, are critical for oligomeric peptoids to permeate bacterial cell membranes. The outer surface of membrane was modeled by Langmuir monolayers of desired lipid composition and subjected to the constant-pressure insertion assays, epifluorescence microscopy (EFM), synchrotron X-ray reflectivity (XR) and grazing incident-angle X-ray diffraction (GIXD). Our results shed light on the critical details in peptoid mode of action. We believe this will aid in the rational design and of novel anti-infective drugs. Additionally, we have applied our experimental system to model the processes occurring at the air-water interface in lungs. Alveoli are coated by a complex lipidprotein mixture referred to as pulmonary surfactant. This facilitates respiration and prevents alveolar collapse. Patients with respiratory distress receive surfactant replacement therapy that often has the serious drawbacks. X-ray scattering data shows that the structural organization of adsorbed films correlates with surfactant delivery methods onto the respiratory surface. We anticipate that our findings will contribute to the development of novel clinical approaches for treating respiratory diseases.
Ph.D. in Biology, May 2017
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Title: UNEQUAL GRANULAR TEMPERATURE THEORY FOR MOTION OF RED BLOOD CELLS AND PLATELETS
Creator: Aralaguppe Deepak Chandra, Vishak Chandra
Date: 2015, 2015-07
Description: Blood is a multiphase mixture of liquid plasma and solid blood cells. The primary objective of this thesis is to numerically model the motion...
Show moreBlood is a multiphase mixture of liquid plasma and solid blood cells. The primary objective of this thesis is to numerically model the motion of red blood cells and platelets in blood vessels using kinetic theory based multiphase flow transport phenomena. Many experimental observations over the years have concluded that the concentration of platelets and red blood cells vary across the radius of the blood vessel. It has been shown that shear drives the platelets towards the wall, while the red blood cells move towards the center of the blood vessel. Other studies have observed that the platelet adhesion at the walls of the vessel is strongly dependent on the wall shear rate and the concentration of red blood cells. Platelet adhesion to the walls of the vessel has been explained by various shear induced diffusion models over the past few years. The diffusion models are heavily dependent on empirical relations which do not fully explain the phenomena behind the migration. In this study we postulate the dependence of red blood cell concentration on the migration of platelets using kinetic theory. The experimentally measured motion of platelets to the wall and red blood cells to the center is explained by unequal granular temperature kinetic theory. The migration of platelets in the presence of red blood cells is caused by the high granular pressure produced by the random oscillations of the red blood cells and the dissipation of platelet random energy at the walls. At the wall the shear has the highest value. This produces a high granular pressure and temperature which drive the red blood cells towards the center. An analytical solution for the platelet concentration was derived.
M.S. in Chemical Engineering, July 2015
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Title: Enhancing the Functionality of Residential Garage Door Operators Using CCD Camera Technology (Spring 2002) IPRO 324: Enhancing the Functionality of Residential garage Door Operator Using CCD Camera Technology IPRO324 Spring2002 Final Presentation
Creator: Henandez, Paulo, Girtley, Jason, Horng, Steven, Saric, Marin, Lee, Seungbi, Aluko, Obadamilola, V., Sandeep, Rami, Amit, Bango, Eric, Meskovic, Alen, Fung, Richard
Date: 2002, 2002-05
Description: Chamberlain is interested in exploring new devices that can enhance the functionality of its garage door operator systems. Residential garage...
Show moreChamberlain is interested in exploring new devices that can enhance the functionality of its garage door operator systems. Residential garage door operators currently utilize an IR emitter and detector pair to identify the presence of an object breaking the "beam". This sensor is used to reduce the risk of a moving garage door striking an object in its path.The IPRO team will investigate the use of an inexpensive CCD camera to replace, and potentially expand, this functionality. The scope of this project will include but not necessarily be limited to: (a) understanding regulatory requirements for devices currently used on operators, and attempting to anticipate how current requirements will be interpreted and or modified to cover this new sensor, (b) identifying optical and electronic requirements to meet anticipated regulatory requirements, (c) examining current patents for devices utilizing similar technology, (d) developing a single sample device optimized for minimum development time and (e) estimating the projected cost for this system, when optimized for functionality, cost and produceability.
Sponsorship: Chamberlain, Inc.
Project Plan for IPRO 324: Enhancing the Functionality of Residential Garage Door Operators Using CCD Camera Technology for the Spring 2002 semester
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Title: Intranet Mediators (Spring 2002) IPRO 356: Intranet_Mediators_IPRO356_Spring2002_Final_Presentation
Creator: Saelee, Michael, Beitzel, Steve, Jensen, Eric, Pilotto, Angelo, Aqeel, Syed, Guico, Robert, Prokop, Joe, Tanabe, Davin, Yap, Dawn, Zatopek, Michael
Date: 2002, 2002-05
Description: This IPRO is being run as part of the IIT Information Retrieval Lab. This is one of the only labs in the country dedciated to next generation...
Show moreThis IPRO is being run as part of the IIT Information Retrieval Lab. This is one of the only labs in the country dedciated to next generation search engines. Team members will learn all about search engines and will help build one different from existing search engines. Current web search engines only search unstructured data (web documents). A lot of data is available that is structured (weather, census, sports, etc.). A search engine that could search both structured data and text would be able to answer questions such as "show me the top three restaurants in Chicago" without simply looking for the word "three." Previous IPRO teams have been building a Java-based metasearch engine. Numerous issues have arisen. How do we identify which data source will be best for the query? What is the best user interface for the system? For Spring 2002, the team will extend the search engine to include more sources. The team could really use the talents of non-computer science students to help test the system and improve the user interface.
Sponsorship: IIT Internal R&D in conjunction with the Ed Kaplan Entrepreneurial Studies Program
Project Plan for IPRO 356: Intranet Mediators for the Spring 2002 semester
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Title: Developing an Operations and Marketing Plan for WIIT (Spring 2003) IPRO397-322
Creator: Curtis, Chris, Wheeler, Neeva, Okuley, Nick, Berger, Joshua, Adams, Aaron, Magu, Luis, Ernst, Nathan, Prezas, Panos, Lanh, Saroeun, Tchervenski, Nick, Todova, Teodora
Date: 2003, 2003-05
Description: The student run radio station will continue in an expansion mode. The Spring semester's IPRO team will focus on the following goals:Community...
Show moreThe student run radio station will continue in an expansion mode. The Spring semester's IPRO team will focus on the following goals:Community Service1. Involve more schools in the program2. Involve more volunteers in the community service sideInternet Design1. Expand all modules2. Develop website more in the areas of underwriting and a voting/polling system3. Improve the look and feel of the siteMarketing1. Work on the Alumni Dinner2. Look for different ways of marketing while continuing on the already successful course of action3. Work with underwriting Underwriting1. Use prior knowledge of businesses to be more successful2. Develop use the student discount cards3. Get local restaurant's menus on the websiteCampus Services1. Work with everyone needed to insure the supreme excellence of the new Student Center broadcasting station2. Make sure equipment is ordered and ready3. Secure space under commons Happy Land Database (campus services)1. Managing the implementation of the CD database
Sponsorship: IIT Collaboratory for Interprofessional Studies
Project Plan for IPRO 397-322: Developing an Operations and Marketing Plan for WIIT for the Spring 2003 semester
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Title: TechNews (Spring 2003) IPRO 320
Creator: Babb, Chris, Brooks, Timothy, Mcgill, Jeff, Anderson, James, Mayer, Ryan, Miller, Mike, Tarlea, Alina
Date: 2003, 2003-05
Description: Tech News, IIT�s newspaper, will offer an opportunity for interdisciplinary activities to support the development and services of the...
Show moreTech News, IIT�s newspaper, will offer an opportunity for interdisciplinary activities to support the development and services of the newspaper. Students joining this team will have an interest in applying the latest advances in computers; developing management skills; reporting, researching and investigating interesting topics and stories; exploring issues of ethics, social responsibility and professional integrity in the context of a newspaper operation; or testing and implementing exciting new programs. This project offers a great opportunity to meet and serve a lot of different people on campus and in the community. This will increase the interaction and liaison of Tech News with campus organizations, our fellow students, faculty and staff at other campuses, and members of the communities in proximity to the IIT campus. This IPRO team will focus on achieving the following broad goals during the semester: (1) increase community involvement with all students, (2) develop a neighborhood participation program, (3) develop a program for staff membership (recruitment, retention and alliances), (4) design and perform a comprehensive readership survey (focusing on student needs, campus activities and student clubs), (5) prepare an orientation issue for Fall 2003 freshmen, and (6) develop a long term plan.
Sponsorship: IIT Collaboratory for Interprofessional Projects
Project Plan for IPRO 320: TechNews for the Spring 2003 semester
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Title: Intranet Mediators (Spring 2001) EnPRO 307
Creator: Saelee, M., Ahuja, R., Beitzel, S., Jensen, E., Pilotto, A., Schmeltzer, D., Yap, D.
Date: 2001, 2001-05
Description: Current web search engines only search unstructured data (web documents). A lot of data is available that is structured (weather, census,...
Show moreCurrent web search engines only search unstructured data (web documents). A lot of data is available that is structured (weather, census, sports, etc.). A search engine that could search both structured data and text would be able to answer questions such as "show me the top three restaurants in Chicago" without simply looking for the word "three." The team has been building a Java-based metasearch engine in IPRO 334 duringFall 2000. Numerous issues have arisen. How do we identify which data source will be best for the query? What is the best user interface for the system? For Spring 2001, the team will extend the search engine to include more sources. The team could really use the talents of non-computer science students to help test the system and improve the user interface. Students should plan to work on this at least ten hours a week - anything less will resultin a poor grade for the IPRO. Students for this IPRO are graded heavily based on the success of the team, not just individual performance. Weekly progress reports are required. Note that graduate students in Computer Science are not able to use IPRO classes for credit toward a graduate degree.
Sponsorship: IIT Internal R&D
Project Plan for EnPRO 307: Intranet Mediators for the Spring 2001 semester
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Title: Intranet Mediators (Fall 2001) EnPRO 356: Intranet Mediators EnPRO356 Fall2001 Final Presentation
Creator: Beitzel, Steve, Jensen, Eric, Evans, Minh, Krahn, Andy, Lagunova, Natasha, Oenoki, Kazushi, Pilotto, Angelo, Schmeltzer, Dan, Tanabe, Davin, Lee, Michael
Date: 2001, 2001-12
Description: Current web search engines only search unstructured data (web documents). A lot of data is available that is structured (weather, census,...
Show moreCurrent web search engines only search unstructured data (web documents). A lot of data is available that is structured (weather, census, sports, etc.). A search engine that could search both structured data and text would be able to answer questions such as "show me the top three restaurants in Chicago" without simply looking for the word "three." Previous IPRO teams have been building a Java-based metasearch engine. Numerous issues have arisen. How do we identify which data source will be best for the query? What is the best user interface for the system? For Fall 2001, the team will extend the search engine to include more sources. The team could really use the talents of non-computer science students to help test the system and improve the user interface. Students should plan to work on this at least ten hours a week - anything less will result in a poor grade for the IPRO. Students for this IPRO are graded heavily based on the success of the team, not just individual performance. Weekly progress reports are required.
Sponsorship: IIT Collaboratory for Interprofessional Studies
Project Plan for EnPRO 356: Intranet Mediators for the Fall 2001 semester
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Title: Hybrid Electric Bicycle (Fall 2003) IPRO 315: Hybrid Electric Bicycle IPRO315 Fall2003 Final Presentation
Creator: Booth, Nicole, Austin, Kristen, Schilinger, Peter, Mohiuddin, Imran, Ruiz, Francisco, Iudicello, Jeff, Simmons, Lillateese, Klint, Kylie
Date: 2003, 2003-12
Description: Hybrid electric vehicles (HEV) combine the internal combustion engine (ICE) of a conventional vehicle with the battery and electric motor of...
Show moreHybrid electric vehicles (HEV) combine the internal combustion engine (ICE) of a conventional vehicle with the battery and electric motor of an electric vehicle. Hybrid electric propulsion, currently available in a limited selection of automobiles, improves fuel economy while enhancing torque when acceleration is required. In a parallel hybrid, onboard computers control the utilization of the ICE and electric motor, by selecting one or both power sources to drive the vehicle. A battery delivers power to the electric motor and is recharged by a generator driven by the ICE and by regenerative braking. This IPRO will seek to obtain similar benefits for a bicycle equipped with an electric motor and rechargeable battery, by substituting the cyclist in place of the hybrid electric's ICE. Regenerative braking and downhill pedaling will be investigated to recharge the battery. The intent of this IPRO is to create an understanding and interest in HEVs.This is the second offering of this IPRO. This term we continue our study and construction of a lightweight bicycle, exploring front and/or rear motors, using a lithium-ion battery that is currently being built to our specifications. Working with Dr. Emadi, the IPRO group may design and build appropriate power electronics to support motor drive as well as regenerative braking. A future project might explore the combination of ultra capacitors, for energy storage, and a fuelcell, to produce energy for propulsion.
Sponsorship: IIT Collaboratory for Interprofessional Studies
Project Plan for IPRO 315: Hybrid Electric Vehicle for the Fall 2003 semester
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Title: Window Solar Control (Spring 2002) IPRO 330: Window_Solar_Control_IPRO330_Spring2002_Final_Presentation
Creator: Alkhader, Maen, Patel, Shivanee, Miller, Mike, Khan, Asim
Date: 2002, 2002-05
Description: The Community Energy Cooperative is sponsoring a product development effort to create high performance window awnings. The overall objective...
Show moreThe Community Energy Cooperative is sponsoring a product development effort to create high performance window awnings. The overall objective is to develop a simple, low-cost easy-to-install, effective and pleasing exterior window solar control. Available products that reduce window solar heat gain range from reflective shades to new windows with low-emittance glass. In some cases, such as reflective film directly applied to glass, a 70 percent reduction in solar heat is possible. In general, however, no current product meets the full range of desired objectives. Objectives of a new awning design include: (1) inexpensive; (2) preserve window egress and ventilation functions; (3) permanently installed; (3) substantial cooling load reduction; (4) does not reduce solar heat in winter; (5) enhances daylight brightness, distribution within room and light quality; (6) minimal reduction in view; and (7) little (or favorable) influence on building appearance. A general concept for a new type of window solar control product has been envisioned by the Community Energy Cooperative. It is the purpose of the IPRO team over a two-semester period to refine the design concept, fabricate a prototype, demonstrate its effectiveness, assure its cost effectiveness and plan for its commercialization. The sequence of work will include literature search, modeling, design, building a prototype, and other activities leading to a production franchise agreement. Additional project tasks would include computer-simulation and field measurement of air conditioning and lighting performance change associated with awnings. This Project will add to the body of scholarly work on building energy performance and windows. The Community Energy Cooperative will make available various resources, including focus groups and contacts with product users, software and locations for test installations. The project will establish a format for community-based energy efforts that partner with colleges and universities.
Sponsorship: Community Energy Cooperative
Project Plan for IPRO 330: Window Solar Energy for the Spring 2002 semester
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Title: Energy and Environment Based Architectural Research & Design (Spring 2002) IPRO 323: Energy_and_Environment_Based_Architectural_Research_and_Design_IPRO323_Spring2002_Final_Presentation
Creator: Fard, Abbaszadeh Sahar, Ibrahim, Magdy, Park, Sang Min, Veselinovic, Goran, Geroulis, Michael, Cruz, Emerald, Kelly, Russell, Phillips, Kelby, Lau, Erika, Chung, Allan, Morzyc, Alicja, Panek, Katherine, Trojniak, Rafal, Chan, Ching, Pecaut, Meghan, Phillips, Lindsey, Staley, Shane
Date: 2002, 2002-05
Description: The goal of this IPRO research/design project is to establish an ongoing energy-based architectural studio. The studio will focus on a...
Show moreThe goal of this IPRO research/design project is to establish an ongoing energy-based architectural studio. The studio will focus on a specific project, but in an investigative and experimental manner. The end result of each project is expected to consist of cutting edge architectural solution, which will help provide insight into methods for integrating environmental concerns into architectural design process. The studio will explore the BIPV system, particularly in applications used for exterior wall systems. Also wind energy will be introduced. During the semester students will be directed Focusing on extensive research, data collection, elements and component design, putting this research information together and work towards a total building design.The project will be the trump tower building in Chicago, as planned by SOM. It is expected to be tallest building in the word. The student team will be led by IIT faculty, as well as professionals from the fields of architecture, and mechanical, chemical and structural/architectural engineering, including partners from the sponsoring firm of Skidmore, Owings & Merrill LLP.
Sponsorship: Skidmore Owings & Merrill LLP
Project Plan for IPRO 323: Energy and Environment Based Architectural Research & Design for the Spring 2002 Semester
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Title: WIIT (Spring 2002) IPRO 322: WIIT_IPRO322_Spring2002_Final_Presentation
Date: 2002, 2002-05
Description: The student run radio station continues in an expansion mode as the second IPRO is formed. The station now known as WIIT (88.9 FM) would like...
Show moreThe student run radio station continues in an expansion mode as the second IPRO is formed. The station now known as WIIT (88.9 FM) would like to expand its broadcast schedule to 24/7. The project team will suggest what type of programming and how to market the station to the students and surrounding communities. The research on programming has been completed and requires an operations plan. One project will address how to attract students to fill on the air positions. The marketing section last semester developed a package for underwriters that would enable the station to attract underwriters. Other projects concern increased coverage, and purchase of new equipment The project will be managed as an educational station by developing more viable radio station activities to offer students real experience in putting a five phase goal oriented project together to increase awareness and listenernship of the station. Another project will be to have the radio station offer mentorship opportunities for local high school students interested in radio. The strategic plan will serve the university and the surrounding area.
Sponsorship: NA
Project Plan for IPRO 322: WIIT for the Spring 2002 semester
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Title: Remixed: Reuse, Recycles, Mixed Use, Mixed Income: REMIXED FINAL BOOK
Creator: Hamburg, Michael
Date: 2012-05-04, 2012-05
Description: A mixed use, mixed income proposal for the Chicago south side, adaptively reusing shipping containers to keep construction costs low

Title: Arabic Stemmer (Spring 2003) EnPRO 356: Arabic Stemmer EnPRO356 Spring2003 Final Presentation
Creator: Lee, Michael, Beitzel, Steve, Jensen, Eric, Aqeel, Syed, Bhatt, Chirag, Kutty, Raghu, Ping, Fan, Samaranayake, Nayana, Samuels, Aaron, Shah, Palak, Stein, Sterling, Tandon, Mudit, Taylor, George
Date: 2003, 2003-05
Description: This EnPRO will work on next generation search tools for Arabic processing. You do not have to be a Computer Science major or know anything...
Show moreThis EnPRO will work on next generation search tools for Arabic processing. You do not have to be a Computer Science major or know anything about programming to be a major contributor to this project. This will be both a regular IPRO and an ENPRO so you will learn about the business side of things as well. Finally, if you are fluent in Arabic, this is really the IPRO for you. Your Arabic language skills will be heavily used. As with all regular courses, ten hours per week outside of class will be required
Sponsorship: IIT Collaboratory for Interprofessional Studies
Project Plan for EnPRO 356: Arabic Stemmer for the Spring 2003 semester
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Title: Enhancing the Functionality of Residential Garage Door Operators Using CCD Camera Technology (Spring 2003) IPRO 324: Enhancing the Functionality of Residential Garage Door Operators Using CCD Camera Technology IPRO324 Spring2003 Final Presentation
Date: 2003, 2003-05
Description: Located in Elmhurst, Illinois, The Chamberlain Group, Inc. is the world'slargest manufacturer of residential garage door openers and...
Show moreLocated in Elmhurst, Illinois, The Chamberlain Group, Inc. is the world'slargest manufacturer of residential garage door openers and commercial andgate operators for use on cars, boats and planes. Chamberlain leads the industry in product innovation and quality, and is the low-cost producer. At this time, through its Advanced Development group, Chamberlain is interested in exploring new devices that can enhance the functionality of its garage door operator systems. Residential garage door operators currently utilize an IR emitter and detector pair to identify the presence of an object breaking the "beam". This sensor is used to reduce the risk of a moving garage door striking an object in its path.The IPRO team will investigate the use of an inexpensive CCD camera to replace, and potentially expand, this functionality. The scope of this project will include but not necessarily be limited to: (a) understanding regulatory requirements for devices currently used on operators, and attempting to anticipate how current requirements will be interpreted and or modified to cover this new sensor, (b) identifying optical and electronic requirements to meet anticipated regulatory requirements, (c) examining current patents for devices utilizing similar technology, (d) developing a single sample device optimized for minimum development time and (e) estimating the projected cost for this system, when optimized for functionality, cost and produceability.
Sponsorship: Chamberlain Group
Project Plan for IPRO 324: Enhancing the Functionality of Residential Garage Door Operators Using CCD Camera Technology for the Spring 2003 semester
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Title: the evolution of the south fork turning basin: Grilli_Preliminary_Research
Creator: Grilli, Graham
Date: 5/4/2011, 2011-05
Description: a historical analysis of the South Fork Turning basin from 1833-2040 including proposals for future timeline. wetland remediation coupled with...
Show morea historical analysis of the South Fork Turning basin from 1833-2040 including proposals for future timeline. wetland remediation coupled with modular housing and adaptive reuse solutions. prototype for other potential developments along river's edge leading to healthier Great Lakes basin.
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Title: Digital Urban Park
Creator: Thornton, Alastair
Date: 5/4/2011, 2011-05
Description: This project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through...
Show moreThis project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through three parts and varying levels of group interaction between both the users of the space and by the spaces direct influence from the internet.
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Title: Digital Urban Park: Apr 27 Board V2
Creator: Thornton, Alastair
Date: 5/4/2011, 2011-05
Description: This project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through...
Show moreThis project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through three parts and varying levels of group interaction between both the users of the space and by the spaces direct influence from the internet.
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Title: Digital Urban Park: Thornton Final
Creator: Thornton, Alastair
Date: 5/4/2011, 2011-05
Description: This project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through...
Show moreThis project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through three parts and varying levels of group interaction between both the users of the space and by the spaces direct influence from the internet.
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Title: Remixed: Reuse, Recycles, Mixed Use, Mixed Income
Creator: Hamburg, Michael
Date: 2012-05-04, 2012-05
Description: A mixed use, mixed income proposal for the Chicago south side, adaptively reusing shipping containers to keep construction costs low

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