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Title: BIOPHYSICAL AND BIOCHEMICAL STUDY OF NATIVE AND EDITED DYSTROPHIN ROD REGION
Creator: Mangat, Khushdeep
Date: 2014, 2014-12
Description: Duchenne Muscular Dystrophy (DMD) is a severe X-linked recessive disease affecting 1 in 3500 boys that is characterized by the degeneration of...
Show moreDuchenne Muscular Dystrophy (DMD) is a severe X-linked recessive disease affecting 1 in 3500 boys that is characterized by the degeneration of muscle function and strength. The cause of this disease lies in gene defects that eliminate expression of the protein dystrophin. Becker Muscular Dystrophy, BMD is a milder form of disease that has a later onset and much longer survival (up to the 7th decade of life, compared to median survival of 25 years for DMD patients) because of the presence of low levels of modified dystrophin protein. BMD is very heterogeneous, however, and many cases are nearly as severe as DMD. A major therapy for DMD involves exon skipping, which produces modified forms of dystrophin that are very similar to BMD. However, how these edits impact the function of dystrophin, and how they are linked to the severity of BMD or the BMD-like state produced in DMD exon skip therapy is unknown. We investigated this in two specific cases involving a specific panel of BMD defects linked to a major cause of death, dilated cardiomyopathy (DCM). We also investigated the contribution of various exons to interaction with a signaling partner of dystrophin, neuronal nitric oxide synthetase (nNOS).
Ph.D. in Biological and Chemical Sciences, December 2014
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Title: Design and Global Market Analysis of a Tool Cabinet (Semester Unknown) IPRO 341: DesignandGlobalMarketAnalysisOfAToolCabinetIPRO341FinalPresentationSp10
Creator: Hamann, Eric, Falk, Stephen, Kim, Taehoon, Wiese, Ian, Kozmel, Tom, Di Sciullo Jones, Alex, Gavris, Calin, Chong, Hon-kyu, Eckhardt, Johnathan, Aleem Syed, Abdul, Vankley, Robert, Esparza, Tristan, Syzdykov, Kaisar, Turner, Alvin
Date: 2010, 2010-05
Description: The objective of IPRO 341 is to assist Versatility Tool Works with the design, testing, and marketing of an industrial strength tool cabinet....
Show moreThe objective of IPRO 341 is to assist Versatility Tool Works with the design, testing, and marketing of an industrial strength tool cabinet. Ideally, one or more of the drawers in the cabinet should be capable of holding 450 pounds of equipment, and have a lifespan of 20,000 cycles. (One (1) cycle is defined as one opening and closing of the drawer.) Extra features to include in the design of the cabinet will also be investigated to try to make the cabinet more marketable. However, it will be important to first determine what progress has been made thus far so that this semester’s design improvements can be better demonstrated.
Deliverables
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Title: Hostile Spaces and Hostel Spaces: Re-Visioning Highway Infrastructure: Kevin_Smith Final Thesis Board 02-0f-03
Creator: Smith, Kevin
Date: 2010-07-30

Title: Social Network Analysis for Pace Suburban Bus Stakeholders (semester?), IPRO 321: Pace Project IPRO 321 Final Report Sp05
Creator: Hahn, Young Ae, Basu, Nivedita, Block, Nathaniel, Cechova, Lenka, Colbath, Geoff, Dronamraju, Rahul, Dulinskas, Alexis, Gajera, Rinku, Hart, Joseph, Patel, Griva, Piedra, Carmelina, Sabady, Stacie, Schubert, Hannah, Thongsomjit, Papinya, Vandermolen, Douglas
Date: 2005-05, 2005-05
Description: The Communication Design Workshop is an IPRO and is cross-listed with this main campus program. The sponsor is Pace, a successful and forward...
Show moreThe Communication Design Workshop is an IPRO and is cross-listed with this main campus program. The sponsor is Pace, a successful and forward looking suburban Chicago bus company serving a six county market the size of Rhode Island. The focus of the workshop is to identify factors that will help Pace retain riders. Retention is a significant issue as it has direct financial implications and Pace does not know why they lose riders. Communication issues may be part of the retention problem. Pace will share existing research with us — we will extend and supplement this work.
Sponsorship: Pace
Deliverables for IPRO 321: Social Network Analysis for Pace Suburban Bus Stakeholders for the Spring 2005 semester
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Title: Pritzker Mediatheque: Bookclet
Creator: Song, Youkeun
Date: 5/4/2011, 2011-05
Description: This project is about Renovation of Pritzker Park with refurbishing an underutilized urban pocket park, by adding a public community facility.
...
Show moreThis project is about Renovation of Pritzker Park with refurbishing an underutilized urban pocket park, by adding a public community facility.
Sponsorship: Denison, Dirk
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Title: Solar Hydrogen Hybrid System (Semester 1 of Unknown), IPRO 301: Solar Hydrogen Hybrid System IPRO 301 IPRO Day Presentation Sp04
Creator: Alworth, Thomas, Bachmann, Matthew, Barraza, Esteban, Bednarz, Isabella, Carhill, Gabriel, Dunaway, Eric, Easley, Dylan, Lee, Donghoon, Lefief, Christina, Levinsky, Aaron, Massie, Dierre, Mccann, Sean, Nicklas, Jeremy, Okma, Carrie, Resurreccion, Karen, Ryu, Anna, Soorma, Luqman, Tudor, Rafael, Kustwin, Brian, Chowdary, Venakta
Date: 2004-10, 2004-03
Description: Design and implement a clean, energy-efficient bill board sign system.
Sponsorship: bp Solar, DCCA, ALCAD, ComEd, Proton Energy Systems, IIT
Del...
Show moreDesign and implement a clean, energy-efficient bill board sign system.
Sponsorship: bp Solar, DCCA, ALCAD, ComEd, Proton Energy Systems, IIT
Deliverables
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Title: Orthotics and Prosthetics in Latin America (Semester Unknown): OrthoticsAndProstheticsInLatinAmericaIPRO309ProjectPlanF09
Creator: Ashley, Trevor, Claxton, Matt, Conover, Stephen, Gotanco, Francis, Mathai, Alexander, Nizich, Adam, Park, Yong, Quikr, Kerry, Ray, Monmayuri, Vasquez, Raul
Date: 2009, 2009-12
Description: The overall goal of our IPRO team is to create a program for delivering orthotics and prosthetics that is sustainable. This will be...
Show moreThe overall goal of our IPRO team is to create a program for delivering orthotics and prosthetics that is sustainable. This will be accomplished by improving the quality of the product by increasing availability of funding, improving cost effectiveness of prosthetics, and promoting awareness of treatment available. Our IPRO team has divided the project into three separate subgroups: Business, Technical, and Impact.
Deliverables
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Title: PHYSICS-PRESERVING FINITE DIFFERENCE SCHEMES FOR THE POISSON-NERNST-PLANCK EQUATIONS
Creator: Flavell, Allen
Date: 2014, 2014-07
Description: The Poisson-Nernst-Planck equations are a system of nonlinear di erential equations that describe ow of charged particles in solution. This...
Show moreThe Poisson-Nernst-Planck equations are a system of nonlinear di erential equations that describe ow of charged particles in solution. This dissertation is about the design of numerical schemes to solve this system which preserves global properties exhibited by the system. There are two major advances presented. The rst is the design of schemes that conserve mass globally when the system is coupled with no- ux boundary conditions. Most notably, a scheme using central di erencing and TR-BDF2 achieves second order accuracy in both space and time, while also conserving global mass is presented. The second is the design of a more general scheme that preserves the time-varying properties of the free energy of the system. One such a scheme uses central di erencing in space and trapezoidal integration in time to achieve second order accuracy in both space and time, while also preserving the energy dynamics, but at the cost of requiring positivity of the solution. There is also a discussion of solution methods: the classic Newton iteration scheme is compared with a modi ed Gummel iteration scheme for the purpose of solving the transient equations. The intended application of this work is the modeling of ion channels, and many of the simulations presented use parameters consistent with models of ion channels.
Ph.D. in Applied Mathematics, July 2014
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Title: DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF VITAMINS A AND D IN FLUID MILK PRODUCTS
Creator: Li, Wenjing
Date: 2013, 2013-12
Description: Measurement of fortification levels for vitamins A and D in fluid milk products is required by the U.S. Food and Drug Administration (FDA)...
Show moreMeasurement of fortification levels for vitamins A and D in fluid milk products is required by the U.S. Food and Drug Administration (FDA) according to Pasteurized Milk Ordinance. In the current study, a high performance liquid chromatographic (HPLC) method was developed for simultaneous determination of retinyl palmitate (vitamin A) and cholecalciferol (vitamin D3) in fortified milk, which will enhance the efficiency of routine monitoring of fortification for processors as well as laboratories. Saponification conditions and extraction solution compositions were studies for best recovery and simplification of the extraction procedures. Saponification conditions studied included temperature (20, 40 and 60℃), time (0.5 to 16 hour) and concentration of KOH (20, 30, 40 and 50%). The variables studied for extraction included solvent compositions (hexane, diethyl ether, ethyl acetate and dichloromethane) and corresponding polarities (0.1, 0.25, 0.5 and 0.75), and number of extractions (once, twice and three times). Freezing and centrifuging steps were also investigated to compare to SPE clean-up, as an alternative method to clean-up before injection. The optimum parameters found were: saponification conditions at 60℃ for 2 hours with 40% (w/v) KOH liquid-liquid extraction with hexane: diethyl ether (80:20, v:v). Vitamins A and D3 were quantitated using an HPLC system with fluorescence detector (FLD) and diode array detector (DAD) respectively within the same injection. Spike recoveries from three different fat levels (skim, 2% and whole) of commercial pasteurized milk samples were in the range of 94 to 110% for both vitamins A and D3 at three spike concentration levels. In addition, at National Institute of Standards and Technology (NIST) Standard Reference Material (SRM 1849a) was used xii for method accuracy evaluation. With eight replicates, the average vitamin A (expressed as retinol equivalents) concentration was 7.52 ± 0.23 μg/g, vitamin D3 concentration was 0.114 ± 0.0062 μg/g, an excellent agreement with the certified value of 7.68 ± 0.23 μg/g for vitamin A and 0.11 ± 0.017 μg/g for vitamin D3. In summary, an HPLC method for simultaneous determination of vitamins A and D3 in fluid milk products has been developed. The method showed high efficiency and accuracy of analysis during a single laboratory validation.
M.S. in Food Safety and Technology, December 2013
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Title: OPTIMAL MATERIAL SELECTION MODEL FOR LEED CERTIFICATION USING GENETIC ALGORITHMS
Creator: Kim, Taehyoung
Date: 2012-12-16, 2012-12
Description: Material selection is an important part of building design because it has great impact on the environment, as buildings during/after...
Show moreMaterial selection is an important part of building design because it has great impact on the environment, as buildings during/after construction are responsible for a large portion of carbon emissions and use many resources and considerable energy. Selecting green materials is an emergent issue in both design firms and construction companies. Green building certification such as LEED systems originated from the desire to improve environmental, economic, financial, and social benefits. The current approach to material selection for sustainability is based only on the designer’s past experiences. An arbitrary approach based on subjective opinions causes unnecessary expense, longer construction duration, and failure to meet desired environmental goals. In order to help decision-makers with the selection of the right materials, this study proposes a model that uses Genetic Algorithms in MATLAB and that optimizes the desired points in LEED Certification within budget constraints. This model can be applied to any project that is pursuing LEED Certification. If the user specifies the desired LEED points, the system recommends the least expensive combination of materials extracted from a database containing detailed information about a large member of materials. The modified model uses multi-objective genetic algorithms to establish trade-off between budget constraints and LEED points. The proposed system is expected to be a useful tool for inexperienced designers and a valuable guideline for designers with extensive experience.
M.S. in Civil Engineering, December 2012
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Title: Planning the 21st Century Urban Farm: From High Rise to Neighborhood (sequence unknown), IPRO 336 - Deliverables
Creator: Bhatti, Talha, Binet, Adrien, Bredau, Jason, Chen, Emily, Davis, Jacob, Gaonkar, Gaurav, Garcia, Raul, Guerrero, Fernando, Gulling, Richard, Kagehiro, Michael, Moshfeghian, Elnaz, Nunez-gimeno, Jose, Phillips, Zachary, Plumb, Isaac, Ryan, Emily, Skaggs, Jake, Sobon, Konrad, Valmores, Travis
Date: 2009-12
Description: The purpose of this IPRO is to establish a strong foundation for the future of urban agriculture. The growing problems regarding the...
Show moreThe purpose of this IPRO is to establish a strong foundation for the future of urban agriculture. The growing problems regarding the traditional methods of agriculture, and the rate of growth of the world population, the team plans to design a method to grow food more efficiently and economically in urban areas. The team is looking at large, industrial warehouse-type buildings that have outlived their primary use, and creating a plan that utilizes these buildings to grow enough food for the surrounding communities.
Sponsorship: John Edel of Bubbly Dynamics, LLC
Deliverables for IPRO 336: Planning the 21st Century Urban Farm: From High Rise to Neighborhood for the fall 2009 semester
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Title: BUOY (Semester Unknown) IPRO 310: BUOYIPRO310Brochure2Sp09
Creator: Baar, Coleman, Freund, Ryan, Kruse, Kevin, Li, Li, Ma, Zhi, Murdock-barriball, Meghan, Ng, Man, Rehman, Mohammed, Reilly, Jeffrey, Turrentine, Lorne, Yew, Hsuen, Zhang, Bingjian
Date: 2009, 2009-05
Description: The problem posed with blind and visually impaired (BVI) swimmers is one of safety and independence. BVI individuals need to be able to...
Show moreThe problem posed with blind and visually impaired (BVI) swimmers is one of safety and independence. BVI individuals need to be able to orientate themselves in a swimming pool and avoid obstructions like lane-lines, pool walls and other swimmers for a safe experience. Additionally, it is important to BVI swimmers to maintain their independence and maintain a low profile during this experience. The Buoy team will focus on the design, testing and implementation of assistive technology focused on a pool environment with continuous input and feedback from the BVI community. A current passive device created in previous IPROs will be field-tested in a BVI pool for the semester in order to identify failure-modes of the device and collect real-world BVI user feedback to discover areas for improvement. Additionally, two groups have been organized to assess the use of invisible-fence and ultrasound technology in the creation of new assistive technology. Surveys and interviews will be conducted with the BVI community on a continuous basis to ensure the Buoy team is meeting the needs of the market.
Deliverables
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Title: Small Town Sustainable Economic Development Feasibility of a Biochar System in Orange, Massachusetts (Semester Unknown) IPRO 350: SmallTownSustainableEconomicDevelopmentIPRO350FinalPresentationSp11
Creator: Adejinle, Remi, Butail, Gokul, Cosenza, Samantha, Graaff, Tillman De, Futagami, Takahiro, Hinshaw, Ben, Khan, Asfandyar, Latour, Catherine, Lee, Brandon, Stewart, Dashiell, Wang, Yani
Date: 2011, 2011-05
Description: The purpose of the team is to design a model of a sustainable waste management system for the town of Orange, Massachusetts. We seek to foster...
Show moreThe purpose of the team is to design a model of a sustainable waste management system for the town of Orange, Massachusetts. We seek to foster the economic attractiveness and vitality of the town by designing a better and more sustainable way to manage the town’s waste.
Sponsorship: Town of Orange, Massachusetts
Deliverables
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Title: Kalleidos (Spring 2011) IPRO 303: KalleidosIPRO303ProjectPlanSp11_redacted
Creator: Rakauskaite, Ausrine, Siver, Ben, Pyrkh, Hanna, Kovacs, Hilary, Jewell, John, Jin, Keojin, Arroyo, Marcos, Michael, Mark, Koto, Melanie, Curran, Morgan, Kushaare, Rishi, Ri, Sujin, Liu, Xiaochen
Date: 2011, 2011-05
Description: “Over the last few years there has been an explosion of different websites that allow average person to contribute different content such as...
Show more“Over the last few years there has been an explosion of different websites that allow average person to contribute different content such as pictures, comments, stories and reviews about places around them. While there are many companies that focus on aggregating such data into common stream - complexity of interpreting such data in a meaningful actionable way remains a challenge for many companies including NAVTEQ.” [Appendix B]  Identify new content from real time feeds which include 1. Points of Interest and their attribution (e.g. Hours of Operation, Languages Spoken at locale, etc…) 2. Any associated content (e.g. events, relationships to other Points of Interest (e.g. same owner, etc…)  Create visualizations based on this content - some basic examples could include 1. Hot/Not So Hot real estate areas (new construction, sales) based on agent and broker social media updates 2. High/Low crime areas based on social media stream 3. Hot/Not city zones based on number of people tweeting/updating Facebook/checking in/etc… in certain areas, parties, POIs.
Sponsorship: NAVTEQ
Deliverables
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Title: Insight: Anticipating the Future, Assessing the Impact (semester?), IPRO 341: Insight IPRO 341 IPRO Day Presentation F06
Creator: Bastyzyk, Marta B., Hernandez, Jose, Kim, Tae Young, Lerash, Kevin, Lybolt, Crystal, Seatton, Brandon, Skontos, George, Sopko, Tyge, Vaks, Nir, Agan, Amber, Boone, Elizabeth, Buente, Adam, Coleman, Jessica, Gerding, Eric, Glass, Andrew, Goyak, Matt, Holt, Nicole, Mullendore, Jessica, Perchlik, Emily, Ripley, Paul
Date: 2006-12, 2006-12
Description: IPRO 341’s objective is to extensively research and evaluate the societal, economical and environmental implications of nanotechnology-based...
Show moreIPRO 341’s objective is to extensively research and evaluate the societal, economical and environmental implications of nanotechnology-based products, mainly building materials, and detail the possible obstacles in integration of this technology into design, public policy issues and general public engagement
Deliverables for IPRO 341: Insight: Anticipating the Future, Assessing the Impact for the Fall 2006 semester
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Title: Assisting Cardiac Arrest Patients (Semester Unknown) IPRO 319: Assisting Cardiac Arrest Patients IPRO 319 Final Presentation F08
Creator: Alemayehu, Matti, Bunce, Alex, Jessica, Shaw, Toe, Myint, Untiveros, Gustavo, Zhang, Caidi, Jose, Jerry, Butkovich, Paul, Cosenza, Matthew, Martin, Rebecca
Date: 2008, 2008-12
Description: Sudden Cardiac Arrest is a leading cause of death in the United States, accounting for an estimated 325,000 deaths each year according to the...
Show moreSudden Cardiac Arrest is a leading cause of death in the United States, accounting for an estimated 325,000 deaths each year according to the Heart Rhythm Foundation. Cardiac arrest is different from a typical heart attack because it involves a complete stopping of the heart. Brain injury is likely to occur if the cardiac arrest is untreated for more than 5 minutes and a person cannot be revived after 10 minutes of no action. This is because the arrest sets off a chain of metabolic reactions, which leads to swelling of the brain tissue. Cardiac arrest results in ischemia reperfusion injury, which is when circulation is restored and high levels of oxygen rich blood rushes back into the brain causing brain damage. Decreasing the metabolism of the victim may result in a decrease of ischemia reperfusion injury. Reducing the oxygen level that enters the body when the victim revives and slowly increasing this level may also reduce reperfusion injury. However, current procedures dictate that 100% oxygen be given to cardiac arrest victim.
Deliverables
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Title: Alumni Memorial Hall Renovation (Semester Unkown) IPRO 335: Alumni Memorial Hall Renovation IPRO 335 Final Presentation Sp08
Creator: Denney, Thomas, Ericksen, Michael, Forkan, Garret, Healy, Kieran, Hong, Ei Sheng, Kim, Yong-wan, Kirk, Justin, Ontiveros, Adrian Jesus, Rogers, Eric, Roth, Nathaniel, Sharadendu, Dipti, Sissala, Amy, Warner, Alexander, Weston, Brad
Date: 2008, 2008-05
Description: The scope of I-Pro 335 is both a conclusion to unfinished work from the previous two semesters along with new projects that will start and end...
Show moreThe scope of I-Pro 335 is both a conclusion to unfinished work from the previous two semesters along with new projects that will start and end this semester. Work to be concluded and closed-out from last semester:  Final LEED (Leadership in Energy and Environmental Design) documentation and identification of individuals that might be part of a LEED team should the school desire to pursue that route.  Final design of Americans with Disabilities Act (A.D.A.) elements including a re-design of the elevator, and approval by the client.  Using the Code of Ethics written last semester as a base line, the code will be rewritten to strengthen its objective to provide guidance for the I-Pro. New projects to begin and completed this semester are:  The roof re-design- Green roof options. This may also include storm water retention and grey water recycling systems, as well as any updates to the buildings primary plumbing systems.  Heating, Ventilation, and Air Conditioning (HVAC) - Lab hoods, air conditioning load calculations and Hydronic Heating.  Electrical systems design- Illumination calculations and design, Alarm systems, and ‘Off-heating’ load calculations from equipment to be housed in Alumni Memorial Hall (A.M.H.).  Construction schedule.  Cost estimate.
Deliverables
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Title: Large Scale Structure Design (Semester Unknown) IPRO 315
Creator: Brady, Brian, Butkovich, Paul, Chung, Chun, Dominikowski, Marek, Herbert, Greg, Hussaini, Muddasir, Magdel, Irina, Mallinger, Nicolle, Omeralovic, Enis, Palma, Jennifer, Rathakrishnan, Malar, Ratnani, Shoaib, Russeva, Diyana, Russo, Ben, Shim, Mary, Sisay, Mary, Varhegyi, Aron, Velichekov, Veselin
Date: 2008, 2008-05
Description: The plan for this IPRO is to develop a design for a large scale parking garage that can accommodate about 500 cars. The objective of this...
Show moreThe plan for this IPRO is to develop a design for a large scale parking garage that can accommodate about 500 cars. The objective of this project is to develop a design that goes beyond the standard parking systems used today. Rather, the attempt is to have a design which is more representative of “parking garages of future.” And as such, such features as quick handling of incoming and outgoing cars, efficiency in storage and aesthetics are considered in design. The building will be completely self-sufficient and will have to incorporate the architecture of the various buildings on campus. The design could have separate entrance and exit ramp towers, ramps incorporated with parking, or the futuristic design may be automated. An automated system will include a vehicle elevator of lift system to move the vehicle so the driver does not have to. The structure could be built with reinforced concrete or steel. The design will also include accessibility following the requirements set forth in the Americans with Disabilities Act.
Deliverables
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Title: Interdisciplinary Design Education And Strategy (Semester Unknown) IPRO 301: InterdisciplinaryDesignEducationAndStrategyIPRO301Poster1Su09
Creator: Scanlon, Ed, Brierley, Philip, Choe, Mihee, Cornelius, Joel, Hansen, Kai, Horozova Nalls, Gergana, Hussain, Faraz, Krupp, Kevin, Laurence, Alexis, Lucchesi, Kristin, Mceneff, Aaran, Natale, Vito, Nikamalfard, Mehrdad, Phillips, Timothy, Radtke, Dennis, Robledo, Ruben, Workman, Jessica, Valadez, Julia
Date: 2009, 2009-07
Description: For years, the IPRO Program at IIT has been forced to operate wherever space can be found. Often, facilities are not equipped for the needs of...
Show moreFor years, the IPRO Program at IIT has been forced to operate wherever space can be found. Often, facilities are not equipped for the needs of the program. It has become necessary to find a way to give the IPRO Program its own dedicated space. If we give the program its own space, then what is needed in that space? What needs to be done with it? What types of spaces are necessary? What technologies will be used? IPRO 301 exists to answer these questions. We will provide ideas to IIT that can solve these problems. ii
Deliverables
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Title: Using Infrared Imaging to Monitor and Control Welding
Creator: Bangs, Edmund R., Longinow, Nicholas E., Blaha, James R.
Date: 2009-05-08, 1989-10-31
Description: The technique and arrangement of distributed, real time, intelligent control of welding including IR detection and measurement of process...
Show moreThe technique and arrangement of distributed, real time, intelligent control of welding including IR detection and measurement of process conditions, and controlling process parameters in view of a knowledge base including a predetermined rule set for interpreting the results of IR detection. The arrangement includes a multilevel communication scheme internally and between hardware nodes of the arrangement, and the data-driven scheduling of inference processes under direction of a semantic network.
Sponsorship: IIT Research Institute
United States Patent
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