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- Title
- Orthotics and Prosthetics in Latin America (sequence unknown), IPRO 309 - Deliverables
- Creator
- Ashley, Trevor, Claxton, Matt, Conover, Stephen, Gotanco, Francis, Mathai, Alexander, Nizich, Adam, Park, Yong, Quikr, Kerry, Ray, Monmayuri, Vasquez, Raul
- Date
- 2009-12
- Description
-
The overall goal of our IPRO team is to create a program for delivering orthotics and prosthetics that is sustainable. This will be...
Show moreThe overall goal of our IPRO team is to create a program for delivering orthotics and prosthetics that is sustainable. This will be accomplished by improving the quality of the product by increasing availability of funding, improving cost effectiveness of prosthetics, and promoting awareness of treatment available.
Deliverables for IPRO 309: Orthotics and Prosthetics in Latin America for the fall 2009 semester.
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- Title
- A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 IPRO Day Presentation F09
- Creator
- Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
- Date
- 2009-12
- Description
-
Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
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- Title
- DETECTING GNSS SPOOFING ATTACKS USING INS COUPLING
- Creator
- Tanil, Cagatay
- Date
- 2016, 2016-12
- Description
-
Vulnerability of Global Navigation Satellite Systems (GNSS) users to signal spoofing is a critical threat to positioning integrity, especially...
Show moreVulnerability of Global Navigation Satellite Systems (GNSS) users to signal spoofing is a critical threat to positioning integrity, especially in aviation applications, where the consequences are potentially catastrophic. In response, this research describes and evaluates a new approach to directly detect spoofing using integrated Inertial Navigation Systems (INS) and fault detection concepts based on integrity monitoring. The monitors developed here can be implemented into positioning systems using INS/GNSS integration via 1) tightly-coupled, 2) loosely-coupled, and 3) uncoupled schemes. New evaluation methods enable the statistical computation of integrity risk resulting from a worst-case spoofing attack – without needing to simulate an unmanageably large number of individual aircraft approaches. Integrity risk is an absolute measure of safety and a well-established metric in aircraft navigation. A novel closed-form solution to the worst-case time sequence of GNSS signals is derived to maximize the integrity risk for each monitor and used in the covariance analyses. This methodology tests the performance of the monitors against the most sophisticated spoofers, capable of tracking the aircraft position – for example, by means of remote tracking or onboard sensing. Another contribution is a comprehensive closed-loop model that encapsulates the vehicle and compensator (estimator and controller) dynamics. A sensitivity analysis uses this model to quantify the leveraging impact of the vehicle’s dynamic responses (e.g., to wind gusts, or to autopilot’s acceleration commands) on the monitor’s detection capability. The performance of the monitors is evaluated for two safety-critical terminal area navigation applications: 1) autonomous shipboard landing and 2) Boeing 747 (B747) landing assisted with Ground Based Augmentation Systems (GBAS). It is demonstrated that for both systems, the monitors are capable of meeting the most stringent precision approach and landing integrity requirements of the International Civil Aviation Organization (ICAO). The statistical evaluation methods developed here can be used as a baseline procedure in the Federal Aviation Administration’s (FAA) certification of spoof-free navigation systems. The final contribution is an investigation of INS sensor quality on detection performance. This determines the minimum sensor requirements to perform standalone GNSS positioning in general en route applications with guaranteed spoofing detection integrity.
Ph.D. in Mechanical and Aerospace Engineering, December 2016
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- Title
- Widget Applications to Enhance the Tru2Way Consumer Experience (sequence unknown), IPRO 312 - Deliverables: IPRO 312 Project Plan F09
- Creator
- Alsharief, Yagoob, Aulfata, Muluken, Curtis, Christopher, Dhewaju, Anusuya, Mooney, Kevin, Mutyaba, Kevin, Ndoping, Marco, Onaissi, Samah, Peterson, Naomi, Siwek, Steven, Wallace, Sean, Yi, Won-jae
- Date
- 2009-12
- Description
-
The IPRO teams objectives are to provide Comcast with feedback from an outside perspective, allowing them to see where their Tru2Way system...
Show moreThe IPRO teams objectives are to provide Comcast with feedback from an outside perspective, allowing them to see where their Tru2Way system needs additional attention or support.
Sponsorship: Comcast
Deliverables for IPRO 312: Widget Applications to Enhance the Tru2Way Consumer Experience for the fall 2009 semester
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- Title
- Cure for the IKIA Syndrome : presented at IACRL 2008 conference: List of failures
- Creator
- Uth, Charles, Link, Jeanne
- Date
- 2008-02
- Description
-
Informal observations of a practical and creative approach piloting Blended Library Instruction for undergraduate Civil Architecture and...
Show moreInformal observations of a practical and creative approach piloting Blended Library Instruction for undergraduate Civil Architecture and Engineering students, in collaboration with faculty. At Illinois Institute of Technology students don’t receive library instruction as a required class or in tandem with a composition class. Faculty will schedule one-time sessions, which ideally should be planned with a class assignment in mind, but students are rarely engaged with a one time instruction. Many have IKIA syndrome or I Know It Already syndrome. The Millennials are a group that has integrated technology into every aspect of their lives and they assume that retrieving useful or necessary information will be easy. When they discover this isn’t the case lack of time, heightened anxiety, and increased frustration can prevent them from doing their best work. By intentionally creating a similar crisis prior to library instruction, students were more interested in what they stood to gain during pending library instruction. In this presentation we will discuss: 1) A creative means of delivering library instruction to a traditionally challenging population: engineering undergraduate students 2) Qualitative information collected via multiple assignments and interpreted in a quantitative fashion, as well as our observations. 3) A method for preparing students for library instruction that can be applied in almost any discipline without asking the instructor to sacrifice class time.
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- Title
- Optimal Behavior Modeling and Analysis of Electricity Market Participants
- Creator
- Li, Jie
- Date
- 2012-04-27, 2012-05
- Description
-
n restructured electricity power markets, competition among market participants is a key issue of concern for both the ISO (Independent System...
Show moren restructured electricity power markets, competition among market participants is a key issue of concern for both the ISO (Independent System Operator) and the market participants themselves. This dissertation analyzes the market behavior of both the generation side and demand side participants, and provides solution guidelines for devising effective competition strategies for market players’ profit maximization objectives. Generation side is the most competitive part in the electricity market with the unbundling of generation, transmission and distribution. Acting as self-interested entities, GENCOs (Generation Companies) are seeking effective and computationally efficient methodology for generation resource scheduling, while keeping its financial risks at acceptable levels when constituting bidding strategies. To help GENCOs achieve such goal, this dissertation propose a game theory based supply function like bidding model to construct the optimal bidding strategies for GENCOs in both energy and ancillary service markets. On the demand side, demand participation in the electricity market has already been advocated for a long time for its benefit to the entire market and the society as a whole. This dissertation focuses on a specific large electricity consumer type – Internet Data Center (IDC). By analyzing the unique energy consumption pattern for different IDC applications, this dissertation devises effective electric demand management solution for IDCs to conserve electricity energy consumption and cut electric bill, and quantifies the demand response effect of IDC on the electricity market.
Ph.D. in Electrical Engineering, May 2012
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- Title
- Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry (sequence unknown), IPRO 333 - Deliverables
- Creator
- Bonesz, Andrew, Clark, Howard, Douglas, Carlie, Gajdorus, Michael, Gottschall, Keenan, Hendricks, Rachel, Kimball, Clayton, Linares, Jared, Marks, Paul, Mellom, James, Oblenida, Cindy, Pop, Sabina, Stelcel, Carl, Young, Jeremy, Zhou, Raymond
- Date
- 2009-12
- Description
-
The primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the...
Show moreThe primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the resources of the Museum of Science and Industry (MSI) in Chicago. This partnership endeavors to help the museum's Fabrication Laboratory (Fab Lab) maximize its potential as a resource for museum guests, young and old, as well as for IIT students, staff, and faculty.
Sponsorship: Museum of Science and Industry. Steven Willis- Director, Fabrication Lab
Deliverables for IPRO 333: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry for the fall 2009 semester
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- Title
- Statistical monitoring of multivariable dynamic processes with state-space models
- Creator
- Negiz, A., Cinar, A.
- Date
- 1997-08
- Publisher
- AMER INST CHEMICAL ENGINEERS
- Description
-
Industrial continuous processes may have a large number of process variables and are usually operated for extended periods at fixed operating...
Show moreIndustrial continuous processes may have a large number of process variables and are usually operated for extended periods at fixed operating points under closed-loop control, yielding process measurements that are autocorrelated, cross-correlated and collinear. A statistical process monitoring (SPM) method based on multivariate statistics and system theory is introduced to monitor the variability of such processes. The statistical model that describes the in-control variability is based on a canonical-variate (CV) stare-space model that is an equivalent representation of a vector autoregressive moving-average rime-series model. The CV state variables obtained from the state-space model are linear combinations of the past process measurements that explain the variability of the future measurements the most. Because of this distinctive feature, the CV state variables are regarded as the principal dynamic directions A T-2 statistic based on the CV state variables is used for developing an SPM procedure. Simple examples based on simulated data and an experimental application based on a high-temperature short-time milk pasteurization process illustrate advantages of the proposed SPM method.
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- Title
- Particle production sources in heavy ion collisions at RHIC and LHC, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
- Creator
- Wolschin, Georg
- Date
- 2013-09-15, 2013-09-15
- Publisher
- IIT Press
- Description
-
A nonequilibrium statistical relativistic diffusion model (RDM) with three sources is applied to the analysis of charged-hadron distributions...
Show moreA nonequilibrium statistical relativistic diffusion model (RDM) with three sources is applied to the analysis of charged-hadron distributions in Au–Au collisions at RHIC energies, in Pb–Pb collisions at the current LHC energy of 2.76 TeV, and in p–Pb at 5.02 TeV. The relative sizes of the particle production sources at RHIC and LHC energies are investigated in pseudorapidity space as functions of incident energy. The midrapidity source that arises mostly from gluon-gluon collisions becomes more important than the fragmentation sources as the energy increases from RHIC to LHC.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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- Title
- Development and Application of an Occupational Odor Hazard Index
- Creator
- Wang, Tingting
- Date
- 2011-04-24, 2011-05
- Description
-
Odors emitted from wastewater treatment and sludge processing facilities may lead to employee complaints regarding discomfort, stress or...
Show moreOdors emitted from wastewater treatment and sludge processing facilities may lead to employee complaints regarding discomfort, stress or disease, and affect productivity and worker turnover in Water Reclamation Plants (WRPs). This study reports and assesses a comprehensive method that estimates the odor perception and associated hazards from exposures to odors in a post-digestion dewatering building in a WRP and its vicinity areas. An Odor Reference Concentration (ORfC) is developed as an index of acceptable odor level. This index is applied to ensure that the majority of building occupants (80 percent or more) do not perceive the odor. This index is developed to fill the lack of a uniform standard and method to assess hazard of exposed individuals to odors in occupational environments and to regulate odor exposures.A comprehensive odor and odorant concentration database was formulated by a monitoring study in the occupational environment of a post-digestion dewatering building. The presence of odorants in the building are at concentrations below occupational exposure limits but higher than odor detection threshold values. This finding indicates that reducing odorant concentrations below exposure limits does not assure an odor-free environment. A model is formulated and validated for this dewatering building associating odor perception with concentrations of total sulfur compounds and relative humidity and is used for prediction of indoor odor concentrations under various conditions. Odor and odorant emission rates as the strength of sources are input variables of the indoor air quality model. In this study, odor and odorant emission rates from freshly dewatered biosolids in a dewatering building were measured using two widely used dynamic methods: the USEPA flux chamber and wind tunnel, and results from the two methods are not significantly different. Comparison of the two methods indicates that both methods can be used to estimate odor and odorant emission rates but the most effective and efficient method depends on prevailing environmental conditions. The ORfC established based on the comprehensive odor and odorant concentration database for this dewatering building is 13D/T (dilution to threshold). This index is used to evaluate seven control strategies recommended to reduce odor levels. If indoor odor concentrations in the occupational environment exceed the ORfC, then the hazard of odor exposures is unacceptable. Deterministic results of this study indicate that if appropriate control strategy is applied, odor concentration in the dewatering building would reach to below levels that cause unnecessary stress and other effects. The control strategy focus of this work is reduction of the indoor odor perception. But indoor control strategies must not cause outdoor odor problems to surrounding residential areas. Therefore, the potential impact of the control strategy recommended is also investigated in this thesis using the US EPA recommended air dispersion modeling AERMOD. Predictions of hydrogen sulfide concentrations at surrounding areas of the plant indicate that only one strategy, which proposes to add a new exhaust system in the dewatering building, would cause the ambient hydrogen sulfide concentration to be 7% higher than the odor detection threshold; other six strategies would not induce odor annoyance to surrounding areas. Acute and long-term ambient hydrogen sulfide exposure limits based on human health and irritation effects would not be violated under any of the seven control strategies.
Ph.D. in Environmental Engineering, May 2011
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- Title
- Church & School Energy Efficiency and Financing Program (sequence unknown), IPRO 328 - Deliverables: IPRO 328 Final Report F09_redacted
- Creator
- Ciuffini, Kathryn, Kim, Ja Young, Knapczyk, Robert, Mckinley, Matthew, O'brien, Patrick, Maddamma, Todd, Schafer, Michael, Soderling, Philip, Wedster, Bonnie
- Date
- 2009-12
- Description
-
The Fall 2009 IPRO 328 team envisions the development and ultimately execution of a volunteer program which would facilitate the...
Show moreThe Fall 2009 IPRO 328 team envisions the development and ultimately execution of a volunteer program which would facilitate the implementation of energy saving improvements in a church and/or parochial school within the surrounding neighborhoods of IIT campus.
Sponsorship: Vince Cushing of Clean Urban Energy
Deliverables for IPRO 328: Church & School Energy Efficiency and Financing Program for the fall 2009 semester
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- Title
- Cessation of Screech in Underexpanded Jets
- Creator
- Raman, G.
- Date
- 1997-04-10
- Publisher
- Cambridge Univ Press
- Description
-
In significantly underexpanded jets, screech inherently ceases to exist. This paper studies screech cessation in a supersonic rectangular jet...
Show moreIn significantly underexpanded jets, screech inherently ceases to exist. This paper studies screech cessation in a supersonic rectangular jet and provides an explanation for its occurrence. Experimental data are presented for fully expanded Mach numbers, M-j, ranging from 1.1 to 1.9. Screech becomes unsteady beyond M-j = 1.65 and ceases to exist beyond M-j = 1.75. The reason for this cessation has remained a mystery, and this paper examines three suspects: (i) the theory of a frequency mismatch between screech tones and the band of the most-amplified jet instability waves, (ii) the notion that Mach disk formation disrupts the shock-cell structure and weakens the screech-producing shocks, and (iii) the idea that acoustic feedback and receptivity diminish at high levels of underexpansion. A thorough interrogation of experimental data shows that (i) is not the main cause of screech cessation here, (ii) plays an insignificant role, and (iii) appears to have been largely responsible for screech cessation. Cessation occurs because feedback to the jet lip is diminished due to excessive expansion of the jet boundary. Further, since the jet lip now reflects and scatters low intensity sound, the end result is poor receptivity at the initial shear layer. This theory is substantiated by the re-activation of screech when the nozzle lip thickness is made larger than the expanded jet boundary. Finally, increasing lip thickness is seen to produce a systematic shift (to higher M-j) of the onset of cessation. The results of this study are of direct relevance to the sonic fatigue problem in aircraft structures, because understanding screech helps prevent such damage.
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- Title
- Interactive Urban Landmark Kiosks for Memorial Walk of Martin Luther King (sequence unknown), IPRO 314 - Deliverables: IPRO 314 IPRO Day Presentation F09
- Creator
- O’leary, Kevin, Petty, Sonya, Qi, Tianshu, Tan, Sophia, Noor, Nashrah, Schleich, Kenneth, Akhtar, Ayesha, Cheng, Eric, Kim, James, Parker, Joseph, Saha, Sougata
- Date
- 2009-12
- Description
-
The objective of this IPRO is to help the students of Gage Park H.S. bring their vision of a memorial to a historical event into existence.
Spo...
Show moreThe objective of this IPRO is to help the students of Gage Park H.S. bring their vision of a memorial to a historical event into existence.
Sponsorship: Gage Park High School
Deliverables for IPRO 314: Interactive Urban Landmark Kiosks for Memorial Walk of Martin Luther King for the fall 2009 semester.
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- Title
- INVESTIGATION OF ANION EXCHANGE MEMBRANES FOR ELECTROCHEMICAL ENERGY CONVERSION AND STORAGE SYSTEMS
- Creator
- Wang, Lihui
- Date
- 2017, 2017-05
- Description
-
The alkaline stability of poly (arylene ether) backbones in anion exchange membranes (AEMs) derivatized with quaternary benzyl N, N-...
Show moreThe alkaline stability of poly (arylene ether) backbones in anion exchange membranes (AEMs) derivatized with quaternary benzyl N, N- dimethylhexylammmonium (DMH+) and trimethylammonium (TMA+) cation groups were investigated in poly (2,6- dimethyl 1,4-phenylene) oxide (PPO) and Udel® polysulfone (PSF) polymers. Previous studies have demonstrated that quaternary ammonium and phosphonium groups trigger backbone degradation in commercially available poly (arylene ether)-based AEMs, despite the base polymers’ resilience to alkaline solutions. Herein, I demonstrate that the electron withdrawing or donating character in the poly (arylene ether) backbone ultimately dictates whether the prepared AEMs will become brittle in alkaline media due to cation-triggered backbone degradation (Arges, Parrondo, Johnson, Nadhan, & Ramani, 2012a; Christopher G. Arges, Lihui Wang, Javier Parrondo, & Vijay Ramani, 2013). Mitigation of cation-triggered backbone degradation was only achieved when electron withdrawing substituents (not including the cation), such as sulfone or bromine, were eliminated from the polymer backbone (or, alternately, when electron donating groups were present). Hence, PPO AEMs prepared through chloromethylation, rather than free radical bromination, were resistant to backbone hydrolysis in alkaline media because each cation-functionalized repeat unit had two electron-donating methyl groups rather than a single methyl group. This study presents some design rules for preparing mechanically stable poly (arylene ether) AEMs from low cost, commercially available polymers for alkaline electrochemical devices.
Ph.D. in Chemical Engineering, May 2017
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- Title
- Study of pp interactions at high multiplicity at U-70, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
- Creator
- Aleev, A., Avdeichikov, V., Balandin, V., Borzunov, Yu., Chencov, Yu., Dunin, V., Furmanec, N., Kekelidze, G., Kireev, V., Kokoulina, E., Ladygin, V., Myalkovsky, V., Nikitin, V., Peshehonov, V., Petukhov, Yu., Rufanov, I., Yukaev, A., Zhidkov, N., Basiladze, S., Bogdanova, G., Erofeeva, I., Grishin, N., Grishkevich, Ya., Karmanov, D., Kramarenko, V., Leflat, A., Merkin, M., Popov, V., Tihonova, L., Vishnevskaya, A., Volkov, V., Voronin, A., Zverev, E., Ardashev, E., Afonin, A., Golovkin, V., Golovnya, S., Gorokhov, S., Kholodenko, A., Kiryakov, A., Kurchaniniv, L., Lobanov, I., Lobanova, E., Mitrofanov, G., Petrov, V., Pleskach, A., Polkovnikov, M., Ronzhin, V., Ryadovikov, V., Senko, V., Soldatov, M., Shalanda, N., Tsyupa, Yu., Vorobiev, A., Yakimchuk, V., Zapolsky, V., Kutov, A.
- Date
- 2013-09-15, 2013-09-15
- Publisher
- IIT Press
- Description
-
The E190 Experiment is aimed at the search for collective phenomena in a quark-gluon system and a hadron system. It is carried out at U-70 in...
Show moreThe E190 Experiment is aimed at the search for collective phenomena in a quark-gluon system and a hadron system. It is carried out at U-70 in IHEP, Protvino. The evidence of Bose-Einstein condensation of pions has been confirmed with a twofold increasing of sampling at a level of 7 standard deviations. We study soft photon (smaller than 60 MeV) yield by using of an electromagnetic calorimeter with low energy threshold. In the gluon dominance model we explain multiparticle production by the active gluons. In this model the estimation of the contribution of charge exchange has been obtained.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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- Title
- Power Measurement for Road Bicycles: Towards a Universal Solution (sequence unknown), IPRO 324 - Deliverables: IPRO 324 Project Plan F09_redacted
- Creator
- Adrianzen, Luis, Allen, Ross, Antonio, Chris, Callan, Mark, Claxton, Sara, Diesse, Patrick, Gaylord, Matthew, Herbert, Greg, Shaffer, Dan, Wegrzyn, Celeste
- Date
- 2009-12
- Description
-
The goal of the IPRO is to try to find an inexpensive, but accurate way of measuring the power output of a rider on a bicycle. Problems with...
Show moreThe goal of the IPRO is to try to find an inexpensive, but accurate way of measuring the power output of a rider on a bicycle. Problems with systems currently available are: some products are not compatible with all bike systems causing the need to purchase new parts, the cost of the available products is expensive, and some of the available measuring systems are not very accurate.
Deliverables for IPRO 324: Power Measurement for Road Bicycles: Towards a Universal Solution for the fall 2009 semester
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- Title
- HACCP with multivariate process monitoring and fault diagnosis techniques: application to a food pasteurization process
- Creator
- Tokatli, F., Cinar, A., Schlesser, J. E.
- Date
- 2005-06
- Publisher
- ELSEVIER SCI LTD
- Description
-
Multivariate statistical process monitoring (SPM), and fault detection and diagnosis (FDD) methods are developed to monitor the critical...
Show moreMultivariate statistical process monitoring (SPM), and fault detection and diagnosis (FDD) methods are developed to monitor the critical control points (CCPs) in a continuous food pasteurization process. Multivariate SPM techniques effectively use information from all process variables to detect abnormal process behavior. Fault diagnosis techniques isolate the source cause of the deviation in process variable(s). The methods developed are illustrated by implementing them to monitor the critical control points and diagnose causes of abnormal operation of a high temperature short time (HTST) pasteurization pilot plant. The detection power of multivariate SPM and FDD techniques over univariate SPM techniques is shown and their integrated use to ensure the product safety and quality in food processes is demonstrated.
Endnote format citation for DOI:10.1016/j.foodcont.2004.04.008
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- Title
- Ozone Delivery System Binder
- Creator
- Cooper, Kerri, Lee, Alvin, Slade, Peter
- Date
- 2010-09-10T18:51:34Z
- Description
-
Development and validation of the Ozone Delivery System
- Title
- Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry (sequence unknown), IPRO 333 - Deliverables: IPRO 333 Final Report F09
- Creator
- Bonesz, Andrew, Clark, Howard, Douglas, Carlie, Gajdorus, Michael, Gottschall, Keenan, Hendricks, Rachel, Kimball, Clayton, Linares, Jared, Marks, Paul, Mellom, James, Oblenida, Cindy, Pop, Sabina, Stelcel, Carl, Young, Jeremy, Zhou, Raymond
- Date
- 2009-12
- Description
-
The primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the...
Show moreThe primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the resources of the Museum of Science and Industry (MSI) in Chicago. This partnership endeavors to help the museum's Fabrication Laboratory (Fab Lab) maximize its potential as a resource for museum guests, young and old, as well as for IIT students, staff, and faculty.
Sponsorship: Museum of Science and Industry. Steven Willis- Director, Fabrication Lab
Deliverables for IPRO 333: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry for the fall 2009 semester
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- Title
- THE EFFECT OF FLOW ON MICROPARTICLE TRANSPORT AND THE ROLE OF MICROPARTICLES IN THROMBOSIS
- Creator
- Lee, Ying-hui
- Date
- 2012-11-27, 2012-12
- Description
-
Elevated monocyte/macrophage-derived microparticles (MPs) have been found to correlate with thrombotic complications. These MPs carry tissue...
Show moreElevated monocyte/macrophage-derived microparticles (MPs) have been found to correlate with thrombotic complications. These MPs carry tissue factor (TF), the principal coagulation pathway initiator, as their parental cells and expose anionic phospholipid phosphatidylserine (PS), which can promote thrombin generation and fibrin formation. During thrombus development, MPs may be delivered to the injured/dysfunctional vascular endothelium or biomaterial surfaces and influence the process of thrombosis. MPs are submicron membrane vesicles that may have increased transport and/or binding capabilities compared to platelets or other cell types due to their decreased size and their higher Brownian diffusion. MPs and their surface molecules can be delivered to surfaces, either biological or prosthetic, and alter the local environment. Little is known of the mechanisms by which MPs are transported to and impart their biological activity on surfaces, especially in blood. Such a transfer of activity will depend on the ability of MPs to be transported to the surface, the strength of adhesion of the MPs on the surface and the nature of the activity/host interaction. In the present study, physical and biological properties of MPs generated from macrophage-like cell lines by endotoxin stimulation were characterized, the transport of MPs to surface by flow was investigated, and the import biological activity on surfaces was elucidated. We observed that the deposition of MPs suspended in buffer on glass surfaces was strongly shear-dependent using a well-defined parallel plate flow chamber. The diffusivity coefficients of MPs at shear rate ranges ranging from 100 to 3200 s-1 were determined from the classical mass transport equation proposed by Leveque and the values were found to be of the same order of magnitude as predicted by Brownian xi diffusion. MPs non-specific attachment to glass was dominated by electrostatic interactions; this was verified by changing the surrounding ionic strength of the suspending solution. In addition to shear rate, red blood cells (RBCs) also influenced MP adhesion due to the complex movement of RBCs. Such movement has been shown to enhance the adhesion of platelets (1-2 micron size cells) to surfaces in flowing blood. MP lateral transport was enhanced at low concentrations of RBCs and reduced at higher concentration of RBCs. The reduction of MP deposition was due to the competition for surface binding sites between the two populations of MPs. The two types of MPs studied here, those produced by macrophages after endotoxin stimulation and those produced by RBCs during experimental preparation (repeated centrifugal washing) have the capability of nonspecific binding to artificial surfaces in a competitive manner. Finally, we demonstrated that the amount of adherent MPs on surfaces influenced fibrin formation via both a TF-dependent and a negatively charged phospholipid pathway. These findings suggest that procoagulant MPs may modulate thrombotic events under certain conditions, especially in MP-associated diseases. The knowledge of the effects of flow on MP transport and the influence of increased MPs on thrombosis may provide novel insights for the transfer of biological activity to relatively passive surfaces.
PH.D in in Biomedical Engineering, December 2012
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