Search results

Title: CONTROLLED AND EXTENDED RELEASE OF ANTIANGIOGENIC AGENTS FOR THE ENHANCED TREATMENT OF CHOROIDAL NEOVASCULARIZATION
Creator: Osswald, Christian R.
Date: 2015, 2015-07
Description: Current U.S. Food and Drug Administration (FDA)-approved drug therapies for choroidal neovascularization (CNV) secondary to age-related...
Show moreCurrent U.S. Food and Drug Administration (FDA)-approved drug therapies for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD), also known as wet AMD, require monthly or bimonthly intravitreal (IVT) injections of bolus antiangiogenic agents such as anti-vascular endothelial growth factors (anti-VEGFs) [1]. Less-frequent administration of anti-VEGFs via controlled and extended release is needed to lower the socio-economic impact and lessen the potential side-effects associated with frequent IVT injections. While a controlled delivery system is beneficial, the challenges of initial burst (IB), maintenance of drug bioactivity, and understanding the drug distribution in the diseased eye must be addressed to design an optimal system to address this need. The main goal of this study was to develop a drug delivery system (DDS) capable of delivering anti-VEGF for six months. Additionally, we propose that controlled and extended release of anti-VEGF will yield a greater reduction in CNV growth compared to bolus administration of the same drug. Thus, the current monthly/bimonthly treatment regimen could be replaced by, say, a semi-annual treatment. To accomplish this goal, three specific aims were performed: 1) Development of an injectable microsphere-hydrogel DDS with minimal IB and prolonged release of bioactive anti-VEGF; 2) Verification and validation of the efficacy of said DDS in vivo; and 3) A proof-of-concept finite element analysis comparing the drug distribution throughout a diseased eye to that of a healthy eye.
Ph.D. in Biomedical Engineering, July 2015
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Midterm Presentation F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Brochure F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Project Plan F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 IPRO Day Presentation F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Poster F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Final Report F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327: A Video Annotation and Indexing System IPRO327 Final Report F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327: A Video Annotation and Indexing System IPRO327 MidTerm Presentation F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327: A Video Annotation and Indexing System IPRO327 Project Plan F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327: A Video Annotation and Indexing System IPRO327 Poster F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327: A Video Annotation and Indexing System IPRO327 Brochure F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

Title: A Video Annotation and Indexing System (Semester Unknown) IPRO 327: A Video Annotation and Indexing System IPRO327 Final Presentation F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009, 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables
Show less

repository.iit

Search the repository

Query

Refine Results

Type

Date

Department

Subject

Creator

Rights