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Title: ENHANCED DEGRADATION AND PEPTIDE SPECIFICITY OF MMP-SENSITIVE SCAFFOLDS FOR NEOVASCULARIZATION OF ENGINEERED TISSUES
Creator: Sokic, Sonja
Date: 2013, 2013-07
Description: Biomaterial strategies for engineering tissues of clinically relevant size require the formation of rapid and stable neovascularization. The...
Show moreBiomaterial strategies for engineering tissues of clinically relevant size require the formation of rapid and stable neovascularization. The ability of an engineered scaffold to induce vascularization is highly dependent on its rate of degradation. During the process of material degradation, the scaffold should degrade in a manner allowing for cellular infiltration, lumen formation, and extracellular matrix (ECM) synthesis. Matrix metalloproteinases (MMPs) play a key role in mediating cell-induced proteolytic matrix degradation, remodeling, and controlled neovascularization. Poly (ethylene glycol) PEG hydrogels have been extensively investigated as scaffolds for tissue engineering applications due to their ease of chemical modification allowing for the recapitulation of key aspects of the neovascularization process. The goal of the work described in this thesis was to develop strategies to enhance and control the degradation of MMP-sensitive PEG diacrylate (PEGDA) hydrogels without inducing changes to the bulk physical and mechanical properties of the material and to further study the effect of the cleavage site concentration and MMP-sensitive peptide substrate specificity on the rate of neovascularization and tissue remodeling in vitro and in vivo. In the first part of this study, a detailed investigation was completed to investigate the effects of the mechanical and physical properties of the scaffolds as well as the role of proteolytically mediated hydrogel degradation on 3D fibroblast invasion within MMPsensitive PEGDA hydrogels. Initial studies focused on the use of a modified version of a previously published multistep conjugation method to generate degradable PEGDA macromer conjugates containing variations in the number of MMP-sensitive domains. Theoretical and experimental characterization of this multistep conjugation demonstrated xi that this method leads to the formation of multiple species that directly affect the compressive modulus and degradation rate of the scaffold making it difficult to control degradation independent of alterations in the bulk physical and mechanical hydrogel properties. After manipulation of multiple polymerization conditions, hydrogels with similar compressive moduli but different hydrogel degradation rates were synthesized. These initial studies showed that an increase in the incorporation of proteolytically sensitive domains in PEGDA hydrogels of similar modulus lead to enhanced degradation and 3D fibroblast invasion. In this study, the role of soluble FGF-1 on fibroblast invasion within these scaffolds was investigated and it was demonstrated that the inclusion of FGF-1 in the scaffolds results in further enhancement of fibroblast invasion in a dosedependent fashion. Further studies were necessary to develop a more controllable and robust approach in tuning scaffold degradation independent of alterations in the bulk physical and mechanical properties. In order to address this, a novel approach was developed to engineer protease-sensitive peptides with multiple proteolytic cleavage sites that could be covalently crosslinked into hydrogels without compromising the physical and mechanical biomaterial properties. This approach avoided the need for utilizing a multistep conjugation process as peptides could be incorporated into the backbone of PEG using a single step conjugation. Using this approach, hydrogels formed with the engineered peptides led to significantly enhanced degradation and neovascularization in vitro as compared to scaffolds with a single protease sensitive peptide between crosslinks. In addition, hydrogels with enhanced susceptibility to degradation promoted vascularization over a wider range of matrix properties. This approach allowed for controlled xii concentration of the proteolytic cleavage sites within the matrix and thus tuning of hydrogel degradation for tissue engineering applications. In the final study, MMP-sensitive peptide substrates specific to degradation by MMPs known to be expressed during neovascularization were screened for degradation and their role in neovascularization. MMP-sensitive PEGDA hydrogels (SSite and TriSite) were synthesized with peptide substrates sensitive to cleavage by MMP-2, MMP- 9, MMP-14, a mixed sequence of MMP-2, 9 and 14, and compared to the peptide substrate used in the previous studies, which is degraded by collagenase enzymes. The hydrogels were evaluated for their sensitivity and specificity to degradation by MMPs, in terms of cleavage site concentration, and for their role in neovascularization and tissue remodeling in vitro and in vivo. The presented approach allows for the incorporation of varying cleavage site concentration and MMP-sensitive peptide substrates into PEG hydrogels without alterations in the mechanical and physical properties of the hydrogels. Results showed that without the incorporation of growth factors in this scaffold, vascularization and tissue invasion was supported in all MMP-sensitive hydrogel groups regardless of the MMP-sensitive peptide substrate embedded in the matrix. In addition, the cleavage site concentration had a profound impact in enhancing vascularization in vitro and tissue invasion in vivo. These techniques can be used to tune the properties of polymer scaffolds for neovascularization and tissue remodeling. In addition, these studies provide insight into the effect of the physical, mechanical, and degradative properties of these systems and on the role of cleavage site concentration, and MMP substrate specificity on xiii neovascularization and tissue invasion within proteolytically degradable PEG hydrogel constructs.
PH.D in Biomedical Engineering, July 2013
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Title: Design of a Large Scale Structure (sequence 315), IPRO 315 - Deliverables: IPRO 315 IPRO Day Presentation F09
Creator: Aguilar-wedge, Carmen, Animashaun, Oladipo, Baur, Alex, Cullen, Michael, Hadi, Shuaib, Hedge, Namrata, Kuo, Steve, Lee, Christopher, Lee, Yongdoo, Rybaltowski, Karol, Scully, Dawveed, Shen, Jie-hua, Yousef, Shadi
Date: 2009-12
Description: Located in Oakbrook, IL the architects and engineers of IPRO 315 will design a 22 story hotel. Together architects and engineers will modify...
Show moreLocated in Oakbrook, IL the architects and engineers of IPRO 315 will design a 22 story hotel. Together architects and engineers will modify and re analyze a structure created by pervious designers, and select any new materials for construction. In creating the hotel students will be responsible for the structural analysis of columns, beams, foundation, steel, and concrete design required to insure all serviceability requirements. The students will be required to follow the 2006 International Building Code, and secure the safety of all possible occupants. Management, leadership, ethics, and teamwork will be an integral part of building a large scale structure as students learn to work together on a “real life” project.
Deliverables for IPRO 315: Design of a Large Scale Structure for the fall 2009 semester
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Title: Alleviating Homelessness in Chicago
Creator: Degroff, Justin
Date: 2011, 2011-05
Description: Alleviating homelessness in Chicago through the creation of a network of self-sufficient, revenue generating support nodes.

Title: Digital Urban Park
Creator: Thornton, Alastair
Date: 5/4/2011, 2011-05
Description: This project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through...
Show moreThis project is a park that utilizes social networks and interactivity to convey and make physical the internet. This is explored through three parts and varying levels of group interaction between both the users of the space and by the spaces direct influence from the internet.
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Title: Power Measurement for Road Bicycles: Towards a Universal Solution (sequence unknown), IPRO 324 - Deliverables: IPRO 324 Brochure F09
Creator: Adrianzen, Luis, Allen, Ross, Antonio, Chris, Callan, Mark, Claxton, Sara, Diesse, Patrick, Gaylord, Matthew, Herbert, Greg, Shaffer, Dan, Wegrzyn, Celeste
Date: 2009-12
Description: The goal of the IPRO is to try to find an inexpensive, but accurate way of measuring the power output of a rider on a bicycle. Problems with...
Show moreThe goal of the IPRO is to try to find an inexpensive, but accurate way of measuring the power output of a rider on a bicycle. Problems with systems currently available are: some products are not compatible with all bike systems causing the need to purchase new parts, the cost of the available products is expensive, and some of the available measuring systems are not very accurate.
Deliverables for IPRO 324: Power Measurement for Road Bicycles: Towards a Universal Solution for the fall 2009 semester
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Title: HIGH PERFORMANCE, HIGH STABILITY AND LOW POWER SRAM DESIGN BY USING CARBON NANOTUBE FIELD EFFECT TRANSISTORS
Creator: Wang, Wei
Date: 2012-07-07, 2012-07
Description: As the feature size of silicon semiconductor devices scales down to nanometer range, planar bulk CMOS design and fabrication encounter...
Show moreAs the feature size of silicon semiconductor devices scales down to nanometer range, planar bulk CMOS design and fabrication encounter significant challenges. This situation is exacerbated when it comes to SRAM, as SRAM takes a large part of power consumption and area overhead in modern VLSI processor designs. To achieve higher performance, stability and lower power consumption, carbon nanotube (CNT) has been introduced to SRAM design as an alternative material. The semiconducting single-walled CNTs are promising candidates for the channel material of CMOS devices because of two advantages over the other semiconductor materials: high ON current, leading to high speed and low OFF current, leading to less leakage power. In this research work, characterizing work of technology parameters for 6T carbon nanotube field effect transistor (CNFET) SRAM cell is performed for basic understanding of the relationship between SRAM delay/power and CNFET technology parameters. Stability issue is studied by investigating the diameter and transistor ratio impacts on the SRAM static noise margin (SNM). A stability-optimized 6T CNFET SRAM cell achieves 38.88% reading delay reduction, 21.61% writing delay reduction, 85.65% reading power reduction, 5.88% writing power reduction, 97.80% leakage power reduction, 41.41% SNM increment, 91.23% reading power-delay product (PDP) reduction and 26.23% writing PDP reduction, compared with conventional silicon MOSFET SRAM cell. To mitigate major CNT imperfection impacts on CNFET circuits, a misalignment immune SRAM design method is proposed to eliminate CNT misalignment problem by using etching region defined in circuit layout; and a diameter variation sensing and compensating system is designed to mitigate the negative impacts of CNT diameter variation on SRAM delay and power consumption. A hybrid silicon/CNT 4T SRAM cell design is proposed for low-power high-density cache application, which is better than conventionally used 6T SRAM in terms of power consumption and circuit area. Finally, a design flow of high performance, high stability and low power SRAM is summarized.
Ph.D. in Electrical Engineering, July 2012
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Title: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry (sequence unknown), IPRO 333 - Deliverables: IPRO 333 IPRO Day Presentation F09
Creator: Bonesz, Andrew, Clark, Howard, Douglas, Carlie, Gajdorus, Michael, Gottschall, Keenan, Hendricks, Rachel, Kimball, Clayton, Linares, Jared, Marks, Paul, Mellom, James, Oblenida, Cindy, Pop, Sabina, Stelcel, Carl, Young, Jeremy, Zhou, Raymond
Date: 2009-12
Description: The primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the...
Show moreThe primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the resources of the Museum of Science and Industry (MSI) in Chicago. This partnership endeavors to help the museum's Fabrication Laboratory (Fab Lab) maximize its potential as a resource for museum guests, young and old, as well as for IIT students, staff, and faculty.
Sponsorship: Museum of Science and Industry. Steven Willis- Director, Fabrication Lab
Deliverables for IPRO 333: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry for the fall 2009 semester
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Title: Developing Web Applications for the Northern Illinois Hockey League (sequence unknown), IPRO 308 - Deliverables: IPRO 308 IPRO Day Presentation F09
Creator: Lucchesi, Kristin, Barksdale, Dustin, Hays, Julian, Bartus, Kryzystof, Perkins, William, Savage, Christopher, Scheer, Colin, Semenov, Vladimir, Vidutis, Mantas
Date: 2009-12
Description: The NIHL is the largest hockey league in Illinois. It is also the largest youth all star hockey league in the US, serving over 300 youth teams...
Show moreThe NIHL is the largest hockey league in Illinois. It is also the largest youth all star hockey league in the US, serving over 300 youth teams and over 4,000 players. The team's purpose is to make the NIHL a web-based scheduling and scoring applications that can support their annual operations.
Sponsorship: Northern Illinois Hockey League(NIHL)
Deliverables for IPRO 308: Developing Web Applications for the Northern Illinois Hockey League for the fall 2009 semester
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Title: Green Building Design Concept & Integration (sequence unknown), IPRO 335 - Deliverables: IPRO 335 Project Plan F09
Creator: Avanessian, Aris, Banda, Justine, Bergerson, Joshua, Burke, Jeffrey, Christo, Robert, Dexter, Eric, Kim, Kibum, Mey, Andrew, Okunaga, Jonathan, Razeq, Ali, Schaefer, Jacqueline, Thovar Leon, Adrian, Um, Hye
Date: 2009-12
Description: The scope of this IPRO project spans structural, architectural, foundation, HVAC, lighting and electric system designs, as well as building...
Show moreThe scope of this IPRO project spans structural, architectural, foundation, HVAC, lighting and electric system designs, as well as building cost estimating and professional ethics. The IPRO team will become informed about and apply principles associated with green design concepts, energy sustainability, post occupancy comfort, acoustic design issues, smart building concepts, health issues (abatement of mold- and allergy-causing agents), and safety considerations.
Deliverables for IPRO 335: Green Building Design Concept & Integration for the fall 2009 semester
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Title: Teacher Knowledge Share (Semester Unknown) IPRO 320: Teacher Knowledge Share IPRO 320 Ethics F08
Creator: Bern, David, Bochantin, Marike, Hartline, Julian, Mccall, Ian, Mick, Emily, Peake, Andrew, Pierce, Alison, Pindrik, Dmitriy, Quinn, Michael, Stanford, Carly, Tilatti, Michael
Date: 2008, 2008-12
Description: The goal of IPRO 320 is to create an online professional network for school teachers at the kindergarten through twelfth grade level to allow...
Show moreThe goal of IPRO 320 is to create an online professional network for school teachers at the kindergarten through twelfth grade level to allow for the sharing of ideas, lesson plans and other professionally relevant information. This is a continuing project which saw limited success in the previous semester in that a functioning web site was constructed based on surveys of public school teachers but it saw very little use. This semester, the planned approach is to build on the research generated last semester by performing additional market research with teachers. Following that, IPRO 320 will rework much of the previous web site by refining some of the features, adding additional ones as the research indicates and improving the website in general, both functionally and aesthetically.
Deliverables
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Title: Center for Interdisciplinary Education: tA_Final Book
Creator: Alvarez, Tomas
Date: 4/20/2011, 2011-05
Description: This project consists of developing an efficient collegiate building in which the disciplines of Business, Mathematics, and Science can...
Show moreThis project consists of developing an efficient collegiate building in which the disciplines of Business, Mathematics, and Science can interact, collaborate, and ultimately create new knowledge by merging existing information. "All disciplines have imported aspects of other fields to clarify their own disciplinary perspectives."
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Title: Sustainable Theme Park and Museum
Creator: Fujishima, Kenta
Date: 5/4/2011, 2011-05
Description: An indoor facility consisting of both theme park and museum components with the integration of green and sustainable elements.

Title: Devices that Assist Blind & Visually-Impaired Individuals in Swimming and Other Exercise Activities (sequence unknown), IPRO 310 - Deliverables: IPRO 310 IPRO Day Presentation F09
Creator: Dykeman, Kimberly, Healton, Michaela, Lipman, Timothy, Ludwig, Ross, Park, Jay, Reilly, Jeffrey, Sarkar, Smita, Sirk, Phillip, Toro, Branden
Date: 2009-12
Description: The objective is to develop, test, and implement assistive technology with the community that promotes safety and improves independence of...
Show moreThe objective is to develop, test, and implement assistive technology with the community that promotes safety and improves independence of blind and visually impaired (BVI) swimmers.
Sponsorship: Chicago Lighthouse for the Blind & Visually-Impaired. Notre Dame University
Deliverables for IPRO 310:Devices that Assist Blind & Visually-Impaired Individuals in Swimming and Other Exercise Activities for the fall 2009 semester.
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Title: CONTROLLER DESIGN AND DISTRIBUTED CONTROL WITHIN MULTI-AGENT SYSTEMS
Creator: Shao, Quan Min
Date: 2013, 2013-12
Description: None
PH.D in Chemical and Biological Engineering, December 2013

Title: Interactive Urban Landmark Kiosks for Memorial Walk of Martin Luther King (sequence unknown), IPRO 314 - Deliverables: IPRO 314 Final Report F09
Creator: O’leary, Kevin, Petty, Sonya, Qi, Tianshu, Tan, Sophia, Noor, Nashrah, Schleich, Kenneth, Akhtar, Ayesha, Cheng, Eric, Kim, James, Parker, Joseph, Saha, Sougata
Date: 2009-12
Description: The objective of this IPRO is to help the students of Gage Park H.S. bring their vision of a memorial to a historical event into existence.
Spo...
Show moreThe objective of this IPRO is to help the students of Gage Park H.S. bring their vision of a memorial to a historical event into existence.
Sponsorship: Gage Park High School
Deliverables for IPRO 314: Interactive Urban Landmark Kiosks for Memorial Walk of Martin Luther King for the fall 2009 semester.
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Title: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry (sequence unknown), IPRO 333 - Deliverables: IPRO 333 Project Plan F09
Creator: Bonesz, Andrew, Clark, Howard, Douglas, Carlie, Gajdorus, Michael, Gottschall, Keenan, Hendricks, Rachel, Kimball, Clayton, Linares, Jared, Marks, Paul, Mellom, James, Oblenida, Cindy, Pop, Sabina, Stelcel, Carl, Young, Jeremy, Zhou, Raymond
Date: 2009-12
Description: The primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the...
Show moreThe primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the resources of the Museum of Science and Industry (MSI) in Chicago. This partnership endeavors to help the museum's Fabrication Laboratory (Fab Lab) maximize its potential as a resource for museum guests, young and old, as well as for IIT students, staff, and faculty.
Sponsorship: Museum of Science and Industry. Steven Willis- Director, Fabrication Lab
Deliverables for IPRO 333: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry for the fall 2009 semester
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Title: Our Energy Future: Lessons in Sustainability AND IPRO Teams for K-12: The Education Outreach Service Learning Cluster (sequence unknown), IPRO 332 - Deliverables: IPRO 332 Poster F09
Creator: Chavez, Jorge, Johnson, Ross, Chin, Jason, Grande, Gina, Lay, Livia, Mccloat, Declain, Nguyen, Nam, Olechno, Patrick, Randle, Jennifer, Tyler Ii, Micheal, Vega, Mayra, Weiner, Andrew, Zajac, Gregory
Date: 2009-12
Description: The mission of the IPRO is to educate the community, focusing mainly on elementary and high school students, on the issues of sustainability...
Show moreThe mission of the IPRO is to educate the community, focusing mainly on elementary and high school students, on the issues of sustainability and energy conservation. The group looks to expand on the work that has been completed in previous semesters, by adding multi-media presentations to enhance the current teaching modules. Previous modules have presented to classrooms simply with information, and the team looks to add upon this by adding interactive and entertaining materials to intrigue the audience.
Deliverables for IPRO 332: IOur Energy Future: Lessons in Sustainability AND IPRO Teams for K-12: The Education Outreach Service Learning Cluster for the fall 2009 semester
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Title: Chicago Intermodal Commuter Transit Development: Strailman_Chris_MastersProject_2011
Creator: Strailman, Chris
Date: 4/27/2011, 2011-05
Description: This project focuses on the connectivity of different forms of transit and different neighborhoods in Chicago. Starting at the scale of city...
Show moreThis project focuses on the connectivity of different forms of transit and different neighborhoods in Chicago. Starting at the scale of city wide transit systems, it narrows down to a specific node and deals with the design and planning of a transit oriented development.
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Title: Multi- Generational Housing in China: Mixed-use Multi- Generational Housing in China Final Poster
Creator: Liu, Ling
Date: 2011-05, 2011-05
Description: In China, too much population causes early retire age, one child policy, extremely high housing pressure, too little land for open space,...
Show moreIn China, too much population causes early retire age, one child policy, extremely high housing pressure, too little land for open space, little or no public facilities. Also, it causes the lost of many long tradition. The losing of multi- generational living is just one of them. This project is a humanistic response to the social problems.
Sponsorship: Denison, Dirk
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Title: Polarised Drell-Yan physics at COMPASS, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
Creator: Franco, Celso
Date: 2013-09-15, 2013-09-15
Publisher: IIT Press
Description: The COMPASS experiment at CERN is one of the leading experiments studying the spin structure of the nucleon. Until now, the Parton...
Show moreThe COMPASS experiment at CERN is one of the leading experiments studying the spin structure of the nucleon. Until now, the Parton Distribution Functions (PDFs) and the Transverse Momentum Dependent Parton Distribution Functions (TMD PDFs) of protons and deuterons have been studied in Semi-Inclusive Deep Inelastic Scattering (SIDIS) measurements. The polarised Drell-Yan (DY) process is a complementary way to access the TMD PDFs, as it allows us to measure convolutions of only PDFs without involving fragmentation functions (FFs). COMPASS aims to perform the first ever polarised DY experiment in the world, which is foreseen to start in late 2014. By detecting dimuons from DY events we will be able to extract azimuthal spin asymmetries, each containing a convolution of two TMD PDFs, one from a negative pion beam with a momentum of 190 GeV/c and the other one from a transversely polarised proton target (NH₃). After their disentangling we can access four of the eight TMD PDFs needed to describe the nucleon structure at leading twist, like the Sivers and the Boer-Mulders functions. The opportunity to study, in the same experiment, the TMD PDFs from both SIDIS and DY processes is unique at COMPASS. Therefore, we are in privileged conditions to confirm or to deny the expected sign change in Sivers and Boer-Mulders functions when accessed via DY or SIDIS processes. An overview of the preparation and future measurements of the polarised DY experiment will be provided.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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