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Title: Control of complex distributed systems with distributed intelligent agents
Creator: Tatara, Eric, Cinar, Ali, Teymour, Fouad
Date: 2007-06
Publisher: ELSEVIER SCI LTD
Description: Control of spatially distributed systems is a challenging problem because of their complex nature, nonlinearity, and generally high order. The...
Show moreControl of spatially distributed systems is a challenging problem because of their complex nature, nonlinearity, and generally high order. The lack of accurate and computationally efficient model-based techniques for large, spatially distributed systems leads to challenges in controlling the system. Agent-based control structures provide a powerful tool to manago distributed systems by utilizing (organizing) local and global information obtained from the system. A hierarchical, agent-based system with local and global controller agents is developed to control networks of interconnected chemical reactors (CSTRs). The global controller agent dynamically updates local controller agent's objectives as the reactor network conditions change. One challenge posed is control of the spatial distribution of autocatalytic species in a network of reactors hosting multiple species. The multi-agent control system is able to intelligently manipulate the network flow rates such that the desired spatial distribution of species is achieved. Furthermore, the robustness and flexibility of the agent-based control system is illustrated through examples of disturbance rejection and scalability with respect to the size of the network.
Endnote format citation for DOI:10.1016/j.jprocont.2006.06.008
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Title: A PARAMETRIC STUDY OF THE THERMAL PERFORMANCE OF DIFFERENT WALL SYSTEMS AT VARIOUS CLIMATE ZONES
Creator: Lai, Se Yen
Date: 2013, 2013-12
Description: One of the most common energy conservative measures used is designing an air-tight and a well-insulated envelope. While there is an abundance...
Show moreOne of the most common energy conservative measures used is designing an air-tight and a well-insulated envelope. While there is an abundance of high-efficiency building envelope designs in the market which offer low thermal conductivity and high R-values as well as various studies on the thermal performance of various wall constructions, the results were often based on simplified study model and are not incompliance with the current building code. Most studies also focus on only one particular climate zone and one type of wall construction. This research aims to examine the thermal performance of different types of wall construction based on the traditional building envelope design materials in various climate zones based on insulation and air cavity placements on a non-simplified reference model that is used for construction. Study models developed are incompliance with the American Society of Heating, Refrigerating, and Air-Conditioning Engineers [ASHRAE] 90.1-2010 based on U.S. Department of Energy [DOE] Commercial Prototype Building Model. The thermal performance of the wall will be determined using two different methods. The first method will be using Building Energy Modeling [BEM] software where the exterior wall construction will be modified based on DOE reference models where the results for the overall annual energy consumption [AEC] will be compared. AEC results showed small differences between study models which are negligible. The second method is the Total Thermal Constant [TTC] method, where the thermal lag will be compared. The building structures that will be used are a steel-framed structure which represents a medium office and a wood-framed structure which represents a quick service restaurant. TTC results were able to determine the least favorable study model.
M.S. in Civil Engineering, December 2013
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Title: Online batch/fed-batch process performance monitoring, quality prediction, and variable-contribution analysis for diagnosis
Creator: Undey, C., Ertunc, S., Cinar, A.
Date: 2003-10-01
Publisher: AMER CHEMICAL SOC
Description: An integrated online multivariate statistical process monitoring (MSPM), quality prediction, and fault diagnosis framework is developed for...
Show moreAn integrated online multivariate statistical process monitoring (MSPM), quality prediction, and fault diagnosis framework is developed for batch processes. Batch data from I batches, with J process variables measured at K time points generate a three-way array of size I x K x J. Unfolding this three-way array into a two-way matrix of size IK x J by preserving the variable direction is advantageous for developing online MSPM methods because it does not require estimation of future portions of new batches. Two different multiway partial least squares (MPLS) models are developed. The first model (MPLSV) is developed between the data matrix (IK x J) and the local batch time (or an indicator variable) for online MSPM. The second model (MPLSB) is developed between the rearranged data matrix in the batch direction (I x KJ) and the final quality matrix for online prediction of end-of-batch quality. The problem of discontinuity in process variable measurements due to operation switching (or moving to a different phase) that causes problems in alignment and modeling is addressed. Control limits on variable contribution plots are used to improve fault diagnosis capabilities of the MSPM framework. Case studies from a simulated fed-batch penicillin fermentation illustrate the implementation of the methodology.
Endnote format citation for DOI:10.1021/ie0208218
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Title: A UNIFIED BOUNDARY CONTROL LAW FOR DC-DC CONVERTERS USING A NORMALIZED STATE PLANE
Creator: Nie, Yue
Date: 2015, 2015-05
Description: This thesis proposes a unified boundary control law for DC-DC converters (Buck, Boost, and Buck-Boost) which improves both the transient and...
Show moreThis thesis proposes a unified boundary control law for DC-DC converters (Buck, Boost, and Buck-Boost) which improves both the transient and steady state response in comparison to boundary control laws using first or second order switching surface. A new set of switching zones on normalized state plane are defined to decide switching behavior every sample period. Additionally, non-ideal operations and a parameter self-adaptive algorithm are proposed and verified in simulation. The parameter self-adaptive algorithm enhances the system robustness and reduces the parameter sensitivity. The transient bandwidth for the load disturbance rejection and command tracking approaches the physical limits of DC-DC converters. Simulation results are presented to illustrate the major benefits of the proposed uni ed boundary control law.
M.S. in Electrical Engineering, May 2015
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Title: Widget Applications to Enhance the Tru2Way Consumer Experience (sequence unknown), IPRO 312 - Deliverables: IPRO 312 Brochure F09
Creator: Alsharief, Yagoob, Aulfata, Muluken, Curtis, Christopher, Dhewaju, Anusuya, Mooney, Kevin, Mutyaba, Kevin, Ndoping, Marco, Onaissi, Samah, Peterson, Naomi, Siwek, Steven, Wallace, Sean, Yi, Won-jae
Date: 2009-12
Description: The IPRO teams objectives are to provide Comcast with feedback from an outside perspective, allowing them to see where their Tru2Way system...
Show moreThe IPRO teams objectives are to provide Comcast with feedback from an outside perspective, allowing them to see where their Tru2Way system needs additional attention or support.
Sponsorship: Comcast
Deliverables for IPRO 312: Widget Applications to Enhance the Tru2Way Consumer Experience for the fall 2009 semester
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Title: Power Measurement for Road Bicycles: Towards a Universal Solution (sequence unknown), IPRO 324 - Deliverables
Creator: Adrianzen, Luis, Allen, Ross, Antonio, Chris, Callan, Mark, Claxton, Sara, Diesse, Patrick, Gaylord, Matthew, Herbert, Greg, Shaffer, Dan, Wegrzyn, Celeste
Date: 2009-12
Description: The goal of the IPRO is to try to find an inexpensive, but accurate way of measuring the power output of a rider on a bicycle. Problems with...
Show moreThe goal of the IPRO is to try to find an inexpensive, but accurate way of measuring the power output of a rider on a bicycle. Problems with systems currently available are: some products are not compatible with all bike systems causing the need to purchase new parts, the cost of the available products is expensive, and some of the available measuring systems are not very accurate.
Deliverables for IPRO 324: Power Measurement for Road Bicycles: Towards a Universal Solution for the fall 2009 semester
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Title: Boosted heavy particles and jet substructure with the CMS detector, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
Creator: Marchesini, Ivan
Date: 2013-09-15, 2013-09-15
Publisher: IIT Press
Description: In the last years, the understanding of jets and jet substructure has become increasingly important, in particular in the context of new...
Show moreIn the last years, the understanding of jets and jet substructure has become increasingly important, in particular in the context of new physics searches. Many new physics models involve highly boosted hadronically-decaying particles, which result in jet-like objects with large masses and an intrinsic substructure. Discrimination of these heavy jets from ordinary quark and gluon jets is possible through a plethora of new techniques. The understanding of jets can be exploited also for the identification of pileup jets and for the discrimination between quark jets and gluon jets. A sampling of these techniques is discussed together with their validation on collider data recorded in proton-proton collisions at √s = 8TeV with the CMS detector in the year 2012. The commissioning in the boosted regime of algorithms used to identify jets originating from bottom quarks is also discussed. Many studies have highlighted the potential of using jet substructure techniques to improve the sensitivity in physics searches. An overview of recent CMS results employing these techniques is presented.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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Title: Finding Uses for Alternative Fuels in Intermodal Transportation Hubs (sequence unknown), IPRO 307 - Deliverables: 307_redacted
Creator: Balakirev, Konstantin, Beau‐luby, Ryan, Bouikidis, John, Cargill, Matthew, Dziuba, David, Kehoe, Matthew, Slonski, Bryan, Tesfaye, Melat, Wiese, Matthew, Wiseman, Christopher, Zook, Joel
Date: 2009-12
Description: Chicago, being the third largest freight hub in the world, needs an efficient movement of goods for the increasing freight shipments.
Sponsorsh...
Show moreChicago, being the third largest freight hub in the world, needs an efficient movement of goods for the increasing freight shipments.
Sponsorship: Mi-Jack
Deliverables for IPRO 307: Finding Uses for Alternative Fuels in Intermodal Transportation Hubs for the fall 2009 semester.
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Title: SUBSTATION PLANNING FOR RURAL DISTRIBUTION SYSTEMS IN AFRICAN COUNTRIES
Creator: Soyoye, Oluwadamilola
Date: 2016, 2016-12
Description: In sub-Saharan Africa, only 35% of the population is connected to grid electricity [2]. Grid-connected parts face serious transmission and...
Show moreIn sub-Saharan Africa, only 35% of the population is connected to grid electricity [2]. Grid-connected parts face serious transmission and distribution challenges. There is also the challenge of electricity demand being greater than electricity supply. These issues in all levels of the traditional power system – generation, transmission and distribution have led to gross inadequacy of electricity supply. This research focuses on the capital intensive Power Distribution Planning (PDP). Most problems in the distribution system affect the consumer directly. Distribution substation planning, a critical part of the PDP, particularly addresses the issue of overloaded distribution systems. It is not uncommon for substation transformers in some African communities to become damaged because of overloading. The choice of location, sizing, siting and number of substations is determined by considering load distribution, feeder lengths and sizes, and the interruption costs. The research illustrates a framework for substation planning, incorporating possible future load growths over a particular period to forestall unwanted failures in the distribution system. A direct algorithm is used, where the substation capacity is computed manually from the load levels at different points. This algorithm is later combined with the Mixed Integer Linear Programming (MILP) approach solved with the CPLEX solver in MATLAB.
M.S. in Electrical Engineering, December 2016
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Title: High Speed Jet Flows, 1995: Presented at the 1995 ASME/JSME Fluids Engineering and Laser Anemometry Conference and Exhibition, August 13-18, 1995, Hilton Head, South Carolina
Creator: Raman, Ganesh, Kaji, S., Freitas, Christopher J.
Date: 1995
Publisher: American Society of Mechanical Engineers

Title: Tests on enameled wire
Creator: Gault, Mark E.
Date: 2009, 1911
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/testsonenameledw00gaul
Thesis (B.S.)--Armour Institute of Technology; Bibliography: leaf 26

Title: MINIMIZING SALMONELLA CONTAMINATION IN SPROUTS BY CONTROLLING THE GERMINATION TEMPERATURE
Creator: Zhang, Hanshuai
Date: 2013, 2013-12
Description: Since 1990, contaminated sprouts have been linked to at least 46 outbreaks and over 2,500 cases of illness in the US [13]. Unlike other ready...
Show moreSince 1990, contaminated sprouts have been linked to at least 46 outbreaks and over 2,500 cases of illness in the US [13]. Unlike other ready-to-eat produce, sprouts pose a particular concern as the conditions that promote germination of their seeds also facilitate the growth of pathogens [6]. To address sprout’s propensity to microbial contamination, the U.S. Food and Drug Administration (FDA) has recommended that seeds destined for sprout production be disinfected with chemical sanitizers such as 20,000 ppm of calcium hypochlorite, Ca(OCl)2 [29]. However, this disinfectant often cannot completely eliminate pathogen that may be present in seeds [4, 23]; in which case, the surviving bacteria can re-grow to significant numbers during germination and cause severe illness upon consumption [45]. Therefore, maintaining control of the germination conditions to present the proliferation of pathogens is a crucial step in the overall approach to reduce microbial hazards in finished sprouts. This study examines the effects of temperature on the proliferation of Salmonella during germination, and how this temperature effect is influenced by factors such as pathogen load, seed-lot, and the presence or absence of chemical treatment with Ca(OCl)2 was also evaluated. Alfalfa seeds artificially inoculated with ~3 log CFU/g of Salmonella were used as the contaminated seeds. They were mixed at different levels (0.01, 0.1, 1.0, or 10.0% by weight) with 200g of non-contaminated seeds and then were allowed to germinate in glass jars for 3 or 5 days at 10, 20, or 30°C. The same experiment was repeated for the spiking seeds that were treated with 20,000 ppm Ca(ClO)2 for 15 min prior to sprouting. Sprout samples were taken from each jar daily and analyzed for the level of Salmonella ix by either plating on XLD plates or the three-tube most probable number method as described in the FDA BAM. The level of Salmonella increased during sprouting at all three temperatures and reached the highest level at 48h. Sprouting at 10°C yielded the least number of Salmonella when all other factors were controlled. At all spiking levels, or the percentage of seeds contaminated before sprouting, level of Salmonella increased during sprouting, and at 20°C and 30°C, the level of Salmonella reached to a similar level of 5 log CFU/g and 7 log CFU/g respectively. At 1.0% spiking level, the level of Salmonella increased by approximately 1.5, 4.0, and 6.0 log CFU/g in sprouts grown at 10, 20, and 30°C respectively. Difference in the level of microflora background between different seed lots did not appear to affect Salmonella proliferation during sprouting. Treatments with 20,000 ppm free chlorine in some cases lowered the levels of Salmonella to undetectable levels, while in other cases, it caused an approx. 3 log reduction in Salmonella count on seeds. The surviving ones could still proliferate during sprouting although with a delay and a much slower rate, and did not reach the maximal level at 48 h of sprouting. However, Ca(OCl)2 did not prevent the re-growth of Salmonella during germination. In conclusion, these results showed that sprouting temperatures do affect Salmonella proliferations. We recommend lowering the sprouting temperature in conjunction with chemical treatment of prior to sprouting seeds to reduce microbial hazards in sprouts.
M.S. in Food Safety and Technology, December 2013
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Title: LARGE-SCALE SIMULATION OF ELECTRIC POWER SYSTEMS FOR WIND
Creator: Wei, Tian
Date: 2011-08, 2011-07
Description: The utilization of wind energy will pose great socioeconomic benefits with reductions in power plant emissions and the supply of zero cost...
Show moreThe utilization of wind energy will pose great socioeconomic benefits with reductions in power plant emissions and the supply of zero cost energy; however, largescale wind energy integration could introduce inevitable challenges to regional transmission systems and hourly system operations. This thesis addresses the congestion identification, simulation and analysis of large-scale electric power systems in different scenarios, large-scale wind energy integration and related transmission expansion issues. A methodology based on the security-constrained unit commitment (SCUC) is applied to analyze the transmission congestions in the Eastern Interconnection of the United States. The identified congestions are visualized along with the Geographical Information System (GIS) data and compared with the results in National Electric Transmission Congestion Study (NETCS) published by the Department of Energy of the United States in 2006. The study also provides the locational marginal price (LMP) information in the Eastern Interconnection, which is not available in the NETCS report. This thesis implements a comprehensive simulation and scenario analysis of the Illinois electric power system for the year 2011. Possible scenarios representing electrical load sensitivities to economic growth, fuel price variations, and the impact of carbon cost, are studied. This thesis presents the hourly simulation results for the large-scale wind energy integration in the Eastern Interconnection of the United States. An hourly unit commitment is applied for the simulation of the economics of wind energy integration in the year 2030. The energy portfolio for supplying the hourly load in 2030 is developed based on wind integration levels. The sensitivities of fuel price, wind energy quantity, xvii load forecast, carbon cost, and load management to the proposed 2030 wind integration are studied. This thesis identifies transmission congestions and expands the existing transmission system in the Eastern Interconnection of the United States for accommodating a large-scale integration of wind energy. Violated transmission flows which would cause the infeasibility of hourly SCUC are identified. An iterative transmission expansion analysis is implemented to identify the minimum required additions to the Eastern Interconnection for mitigating hourly transmission congestions.
Ph.D. in Electrical Engineering, July 2011
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Title: DIRECT DIFFEOMORPHIC REPARAMETERIZATION FOR CORRESPONDENCE OPTIMIZATION IN STATISTICAL SHAPE MODELING
Creator: Li, Kang
Date: 2015, 2015-05
Description: This dissertation proposes an efficient optimization approach for obtaining shape correspondence across a group of objects for statistical...
Show moreThis dissertation proposes an efficient optimization approach for obtaining shape correspondence across a group of objects for statistical shape modeling. With each shape represented in a B-spline based parametric form, the correspondence across the shape population is cast as an issue of seeking a reparametrization for each shape so that a quality measure of the resulting shape correspondence across the group is optimized. The quality measure is the description length of covariance matrix of the shape population, with landmarks sampled on each shape. The movement of landmarks on each B-spline shape is controlled by the reparameterization of the B-spline shape. The reparameterization itself is also represented with B-splines and B-spline coefficients are used as optimization parameters. We have developed formulations for ensuring the bijectivity of the reparameterization. A gradient-based optimization approach is developed, including techniques such as constraint aggregation and adjoint senstivity for efficient, direct di↵eomorphic reparameterization of landmarks to improve the group-wise shape correspondence. Numerical experiments on both synthetic and real 2D and 3D data sets demonstrate the efficiency and e↵ectiveness of the proposed approach.This dissertation proposes an efficient optimization approach for obtaining shape correspondence across a group of objects for statistical shape modeling. With each shape represented in a B-spline based parametric form, the correspondence across the shape population is cast as an issue of seeking a reparametrization for each shape so that a quality measure of the resulting shape correspondence across the group is optimized. The quality measure is the description length of covariance matrix of the shape population, with landmarks sampled on each shape. The movement of landmarks on each B-spline shape is controlled by the reparameterization of the B-spline shape. The reparameterization itself is also represented with B-splines and B-spline coefficients are used as optimization parameters. We have developed formulations for ensuring the bijectivity of the reparameterization. A gradient-based optimization approach is developed, including techniques such as constraint aggregation and adjoint senstivity for efficient, direct di↵eomorphic reparameterization of landmarks to improve the group-wise shape correspondence. Numerical experiments on both synthetic and real 2D and 3D data sets demonstrate the efficiency and e↵ectiveness of the proposed approach.
Ph.D. in Mechanical and Aerospace Engineering, May 2015
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Title: Estimation of Future Glucose Concentrations with Subject-Specific Recursive Linear Models
Creator: Eren-oruklu, Meriyan, Cinar, Ali, Quinn, Lauretta, Smith, Donald
Date: 2009-04
Publisher: MARY ANN LIEBERT INC
Description: Background: Estimation of future glucose concentrations is a crucial task for diabetes management. Predicted glucose values can be used for...
Show moreBackground: Estimation of future glucose concentrations is a crucial task for diabetes management. Predicted glucose values can be used for early hypoglycemic/hyperglycemic alarms or for adjustment of insulin injections or insulin infusion rates of manual or automated pumps. Continuous glucose monitoring (CGM) technologies provide glucose readings at a high frequency and consequently detailed insight into the subject's glucose variations. The objective of this research is to develop reliable subject-specific glucose prediction models using CGM data. Methods: Two separate patient databases collected under hospitalized (disturbance-free) and normal daily life conditions are used for validation of the proposed glucose prediction algorithm. Both databases consist of glucose concentration data collected at 5-min intervals using a CGM device. Using time-series analysis, low-order linear models are developed from patients' own CGM data. The time-series models are integrated with recursive identification and change detection methods, which enables dynamic adaptation of the model to inter-/intra-subject variability and glycemic disturbances. Prediction performance is evaluated in terms of glucose prediction error and Clarke Error Grid analysis (CG-EGA). Results: Prediction errors are significantly reduced with recursive identification of the models, and predictions are further improved with inclusion of a parameter change detection method. CG-EGA analysis results in accurate readings of 90% or more. Conclusions: Subject-specific glucose prediction strategy has been developed. Including a change detection method to the recursive algorithm improves the prediction accuracy. The proposed modeling algorithm with small number of parameters is a good candidate for installation in portable devices for early hypoglycemic/hyperglycemic alarms and for closing the glucose regulation loop with an insulin pump.
Endnote format citation
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Title: THE RELATIONSHIPS OF BIOLOGICAL, PSYCHOLOGICAL, AND SOCIAL FACTORS TO PERCEIVED SEIZURE SEVERITY IN INDIVIDUALS WITH TEMPORAL LOBE EPILEPSY
Creator: Fong, Wing Man
Date: 2012-12-17, 2012-12
Description: Epilepsy is a chronic neurological condition that can cause negative consequences in all areas of life for people with the condition. Research...
Show moreEpilepsy is a chronic neurological condition that can cause negative consequences in all areas of life for people with the condition. Research evidence has led to the goal of treatment to gradually shift from targeting only reducing the frequency of seizures to decreasing individual’s perception of seizure severity. While several studies have suggested that psychological and social factors, in addition to epilepsy-related biological factors, can also impact seizure severity perception, this area has received much less attention in relation to individuals’ perception of seizure severity. Therefore, this study examined individuals’ perception of seizure severity using a biopsychosocial framework which takes into account biological, psychological, and social factors to develop a comprehensive understanding about the perception of seizure severity. 57 individuals from a neurology clinic at a tertiary medical center with a primary diagnosis of localization-related temporal lobe epilepsy participated in this study. They were interviewed for demographic information and were assessed using Quality of Life in Epilepsy-89, Beck Depression Inventory, Stressful Life Events Scale, and Liverpool Seizure Severity Scale. A Multiple regression analysis indicated that the number of antiepileptic drugs, perceived memory function, the number of stressful life events, and social support were all significant predictors of perceived seizure severity. The current findings supported a biopsychosocial approach in understanding the perception of seizure severity among people with epilepsy. Clinical implications of these findings are discussed.
M.S. in Psychology, December 2012
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Title: DEPTH MAP PROCESSING FOR MULTI-VIEW VIDEO PLUS DEPTH
Creator: Vijayanagar, Krisha Rao
Date: 2014, 2014-05
Description: The world of multimedia and visual entertainment has grown in leaps and bounds in the past decade with 3-D television being one of the biggest...
Show moreThe world of multimedia and visual entertainment has grown in leaps and bounds in the past decade with 3-D television being one of the biggest technologies. Amongst several formats proposed for representing 3-D content, multi- view video plus depth (MVD) format has gained a lot of interest in the past few years. MVD requires that each view of a particular scene be accompanied by a per-pixel depth. This introduces new problems for compression and transmission of MVD content because a depth map has di erent characteristics from a color image. Keeping the MVD format and depth map characteristics in mind, we highlight three majors problems that plague the MVD format, namely, 1. depth map re nement. 2. depth map compression. 3. novel view synthesis using the depth map at the decoder side. In order to re ne a depth map, we propose a multi-resolution anisotropic di usion algorithm that is optimized to run in real-time thus ensuring that the encoder does not su er from additional latency. Next, we propose two unique solutions for compressing them. We rst propose a solution using the Layered Depth Video (LDV) concept using a rate-distortion optimized quadtree decomposition of the LDV using a novel two-mode block truncation code with improved prediction. We also propose a compression solution using compressive sensing (CS) concepts by creating a hybrid rate-optimized CS codec. This codec achieves two goals:- rstly, block classi cation to ensure lower decoder complexity and secondly, rate-distortion optimization of the measurement rate for each block that is to be compressively sensed. We then look at the view synthesis component of the MVD tool-chain which x is a time-sensitive process. Keeping decoding latency in mind, we propose a lookup- table based approach to the 3-D warping process with a simpli ed hole- lling algorithm that is not only competitive quality-wise with other schemes but is several times faster too. It is hopeful that the presented techniques can be used successfully to create MVD architectures for applications that need low-complexity encoding solutions.
PH.D in Electrical Engineering, May 2014
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Title: COMPUTER MODELING OF BREAST LESIONS AND STUDIES OF ANALYZER-BASED X-RAY IMAGING
Creator: Garcia, Luis De Sisternes
Date: 2011-11, 2011-12
Description: Phase-contrast x-ray imaging is an emerging technique that promises to yield highly sensitive medical images of soft tissue, which is...
Show morePhase-contrast x-ray imaging is an emerging technique that promises to yield highly sensitive medical images of soft tissue, which is difficult to observe via conventional radiography given its low X-ray attenuation differences. One of these phase-contrast techniques, known as analyzer-based imaging, has demonstrated that highly detailed breast tissue images can be obtained using synchrotron radiation. However, synchrotron facilities are impractical for clinical use. This thesis introduces studies and exposure consideration towards the application of analyzer-based imaging in a clinical environment, particularly in the context of breast imaging. It also introduces a computational breast lesion model that generates randomized three-dimensional phantoms which follow realistically the characteristics observed in real lesions. Moving analyzer-based imaging to clinical application requires the consideration of photon noise, inherent from the use of a photon-limited conventional source. We summarize the statistical properties in the presence of photon noise of two popular analyzer-based imaging techniques, known as diffraction-enhanced imaging (DEI) and multiple-image radiography (MIR). The statistics for MIR have not been previously derived and are introduced in this thesis. Comparison of the resulting statistical predictions with results obtained by Monte Carlo simulation validated the analysis. An expression for the maximum-likelihood (ML) solution for analyzer-based imaging is presented as a way of minimizing the effects of photon noise in the reconstruction of the object’s absorption, refraction and ultra-small angle scattering properties, and more practical maximum-likelihood expectation-maximization (ML-EM) and maximum-a-posteriori expectation-maximization (MAP-EM) solutions are also introduced. The behavior of the ML-EM and MAP-EM solutions was compared to the results produced by the five best-known analyzer-based reconstruction methods using computer simulations. The ML-EM and MAP-EM reconstructions proved closer to the theoretical values as they do not rely on commonly known limitations and approximations introduced by the other techniques. We introduce the development and evaluation of a new computational breast lesion phantom model that can simulate either massess or microcalcifications. The proposed tool allows the generation of a large number of randomized three-dimensional breast lesion simulations following desired characteristics normally used to describe breast lesions in clinical practice. The initial motivation for the development of this new phantom model was to enable the proposed evaluations of analyzer-based imaging to be achieved. However, the model became a major focus of this thesis because it improves significantly upon those that can be found in previous literature. The proposed lesion model can be used for evaluation studies across different breast imaging techniques, as well as for training purposes, so it is our hope that it could become an important resource for the broader mammography research community. As part of the lesion modeling research, we also introduce methods to computationally modify experimental mammography and analyzer-based images of breast tissue so that they present the generated tumor simulations embedded within their parenchyma realistically. The realism of the simulated lesion images was evaluated by comparison of 83 real tumor cases observed in mammograms with 83 constructed hybrid images in which simulated tumors matching the characteristics observed in the real cases were embedded, with healthy tissue acting as background. As a quantitative comparison, extracted features describing tumor shape and density showed no statistically significant differences between real and simulated tumors. A known computational tumor classification technique based on their shape observed in mammography was implemented and showed no significant performance differences between real and simulated cases, as well as showing good correlation with previously published performance results in real tumors. To measure the realism for use in human observer studies, we conducted a reader study in which 5 experienced radiologists were asked to judge whether each of the 166 images was real or simulated by assigning a score on a 7-point scale. The results were analyzed in a multiple-reader multiple-case statistical framework. The conclusion of the study was that the readers’ accuracy in assessing whether the lesions were real or simulated was not significantly better than random chance. This thesis also incorporates a reader study to evaluate the degree to which photon-limited analyzer-based images may be effective for visualization of breast cancer features. Our motivation was to establish the x-ray intensity that would be required to make these methods feasible, the purpose being to serve as a guide in parameter selection for future design of imaging hardware. We conducted a series of observer studies that quantify the performance of analyzer-based refraction images at different noise levels for the task of identifying subtle details present in breast tumors which are relevant to clinical diagnosis. The cases shown to the readers consisted of hybrid images where simulated lesions of known characteristics were computationally embedded in real breast analyzer-based background images. The original phase-contrast data was obtained using synchrotron radiation and was later modified to simulate the noise and blurring effects produced from a photon-limited source with a 300μm aperture size, similar to those used in a laboratory environment. Results showed that the analyzer-based imaging techniques statistically outperformed conventional mammography for the given task with an average of just 128 recorded photons per pixel in background image regions
Ph.D. in Electrical Engineering, December 2011
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Title: FEASIBILITY OF INDICATOR MICROORGANISMS IN ASSESSING THE EFFICACY OF SANITIZERS IN FRESH PRODUCE WASHING
Creator: Zhong, Zeyan
Date: 2016, 2016-05
Description: Sanitizers have been widely used in controlling cross-contamination during fresh produce washing processes. It is important to identify...
Show moreSanitizers have been widely used in controlling cross-contamination during fresh produce washing processes. It is important to identify different approaches for monitoring the efficacy of sanitizer washing. In this study, our objective was to determine the feasibility of indicator microorganisms in assessing the efficacy of chlorine and peroxyacetic acid (PAA) in fresh-cut produce washing. In inactivation experiments, the survivals of inoculated indicator microorganisms [total viable count (TVC), Enterobacteriaceae and total coliforms] and E. coli O157:H7 were determined after exposure to different concentrations of chlorine or PAA in water with added organic load (TOC~200 mg/l). In small-scale washing experiments, bacterial transfer from lettuce leaves inoculated with indicators or E. coli O157:H7 to wash water containing chlorine or PAA with/without organic matters was evaluated. In the inactivation study, higher log reduction was observed for Enterobacteriaceae and total coliforms than for E. coli O157:H7 after chlorine treatment at an initial concentration of 30 ppm. In the bacterial transfer study [a inoculated leaf (~5 log CFU) in 30 ml of wash water], without additional organic matter, approximately 3.5 log total CFU of all bacteria groups was transferred into wash water. Less than 1.5 log total CFU were detected for Enterobacteriaceae, total coliforms and E. coli O157:H7 in 1 ppm chlorine washing. With introduced organic matter, similar microbial loads of Enterobacteriaceae, total coliforms and E. coli O157:H7 were detected on washed leaves and in wash water with initial chlorine concentration of 1 ppm; when initial chlorine level increased to 10 ppm, less than 2 log total CFU of Enterobacteriaceae and total coliforms was detected while about 3 log total CFU of E. coli O157:H7 transferred to wash water, suggesting that chlorine at an initial concentration of 10 ppm could not prevent cross-contamination in the presence of organic load. The indicators showed different levels of survival and transfer from E. coli O157:H7 in this study and were unreliable to effectively monitor the behavior of the pathogen during chlorine wash in fresh produce processes. Enterobacteriaceae and total coliforms were more vulnerable to 40 ppm PAA treatment than E. coli O157:H7 in PAA inactivation experiments. No survival, except for TVC, was observed after 80 ppm of PAA inactivation. In the bacterial transfer study, 40 ppm PAA in wash water was found unable to prevent cross-contamination of indicators and E. coli O157:H7 from leaves to water. Further investigation is needed to compare the bacterial transfer levels of E. coli O157:H7 and the indicators at higher PAA levels.
M.S. in Food Safety and Technology, May 2016
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Title: Nutrition and Diabetes: Pathophysiology and Management
Creator: Opara, Emmanuel C.
Date: 2006
Publisher: CRC, Taylor & Francis

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