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Title: CHARACTERIZATION OF VERY LARGE YET VERY MILD BMD TYPE EDITS OF DYSTROPHIN
Creator: Lin, Yi-hsiu
Date: 2014, 2014-12
Description: Duchenne muscular dystrophy, DMD, is a severe X-linked recessive disease that kills boys in their second or third decade of life. A related...
Show moreDuchenne muscular dystrophy, DMD, is a severe X-linked recessive disease that kills boys in their second or third decade of life. A related condition Becker Muscular Dystrophy, BMD, is very heterogeneous with clinical severity ranging from nearly as bad as DMD, to nearly benign. Both of these are caused by defects in the dystrophin gene, which encodes a 427 kDa cytoskeletal protein, dystrophin, which can provide a mechanical link between the cytoskeleton and the muscle membrane and stables muscle tissue. In general, DMD results from defects that eliminate all dystrophin expression, whereas BMD patients carry mutated products: modified and malfunctioned dystrophin proteins. Since DMD is invariably fatal, monogenic, has a high incidence (1:3500 male births) and afflicts a charismatic patient profile, it has been an attractive target for gene therapy. However, the huge size of the dystrophin gene (2.4 Mbp) and more importantly its processed mRNA (14.2 kb) poses a problem for viral gene therapy which is limited to payloads of about 8 kb. This has prompted efforts to reduce the size of the dystrophin protein while still maintaining functionality. A major inspiration for such efforts was the identification of a very unusual, very large deletion serendipitously found in an extremely mild BMD case. The patient identified with this defect was ambulatory at 65 year of ages. This edit removes more than half the central rod region, from exon 17 to 48, Δe17-48, and, fortunately, the size of this BMD type edit protein is available for viral vector loading. In this project, edited dystrophin with central rod region deletion (D2:22 Δe17-48) and other two related edits, D2:22 Δe17-47 (exon 48 is added in D2:22 Δe17-48) and D2:22 Δe17-49 (exon 49 is deleted from D2:22 Δe17-48), were studied. According to these results, D2:22 Δe17-47 demonstrated the best biophysical and biochemical properties, but D2:22 Δe17-48 displayed higher to protease sensitivity, and D2:22 Δe17-49 had the worst thermal stability. This work will help us to understand the factors that result in benign large scale edits, and facilitate the development of effective viral gene therapy vectors.
M.S. in Biology, December 2014
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Title: PRENATAL ULTRASOUND CONSULTATION AND MATERNAL FEELINGS IN THE SECOND TRIMESTER OF PREGNANCY
Creator: Stockman, Alexandria
Date: 2015, 2015-07
Description: NO ABSTRACT
M.S. in Psychology, July 2015

Title: Alcometre: Preventing Drunk Driving via Sensor Technology (sequence unknown), IPRO 351 - Project Plan: IPRO 351 Project Plan F09
Creator: Abdullah, Khairul, Adeola, Olaoluwa, Apampa, Kunle, Arrowood, Renee, Entler, Jason, Geelen, Jeremy, Hwang, Kyu Sung, Liu, Xingshuo, Morales, Eduardo
Date: 2009-12
Description: The purpose of IPRO 351 is to research and develop a device that will be a non- invasive blood alcohol concentration (BAC) meter. Our mission...
Show moreThe purpose of IPRO 351 is to research and develop a device that will be a non- invasive blood alcohol concentration (BAC) meter. Our mission is to provide a safe and accurate BAC device that will help reduce the amount of people who drive while impaired. IPRO 351 has a vision of having a non-invasive biometric blood alcohol ignition interlock device (BBAIID) that can be installed on any vehicle.
Project plan for IPRO 351: Alcometre: Preventing Drunk Driving via Sensor Technology for the fall 2009 semester
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Title: Automated control and monitoring of thermal processing using high temperature, short time pasteurization
Creator: Schlesser, J. E., Armstrong, D. J., Cinar, A., Ramanauskas, P., Negiz, A.
Date: 1997-10
Publisher: AMER DAIRY SCIENCE ASSOC
Description: High temperature, short time pasteurization was used to evaluate a computer-based system for controlling the pasteurization process, acquiring...
Show moreHigh temperature, short time pasteurization was used to evaluate a computer-based system for controlling the pasteurization process, acquiring data, and monitoring records. Software was used for the control of hot water temperature, flow rate through the centrifugal timing pump, and diversion of under-processed product. Three types of control strategies were conducted: single loop, cascade, and multivariable. The single loop control strategy showed the most rapid responses to temperature changes, but the temperature response curve was slowest to return to its set point. The cascade control strategy showed slower recoveries to temperature changes, but the temperature response curve was smoother. The multivariable control strategy responded slightly faster than the cascade control strategy, and the temperature response curve was slightly smoother than the cascade control strategy. The multivariable control strategy was able to control the flow diversion valve by the use of a lethality controller. The data acquisition system, used to monitor the data obtained from the high temperature, short-time pasteurization system, was within +/- 0.1 degrees C of the temperature recorded by the safety thermal limit recorder. Reliability was determined by examining the changes in the position of the flow diversion valve to identify process deviations and by comparing the changes to the event marker on circular charts. The data acquisition system was an effective alternative for monitoring the completeness of data.
Endnote format citation
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Title: Street pavement for Rushville, Illinois
Date: 2009, 1914
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/streetpavementfo00pome
Thesis (B.S.)--Armour Institute of Technology; Includes folded leaves in back pocket

Title: Vacuum jacketing vs. steam jacketing
Creator: Gentry, T. E., Wernick, F. E.
Date: 2009, 1910
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/vacuumjacketingv00gent
Thesis (B.S.)--Armour Institute of Technology

Title: Using Assessment Data to Improve Library Services : presented at ILA 2007 conference: outline
Creator: Stewart, Christopher, Uth, Charles
Date: 2007-10
Description: IIT Libraries conducted LibQUAL+ service quality assessment in 2004 and 2006. This presentation will outline strategies we undertook to...
Show moreIIT Libraries conducted LibQUAL+ service quality assessment in 2004 and 2006. This presentation will outline strategies we undertook to address issues identified in the 2004 assessment, and evaluate their success based on assessment results in 2006. We will also discuss the importance of measuring academic library effectiveness in higher education’s emerging outcomes-based culture.
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Title: Integration of Process Improvement (sequence unknown), IPRO 304 - Deliverables: IPRO 304 Poster F09
Creator: Bauer, Jessie, Bergeron, Tony, Campen, Matt, Gruchalski, Erik, Choi, Tae Ki, Marx, Ryan, Murti, Chaitanya, Robbins, Brian, Sohal, Atinder Pal, Stenson, Amanda, Taboada, Alejandro, Zhang, Bingjian
Date: 2009-12
Description: A. Finkl and Sons require an effective way of detecting carbide inserts on the steel milling machine. These inserts break off due to stress...
Show moreA. Finkl and Sons require an effective way of detecting carbide inserts on the steel milling machine. These inserts break off due to stress and shape of metal and need to be replaced immediately to avoid further damage to the machine and the steel to be milled.
Sponsorship: A. Finkl and Sona
Deliverables for IPRO 304: Integration of Process Improvements for the fall 2009 semester.
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Title: INTERACTION IN THE SIXTH SENSE
Creator: Ghods, Ramin
Date: 2014, 2014-05
Description: Every experience of architecture is rooted in multi-sensory and embodied interactions with surroundings. All sensory modalities as well as...
Show moreEvery experience of architecture is rooted in multi-sensory and embodied interactions with surroundings. All sensory modalities as well as linguistic paradigms are integrated in the sensorimotor cortex of brain where mirror neurons are originated therein. Neurological understanding, on the other hand, suggests that meaning is always contextually grounded. Metaphor, in its very essence, is an expression to convey meaning to spectator. It stimulates ventra premotor cortex of brain, wherein mirror neurons activate the embodied simulation of actions, emotions, and corporeal sensations. So conceptual metaphors in everyday language are highly based on bodily interaction and encountering with surroundings. Additionally, they are also rooted in context and primordial images. Metaphor creates an interactive atmosphere in which symbolic and literal meanings are conveyed to beholders. Atmosphere is the essence of a space, in other words, understanding this atmosphere is the most crucial for understanding architecture. Spatial experiencing in its complete entirely could be taken through the emissions of atmosphere. In general, interaction in the 6th sense is focusing on a methodology of design to facilitate immediate perception of spatial settings of architecture. Far from abstraction and intellectualism, an atmosphere conveyed meaning through sensual perceptions. In this case, several modalities of architectural design, including materializes and de-materialized qualities such as light, texture, geometry, reflection, smell, sound, air, have been identified as contributing to atmosphere.
M.S. in in Architecture, May 2014
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Title: Gerry-meandering: An Assessment of the Congressional District Model of Depository Allocation (preprint): AhrensGriffinedrev1a
Creator: Ahrens, Aric G., Griffin, Luke A.
Date: 2003-06
Description: The preprint of a published article dealing with the effect of allocating Federal Depositories by Congressional district. Conclusions drawn...
Show moreThe preprint of a published article dealing with the effect of allocating Federal Depositories by Congressional district. Conclusions drawn include the fact that due to redistricting that occurs after each decennial census, over time some districts may have within their boundaries a greater number than the two depositories that Congressional district allocation was intended to produce. Likewise, over time shifting boundaries of districts have created districts that have no depositories whatsoever.
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Title: A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Project Plan F09
Creator: Dhagam, Karthik, Donchev, Alexander, Homawoo, Sergio, Litas, Alexander, Orlichenko, Anton, Osswald, Christian, Petsod, Jason, Rawlings, Ori, Shaffer, Joshua, Smith, Antoinette, Yates, Andrew, Yu, Hee Jeoung
Date: 2009-12
Description: Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the...
Show moreMuch information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.
Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semester
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Title: OPTIMAL DECISION-MAKING OF INTERDEPENDENT TRANSPORTATION INVESTMENT ALTERNATIVES UNDER RISK AND UNCERTAINTY
Creator: Zhou, Bei
Date: 2012-07-12, 2012-07
Description: With increasing demand for a more efficient transportation system and decreasing budget levels, transportation investment decision-making that...
Show moreWith increasing demand for a more efficient transportation system and decreasing budget levels, transportation investment decision-making that aims to select the optimal project portfolio which yields maximized overall networkwide benefits in terms of economy, society and environment has increasingly become important. This dissertation has conducted an in-depth investigation into project evaluation and project selection that are crucial steps of transportation decision-making. It begins with information search through a review of existing methods for project evaluation and selection. Several limitations of existing methods have been revealed. In particular, they are in lack of considerations in network impacts of a single investment project, interdependencies of simultaneously implementing multiple projects, and restrictions of total risk of overall benefits of selected projects within an acceptable level. Then, a new methodology is proposed for networkwide traffic assignments, project evaluation, and project selection. A state-of-art large scale transportation simulation software, the TRansportation ANalysis and SIMulation System (TRANSIMS) toolbox, is utilized to perform networkwide dynamic traffic assignments to general redistributed traffic volumes after project implementation needed as inputs for project evaluation. For project evaluation, a life-cycle cost analysis approach is developed to consider all agency costs and user costs in the service life-cycle of two primary categories of highway facilities: pavements and bridges. In order to enhance the robustness of analytical results, risk and uncertainty of input factors concerning traffic volumes, project costs, and discount rates are incorporated into the life-cycle cost computation using @Risk Palisade software, Version 5.5. For project selection, two-stage enhanced Knapsack model, hypergraph Knapsack, and two-stage hypergraph Knapsack model are proposed to choose the best sub-collection of interdependent projects to yield maximized overall benefits at various budget levels, while controlling the total risk within an acceptable level. In terms of two-stage Knapsack model, the Markowitz mean-variance model is utilized for stage-one optimization to generate minimized total risk of all projects subject to constraints of available budget and minimum benefits to be expected for individual projects. At the second stage, the Knapsack model is enhanced by adding stage-one optimization solution as one more constraint. Such a treatment could help control the total risk of overall benefits of all selected projects at a desirable level. Moreover, a hypergraph Knapsack model is introduced to capture project network impacts and interdependency relationships. In order to simultaneously address issues of networkwide project impacts, interdependencies, and total risk levels, a two-stage hypergraph Knapsack model is developed. Efficient solution algorithms are developed and coded to Frontline Solver Xpress V55 software to solve the two-stage Knapsack model, hypergraph Knapsack model, and two-stage hypergraph Knapsack model, respectively. Three computational studies are performed to apply the proposed methodology using two sets of data, including six-year data on 672 candidate projects proposed by Indiana Department of Transportation for state highway programming and 6 mega projects proposed by Illinois State Toll Highway Authority for tollway network major capital improvements. It has generally found that the use of two-stage Knapsack model could readily control the total risk of overall benefits of selected projects at a desirable level, but it may result in significant changes in the overall benefits for different budget levels where significant differences in risks are associated with individual projects. The hypergraph Knapsack model could effectively handle issues of networkwide project impacts and interdependency relationships. However, the two-stage hypergraph Knapsack model appears to be most robust in that it could simultaneously resolve the issues of networkwide project impacts, interdependency relationships, and total risks of overall project benefits, thus generating most reliable information to support rational transportation investment decision-making.
Ph.D. in Civil Engineering, July 2012
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Title: SYSTEM SUPPORT FOR RESILIENCE IN LARGE-SCALE PARALLEL SYSTEMS: FROM CHECKPOINTING TO MAPREDUCE
Creator: Jin, Hui
Date: 2012-05-31, 2012-05
Description: High-Performance Computing (HPC) has passed the Petascale mark and is moving forward to Exascale. As the system ensemble size continues to...
Show moreHigh-Performance Computing (HPC) has passed the Petascale mark and is moving forward to Exascale. As the system ensemble size continues to grow, the occurrence of failures is the norm rather than the exception during the execution of parallel applications. Resilience is widely recognized as one of the key obstacles towards Exascale computing. Checkpointing is currently the de-facto fault tolerant mechanism for parallel applications. However, parallel checkpointing at scale usually generates bursts of concurrent I/O requests, imposes considerable overhead to I/O subsystems, and limits the scalability of parallel applications. Despite the doubt in the feasibility of checkpointing continues to increase, there is still no promising alternative on the horizon yet to replace checkpointing. MapReduce is a new programming model for massive data processing. It has demonstrated a compelling potential in reshaping the landscape of HPC from various perspectives. The resilience of MapReduce applications and its potential in benefiting HPC fault tolerance are active research topics that require extensive investigation. This thesis work targets at building a systematic framework to support resilience in large-scale parallel systems. We address the identified checkpointing performance issue through a three-fold approach: reduce the I/O overhead, exploit storage alternatives, and determine the optimistic checkpointing frequency. This three-fold approach is achieved with three different mechanisms, namely system coordination and scheduling, the utilization of MapReduce framework, and stochastic modeling. To deal with the increasing concerns about MapReduce resilience, we also strive to improve the reliability of MapReduce applications, and investigate the tradeoffs in the programming model selection (e.g., MPI v.s. MapReduce) from the perspective of resilience. This thesis provides a thorough study and a practical solution for solving the outstanding resilience problem of large-scale MPI-based HPC applications and beyond. It makes a noticeable contribution to the state-of-the-art and opens a new research direction for many to follow.
Ph.D. in Computer Science, May 2012
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Title: Teacher Knowledge Share (Semester Unknown) IPRO 320: Teacher Knowledge Share IPRO 320 Poster1 F08
Creator: Bern, David, Bochantin, Marike, Hartline, Julian, Mccall, Ian, Mick, Emily, Peake, Andrew, Pierce, Alison, Pindrik, Dmitriy, Quinn, Michael, Stanford, Carly, Tilatti, Michael
Date: 2008, 2008-12
Description: The goal of IPRO 320 is to create an online professional network for school teachers at the kindergarten through twelfth grade level to allow...
Show moreThe goal of IPRO 320 is to create an online professional network for school teachers at the kindergarten through twelfth grade level to allow for the sharing of ideas, lesson plans and other professionally relevant information. This is a continuing project which saw limited success in the previous semester in that a functioning web site was constructed based on surveys of public school teachers but it saw very little use. This semester, the planned approach is to build on the research generated last semester by performing additional market research with teachers. Following that, IPRO 320 will rework much of the previous web site by refining some of the features, adding additional ones as the research indicates and improving the website in general, both functionally and aesthetically.
Deliverables
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Title: Agent-based control of autocatalytic replicators in networks of reactors
Creator: Tatara, E., Birol, I., Teymour, F., Cinar, A.
Date: 2005-03-15
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Description: Spatially distributed systems such as reactor networks hosting multiple autocatalytic species demonstrate a rich spectrum of complex behavior....
Show moreSpatially distributed systems such as reactor networks hosting multiple autocatalytic species demonstrate a rich spectrum of complex behavior. From a control systems perspective, spatially distributed systems offer a difficult control challenge because of their distributed nature, nonlinearity, and high order. Furthermore, manipulation of the network states may require simultaneous control actions in different parts of the system and may need transients through several operating regimes to achieve the desired operation. The lack of accurate and computationally efficient model-based techniques for large, spatially distributed systems results in complications in controlling the system, either in disturbance rejection or changing the operational regimes of the system. A hierarchical, agent-based control structure is presented whereby local control objectives may be changed in order to achieve the global control objective. The performance of the control system is demonstrated for several global objectives. The challenge posed is to control the spatial distribution of autocatalytic species in a network of five reactors hosting two species using the interaction flow rates as the manipulated variables. The multi-agent control system is able to effectively explore the parameter space of the network and intelligently manipulate the network flow rates such that the desired spatial distribution of species is achieved.
Endnote format citation for DOI:10.1016/j.compchemeng.2004.09.022
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Title: INFORMATION PROPAGATION DYNAMIC THROUGH VEHICLE TO VEHICLE COMMUNICATION NETWORK ON A ROAD SEGMENT
Creator: Wang, Lu
Date: 2015, 2015-12
Description: Vehicle-to-vehicle communication system enables vehicles to share various traffic information such as road surface condition, real-time...
Show moreVehicle-to-vehicle communication system enables vehicles to share various traffic information such as road surface condition, real-time traffic congestion, crashing alert or weather situation. Thus, it has a great potential to improve traffic safety, mobility and environmental sustainability. To grant this great promise, information availability plays a critical roles. Accordingly, many previous studies have investigated statistic characteristics (such as mean and variance) of information propagation (such as speed/time delay via instantaneous transmission, connectivity, etc.) integrating traffic flow features. However, few of them are able to capture the information spread dynamics based on V2V. Motivated by this view, this research seeks to develop a discrete mathematical approach to capture information coverage dynamics built upon traffic flow dynamics, which is described by discrete traffic flow dynamics, i.e., cell transmission model. The approach is entailed by developed mathematical model to capture inner-cell information propagation delay and inter-cell transmission based on the proposed information-traffic cell transmission model. The development of the proposed methodology considers a single or two piece(s) of information is (are) sequentially landed on a one-way or two-way road segment underVehicle-to-vehicle communication system enables vehicles to share various traffic information such as road surface condition, real-time traffic congestion, crashing alert or weather situation. Thus, it has a great potential to improve traffic safety, mobility and environmental sustainability. To grant this great promise, information availability plays a critical roles. Accordingly, many previous studies have investigated statistic characteristics (such as mean and variance) of information propagation (such as speed/time delay via instantaneous transmission, connectivity, etc.) integrating traffic flow features. However, few of them are able to capture the information spread dynamics based on V2V. Motivated by this view, this research seeks to develop a discrete mathematical approach to capture information coverage dynamics built upon traffic flow dynamics, which is described by discrete traffic flow dynamics, i.e., cell transmission model. The approach is entailed by developed mathematical model to capture inner-cell information propagation delay and inter-cell transmission based on the proposed information-traffic cell transmission model. The development of the proposed methodology considers a single or two piece(s) of information is (are) sequentially landed on a one-way or two-way road segment under sparse or congested traffic flow considered. Next-Generation simulation field data and Paramics simulated data are used to verify the accuracy of the experiments. Our experimental results show that the proposed model can accurately track information spread dynamics with mean absolute error less than 5% over all experiments. Key words: Vehicle-to-vehicle communication system; cell transmission model; time delay; information propagation coverage.
M.S. in Civil Engineering, December 2015
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Title: Planning the 21st Century Urban Farm: From High Rise to Neighborhood (sequence unknown), IPRO 336 - Deliverables: IPRO 336 IPRO Day Presentation F09
Creator: Bhatti, Talha, Binet, Adrien, Bredau, Jason, Chen, Emily, Davis, Jacob, Gaonkar, Gaurav, Garcia, Raul, Guerrero, Fernando, Gulling, Richard, Kagehiro, Michael, Moshfeghian, Elnaz, Nunez-gimeno, Jose, Phillips, Zachary, Plumb, Isaac, Ryan, Emily, Skaggs, Jake, Sobon, Konrad, Valmores, Travis
Date: 2009-12
Description: The purpose of this IPRO is to establish a strong foundation for the future of urban agriculture. The growing problems regarding the...
Show moreThe purpose of this IPRO is to establish a strong foundation for the future of urban agriculture. The growing problems regarding the traditional methods of agriculture, and the rate of growth of the world population, the team plans to design a method to grow food more efficiently and economically in urban areas. The team is looking at large, industrial warehouse-type buildings that have outlived their primary use, and creating a plan that utilizes these buildings to grow enough food for the surrounding communities.
Sponsorship: John Edel of Bubbly Dynamics, LLC
Deliverables for IPRO 336: Planning the 21st Century Urban Farm: From High Rise to Neighborhood for the fall 2009 semester
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Title: Zero CommunIITy: A Prototype for a Zero-Energy Residential Development (sequence unknown), IPRO 323 - Deliverables
Creator: Bohac, Adam, Brady, David, Bueno, Juan, Coughlin, Daniel, Depalma, Lowell, Gonzalez, Juan, Gross, Josh, Hernandez, Carlos, Iversen, Jennifer, Mckinley, Keanen, Moceri, Michael, Modi, Nishant, Wisniewski, Anthony, Zacharias, Bryan
Date: 2009-12
Description: The teams purpose is to seek a union between living comfortably and living sustainably. To design for a future Chicago‐area community, which...
Show moreThe teams purpose is to seek a union between living comfortably and living sustainably. To design for a future Chicago‐area community, which first minimizes its energy consumption and then uses the most sustainable methods to fulfill the remaining needs of the inhabitants. Ideally we will design a model community which will challenge conventions within the fields of design, planning, engineering, and everyday living. This community will also serve as an example to Chicago‐area municipalities about the benefits of sustainable planning, design, and living.
Sponsorship: Consultant from A. Epstein & Sons; Jeremy Poling
Deliverables for IPRO 323:Zero CommunIITy: A Prototype for a Zero-Energy Residential Development for the fall 2009 semester
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Title: Washington Park Center for Improvisational Music: Kellen White_Final Booklet_Spring 2010
Creator: White, Kellen
Date: 2010-07-30

Title: HIGH PERFORMANCE LOGIC DESIGN FOR ADAPTIVE FIR FETAL ECG ESTIMATION
Creator: Wang, Sizhou
Date: 2014, 2014-05
Description: This thesis presents realizations of IEEE-754 single precision floating point non-invasive fetal ECG estimation based on QR Decomposition...
Show moreThis thesis presents realizations of IEEE-754 single precision floating point non-invasive fetal ECG estimation based on QR Decomposition Recursive Least Square algorithm (QRD-RLS). Experiments of the system, which is implemented on Xilinx Zynq SoC platform, are carried out with electrocardiogram (ECG) data and the results with analysis are presented. The embedded system design aims for saving resources, streaming pipeline performance and software-aid computation and integration. The challenge of exploiting the system full potential with pseudo-parallel computation on multiple fetal ECG data packets is also examined.
M.S. in Computer and Electrical Engineering, May 2014
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