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Title: Evaluation of the Native Microbiota and Comparative Analysis of a Known Cronobacter Sakazakii and a Newly Isolated Bacillus Cereus Strain in Powdered Infant Formula
Creator: Patil, Sonali Prashant
Date: 2024
Description: There have been numerous reports of Powdered Infant Formula (PIF) recalls and outbreaks due to the absence of a kill step in the post...
Show moreThere have been numerous reports of Powdered Infant Formula (PIF) recalls and outbreaks due to the absence of a kill step in the post-pasteurization processing, improper handling pre and post processing and/or reconstitution, and lack of effective sanitization and cleaning of the food contact surfaces in the manufacturing facilities. The objectives of this present study were to 1) survey and identify background microflora in commercial PIF products through microbiological analysis, 16S rRNA, and whole genome sequencing (WGS); 2) compare the survival rate of a known Cronobacter sakazakii and a newly isolated Bacillus cereus DFPST-SP1 in PIF under a humidity level of 33 ± 3% over a period of 28 d; 3) examine the relative resistance of these two strains to thermal treatments at temperatures 40, 70, and 100 °C followed by storage at room temperature (RT) for 30 min; and 4) evaluate the bactericidal effect of 70% ethanol on the two artificially deposited bacterial strains on stainless steel (SS) and plastic coupons. Three biological trials were conducted for each study. To determine whether the increase, decrease, or difference in the bacterial populations and other parameters like water activity (aw) was statistically significant, a T-test was performed (p ≤ 0.05 was considered significant). Results of 16S rRNA sequencing revealed the presence of certain bacterial species in PIF, such as Lactococcus lactis, B. cereus, Listeria monocytogenes, Staphylococcus aureus, Salmonella enterica, etc. distributed across a relative abundance of >25%, <25%, and ≤3%. After the enrichment and isolation as per Bacteriological Analytical Manual (BAM), C. sakazakii or S. enterica were not detected, while colonies exhibiting a blue-green appearance resembling Listeria spp. and certain Bacillus spp. were subjected to WGS for species-level identification. The assembly_1 from formulation 1 was confirmed as B. cereus sequence type 2255 and was renamed as B. cereus DFPST-SP1 in the contribution of this thesis work. The storage study conducted on PIF inoculated with C. sakazakii and B. cereus DFPST-SP1 at 33% RH showed that there was 0.25-0.27 log CFU/g reduction towards the end of 28 d, but no significant difference was observed between the two strains. The thermal challenge study revealed that the newly isolated B. cereus strain and C. sakazakii used in this study were highly thermotolerant. Based on the sanitizer challenge study, 70% ethanol was significantly more effective in reducing populations of C. sakazakii as compared to B. cereus. Moreover, higher log reductions of C. sakazakii 587 populations on stainless steel coupons compared to plastic coupons were observed, indicating that bacteria adhere more tightly to plastic surfaces than stainless steel (SS). Overall, the findings of this study shed new light on bolstering the safety standards of PIF and highlight the need for improved cleaning and sanitization procedures within manufacturing facilities in order to ensure the safety of reconstituted PIF, thereby enhancing public health, particularly infants and neonates.
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Title: Validation of the Chinese Version of the Penn Inventory of Scrupulosity in a Chinese Student Sample
Creator: De Leonardis, Andrew J.
Date: 2023
Description: Scrupulosity, which is a subtype of obsessive-compulsive disorder (OCD) characterized by religious obsessions and compulsions, has been shown...
Show moreScrupulosity, which is a subtype of obsessive-compulsive disorder (OCD) characterized by religious obsessions and compulsions, has been shown to be particularly debilitating. The current research concerning scrupulosity has mainly examined Western populations. There is a paucity of literature examining scrupulosity in Eastern populations, and no literature to date examining scrupulosity in a Chinese sample. In order to examine scrupulosity in China, a valid measure of scrupulosity is needed. The current study validated a Chinese version of the main measurement of scrupulosity, the Penn Inventory of Scrupulosity - Revised (PIOS-R), in a Chinese student sample. The PIOS-R was translated both linguistically and conceptually in consultation with the Chinese research team. New items were added for review and possible inclusion. 577 university students in China completed an online survey with study measures. This sample was randomly split into two groups, a primary group for the initial Confirmatory Factor Analysis (CFA) and a hold-out sample for follow up analyses. The initial CFA of the PIOS-R found that none of the three models identified met all criteria for adequate fit. A follow up Exploratory Factor Analysis (EFA) was conducted on the same group and found a two-factor model with updated items. This model was successfully cross-validated using a CFA in the hold-out sample. These analyses yielded the Penn Inventory of Scrupulosity – Chinese Version (PIOS-C). Preliminary reliability and validity were established with this revised measure. Having an accurate and valid measure of scrupulosity for the Chinese population will assist in characterizing scrupulosity in China and developing or refining appropriate treatments.
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Title: Developing Advanced Materials for Carbon Dioxide Electroreduction to Value-Added Chemicals and Fuels
Creator: Esmaeilirad, Mohammadreza
Date: 2023
Description: Developing highly efficient electrocatalysts for the carbon dioxide reductionreaction (CO2RR) to value-added fuels and chemicals offers a...
Show moreDeveloping highly efficient electrocatalysts for the carbon dioxide reductionreaction (CO2RR) to value-added fuels and chemicals offers a feasible pathway for renewable energy storage and could help mitigate the ever-increasing carbon dioxide (CO2) emissions from human activities. Different catalysts are known to catalyze CO2RR in aqueous solutions. Most known catalysts are only capable of transferring 2 electrons with needed protons to CO2 producing either carbon monoxide (CO) or formic acid (HCOOH). Copper (Cu) is the only electrocatalytic material that converts CO2 into different types of hydrocarbon products. Additionally, owing to Cu’s natural abundance and low cost, it has been intensively studied for CO2RR for decades. However, the required high input energy (overpotential), low product selectivity towards valuable fuel products, and the lack of long-term stability remain major challenges for Cu-based catalysts. This work aims to develop new materials that produce hydrocarbons at lower overpotentials with higher rates and greater selectivity than current copper catalysts. By implementing a process referred to as the electrocatalyst discovery cycle iterations between predications, catalyst testing, and active site characterization allow for the rational design and discovery of new and improved electrocatalysts for CO2RR. This methodology led to the discovery of different heteroatomic catalysts as low overpotential catalysts for electroreduction of CO2 high energy density hydrocarbon products.
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Title: High-Entropy Stabilization as a Designing Tool for Li-Ion Electrodes
Creator: Bandeira Jovino Marques, Otavio Jose
Date: 2023
Description: High-Entropy oxides (HEOs) form a new class of materials where the configurational entropy plays the stabilizing role of multicomponent...
Show moreHigh-Entropy oxides (HEOs) form a new class of materials where the configurational entropy plays the stabilizing role of multicomponent systems at high temperatures. Recently, it raised much attention for energy storage applications, especially on Li-ion batteries, where the combination of several different elements in a single solid solution can synergistically act to overcome some of its main drawbacks, improving the battery’s performance. The entropy stabilization opens new boundaries on electrode’s design by increasing the compositional space available for different structures and compounds. Not long ago, the high-entropy oxide (Mg0.2Co0.2Ni0.2Cu0.2Zn0.2)O demonstrated a big potential as anode material in Li-ion batteries. Its high capacity and long cycling stability raised a lot of questions about the role of the transition metals in the conversion reaction, and the configurational entropy contribution to the electrochemical reaction, further supporting the electrode’s stability. In order to investigate the structural evolution, the role of the multicomponent oxides and structures on the battery’s performance, and the entropic contribution to the electrode’s stability, this research proposes a systematic and robust methodology around the (Mg0.2Co0.2Ni0.2Cu0.2Zn0.2)O high-entropy oxide (HEO). The project heavily relies on the EXAFS ability to determine the short-range structure and the chemical sensitivity to isolate the elemental contribution of the compound at different cycling and charging states. First, the role of different metallic cations on the electrochemical reaction mechanism of the HEO was analyzed by the change in local structure during different charging steps of a Li-ion battery (Chapter 3). Secondly, the entropy contribution and tunability effects on electrochemical performance were tested in a series of medium and high-entropy oxides derived from the seminal HEO. Mg, Co, Ni, Cu, and Zn were individually removed from the HEO’s composition at a time and tested as Li-ion electrode. Fe was also added to the HEO’s composition (HEO+Fe) in order to prove the tunability effects and entropy contribution (Chapter 4). Operando x-ray absorption spectroscopy (XAS) was used to capture the short lived phases and the transient nature of the conversion reaction, to explain the origins of the extra storage capacity encountered on entropy stabilized systems (Chapter 5). Finally, the role of the high-entropy oxide initial structure was investigated and compared, to check versatility of the elements that can be used on a high-entropy system (Chapter 6).
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Title: Using High-Pressure Reverse Osmosis Technique to Desalinate Produced Water
Creator: Dallalzadeh Atoufi, Hossein
Date: 2023
Description: This dissertation presents a comprehensive investigation into the use of high-pressure reverse osmosis (HPRO) to desalinate produced water (PW...
Show moreThis dissertation presents a comprehensive investigation into the use of high-pressure reverse osmosis (HPRO) to desalinate produced water (PW) in the oil and gas industry, with the aim of developing sustainable water management strategies. The study analyzes fouling mechanisms in HPRO desalination, revealing the applicability of Hermia's fouling mechanism to high-salinity waters and highlighting the negligible impact of complete pore blocking and standard pore blocking in crossflow reverse osmosis (RO) desalination. Furthermore, the research investigates ion transport through commercial polyamide thin film composite membranes using the solution-friction model, elucidating the influence of factors such as pressure, temperature, and crossflow velocity on the initial flux while minimal impact on steady-state flux is observed. The assessment of oil and gas waste discharge in water systems provides insights into potential environmental consequences, and the analysis of the behavior of per- and polyfluoroalkyl substances (PFAS) in contaminated sediments using passive sampling demonstrates the rapid uptake of shorter-chain PFAS compounds due to their lower sorption potential and faster diffusion rates. The dissertation contributes to the development of sustainable water management strategies, addressing the challenges of produced water treatment and environmental contamination in the oil and gas industry, and offers valuable information on fouling mechanisms, impacts of ion transport mechanisms, waste discharge and PFAS behavior, enabling optimized desalination processes, informed waste management practices, and a better understanding of environmental contamination issues.
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Title: Hidden Figures: Vera Jansone at Mies’ IIT
Creator: Garcia-Requejo, Zaida, Jones, Kristin
Date: 2021, 2021-12-15

Title: TechNews, April 03, 2012
Creator: Illinois Institute of Technology
Date: 2012-04-03, 2012-04-03
Collection: Technology News print collection, 1940-2019

Title: Students International House
Creator: Peterhans, Brigitte 1928-2021
Date: 1961

Title: A Limited Case Study: Perspectives of Students, High School Teachers, and College Instructors About Advanced Placement Mathematics Courses
Creator: Joseph, DeJuana V.
Date: 2023
Description: ABSTRACTBackground. The underrepresentation of Black and Latinx students in STEM is highlighted due to structural impediments. Although AP...
Show moreABSTRACTBackground. The underrepresentation of Black and Latinx students in STEM is highlighted due to structural impediments. Although AP mathematics classes are being introduced as a solution, students from underprivileged schools continue to confront challenges. The study project seeks to investigate the obstacles associated with teaching AP mathematics courses in disadvantaged high schools and to gather perspectives from various stakeholders.Methodology. The study employs qualitative one-on-one interviews and an interpretive research paradigm. The sample comprises mathematics faculty, first-year college students, high school AP math teachers, and one high school student. Thematic analysis is used and ethical considerations are taken into account. Limitations include time and resource constraints, a small sample size, and potential inconsistencies in participant responses.Results and Findings. AP mathematics classes may inspire students to continue STEM in college, yet obstacles such as time constraints and knowledge gaps exist. Students' employment choices are influenced by their own interests and abilities. High school math teachers and college professors highlight algebraic skills as crucial for success in college mathematics, particularly in calculus classes.Discussion. The STEM enrollment problem does not only affect minority students; AP math can be a pathway for all kids. Improving AP math readiness for all students is critical for addressing the STEM professional shortage. It is essential to use extra measures to increase student interest in STEM. Strong foundational algebraic knowledge is required for success in higher education, necessitating stakeholders to focus on improving STEM enrollment and completion rates.
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Title: Cardiolipin Modulates the Insertion of Adsorbed Helical Amyloid Beta Peptide Into Model Mitochondrial Membranes
Creator: Kaczmarek, Julia A.
Date: 2023
Description: The loss of mitochondrial phospholipid cardiolipin (CL) may play a role in both the pathogenesis of Alzheimer's Disease (AD) and its treatment...
Show moreThe loss of mitochondrial phospholipid cardiolipin (CL) may play a role in both the pathogenesis of Alzheimer's Disease (AD) and its treatment. An effector molecule of the disease, amyloid-beta (Aβ), has been observed to interact with lipid membranes, but its relevance to mitochondrial membranes containing CL remained elusive. The present study investigated if the presence of CL modulated the insertion of adsorbed helical amyloid beta (Aβ14-40) into model mitochondrial membranes, and if this effect was more pronounced for its N-terminus or C-terminus. I conducted a coarse-grained computer simulation using well-tempered metadynamics to traverse the free energy landscape that maps the translocation of Aβ14-40. Insertion into CL-containing bilayers created larger local membrane deformations and modulated the location of the transition path but had an inconclusive impact on the free energy cost of translocation. Since the generation of toxic calcium-permeable pores depends on the insertion of Aβ into the bilayer, the loss of CL seen in AD may prime the inner mitochondrial membrane for pore formation, but more research is needed to pursue this hypothesis.
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Title: Development of data assimilation for analysis of ion drifts during geomagnetic storms
Creator: Hu, Jiahui
Date: 2024
Description: The primary objective of this dissertation is to gain insight into geomagnetic storm effects at mid-latitudes induced by solar activity....
Show moreThe primary objective of this dissertation is to gain insight into geomagnetic storm effects at mid-latitudes induced by solar activity. Geomagnetic storms affect our everyday lives because they give rise to transient signal loss, data transmission errors, negatively impacting users of satellite navigation systems. The Nighttime Localized Ionospheric Enhancement (NILE) is a localized plasma enhancement that because it is not well understood, drives the design of satellite-based augmentationsystems. To better secure operation of technological infrastructure, it is essential to build a comprehensive understanding of the atmospheric drivers, especially during solar active periods. Instrument measurements and climate models serve as valuable tools in obtaining information regarding the occurrence of space weather events; nonetheless, both sources exhibit quantitative and qualitative limitations. Data assimilation, an evolving technique, integrates measurements and model information to optimize the state estimations. This dissertation presents developments in a data assimilation algorithm known as Estimating Model Parameters from Ionospheric Reverse Engineering (EMPIRE), and its applications in investigating the atmospheric behaviors under varying solar conditions. EMPIRE is a data assimilation algorithm specifically designed for upper atmospheric driver estimation of neutral wind and ion drifts at user-defined spatial and temporal scales. The EMPIRE application in this work aims to contribute to a more comprehensive understanding of the effects of the NILE. EMPIRE utilizes the Kalman filter to optimize state calculations primarily based on electron density rates, provided by other data assimilation algorithms. Earlier runs of the algorithm used pre-defined values for the background state covariance cross time. To address model limitations under changing geomagnetic conditions, the algorithm is enhanced by concurrently updating the background state covariance during assimilation processes. Additionally, representation error is incor- porated as a component of the observation error, and error analysis is performed through a synthetic-data study. Previously, EMPIRE fused Fabry-Perot Interferometer (FPI) neutral wind measurements, demonstrating increased agreement with validation neutral wind data. In this work, this approach is extended to augment Coherent Scatter Radar (CSR) ion drift measurements from Super Dual Auroral Radar Network (SuperDARN), providing additional insights into EMPIRE’s estimated field-perpendicular ion motion. For an in-depth exploration of storm-related NILE, both EMPIRE and another data assimilation method, the Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension coupled with Data Assimilation Research Testbed (WACCM-X + DART), is implemented for a storm event to test the proposed NILE driving mechanism. Furthermore, this dissertation introduces a Kalman smoother technique into the EMPIRE to enhance its ability to assess past storm events, and to explore the potential for algorithm improvements.
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Title: #MeToo: What Urged Users to Post?
Creator: Hirsh, Rachel Anna
Date: 2023
Description: In this dissertation, I explore the motivations that compelled individuals to share their stories during the #MeToo movement, an unprecedented...
Show moreIn this dissertation, I explore the motivations that compelled individuals to share their stories during the #MeToo movement, an unprecedented digital phenomenon that thrust discussions of sexual harassment and assault into the public sphere. The central research question guiding this study was, "What urged users to post during the #MeToo movement?," which worked to uncover why and how the movement became so widespread.. Research demonstrates that when people are sexually harassed or assaulted, often times they do not come forward (Hlavka, 2014). Spencer et al. shares some of the common reasons women do not come forward are that they don’t classify their harassment or assault as a big enough deal, they do not know who or how to report it, they are afraid, they were drunk, they are ashamed, they don’t want to get their assailant in trouble, or they blame themselves (2017). However, those reasons fell by the wayside, as so many people came forward during the #MeToo movement. This paper aims to figure out why that was and how we can continuously get survivors to come forward. This paper also asks the question, did people come forward to share testimony, be part of a movement, or both?Two distinct hypotheses were formulated to unpack the complex dynamics at play The first hypothesis posited that users who engaged with central nodes, encompassing key figures within the #MeToo movement, original contributors, celebrities, and influencers, were more inclined to hold a positive outlook on the movement as a progressive step for women. This data was collected through a quantitative survey, and the analysis yielded inconclusive results, with 79.15% of the sample population expressing support for the movement while only 54.17% reported following central nodes. Qualitative interviews further underscored the multifaceted nature of motivations.The second hypothesis posited that individuals were more inclined to share their personal experiences of harassment or assault online when they observed weak ties within their social networks, such as acquaintances or friends of friends, sharing their own stories. The findings from survey data revealed that 68.87% of participants witnessed weak ties sharing personal experiences or using the #MeToo hashtag on their social media platforms. Qualitative interviews unanimously highlighted the significant influence of observing friends or weak ties posting about their experiences, further underscoring the diversity of motivators behind #MeToo participation.These findings shed light on the multifaceted nature of online activism and the pivotal role of personal networks in shaping the movement's trajectory. In essence, this research demonstrates that while the motivations for user participation in the #MeToo movement are diverse and complex, the presence of weak ties, or distant social relationships or relationships with infrequent interactions, within social networks emerges as a critical influence.
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Title: Modeling and Optimization of Embedded Active Flow Control Systems
Creator: Henry, James M.
Date: 2024
Description: This thesis presents research focused on the aerodynamic performance of circulation control on two-dimensional and quasi-two-dimensional wings...
Show moreThis thesis presents research focused on the aerodynamic performance of circulation control on two-dimensional and quasi-two-dimensional wings. Aerodynamic loads, namely lift, drag, and moment coefficients, are measured through Reynolds Averaged Navier Stokes (RANS) modeling and wind tunnel experiment. A simplified and parameterized RANS model is presented as a rapidly iterable approach to estimating the performance of trailing-edge circulation control on two dimensional airfoils, with the hypothesis that an optimized airfoil shape can be found which maximizes the lift coefficient increment generated by circulation control, through modification of the wing profile. The simplified modeling setup is compared with more conventional approaches to numerical simulation of circulation control. The performance of the simplified modeling scheme is then compared with wind tunnel studies, for both steady-state and dynamic performance, as functions of both momentum coefficient dCμ and chord-based Reynolds number Re_c. The dynamic performance for the model is studied to find an analog to the theoretical unsteady models of Wagner and Theodorsen. An adjoint optimization framework is used to find an optimal airfoil profile for circulation control. The optimized profile is then compared in both a simulation and a wind tunnel test study against a NACA0015 airfoil. In simulation, improvement between 12% and 15% is seen for the lift control authority for all values of dCμ and Re_c tested. In experiment, the optimized profile demonstrated improvements of up to 28% in lift control authority, dCL/dCμfor values of Cμ, and decreased performance for higher values of Cμ.
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Title: Evaluation of the efficacy of power ultrasound technology coupled with organic acids to reduce listeria monocytogenes on peaches and apples
Creator: Joshi, Mayura Anand
Date: 2024
Description: Fresh fruits and vegetables are prone to microbial contamination throughout different phases of human handling, processing, transportation,...
Show moreFresh fruits and vegetables are prone to microbial contamination throughout different phases of human handling, processing, transportation, and distribution. Emerging technologies, such as power ultrasound, have received attention due to their capacity to reduce or eliminate foodborne bacterial pathogens on these commodities. Power ultrasound, when combined with certain antimicrobials, has demonstrated its effectiveness as a valuable tool for washing fresh produce. The objective of this study was to examine the effectiveness of power ultrasound combined with organic acids on the reduction of Listeria monocytogenes on fruits. In this study, peaches and apples were subjected to surface inoculation with a four-strain cocktail of L. monocytogenes and dried for 1 h. Stomacher bags, containing 225 mL of citric, lactic, or malic acids at concentrations of 1%, 2%, or 5%, were employed for treating inoculated peaches and apples. The acid treatment was used alone, or in combination with power ultrasound for 2, 5, or 10 min. Water was used for controls. Before treatment, the initial population of L. monocytogenes on apples was lower compared to the initial population on peaches, with apples showing a 1.94 log CFU/fruit reduction. Water controls demonstrated no significant log reduction in both apples and peaches. The greatest L. monocytogenes reduction on apples occurred when treated with 1% citric acid for 2 min with power ultrasound where L. monocytogenes was significantly reduced from 6.98±0.88 log CFU/fruit to 5.56±0.91 log CFU/fruit. The greatest L. monocytogenes reduction on peaches occurred when treated with 5% citric acid for 5 min with power ultrasound where L. monocytogenes was significantly reduced from 7.44±0.45 log CFU/fruit to 6.68±0.40 log CFU/fruit. Overall, the combined effect of acid and power ultrasound was more pronounced in apples than in peaches. The survival of L. monocytogenes on apples and peaches appeared to be highly dependent on the specific treatment and hurdle technology applied. The combination of ultrasound hurdle technology with acid washing has proven effective in reducing L. monocytogenes on both peaches and apples, with a more significant impact observed on apples. While acid washing is a more economical option compared to ultrasound technology, the efficiency of microorganism reduction is considerably enhanced when power ultrasound is combined with organic acids. Looking ahead, the development of cost-effective power ultrasound methods could facilitate widespread adoption of ultrasound hurdle technology in the produce industry.
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Title: Pilgrim Baptist Church, Chicago, Illinois, ca. 1964
Creator: Weil, F. Peter
Date: 1964
Description: Pilgrim Baptist Church (3301 S. Indiana Ave, Chicago, IL) photographed by Institute of Design student F. Peter Weil. Date is estimated as 1964...
Show morePilgrim Baptist Church (3301 S. Indiana Ave, Chicago, IL) photographed by Institute of Design student F. Peter Weil. Date is estimated as 1964 from other evidence in the collection.
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Collection: F. Peter Weil photographs, 1952-1964

Title: Tidal Blossom
Creator: Pertha, Hilda
Date: 1980
Description: Tidal Blossom, an ink painting by Hilda Pertha. Pertha, who moved to Mendocino, California in 1979, was a friend of Mary Henry's, and likely...
Show moreTidal Blossom, an ink painting by Hilda Pertha. Pertha, who moved to Mendocino, California in 1979, was a friend of Mary Henry's, and likely gifted this painting to Henry.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Jay Doblin with unidentified Institute of Design students, Illinois Institute of Technology, Chicago, Illinois, ca. 1955-1965
Date: 1955-1965
Description: Photograph of Institute of Design Dean Jay Doblin with unidentified ID students and the interior of a partially constructed vehicle, Illinois...
Show morePhotograph of Institute of Design Dean Jay Doblin with unidentified ID students and the interior of a partially constructed vehicle, Illinois Institute of Technology. Photographer unknown. Date of photograph is unknown. Date range listed is approximate.
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Collection: Institute of Design records, 1942-2001

Title: Correlating Microstructural Properties to Macroscopic Shear Mechanics to Improve the Understanding of Tissue Biomechanics
Creator: Cahoon, Stacey Marie
Date: 2023
Description: Understanding tissue biomechanics is of interest for modeling organ injury from external loads, development of tissue surrogate materials, and...
Show moreUnderstanding tissue biomechanics is of interest for modeling organ injury from external loads, development of tissue surrogate materials, and creating new biomarkers for disease. Probing the response of soft tissue in shear can provide information on histopathology, provided a methodology exists that connects the macroscopic mechanical properties with cell-level properties. Two of the available methods to measure the macroscopic shear viscoelastic properties of soft tissue are oscillatory shear rheometry and ultrasound shear wave elastography (SWE). Due to its accuracy, rheometry is the gold standard, but it is destructive, requires excised homogeneous samples, and can only be applied ex-vivo. SWE is an emerging non-invasive imaging technique which requires validation, ostensibly by comparing with rheometry. Histology is the gold standard for providing morphological information on the cell level, which can determine tissue pathology. The challenge is to connect the macroscopic mechanical metrics derived from SWE and rheometry to the tissue microstructure. To address this challenge, mathematical models can be used that employ multiple, judiciously chosen measurements of macroscopic shear properties and histology to estimate intrinsic mechanical properties at the cell level.A class of homogeneous and composite lipid phantoms mimicking the mechanical properties of brain white matter were fabricated to test a novel stereotactic system and an optimized SWE imaging protocol. The shear stiffness measurements obtained with SWE on the whole phantom were validated with rheometry performed on a series of samples made with the same material as the phantoms. The same procedure was applied to porcine brain white matter excised from fresh whole brains (n=3). Cylindrical cores were extracted from the corpus callosum area, sliced into discs and microscopic sections were subsequently removed for histology. Good agreement was found between the SWE and rheometry measurements of shear stiffness, which generally increases with the level of compressive prestress. Immunofluorescence was used to stain separately the axon neurofilaments and myelin sheaths, and digital image analysis of the confocal microscopy images allowed the estimation of axon volume fraction and axon-to-myelin ratio in the corpus callosum. Using these metrics and a composite mechanical model, a connection between the macroscopic shear measurements and the viscoelastic properties of axon and glia matrix was made for porcine brain tissue. Similarly, rheometry was used to measure the macroscopic properties of decellularized porcine myocardium extracellular matrix (ECM) in two different fiber locations, and for three different fiber orientations. The mechanical properties were found to be dependent upon fiber location, but not on fiber orientation. Since collagen is a primary supportive structure for the ECM, several microscopic slices were probed with immunofluorescence to compute the collagen I and collagen IV volume fractions. Another mechanical model was employed to establish a connection between the macroscopic properties and the mechanical properties of the collagen matrix in decellularized porcine myocardial ECM.This dissertation highlights the use and integration of three different experimental techniques (rheometry, ultrasound SWE, and histology) to correlate key microstructural properties of soft, fibrous tissues (ex-vivo healthy porcine brain white matter and myocardium ECM) with macroscopic shear mechanics. The consideration of the effect of compressive prestress is noteworthy. The reported baseline data for the tissues under shear loading and prestress are pertinent to the physiological function of these tissues, and therefore constitute preliminary data and a necessary first step before a systematic study of the biomechanics of the same tissues in vivo is performed.
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Title: Jay Doblin's People Chair with an unidentified aluminum chair, ca. 1960
Date: 1960
Description: Photograph of Jay Doblin's People Chair (right), along with another aluminum chair prototype (left), creator unknown. Doblin, then Dean of the...
Show morePhotograph of Jay Doblin's People Chair (right), along with another aluminum chair prototype (left), creator unknown. Doblin, then Dean of the Institute of Design, designed the People Chair as part of a campaign sponsored by the Alcoa Corporation. It is assumed that the unidentified chair was also designed for this competition. Photographer unknown. Date of photograph is unknown. Date listed is approximate.
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Collection: Institute of Design records, 1942-2001

Title: Postcard for a "Meet the Artist" event with Mary Henry, Gallery House, Palo Alto, California, 1989, recto
Creator: Gallery House
Date: 1989
Description: Postcard for a "Meet the Artist" event with Mary Henry and two upcoming art exhibits (May Miller and Jim Wheaton) at Gallery House in Palo...
Show morePostcard for a "Meet the Artist" event with Mary Henry and two upcoming art exhibits (May Miller and Jim Wheaton) at Gallery House in Palo Alto, California, 1989. The postcard indicates that Mary Henry was a founding member of Gallery House, which was established in 1958 as an artist's cooperative by a group of bay area artists.
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Collection: Mary Dill Henry Papers, 1913-2021

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