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Title: VIBRATIONAL STABILIZATION OF A CHEMICAL REACTOR - AN EXPERIMENTAL-STUDY
Creator: Cinar, A., Deng, J., Meerkov, S. M., Shu, X. S.
Date: 1987-04
Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Description: Vibrational control is a method for modification of dynamic properties of linear and nonlinear systems by introduction of fast, zero-average...
Show moreVibrational control is a method for modification of dynamic properties of linear and nonlinear systems by introduction of fast, zero-average oscillations in a system's parameters. It has been previously shown that forced oscillations introduced in the reactant flow rates to a continuous stirred tank reactor (CSTR) cause a modification of theS- shaped steady-state curve. In the present note experimental evidence is given to show that this modification leads to the operation the CSTR at an asymptotically stable periodic regime located near an unstable steady-state of the reactor system having fixed flow rates. For a given average stabilized state, such a stabilizing mechanism results in a higher production rate or lower energy expenditure compared to a steady operation with shifted input conditions.
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Title: A morphologically structured model for penicillin production
Creator: Birol, G., Undey, C., Parulekar, S. J., Cinar, A.
Date: 2002-03-05
Publisher: JOHN WILEY & SONS INC
Description: A morphologically structured model is proposed to describe penicillin production in fed-batch cultivations. The model accounts for the effects...
Show moreA morphologically structured model is proposed to describe penicillin production in fed-batch cultivations. The model accounts for the effects of dissolved oxygen on cell growth and penicillin production and variations in volume fractions of abiotic and biotic phases due to biomass formation. Penicillin production is considered to occur in the subapical hyphal cell compartment and to be affected by availability of glucose and oxygen. As it stands, the model provides a wide range of applicability in terms of operating conditions. The model has been tested for various conditions and has given satisfactory results. A series of glucose feeding profiles have been considered to demonstrate the capabilities of the proposed model. It is concluded that the model may be valuable for the interpretation of experimental data collected specifically for metabolic flux analysis during fed-batch cultivation because the elements of measured specific production rates are determined from measurements of the concentrations of the components and their mass balances. The proposed model may be further used for developing control strategies and model order reduction algorithms
Endnote format citation for DOI:10.1002/bit.10115
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Title: Intelligent process monitoring by interfacing knowledge-based systems and multivariate statistical monitoring
Creator: Norvilas, A., Negiz, A., Decicco, J., Cinar, A.
Date: 2000-08
Publisher: ELSEVIER SCI LTD
Description: An intelligent process monitoring and fault diagnosis environment has been developed by interfacing multivariate statistical process...
Show moreAn intelligent process monitoring and fault diagnosis environment has been developed by interfacing multivariate statistical process monitoring (MSPM) techniques and knowledge-based systems (KBS) for monitoring multivariable process operation. The real-time KBS developed in G2 is used with multivariate SPM methods based on canonical variate stare space (CVSS) process models. Fault detection is based on T-2 charts of state variables. Contribution plots in G2 are used for determining the process variables that have contributed to the out-of-control signal indicated by large T-2 values, and G2 Diagnostic Assistant (GDA) is used to diagnose the source causes of abnormal process behavior. The MSPM modules developed in Matlab are linked with G2. This intelligent monitoring and diagnosis system can be used to monitor multivariable processes with autocorrelated, cross-correlated, and collinear data. The structure of the integrated system is described and its performance is illustrated by simulation studies.
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Title: Measuring complexity in reactor networks with cubic autocatalytic reactions
Creator: Tatara, E., Birol, I., Cinar, A., Teymour, F.
Date: 2005-04-13
Publisher: AMER CHEMICAL SOC
Description: Systems with high steady-state multiplicity and rich dynamic behavior are difficult to investigate using conventional reductionist methods. A...
Show moreSystems with high steady-state multiplicity and rich dynamic behavior are difficult to investigate using conventional reductionist methods. A network of more than five reactors hosting cubic autocatalytic reactions may potentially have more than 101 steady states and many distinct dynamic regimes, all for the same parameter set. This paper discusses how the static complexity of such systems can be measured to give a holistic picture. To achieve this, stochastic simulations were performed to statistically determine the bifurcation structure of the system, and the gathered information is summarized using a measure akin to fractal dimension. With this measure, the growth of static complexity is investigated as a function of the network size.
Endnote format citation for DOI:10.1021/ie049246t
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Title: STABILITY OF TUBULAR AND AUTOTHERMAL PACKED-BED REACTORS USING PHASE PLANE ANALYSIS
Creator: Chylla, R. W., Adomaitis, R. A., Cinar, A.
Date: 1987-07
Publisher: AMER CHEMICAL SOC
Description: The regions of stability and parametric sensitivity of countercurrent reactor/heat exchangers are determined explicitly in the plane of inlet...
Show moreThe regions of stability and parametric sensitivity of countercurrent reactor/heat exchangers are determined explicitly in the plane of inlet feed temperature-inlet coolant temperature. The concept of phase plane analysis is generalized to include all orders of reaction rate expressions, a broader range of system parameters, and is extended to the case of autothermal reactors. An industrial hydrocarbon oxidation reactor model and an autothermal CO oxidation reactor model have been used to illustrate and to evaluate the analysis method. The approach presented here is appealing since the region of safe inlet temperatures is determined explicitly and the region of safe operation can be optimized with respect to the reactor design parameters.
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Title: VIBRATIONAL CONTROL OF CHEMICAL REACTORS - STABILIZATION AND CONVERSION IMPROVEMENT IN AN EXOTHERMIC CSTR
Creator: Cinar, A., Rigopoulos, K., Shu, X., Meerkov, S. M.
Date: 1987
Publisher: GORDON BREACH SCI PUBL LTD
Description: Vibrational control is an open-loop control strategy implemented by fast zero-average oscillations in the input variables of a system. It has...
Show moreVibrational control is an open-loop control strategy implemented by fast zero-average oscillations in the input variables of a system. It has been previously shown that vibrational control of an exothermic reaction in a CSTR, introduced via oscillations in the input flow rate, modifies the dynamic behavior of the reactor and enables its stabilized operation in the unstable steady-state region. In the present paper it is shown that simultaneous vibrations in input flow rate and concentration lead, in addition to a reduction of the amplitude of oscillations in reactor temperature and/or increase in reactant conversion. It is also shown that the phase shift between the vibrations of the two input variables affects the behavior of the system as well as the amplitude, the frequency and the form of forcing functions.
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Title: Batch process monitoring and its application to polymerization systems
Creator: Undey, C., Ertunc, S., Tatara, E., Teymour, F., Cinar, A.
Date: 2004-01
Publisher: WILEY-V C H VERLAG GMBH
Description: Slight changes in raw material properties or operating conditions during critical periods of operation of batch and semi-batch polymerization...
Show moreSlight changes in raw material properties or operating conditions during critical periods of operation of batch and semi-batch polymerization reactors may have a strong influence on reaction mechanism and impact final product quality. Online process monitoring, fault detection, fault diagnosis, and product quality prediction in real-time ensure safe reactor operation and warn operators about excursions from normal operation that may lead to deterioration in product properties. Multivariate statistical process monitoring and quality prediction using multiway principal components analysis and multiway partial least squares have been successful in detecting abnormalities in process operation and product quality. When abnormal process operation is detected, fault diagnosis tools are used to determine the source cause of the deviation. Illustrative case studies are presented via simulated polyvinyl acetate polymerization.
Endnote format citation for DOI:10.1002/masy.200450210
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Title: PSECMAC Intelligent Insulin Schedule for Diabetic Blood Glucose Management Under Nonmeal Announcement
Creator: Teddy, S. D., Quek, C., Lai, E. M.-k., Cinar, A.
Date: 2010-03
Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Description: Therapeutically, the closed-loop blood glucose-insulin regulation paradigm via a controllable insulin pump offers a potential solution to the...
Show moreTherapeutically, the closed-loop blood glucose-insulin regulation paradigm via a controllable insulin pump offers a potential solution to the management of diabetes. However, the development of such a closed-loop regulatory system to date has been hampered by two main issues: 1) the limited knowledge on the complex human physiological process of glucose-insulin metabolism that prevents a precise modeling of the biological blood glucose control loop; and 2) the vast metabolic biodiversity of the diabetic population due to varying exogneous and endogenous disturbances such as food intake, exercise, stress, and hormonal factors, etc. In addition, current attempts of closed-loop glucose regulatory techniques generally require some form of prior meal announcement and this constitutes a severe limitation to the applicability of such systems. In this paper, we present a novel intelligent insulin schedule based on the pseudo self-evolving cerebellar model articulation controller (PSECMAC) associative learning memory model that emulates the healthy human insulin response to food ingestion. The proposed PSECMAC intelligent insulin schedule requires no prior meal announcement and delivers the necessary insulin dosage based only on the observed blood glucose fluctuations. Using a simulated healthy subject, the proposed PSECMAC insulin schedule is demonstrated to be able to accurately capture the complex human glucose-insulin dynamics and robustly addresses the intraperson metabolic variability. Subsequently, the PSECMAC intelligent insulin schedule is employed on a group of type-1 diabetic patients to regulate their impaired blood glucose levels. Preliminary simulation results are highly encouraging. The work reported in this paper represents a major paradigm shift in the management of diabetes where patient compliance is poor and the need for prior meal announcement under current treatment regimes poses a significant challenge to an active lifestyle.
Endnote format citation for DOI:10.1109/TNN.2009.2036726
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Title: Automated control of high temperature short time pasteurization
Creator: Negiz, A., Cinar, A., Schlesser, J. E., Ramanauskas, P., Armstrong, D. J., Stroup, W.
Date: 1996-12
Publisher: ELSEVIER SCI LTD
Description: Cascade and multivariable control of a high temperature shot? time (HTST) pasteurization system were tested and compared with the performance...
Show moreCascade and multivariable control of a high temperature shot? time (HTST) pasteurization system were tested and compared with the performance of single-loop feedback control. Multivariable control was implemented on the basis of computations of product temperatures that yield equivalent lethality at a residence time of 15 s at 161 degrees F in the holding tube. Both cascade and multivariable controllers reduced product temperature fluctuations and overshoot compared to single-loop feedback control. Multivariable control was based on on-line computation of equivalent total lethality and it permitted operation at variable flow rates or at the most desirable temperatures for product quality and functionality. Copyright (C) 1996 Elsevier Science Ltd.
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Title: Automated control and monitoring of thermal processing using high temperature, short time pasteurization
Creator: Schlesser, J. E., Armstrong, D. J., Cinar, A., Ramanauskas, P., Negiz, A.
Date: 1997-10
Publisher: AMER DAIRY SCIENCE ASSOC
Description: High temperature, short time pasteurization was used to evaluate a computer-based system for controlling the pasteurization process, acquiring...
Show moreHigh temperature, short time pasteurization was used to evaluate a computer-based system for controlling the pasteurization process, acquiring data, and monitoring records. Software was used for the control of hot water temperature, flow rate through the centrifugal timing pump, and diversion of under-processed product. Three types of control strategies were conducted: single loop, cascade, and multivariable. The single loop control strategy showed the most rapid responses to temperature changes, but the temperature response curve was slowest to return to its set point. The cascade control strategy showed slower recoveries to temperature changes, but the temperature response curve was smoother. The multivariable control strategy responded slightly faster than the cascade control strategy, and the temperature response curve was slightly smoother than the cascade control strategy. The multivariable control strategy was able to control the flow diversion valve by the use of a lethality controller. The data acquisition system, used to monitor the data obtained from the high temperature, short-time pasteurization system, was within +/- 0.1 degrees C of the temperature recorded by the safety thermal limit recorder. Reliability was determined by examining the changes in the position of the flow diversion valve to identify process deviations and by comparing the changes to the event marker on circular charts. The data acquisition system was an effective alternative for monitoring the completeness of data.
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Title: Modeling, monitoring and control strategies for high temperature short time pasteurization systems - 2. Lethality-based control
Creator: Negiz, A., Ramanauskas, P., Cinar, A., Schlesser, J. E., Armstrong, D. J.
Date: 1998-02
Publisher: ELSEVIER SCI LTD
Description: A lethality-based control system was designed to provide accurate control of a high temperature shout time (HTST) pasteurizer and to process...
Show moreA lethality-based control system was designed to provide accurate control of a high temperature shout time (HTST) pasteurizer and to process milk products with a lethality equivalent of 161 degrees F (71.67 degrees C) or above for 15 s. This control system provides significant flexibility in operating the process and optimizing functional properties of the food components. Multivariable control of an HTST pasteurizer is implemented by using product total lethality to determine the controller set-points. The equation that relates the temperature and flow rate combinations to the product total lethality, 161 degrees F (71.67 degrees C), 15 s, was modified to permit overprocessing levels specified by plant personnel. By using this equation and the set-point value selected for the other variable, set-point values for the temperature or the flow rate controller were computed. The flow and temperature controllers are integrated into a real-time monitoring and control system. The monitoring and control system includes the multivariable controller, the lethality rate calculation module, statistical monitoring of the total lethality, product flow rate, hot wafer outlet temperature, and holding tube exit temperature measurements, and the display screens for visual inspection of the monitoring tools. This study attempted to achieve compliance of the HTST process operation with the recommended Pasteurized Milk Ordinance by providing a margin between the alarm limits of the monitoring chart and the safety limits.
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Title: Modeling, monitoring and control strategies for high temperature short time pasteurization systems - 1. Empirical model development
Creator: Negiz, A., Ramanauskas, P., Cinar, A., Schlesser, J. E., Armstrong, D. J.
Date: 1998-02
Publisher: ELSEVIER SCI LTD
Description: Dynamic models of high temperature short time (HTST) pasteurization systems can be developed by using empirical model development paradigms...
Show moreDynamic models of high temperature short time (HTST) pasteurization systems can be developed by using empirical model development paradigms such as transfer functions and times series models. Properly designed experiments that excite all output variables provide good data that enable the development of accurate dynamic models. These models are used in feedback control and statistical process monitoring system design. The methodology for time series model development for HTST pasteurization processes is illustrated by using data collected from a pilot scale HTST pasteurization system.
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Title: Modeling, monitoring and control strategies for high temperature short time pasteurization systems - 3. Statistical monitoring of product lethality and process sensor reliability
Creator: Negiz, A., Ramanauskas, P., Cinar, A., Schlesser, J. E., Armstrong, D. J.
Date: 1998-02
Publisher: ELSEVIER SCI LTD
Description: Statistical process monitoring (SPM) is used in food processing industries to improve productivity and product quality. SPM can also provide...
Show moreStatistical process monitoring (SPM) is used in food processing industries to improve productivity and product quality. SPM can also provide information to operators on how close a process is to non-compliance to product safety limits, and carry out periodic checks of sensor accuracy at high frequency. Traditional SPM tools such as Shewhart charts are not appropriate for continuous food processes because of autocorrelation in data. Four alternative SPM techniques are presented and applied to high temperature short time (HTST) dairy pasteurization. The study attempted to achieve compliance of the HTST process operation with the recommended Pasteurized Milk Ordinance by providing a margin between the alarm limits of the monitoring chart and the safety limits. Monitoring of residuals and parameter change detection techniques ave used for monitoring processes with autocorrelated variables. Hotelling's T-2 and residuals of canonical variates techniques are used for monitoring multivariable processes.
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