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Title: Laser Powder Bed Fusion Of Cost-Effective Non-Spherical Ti-6Al-4V Powder
Creator: Asherloo, Mohammadreza
Date: 2023
Description: This comprehensive research delves into the intricate dynamics of Laser Powder Bed Fusion (L-PBF) of Ti-6Al-4V powders, emphasizing the...
Show moreThis comprehensive research delves into the intricate dynamics of Laser Powder Bed Fusion (L-PBF) of Ti-6Al-4V powders, emphasizing the potential of non-spherical, hydride-dehydride (HDH) powders as a cost-efficient alternative to traditional spherical powders. The study systematically explores the interplay between powder morphology, granulometry, and various post-processing treatments in shaping the resultant microstructure, porosity, and mechanical properties of L-PBF fabricated Ti-6Al-4V components.Initial investigations focused on the flowability, packing density, and resultant density of L-PBF parts using HDH powders with varying size distributions. Through meticulous optimization of laser parameters, parts with a relative density exceeding 99.5% were achieved, even at production rates 1.5–2 times higher than conventional LPBF processes. Dynamic synchrotron X-ray imaging provided insights into laser-powder interactions, revealing key mechanisms of porosity formation associated with HDH powders. Further microstructural examinations highlighted the formation of columnar β grains with acicular α/α′ phases in the as-built condition. Mechanical tests, including fatigue assessments under fully-reversed tension-compression conditions, revealed the critical role of surface roughness in fatigue performance. Notably, mechanical grinding significantly improved fatigue strength, especially in the high cycle fatigue region, by eliminating surface micro-notches. X-ray diffraction analyses further elucidated the stress and micro-strain profiles, offering insights into the material's deformation mechanisms. A pivotal discovery was the presence of α/α′ on prior β/β grain boundaries, challenging the prevailing notion that high cooling rates in L-PBF preclude β/β grain boundary variant selection. Electron backscatter diffraction and synchrotron X-ray imaging illuminated the role of powder characteristics in locally modulating cooling rates, leading to β/β grain boundary α′ lath growth. Lastly, the research underscored the multifaceted interdependencies among contouring, powder granulometry, Hot Isostatic Pressing (HIP), and mechanical surface treatments. A pronounced increase in sub-surface porosities was identified when contouring was combined with fine powder granulometry. However, post-HIP treatments induced a phase transformation from martensitic α′ to a basket-weave α+β microstructure, enhancing the material's fatigue resistance to levels comparable to wrought Ti-6Al-4V. In summation, this doctoral research offers a holistic understanding of the L-PBF process for Ti-6Al-4V, emphasizing the viability of non-spherical HDH powders and providing a roadmap for parameter optimization, defect minimization, and mechanical property enhancement in L-PBF-fabricated Ti-6Al-4V structures.
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Title: Ground Monitors to Support Navigation Operations of ARAIM and GBAS
Creator: Patel, Jaymin Harshadkumar
Date: 2023
Description: Receiver Autonomous Integrity Monitoring (RAIM) currently provides safehorizontal navigation guidance to en route civil aircraft using the GPS...
Show moreReceiver Autonomous Integrity Monitoring (RAIM) currently provides safehorizontal navigation guidance to en route civil aircraft using the GPS L1 frequency. As an evolution of RAIM, Advanced RAIM (ARAIM) is being developed to provide vertical guidance in addition to horizontal using multiple constellations and dual frequency thus facilitating precision approach without ground support for civil aircraft. However, navigation guidance during zero-visibility (Category III) precision landing requires an additional support in real time from a Ground Based Augmentation System (GBAS). To improve the aircraft navigation solution, GBAS broadcasts a differential correction and monitors any failure on transmitted satellite signals. This dissertation contributes to ARAIM and GBAS to improve existing navigation operations in order to enable precision approach and landing.The achievable performance of ARAIM is highly dependent on the assumptionson a constellation’s nominal Signal-In-Space (SIS) error models and a priori fault probability. In the framework of ARAIM, an Integrity Support Message (ISM) is envisioned to carry the required SIS error-model parameters and fault statistics for users. The ISM is generated and validated through offline monitoring, and disseminated along the navigation message. The first dissertation contribution is to provide necessary satellite positions and clock biases as a truth product to evaluate nominal SIS range errors (SISREs). An estimator is developed to generate accurate ephemeris parameters to provide these truth products. The estimator’s performance is demonstrated for the Global Positioning System (GPS) constellation by utilizing the International GNSS Service (IGS) ground network to collect dual-frequency raw GPS code and carrier phase measurements. The resulting SISREs from the estimator are predicted to have a standard deviation of 0.5 m. When estimated ephemeris parameters and clock biases are compared with precise IGS orbit and clock products, the resulting SISREs are within ±2! at all times. In the second contribution, a new approach is proposed to generate the ISM by modeling the ephemeris parameter errors directly. In preliminary analysis, an ephemeris parameter error model is developed for the broadcast GPS legacy navigation message (LNAV) under nominal conditions. Then, the proposed approach is demonstrated to provide the nominal bias and standard deviation on GPS SISREs.As a part of fault monitoring in the GBAS, a ground monitor is developedto detect ephemeris failures, incorrect broadcast satellite positions, and hazardous ionosphere storms using either single- or dual frequency. The monitor also addresses the challenge of fault-free differential correction when satellites are rising, newly acquired, and re-acquired. The monitor utilizes differential code and carrier phase measurements across multiple reference receiver antennas as the basis for detection. Finally, the analytical performance of the monitor is demonstrated to meet Category III precision approach and landing requirements.
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Title: Three-Dimensional Co-Culture Systems for Vascularization of Cardiac Tissue
Creator: Rodriguez Arias, Jessica A.
Date: 2023
Description: Myocardial Infarction (MI) is the partial or complete blockage of blood flow to the myocardial tissue resulting in damage and therefore loss...
Show moreMyocardial Infarction (MI) is the partial or complete blockage of blood flow to the myocardial tissue resulting in damage and therefore loss of heart function. In the U.S. every 40 seconds, someone will suffer from MI and the only available treatment is medication to treat the symptoms of heart function loss, but do not treat the underlying cause. Some attempts to treat the underlying cause have arisen in the last decades including cell-based therapies or tissue engineering therapies such as spheroid-based cardiac patches that have shown to be promising. Improvement in the mechanical properties to create suturable engineered tissues remain to be improved for ease of implantation purposes. Cell-laden hydrogel scaffolds can provide improved mechanical properties compared to biomaterial free cell-based therapies but need to allow for vascularization of the engineered tissue. Thus, the goal of this thesis is to provide preliminary studies for the use of a cell adhesive, proteolytically degradable PEG hydrogel scaffold that eventually would be used as an invitro model to evaluate engineered tissue vascularization for cardiac tissue engineering. To construct this model, important cell spheroid parameters on vascular invasion in 3D culture were investigated including the total number of cells/spheroid, the supporting cell for endothelial cells. In order to scale-up scaffolds to size of clinically relevant dimensions, a multilayered hydrogel construct visible light free-radical polymerization approach encapsulating vascular spheroids in multiple layers was also investigated. Results indicate that a total cell number of 5000 cells/spheroid aggregate were feasible due to cell sourcing. In addition, co-cultures of endothelial and mesenchymal stem cells led to maximized vascular invasion of the spheroids compared to fibroblast/endothelial co-culture and endothelial monoculture of spheroids in the hydrogel. Finally, the extent of vascularization of spheroids in each layer of the multilayered hydrogel constructs varied due to the observed differences in mechanical properties and swelling ratio of each layer due to incomplete polymerization of layers. This study demonstrated the importance of support cells and hydrogel mechanical properties in promoting vascularization of spheroid which serves as basis for building cell-laden hydrogel scaffolds for vascularization for cardiac tissues.
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Title: Three-Dimensional Co-Culture Systems for Vascularization of Cardiac Tissue
Creator: Rodriguez Arias, Jessica A.
Date: 2023
Description: Myocardial Infarction (MI) is the partial or complete blockage of blood flow to the myocardial tissue resulting in damage and therefore loss...
Show moreMyocardial Infarction (MI) is the partial or complete blockage of blood flow to the myocardial tissue resulting in damage and therefore loss of heart function. In the U.S. every 40 seconds, someone will suffer from MI and the only available treatment is medication to treat the symptoms of heart function loss, but do not treat the underlying cause. Some attempts to treat the underlying cause have arisen in the last decades including cell-based therapies or tissue engineering therapies such as spheroid-based cardiac patches that have shown to be promising. Improvement in the mechanical properties to create suturable engineered tissues remain to be improved for ease of implantation purposes. Cell-laden hydrogel scaffolds can provide improved mechanical properties compared to biomaterial free cell-based therapies but need to allow for vascularization of the engineered tissue. Thus, the goal of this thesis is to provide preliminary studies for the use of a cell adhesive, proteolytically degradable PEG hydrogel scaffold that eventually would be used as an invitro model to evaluate engineered tissue vascularization for cardiac tissue engineering. To construct this model, important cell spheroid parameters on vascular invasion in 3D culture were investigated including the total number of cells/spheroid, the supporting cell for endothelial cells. In order to scale-up scaffolds to size of clinically relevant dimensions, a multilayered hydrogel construct visible light free-radical polymerization approach encapsulating vascular spheroids in multiple layers was also investigated. Results indicate that a total cell number of 5000 cells/spheroid aggregate were feasible due to cell sourcing. In addition, co-cultures of endothelial and mesenchymal stem cells led to maximized vascular invasion of the spheroids compared to fibroblast/endothelial co-culture and endothelial monoculture of spheroids in the hydrogel. Finally, the extent of vascularization of spheroids in each layer of the multilayered hydrogel constructs varied due to the observed differences in mechanical properties and swelling ratio of each layer due to incomplete polymerization of layers. This study demonstrated the importance of support cells and hydrogel mechanical properties in promoting vascularization of spheroid which serves as basis for building cell-laden hydrogel scaffolds for vascularization for cardiac tissues.
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Title: Design and Synthesis of New Sulfur Cathodes Containing Polysulfide Adsorbing Materials
Creator: Suzanowicz, Artur M
Date: 2023
Description: Lithium-sulfur battery (LSB) technology has tremendous prospects to substitute lithium-ion battery (LIB) technology due to its high...
Show moreLithium-sulfur battery (LSB) technology has tremendous prospects to substitute lithium-ion battery (LIB) technology due to its high theoretical specific capacity and energy density. However, escaping polysulfide intermediates (produced during the redox reaction process) from the cathode structure is the primary reason for rapid capacity fading. Suppressing the polysulfide shuttle (PSS) is a viable solution for this technology to move closer to commercialization and supersede the established LIB technology. In this dissertation, I have analyzed the challenges faced by LSBs and selected methods and materials to address these problems. I have concluded that in order to further pioneer LSBs, it is necessary to address these essential features of the sulfur cathode: superior electrical conductivity to ensure faster redox reaction kinetics and high discharge capacity, high pore volume of the cathode host to maximize sulfur loading/utilization, and polar polysulfide-resistive materials to anchor and suppress the migration of lithium polysulfides.Furthermore, a versatile, low-cost, and practical scalable synthesis method is essential for translating bench-level development to large-scale production. This dissertation covers designing and synthesizing new scalable cathode structures for lithium-sulfur batteries that are inexpensive and highly functional. The rationally chosen cathode components accommodate sulfur, suppress the migration of polysulfide intermediates via chemical interactions, enhance redox kinetics, and provide electrical conductivity to sulfur, rendering excellent electrochemical performance in terms of high initial specific capacity and good long-term cycling performance. TiO2, Ni12P5, and g-C3N4 as polysulfide adsorbing materials (PAMs) have been fully studied in this thesis along with three distinct types of host structures for lithium-sulfur batteries: Polymer, Carbon Cloth, and Reduced Graphene Oxide. I have created adaptable bulk synthesis techniques that are inexpensive, easily scalable, and suitable for bench-level research as well as large-scale manufacturing. The exceptional performance and scalability of these materials make my cathodes attractive options for the commercialization of lithium-sulfur batteries.
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Title: A Limited Case Study: Perspectives of Students, High School Teachers, and College Instructors About Advanced Placement Mathematics Courses
Creator: Joseph, DeJuana V.
Date: 2023
Description: ABSTRACTBackground. The underrepresentation of Black and Latinx students in STEM is highlighted due to structural impediments. Although AP...
Show moreABSTRACTBackground. The underrepresentation of Black and Latinx students in STEM is highlighted due to structural impediments. Although AP mathematics classes are being introduced as a solution, students from underprivileged schools continue to confront challenges. The study project seeks to investigate the obstacles associated with teaching AP mathematics courses in disadvantaged high schools and to gather perspectives from various stakeholders.Methodology. The study employs qualitative one-on-one interviews and an interpretive research paradigm. The sample comprises mathematics faculty, first-year college students, high school AP math teachers, and one high school student. Thematic analysis is used and ethical considerations are taken into account. Limitations include time and resource constraints, a small sample size, and potential inconsistencies in participant responses.Results and Findings. AP mathematics classes may inspire students to continue STEM in college, yet obstacles such as time constraints and knowledge gaps exist. Students' employment choices are influenced by their own interests and abilities. High school math teachers and college professors highlight algebraic skills as crucial for success in college mathematics, particularly in calculus classes.Discussion. The STEM enrollment problem does not only affect minority students; AP math can be a pathway for all kids. Improving AP math readiness for all students is critical for addressing the STEM professional shortage. It is essential to use extra measures to increase student interest in STEM. Strong foundational algebraic knowledge is required for success in higher education, necessitating stakeholders to focus on improving STEM enrollment and completion rates.
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Title: Ground Monitors to Support Navigation Operations of ARAIM and GBAS
Creator: Patel, Jaymin Harshadkumar
Date: 2023
Description: Receiver Autonomous Integrity Monitoring (RAIM) currently provides safehorizontal navigation guidance to en route civil aircraft using the GPS...
Show moreReceiver Autonomous Integrity Monitoring (RAIM) currently provides safehorizontal navigation guidance to en route civil aircraft using the GPS L1 frequency. As an evolution of RAIM, Advanced RAIM (ARAIM) is being developed to provide vertical guidance in addition to horizontal using multiple constellations and dual frequency thus facilitating precision approach without ground support for civil aircraft. However, navigation guidance during zero-visibility (Category III) precision landing requires an additional support in real time from a Ground Based Augmentation System (GBAS). To improve the aircraft navigation solution, GBAS broadcasts a differential correction and monitors any failure on transmitted satellite signals. This dissertation contributes to ARAIM and GBAS to improve existing navigation operations in order to enable precision approach and landing.The achievable performance of ARAIM is highly dependent on the assumptionson a constellation’s nominal Signal-In-Space (SIS) error models and a priori fault probability. In the framework of ARAIM, an Integrity Support Message (ISM) is envisioned to carry the required SIS error-model parameters and fault statistics for users. The ISM is generated and validated through offline monitoring, and disseminated along the navigation message. The first dissertation contribution is to provide necessary satellite positions and clock biases as a truth product to evaluate nominal SIS range errors (SISREs). An estimator is developed to generate accurate ephemeris parameters to provide these truth products. The estimator’s performance is demonstrated for the Global Positioning System (GPS) constellation by utilizing the International GNSS Service (IGS) ground network to collect dual-frequency raw GPS code and carrier phase measurements. The resulting SISREs from the estimator are predicted to have a standard deviation of 0.5 m. When estimated ephemeris parameters and clock biases are compared with precise IGS orbit and clock products, the resulting SISREs are within ±2! at all times. In the second contribution, a new approach is proposed to generate the ISM by modeling the ephemeris parameter errors directly. In preliminary analysis, an ephemeris parameter error model is developed for the broadcast GPS legacy navigation message (LNAV) under nominal conditions. Then, the proposed approach is demonstrated to provide the nominal bias and standard deviation on GPS SISREs.As a part of fault monitoring in the GBAS, a ground monitor is developedto detect ephemeris failures, incorrect broadcast satellite positions, and hazardous ionosphere storms using either single- or dual frequency. The monitor also addresses the challenge of fault-free differential correction when satellites are rising, newly acquired, and re-acquired. The monitor utilizes differential code and carrier phase measurements across multiple reference receiver antennas as the basis for detection. Finally, the analytical performance of the monitor is demonstrated to meet Category III precision approach and landing requirements.
Show less

Title: Design and Synthesis of New Sulfur Cathodes Containing Polysulfide Adsorbing Materials
Creator: Suzanowicz, Artur M
Date: 2023
Description: Lithium-sulfur battery (LSB) technology has tremendous prospects to substitute lithium-ion battery (LIB) technology due to its high...
Show moreLithium-sulfur battery (LSB) technology has tremendous prospects to substitute lithium-ion battery (LIB) technology due to its high theoretical specific capacity and energy density. However, escaping polysulfide intermediates (produced during the redox reaction process) from the cathode structure is the primary reason for rapid capacity fading. Suppressing the polysulfide shuttle (PSS) is a viable solution for this technology to move closer to commercialization and supersede the established LIB technology. In this dissertation, I have analyzed the challenges faced by LSBs and selected methods and materials to address these problems. I have concluded that in order to further pioneer LSBs, it is necessary to address these essential features of the sulfur cathode: superior electrical conductivity to ensure faster redox reaction kinetics and high discharge capacity, high pore volume of the cathode host to maximize sulfur loading/utilization, and polar polysulfide-resistive materials to anchor and suppress the migration of lithium polysulfides.Furthermore, a versatile, low-cost, and practical scalable synthesis method is essential for translating bench-level development to large-scale production. This dissertation covers designing and synthesizing new scalable cathode structures for lithium-sulfur batteries that are inexpensive and highly functional. The rationally chosen cathode components accommodate sulfur, suppress the migration of polysulfide intermediates via chemical interactions, enhance redox kinetics, and provide electrical conductivity to sulfur, rendering excellent electrochemical performance in terms of high initial specific capacity and good long-term cycling performance. TiO2, Ni12P5, and g-C3N4 as polysulfide adsorbing materials (PAMs) have been fully studied in this thesis along with three distinct types of host structures for lithium-sulfur batteries: Polymer, Carbon Cloth, and Reduced Graphene Oxide. I have created adaptable bulk synthesis techniques that are inexpensive, easily scalable, and suitable for bench-level research as well as large-scale manufacturing. The exceptional performance and scalability of these materials make my cathodes attractive options for the commercialization of lithium-sulfur batteries.
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Title: DUST MITIGATION OF MICRO-STRUCTURED (GECKO-LIKE) ADHESIVES
Creator: Alizadehyazdi, Vahid
Date: 2019
Description: Controllable adhesives (i.e. those capable of being turned on and off) are used in a wide range of applications including robotic grippers and...
Show moreControllable adhesives (i.e. those capable of being turned on and off) are used in a wide range of applications including robotic grippers and climbing robots. Electromagnets, suction, and microspines have been used to meet this demand, but are typically limited to a specific substrate roughness or material. Microstructured (gecko-like) adhesives on the other hand, offer the potential to be the most universal among controllable adhesives since they can work on a wide variety of surfaces. The development of microstructured (gecko-like) adhesives has focused almost solely on their adhesive strength. However, for practical applications, especially in real-world environments, the adhesive's long-term performance is arguably equally important. One impediment to long-term viability is the adhesive's susceptibility to contamination, which decreases adhesion significantly. To have practical microstructure adhesives in real-world environments, the detrimental effect of dust and other contaminants should be dealt with. The first general approach involves removing adhered dust particles. The second approach is to create adhesives that minimize dust adsorption such that extensive cleaning is not necessary or they can be removed easily. Regarding the first approach, this research describes the use of electrostatic forces and ultrasonic vibration to repel dust particles. Results are non-destructive, non-contact cleaning methods that can be used in conjunction with other cleaning techniques, many of which rely on physical contact between the fibrillar adhesive and substrate. Electrostatic cleaning results show that a two-phase square wave with the lowest practically feasible frequency has the best cleaning results. Combining electrostatic and ultrasonic cleaning results in far higher efficiency than when using electrostatic repulsion or ultrasonic alone. Moreover, I showed that the piezoelectric element in the ultrasonic cleaning method can also be used as a releasing mechanism to turn the adhesive off and as a force/contact sensor. Regarding the second approach, I experimentally explored the effect of the modulus of elasticity, work of separation, and work of adhesion (adhesion energy) on the shear stress and particle detachment capabilities of microstructured adhesives. Particle removal is evaluated using both non-contact cleaning methods (centripetal force and electrostatic particle repulsion) and a dry contact cleaning method (load-drag-unload test). Results show that for a material with a high work of separation, high elastic modulus, and low work of adhesion, it is possible to create a microstructured adhesive with both high shear stress strength and low adhesion to dust particles. Results also show that, for dry contact cleaning, shear stress recovery mostly stems from particle rolling and not particle sliding. Moreover, shear test results show that augmenting the microstructured adhesive with electrostatic adhesion can reduce the negative effects on adhesion of a high elastic modulus materials' conformability to a substrate by providing a preload to the microstructured elements. Finally, I applied mentioned dust mitigation methods on two different gecko-like adhesives grippers. The first design was used to pick up flat objects, while the second one is designed to grip curved objects of different shapes and sizes. Since the second gripper is flexible and piezoelectric is stiff (it can only be applied to rigid backings), only electrostatic dust mitigation is applicable.
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Title: UNDERSTANDING THE FUNDAMENTAL MECHANISMS OF MESO-SCALE ENGINEERING OF GRAIN BOUNDARIES IN NI-BASE SUPERALLOYS
Creator: Alabbad, Bader
Date: 2019
Description: Polycrystalline nickel base superalloys are known to possess high temperature strength, good crack growth resistance and corrosion resistance...
Show morePolycrystalline nickel base superalloys are known to possess high temperature strength, good crack growth resistance and corrosion resistance at high temperatures. Engineering the morphology of the grain boundaries can yield to extent the high temperature resistance for polycrystalline nickel-based superalloys. Meso-scale engineering for grain boundary structures can be utilized through the development of serrated grain boundaries to improve the damage tolerance of polycrystalline nickel- based superalloys. Grain boundary precipitates induce the formation of the grain boundary serrations as precipitates protrude the grain boundary. Understanding and controlling the cooling processes from above the solvus temperature plays an important role in controlling the size and population of γ′ precipitates to modify specific microstructural features that can impact the resulting properties. Two stepped cooling process with a transition just below the γ′ solvus has the ability to form a unique microstructure as heterogeneous nucleation and growth of large γ′ precipitates along the grain boundaries during the initially slow cooling rate. The eventual transition to a standard or conventional cooling rate will then govern the formation of the secondary, intragranular γ′ precipitates. The stepped cooling process was compared to the conventional fast continuous cooling process. The effect of grain boundary misorientation on the precipitation behavior of grain boundary γ′ precipitates revealed coarse grain boundary γ′ precipitates reside along high angle grain boundaries. Mechanical testing was carried out to investigate their mechanical properties to compare and benchmark to those produced via conventional continuous cooling to quantify the extent by which serrated boundaries can be used to improve the properties where the modified microstructures led to great high temperature properties.Nickel-base superalloy 718Plus is a recently developed alloy that is being considered for use in a number of advanced gas turbine engine applications. A constructed heat treatment was proposed to drive the precipitation of fine η precipitates along grain boundaries. Lamellar η phase precipitates were able to induce the formation of serrated grain boundaries. Discontinuous cellular precipitation reaction led the formation of the lamellar η phase precipitates. The characteristic growth of lamellar η phase precipitates was influence by the grain boundary structure. Creep tests were carried out to provide a better understanding of how serrated grain boundaries formed using η phase precipitates can impact the creep properties of ATI 718Plus.
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Title: Feasibility and Properness in Linear Interference Alignment: Flow Tests, Sufficient Conditions, and Approximation Algorithms.
Creator: Al-Dhelaan, Fahad Abdullah
Date: 2019
Description: Interference forms a major challenge in our understanding of the capacity of wireless networks and our ability to achieve this capacity....
Show moreInterference forms a major challenge in our understanding of the capacity of wireless networks and our ability to achieve this capacity. Rather than scheduling transmissions to avoid interference, recent techniques allow for interference to be neutralized and for simultaneous transmission of messages.Linear interference alignment in MIMO networks is the technique of aligning messages, by the transmitters through the use of precoding matrices, so that the undesired messages occupy some minimal sub-space upon their arrival at an unintended receiver. The overlapping of the sub-spaces where these interfering messages fall allows the receiver to neutralize them with minimal dedication of its resources through the application of a decoding matrix.The linear interference alignment problem is to design these precoding and decoding matrices. It has been shown to be NP-hard in the literature.A network is called feasible if such a solution exists. Even deciding whether some network instance is feasible, is non-trivial. The problem of deciding feasibility was shown to be NP-hard in the literature, for constant channel coefficients.We focus on finding efficient and robust feasibility tests in the case of generic channels, where the computational complexity is unknown. We provide efficient and robust tests for the necessary condition of properness, which had previously been identified in the literature but given no efficient tests in the general case.We identify several conditions, each being sufficient for feasibility. We study their relationships and the computational complexity of testing for them. We provide polynomial-time maximum flow test for one sufficient condition in the case of uniform demands. In the case of uniform demands which divide the number of antennas at all receivers or all transmitters, we show that these sufficient and necessary conditions are equivalent with feasibility, thereby admitting efficient maximum-flow tests.We identify a subset of feasible instances where the decoding and precoding matrices can be designed in polynomial-time. Furthermore, we show that any proper instance is within a constant factor of a one of these instances. Then, we provide efficient constant approximation algorithms for the problems of maximizing demand and minimizing antennas such that an instance is feasible.
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Title: DEEP LEARNING FOR IMAGE PROCESSING WITH APPLICATIONS TO MEDICAL IMAGING
Creator: Zarshenas, Amin
Date: 2019
Description: Deep Learning is a subfield of machine learning concerned with algorithms that learn hierarchical data representations. Deep learning has...
Show moreDeep Learning is a subfield of machine learning concerned with algorithms that learn hierarchical data representations. Deep learning has proven extremely successful in many computer vision tasks including object detection and recognition. In this thesis, we aim to develop and design deep-learning models to better perform image processing and tackle three important problems: natural image denoising, computed tomography (CT) dose reduction, and bone suppression in chest radiography (“chest x-ray”: CXR). As the first contribution of this thesis, we aimed to answer to probably the most critical design questions, under the task of natural image denoising. To this end, we defined a class of deep learning models, called neural network convolution (NNC). We investigated several design modules for designing NNC for image processing. Based on our analysis, we design a deep residual NNC (R-NNC) for this task. One of the important challenges in image denoising regards to a scenario in which the images have varying noise levels. Our analysis showed that training a single R-NNC on images at multiple noise levels results in a network that cannot handle very high noise levels; and sometimes, it blurs the high-frequency information on less noisy areas. To address this problem, we designed and developed two new deep-learning structures, namely, noise-specific NNC (NS-NNC) and a DeepFloat model, for the task of image denoising at varying noise levels. Our models achieved the highest denoising performance comparing to the state-of-the-art techniques.As the second contribution of the thesis, we aimed to tackle the task of CT dose reduction by means of our NNC. Studies have shown that high dose of CT scans can increase the risk of radiation-induced cancer in patients dramatically; therefore, it is very important to reduce the radiation dose as much as possible. For this problem, we introduced a mixture of anatomy-specific (AS) NNC experts. The basic idea is to train multiple NNC models for different anatomic segments with different characteristics, and merge the predictions based on the segmentations. Our phantom and clinical analysis showed that more than 90% dose reduction would be achieved using our AS NNC model.We exploited our findings from image denoising and CT dose reduction, to tackle the challenging task of bone suppression in CXRs. Most lung nodules that are missed by radiologists as well as by computer-aided detection systems overlap with bones in CXRs. Our purpose was to develop an imaging system to virtually separate ribs and clavicles from lung nodules and soft-tissue in CXRs. To achieve this, we developed a mixture of anatomy-specific, orientation-frequency-specific (ASOFS) expert deep NNC model. While our model was able to decompose the CXRs, to achieve an even higher bone suppression performance, we employed our deep R-NNC for the bone suppression application. Our model was able to create bone and soft-tissue images from single CXRs, without requiring specialized equipment or increasing the radiation dose.
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Title: Numerical and Experimental Investigation to Improve Radio Frequency Performance of Photonic Band Gap Accelerating Structure
Creator: Zhou, Ning
Date: 2019
Description: In this thesis, the design and experimental work of a Photonic Band Gap (PBG) accelerator cavity with star-shape array is presented. Photonic...
Show moreIn this thesis, the design and experimental work of a Photonic Band Gap (PBG) accelerator cavity with star-shape array is presented. Photonic band gap structures (metallic and/ or dielectric) have been proposed for accelerator applications. These structures act like filters, allowing electromagnetic waves propagating at some frequencies to be transmitted through the lattice, while rejecting the RF fields in some (unwanted) frequency range. Additionally PBG structures are used to support selective field patterns (modes) in a resonator or waveguide by a defect region within the lattice; while damping unwanted higher- or lower-order modes without impacting the supported mode. The unwanted modes affect beam propagation or even distort the beam. Thus, suppression of unwanted modes is important. In this thesis work, a star shape structure is obtained from removing elements in a PBG structure with triangular lattice and employed for integration with a metallic cavity resonator for accelerator applications. Impedance matching is accomplished by adjustment of positions of some elements in the array. The design was fabricated and measured to have an input return loss of over 30 dB at the targeted frequency of 11.4GHz. The measured results are in an excellent agreement with the computer simulation.
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Title: EVALUATING INTEGRITY FOR MOBILE ROBOT LOCALIZATION SAFETY
Creator: Duenas Arana, Guillermo
Date: 2019
Description: Precise localization is paramount for autonomous navigation. Localization errors are not only dangerous by themselves, but can also mislead...
Show morePrecise localization is paramount for autonomous navigation. Localization errors are not only dangerous by themselves, but can also mislead other dependent systems into moving to a hazardous location. Unfortunately, the problem of quantifying robot localization safety is only sparsely addressed in the robotics literature, and most robotics algorithms still quantify pose estimation performance using a covariance matrix or particle spread, which only accounts for nominal sensor errors. This is insufficient for life- and mission-critical applications, such as autonomous vehicles and other co-robots, where ignoring sensor or sensor or processing faults can lead to catastrophic localization errors. Thus, other methods must be employed to ensure safety.In response, this research leverages prior work in aviation integrity monitoring to tackle the more challenging case of evaluating localization safety in mobile robots. In contrast to aviation applications, that heavily rely on the Global Navigation Satellite System (GNSS) for localization, robots often operate in complex, GNSS-denied environments that require a more sophisticated sensor suite to ensure localization safety. Localization integrity risk is the probability that a robot's pose estimate lies outside pre-defined acceptable limits while no alarm is triggered. In this work, the integrity risk is rigorously upper bounded by accounting for both nominal noise and other non-nominal sensor faults, resulting in a safe upper bound on the localization integrity risk.The main contribution of this dissertation is the design and evaluation of a sequential integrity monitoring methodology applicable to mobile robot localization algorithms that use feature extraction and data association. First, faults introduced during the feature extraction and data association processes are distinguished, and the probability of the latter is rigorously upper bounded using analytical methods. The impact of faults in the estimate error's and fault detector's distributions is then determined to quantify integrity risk, which is evaluated under the worst-possible fault combination. To determine the impact of previous faults without a boundlessly growing number of fault hypotheses, this dissertation presents a novel method that uses a preceding time window to build a limited set of hypotheses and a prior estimate bias to account for faults occurring before the start of the time window. The proposed methodology is applicable to Kalman Filter and fixed-lag smoothing localization. Simulated and experimental results are presented to validate the methodology.
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Title: SIMULATION OF H2A.B CONTAINING HISTONE VARIANT NUCLEOSOME
Creator: Kohestani, Havva
Date: 2019
Description: The H2A.B histone is a highly evolving vertebrate specific variant of the H2A histone family. It has been implicated in increased gene...
Show moreThe H2A.B histone is a highly evolving vertebrate specific variant of the H2A histone family. It has been implicated in increased gene expression, and experiments have shown that incorporation of H2A.B into nucleosomes results in more extended structures with fewer wrapped DNA base pairs. To study the molecular mechanisms of H2A.B, we have performed a series of conventional and enhanced sampling molecular dynamics simulation of H2A.B and canonical H2A containing nucleosomes.Results of adaptively biased molecular simulations show that substitution of canonical H2A with H2A.B results in geometrical changes such as unwrapping of 10 to 15 base pairs of DNA on each side of the nucleosome and an increase in the diameter and radius of gyration, which is in agreement with previous AFM, FRET, and SAXS experiments. DNA unwinding is energetically favorable in H2A.B containing compared to canonical nucleosomes, while in both systems we observe a wide range of sampling over various structures of DNA. H3 histone tails excluded simulations, show the importance and effect of N-terminal residues of H3 histones on attachment of DNA at the entry/exit sites to nucleosome protein core. Clustering and hydrogen bond analysis suggest that introduction of H2A.B to nucleosome systems triggers mechanisms leading to rearrangement of hydrogen bond network which may influence the pattern and intensity of interactions between DNA-protein and protein-protein complexes.
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Title: CHARACTERIZATION OF VERY LARGE YET VERY MILD BMD TYPE EDITS OF DYSTROPHIN
Creator: Lin, Yi-hsiu
Date: 2014, 2014-12
Description: Duchenne muscular dystrophy, DMD, is a severe X-linked recessive disease that kills boys in their second or third decade of life. A related...
Show moreDuchenne muscular dystrophy, DMD, is a severe X-linked recessive disease that kills boys in their second or third decade of life. A related condition Becker Muscular Dystrophy, BMD, is very heterogeneous with clinical severity ranging from nearly as bad as DMD, to nearly benign. Both of these are caused by defects in the dystrophin gene, which encodes a 427 kDa cytoskeletal protein, dystrophin, which can provide a mechanical link between the cytoskeleton and the muscle membrane and stables muscle tissue. In general, DMD results from defects that eliminate all dystrophin expression, whereas BMD patients carry mutated products: modified and malfunctioned dystrophin proteins. Since DMD is invariably fatal, monogenic, has a high incidence (1:3500 male births) and afflicts a charismatic patient profile, it has been an attractive target for gene therapy. However, the huge size of the dystrophin gene (2.4 Mbp) and more importantly its processed mRNA (14.2 kb) poses a problem for viral gene therapy which is limited to payloads of about 8 kb. This has prompted efforts to reduce the size of the dystrophin protein while still maintaining functionality. A major inspiration for such efforts was the identification of a very unusual, very large deletion serendipitously found in an extremely mild BMD case. The patient identified with this defect was ambulatory at 65 year of ages. This edit removes more than half the central rod region, from exon 17 to 48, Δe17-48, and, fortunately, the size of this BMD type edit protein is available for viral vector loading. In this project, edited dystrophin with central rod region deletion (D2:22 Δe17-48) and other two related edits, D2:22 Δe17-47 (exon 48 is added in D2:22 Δe17-48) and D2:22 Δe17-49 (exon 49 is deleted from D2:22 Δe17-48), were studied. According to these results, D2:22 Δe17-47 demonstrated the best biophysical and biochemical properties, but D2:22 Δe17-48 displayed higher to protease sensitivity, and D2:22 Δe17-49 had the worst thermal stability. This work will help us to understand the factors that result in benign large scale edits, and facilitate the development of effective viral gene therapy vectors.
M.S. in Biology, December 2014
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Title: THERMODYNAMICS AND PHASE EQUILIBRIA OF HEUSLER ALLOYS
Creator: Chung, Yoonsung
Date: 2011-09, 2011-07
Description: Heusler compounds are of great interest for their properties such as shape memory, thermoelectric, ferromagnetic and spin polarization effects...
Show moreHeusler compounds are of great interest for their properties such as shape memory, thermoelectric, ferromagnetic and spin polarization effects that could lead to new mechanical and electronic devices. Currently, the study of Heusler alloys is focused on their electronic and magnetic properties, but the high temperature thermodynamic properties of these compounds have not been covered as much. A thorough knowledge of the thermodynamic properties and phase equilibria is required for developing this kind of alloys. This thesis is part of a systematic investigation of the thermodynamics and phase equilibria of ternary Heusler alloy systems. In this work, the high temperature reaction calorimeter was used to obtain the standard enthalpy of formation of compounds in the Ni2XSn (X = Ti, Zr, Hf, V and Nb) and Ni2TiX (X = Ga and In) ternary systems. It was confirmed the compound Ni2TaSn does not exist in the Heusler structure A Setaram Ligne 96 drop calorimeter was used to measure the heat content of Ni2TiSn as a function of temperature. Phase equilibria and crystal structures of Ni2TiSn, Ni2TiGa and Ni2TiIn were determined using XRD, SEM and EDS.
M.S. in Materials Science & Engineering, July 2011
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Title: AN INTRINSICALLY CONDUCTING POLYMER-BASED COATING SYSTEM FOR CORROSION PROTECTION OF STEELS
Creator: Yu, Qifeng
Date: 2016, 2016-12
Description: Among the various corrosion protection strategies for structural steels, coating techniques provide the most cost-effective protection and...
Show moreAmong the various corrosion protection strategies for structural steels, coating techniques provide the most cost-effective protection and have been used as the primary mode for corrosion protection. Existing coating techniques have been used mainly for their barrier capability and all have a limited service life. In this research work, a waterborne two-strand polyaniline: poly (acrylic acid) complex was synthesized and utilized to fabricate the primer layer of a two-layer coating system. The techniques of Scanning Kelvin Probe Force Microscopy (SKPFM) and Electrochemical Impedance Spectroscopy (EIS) were used to evaluate the anti-corrosion capability of the polymeric complex when mixed in an epoxy matrix and coated on steel samples as the primer layer. The evaluation results show that coating systems including a PANi-based primer has measurable anticorrosion capability and the anti-corrosion capability of PANi-based primer depends on the usage of PANi and the type of matrix material of the primer layer. In the laboratory condition, a prototype two-layer coating system including the PANi-based primer and a polyurethane topcoat was manufactured. The ASTM Salt-Spray Test and EIS were used to prove the anti-corrosion performance of the prototype using a two-layer, polyurethane-over-epoxy system (no PANi) as the control system. After the proof of concept, a non-waterborne epoxy was used to fabricate a different PANi-based primer. The two types of primers and two other commercial primers (a zinc-rich primer and an epoxy-only primer) were used to make a total of eight two-layer coating systems using two widely used topcoats. Salt-Spray Test, Cyclic Salt Fog/UV Exposure Test, Pull- Off Adhesion Test, and the techniques of EIS, SKPFM, and Scanning Electron Microscope (SEM) were used to evaluate the long-term performance of the eight systems. Based on the laboratory-based recommendations, six groups of two-layer coating systems were then subjected to the outdoor-exposure test to evaluate their anti-corrosion durability at two testing sites. The field durability of the coating systems was evaluated in terms of their surface gloss reduction, color change, adhesion change and surface deteriorations. The matrix material in which the PANi is mixed plays an important role in the longterm anti-corrosion performance of coatings. The waterborne epoxy is effective in dispersing PANi nano-particles and has zero VOC; however, it does not bond to the steel surface as strongly as the regular non-waterborne epoxy. The topcoat material also plays an important role in the long-term anti-corrosion performance of coatings; polyurethane has higher durability than epoxy as a topcoat material. The PANi-based systems possess long-term corrosion protection comparable to the performance of the conventional zincrich three-layer system based on the one-year field evaluation.
Ph.D. in Civil Engineering, December 2016
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Title: FINFET BASED STANDARD CELL LIBRARY CHARACTERIZATION
Creator: Yuan, Yu
Date: 2015, 2015-07
Description: In this work, four standard cell libraries based on FinFET technology have been characterized and implemented. The first library uses the BSIM...
Show moreIn this work, four standard cell libraries based on FinFET technology have been characterized and implemented. The first library uses the BSIM-CMG and PTM-MG models, which represents the common multi-gate devices. Two libraries are based on the BSIM-IMG model, operating in short-gate (corresponding to low-Vt) mode and lowpower (corresponding to high-Vt) mode separately. Synthesis and simulation of BSIMCMG based library is presented and compared to the conventional 45nm CMOS library, FreePDK45. The results show acceptable accuracy of the library based on BSIM-CMG model. For the libraries based on BSIM-IMG model, Short-Gate (SG) mode, Low-Power (LP) mode and the mixed-mode (combining both SG and LP modes) have been analyzed. The results proved that the low-power independent multi-gate FinFET can be used for leakage power reduction, just like the bulk CMOS high-Vt devices. At the end of this work, another library based on CCS model was characterized and verified, which show far better accuracy in terms of both timing and power modeling.
M.S. in Electrical Engineering, July 2015
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Title: DEGRADATION RATE MODEL TO ESTIMATE SOIL CARBON SEQUESTRATION
Creator: Zhai, Wenjuan
Date: 2016, 2016-05
Description: Concern over climate change as a consequence of carbon dioxide (CO2) emissions from human activities has resulted in efforts to better...
Show moreConcern over climate change as a consequence of carbon dioxide (CO2) emissions from human activities has resulted in efforts to better understand potential mitigation measures such as carbon sequestration in soils. Processes shaping natural carbon sequestration may be used to remove excess CO2 from combustion and other anthropogenic sources of carbon, and, alleviate concerns over climate change. Land application of biosolids is a process that increases the amount of soil carbon sequestration and may produce carbon credits in accordance with the definition of UN Climate Change Convention. A dynamic degradation rate model (DRM) has been developed based on a mass balance and first order kinetics to describe the soil organic carbon (SOC) decomposition process, which provides insights on carbon sequestration due to microbial biomass, SOC, CO2 emission rates, residence time of sequestered carbon, and biomass to biosolids ratios. A curve fitting approach was used to produce a best fit average degradation rate for biosolids degradation and microbial biomass yield. This study employed a 34-year biosolids application database from the literature to determine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory resultsdetermine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory resultsdetermine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory resultsdetermine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory results provided by a yearlong study indicates that higher temperatures and moisture content and finer soils are related to larger degradation rates. To summarize, this study has the following contributions: (1) developed a degradation rate model which simulates the biosolids degradation process in soil and identifies two SOC phases in soil, and quantifies the biosolids degradation rate constant, biomass yield, and the C sequestered amount for multiple and long term soil application; (2) assessed the effect of changes in the amount of biosolids applied, soil type, and weather conditions on the C degradation rate by comparing model results to laboratory data; and (3) provides an easy quantitative method for predicting C sequestration from biosolids added to soil.
Ph.D. in Environmental Engineering, May 2016
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