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Title: A MICROFLUIDIC INTESTINAL-MICROBIOTA PLATFORM TO STUDY DRUG METABOLISM
Creator: Wang, Chengyao
Date: 2020
Description: The intestine is the main site that orally administered drugs are primarily metabolized, absorbed, and distributed. The trillions of bacteria...
Show moreThe intestine is the main site that orally administered drugs are primarily metabolized, absorbed, and distributed. The trillions of bacteria that inhabit the intestine influence health and regulate important biochemical factors, such as the activity of enzymes pertinent to drug metabolism. However, this has not been systematically studied partly due to the challenges of recapitulating the unique and complex intestinal microenvironment that includes (1) the presence of mammalian and microbial cells and (2) a unique partitioned oxygenation proﬁle across the lumen to the subepithelial mucosa from anaerobic to the richly vascularized oxygenated. This thesis reports the development of a microfluidic device in which is integrated a membrane synthesized from a key element of mucosal basal lamina, collagen, and precisely controlled partitioned oxygen environment. The device enabled excellent cell viability and long-term function. More importantly, it enabled the coculture of intestinal epithelial cells and aerobic and anaerobic bacteria in the partitioned oxygen environment. These experiments on one hand allowed the measurement of cellular oxygen consumption rate under perfusion, which could be used to study microbial regulation of oxidative metabolism in epithelial cells. On the other hand, the device allowed a systematic examination of the role of different gut bacteria strains on the regulation of factors that are important in drug metabolism, namely, transporters and phase I enzymes. Our studies highlighted the importance of direct communication between the intestinal cells and the gut bacteria with major findings being that species-specific differences exist in the regulation of drug metabolism. This work will be useful for (1) the discovery of novel regulators of drug metabolizing enzymes, (2) developing new pharmacokinetic models, and (3) advancing precision medicine models for patients.
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Title: First-principles study on the stability, electrochemical property, and degradation mechanism of ceramic electrode materials
Creator: Wei, Jialiang
Date: 2023
Description: First-principles studies demonstrate the capability to rapidly and accurately calculate desired properties in battery materials. This thesis...
Show moreFirst-principles studies demonstrate the capability to rapidly and accurately calculate desired properties in battery materials. This thesis focuses on the examination of layered NaCrO2 as a case study to assess the impact of various calculation methods. Additionally, a microscopic analysis is conducted to investigate the failure mode of NaCrO2. Lastly, a successful first-principles based high-throughput screening of electrode materials is performed to identify stable compounds that enable easy Li migration.The layered O3 NaCrO2 compound exhibits promising characteristics as a Na-ion cathode material, including good thermal stability and specific capacity. However, it suffers from poor rate capability. To address this limitation and develop high-rate Na-ion cathodes, we conducted a first-principles study that focused on the stability and Na diffusion in pure and doped NaCrO2. The study utilized various functionals, including those explicitly incorporating van der Waals (vdW) interactions. By including vdW interactions, we observed a significant reduction in interlayer distances within partially desodiated NaCrO2, which directly impacted the prediction of Na diffusion barriers. We established a linear relationship between interlayer distance and diffusion barrier using different functionals. Notably, the increased diffusion barriers were mainly due to the reduced interlayer distances predicted by the vdW-inclusive functionals, rather than the inclusion of vdW interactions in the transition state calculations. Other factors, such as the charge density change introduced by different dopants, also influenced the Na diffusion barriers. Metal doping (Al, Zn, Mn, and Co) at low concentrations in NaCrO2 had minor effects on its thermodynamic stability but significantly promoted Na diffusivity. Among the doped NaCrO2 compounds, Co-doped NaCrO2 exhibited the lowest Na diffusion barriers and emerged as a potential candidate for high-rate Na-ion cathode materials. This study highlights the significance of vdW interactions in layered transition metal oxides and provides strategies to enhance first-principles predictions for such structures.Then, TM migration usually occurs at highly charged states in layered Na transition metal oxide, leading to a deterioration in capacity and reversibility. Furthermore, the formation of hybrid phases, characterized by the intergrowth of octahedral and prismatic Na layers, is known to take place at highly charged states. These hybrid phases often exhibit greater stability compared to simple O3 or P3 stacking configurations. However, there is limited understanding regarding the mechanism and impact of TM migration in these hybrid phases. To address this gap, we conducted a comparative first-principles study to elucidate the connection between structural changes and Cr migration in layered O3 and hybrid-phased NaCrO2. We observed that the hybrid-phased NaCrO2 experienced more significant layer shrinkage than the O3 phase after Cr migration. Three factors were found to affect the Cr migration energy: the Na concentration, local 3D configuration, and 2D in-plane geometry. Low Na concentration and specific 3D configurations facilitated Cr migration. Furthermore, the Cr migration barriers in both O3 and hybrid-phased NaCrO2 were found to be positively correlated with Cr migration energy. Lastly, we surveyed the Cr migration of 17 doped O3 and hybrid-phased NaCrO2 compounds. A uniform distribution of Cr-O bond length usually indicated suppressed Cr migration. We identified optimal dopants for Cr migration suppression by considering both Cr and dopant migration energy. This comparative study on Cr migration in O3 and hybrid-phased NaCrO2 highlights the significant role of hybrid phases in the application of layered cathode materials.Moving from the calculations of single material system, we last conduct a first-principles high-throughput screening of multicomponent transition metal sulfides (TMS) as fast Li-ion intercalation compounds. We compared two representative TMS frameworks, pyrite and spinel, with regard to their selectivity in forming stable disordered TMS. To quantify the ability to form entropy stabilized disordered TMS, we examined the effects of cation permutation on the formation enthalpy range. Although low energy-above-hull (Ehull) is a preliminary requirement for the formation of stable TMS, a narrow formation enthalpy range can also lead to entropy stabilized TMS, as only a small amount of excess energy is required to stabilize the metastable configurations. Among the 70 pyrite and spinel frameworks studied, we selected 13 spinel compounds based on their low Ehull and narrow Ef range. Additionally, these spinel compounds exhibited greater stability compared to their pyrite counterparts. We found that early transition metal elements such as Ti and V were less favorable for the formation of pyrite TMS, while late TM elements, especially Cu, strongly destabilized spinel TMS. The spinel (CrMnCoNi)S2 TMS demonstrated the most promising characteristics with a narrow Ef range. Finally, we calculated and ranked the Li migration barriers in the 13 stable spinel TMS using a bond valence-based method, which allowed for quick screening of ion migration. High oxidation state TM elements, such as Mn4+ and Cr3+, located nearest to the Li migration path, increased the Li migration barrier. (CrMnCoNi)S2 exhibited the lowest Li migration barrier, positioning it as a promising entropy-stabilized spinel intercalation compound.
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Title: Development of Microfluidic Platform to Study Insulin Resistance
Creator: Tanataweethum, Nida
Date: 2020
Description: Insulin resistance, a precursor for the development of type 2 diabetes (T2D), propagates among heterologous tissues through dysregulated lipid...
Show moreInsulin resistance, a precursor for the development of type 2 diabetes (T2D), propagates among heterologous tissues through dysregulated lipid flux, as well as dysregulated glucose production, and secretion of cytokines, adipokines and hepatokines. Although T2D is characterized by systemic insulin resistance, disruption of insulin signaling in the liver and adipose tissue recapitulates many aspects of T2D, including enhance endogenous glucose production as well as defects of insulin action. Mechanistic studies often aim to provide fundamental understanding of the observations from human and animal studies. Due to the complexity of animal models and the multifactorial character of T2D, there is a strong need to develop advanced experimental systems such as in vitro models that can enable the recapitulation of the complex physiology of the in vivo system and enable investigation of the pathological pathways as well as identify novel treatment options. The overall goal of this study was to develop insulin resistant models of adipose tissue and liver to study the metabolic function of each organ as well as to the organ-organ crosstalk. To accomplish this goal, four specific aims were pursued: (1) Establish adipose tissue on-a-chip to study the metabolic function of the adipocytes in flow culture; (2) Develop towards an insulin resistant adipose on-a-chip to study the metabolic function of adipocytes in setting of insulin resistance; (3) Develop insulin resistant liver on-a-chip to investigate the metabolic function of hepatocytes in setting of insulin resistance; (4) Develop adipose-liver on-a-chip in setting of insulin resistance to identify the metabolic interaction between organs.
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Title: The Double-edged Sword of Executive Pay: How the CEO-TMT Pay Gap Influences Firm Performance
Creator: Haddadian Nekah, Pouya
Date: 2024
Description: This study examines the relationship between the chief executive officer (CEO) and top management team (TMT) pay gap and consequent firm...
Show moreThis study examines the relationship between the chief executive officer (CEO) and top management team (TMT) pay gap and consequent firm performance. Drawing on tournament theory and equity theory, I argue that the effect of the CEO-TMT pay gap on consequent firm performance is non-monotonic. Using data from 1995 to 2022 from S&P 1500 US firms, I explicate an inverted U-shaped relationship, such that an increase in the pay gap leads to an increase in firm performance up to a certain point, after which it declines. Additionally, multilevel analyses reveal that this curvilinear relationship is moderated by attributes of the TMT, and the industry in which the firm competes. My findings show that firms with higher TMT gender diversity suffer lower performance loss due to wider pay gaps. Furthermore, when firm executives are paid more compared to the industry norms, or when the firm has a long-tenured CEO, firm performance becomes less sensitive to larger CEO-TMT pay gaps. Lastly, when the firm competes in a masculine industry, firm performance is more negatively affected by larger CEO-TMT pay gaps. Contrary to my expectations, firm gender-diversity friendly policies failed to influence the CEO-TMT pay gap-firm performance relationship.
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Title: Mothers’ Vaccination Decision: The Relation Between Science Skepticism, Social Networks, Vaccination Beliefs, and Fear of ASD
Creator: Lockwood, Maria Izabel Kugelmas Guarita
Date: 2021
Description: Vaccines are instrumental in stopping the spread of disease, yet some parents choose to not vaccinate their children. Despite scientific...
Show moreVaccines are instrumental in stopping the spread of disease, yet some parents choose to not vaccinate their children. Despite scientific evidence that childhood vaccines are safe, there is an increasing number of children in the United States and the United Kingdom who are not getting vaccinated. The current study investigates different factors that may be associated with mothers’ decision to vaccinate their children. This study examines the relations between skepticism in science, vaccination beliefs, fear of having a child with Autism Spectrum Disorder (ASD), social network recommendations, and maternal decision to vaccinate. Participants included 293 expectant mothers in the United States and the United Kingdom. Results indicated that mothers who are pro-vaccine and mothers who are vaccine-hesitant have different score profiles across scales that measure skepticism in science, vaccination beliefs, and fear of having a child with ASD. Specifically, we found that relative to mothers who are vaccine-hesitant, mothers who are pro-vaccine: (1) indicated less skepticism in science; (2) had fewer anti-vaccination beliefs; (3) did not statistically differ on their fear of having a child with ASD; and (4) had a smaller percentage of their social network advocating against vaccination. Thus, the study adds to the research literature, as it illustrates that mothers who are vaccine-hesitant differ from mothers who are pro-vaccine on key factors.
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Title: The Double-edged Sword of Executive Pay: How the CEO-TMT Pay Gap Influences Firm Performance
Creator: Haddadian Nekah, Pouya
Date: 2024
Description: This study examines the relationship between the chief executive officer (CEO) and top management team (TMT) pay gap and consequent firm...
Show moreThis study examines the relationship between the chief executive officer (CEO) and top management team (TMT) pay gap and consequent firm performance. Drawing on tournament theory and equity theory, I argue that the effect of the CEO-TMT pay gap on consequent firm performance is non-monotonic. Using data from 1995 to 2022 from S&P 1500 US firms, I explicate an inverted U-shaped relationship, such that an increase in the pay gap leads to an increase in firm performance up to a certain point, after which it declines. Additionally, multilevel analyses reveal that this curvilinear relationship is moderated by attributes of the TMT, and the industry in which the firm competes. My findings show that firms with higher TMT gender diversity suffer lower performance loss due to wider pay gaps. Furthermore, when firm executives are paid more compared to the industry norms, or when the firm has a long-tenured CEO, firm performance becomes less sensitive to larger CEO-TMT pay gaps. Lastly, when the firm competes in a masculine industry, firm performance is more negatively affected by larger CEO-TMT pay gaps. Contrary to my expectations, firm gender-diversity friendly policies failed to influence the CEO-TMT pay gap-firm performance relationship.
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Title: Cardiolipin Modulates the Insertion of Adsorbed Helical Amyloid Beta Peptide Into Model Mitochondrial Membranes
Creator: Kaczmarek, Julia A.
Date: 2023
Description: The loss of mitochondrial phospholipid cardiolipin (CL) may play a role in both the pathogenesis of Alzheimer's Disease (AD) and its treatment...
Show moreThe loss of mitochondrial phospholipid cardiolipin (CL) may play a role in both the pathogenesis of Alzheimer's Disease (AD) and its treatment. An effector molecule of the disease, amyloid-beta (Aβ), has been observed to interact with lipid membranes, but its relevance to mitochondrial membranes containing CL remained elusive. The present study investigated if the presence of CL modulated the insertion of adsorbed helical amyloid beta (Aβ14-40) into model mitochondrial membranes, and if this effect was more pronounced for its N-terminus or C-terminus. I conducted a coarse-grained computer simulation using well-tempered metadynamics to traverse the free energy landscape that maps the translocation of Aβ14-40. Insertion into CL-containing bilayers created larger local membrane deformations and modulated the location of the transition path but had an inconclusive impact on the free energy cost of translocation. Since the generation of toxic calcium-permeable pores depends on the insertion of Aβ into the bilayer, the loss of CL seen in AD may prime the inner mitochondrial membrane for pore formation, but more research is needed to pursue this hypothesis.
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Title: Approximation Algorithms for Selected Network and Graph Problems
Creator: Wang, Xiaolang
Date: 2023
Description: This dissertation proposes new polynomial-time approximation algorithms for selected optimization problems, including network and classic...
Show moreThis dissertation proposes new polynomial-time approximation algorithms for selected optimization problems, including network and classic graph problems. We employed distinct strategies and techniques to solve these problems. In Chapter 1, we consider a problem we term FCSA, which aims to find an optimum way how clients are assigned to servers such that the largest latency on an interactivity path between two clients (client 1 to server 1, server 1 to server 2, then server 2 to client 2) is minimized. We present a (3/2)-approximation algorithm for FCSA and a (3/2)-approximation algorithm when server capacity constraints are considered. In Chapter 2, we focus on two variants of the Steiner Tree Problem and present better approximation ratios using known algorithms. For the Steiner Tree with minimum number of Steiner points and bounded edge length problem, we provide a polynomial time algorithm with ratio 2.277. For the Steiner Tree in quasi-bipartite graphs, we improve the best-known approximation ratio to 298/245 . In Chapter 3, we address the problem of searching for a maximum weighted series-parallel subgraph in a given graph, and present a (1/2 + 1/60)-approximation for this problem. Although there is currently no known real-life application of this problem, it remains an important and challenging open question in the field.
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Title: Corporate Insider Holdings and Analyst Recommendations
Creator: Gogolak, William Peter
Date: 2022
Description: I pursued two competing theories about insider stock holding levels and analyst recommendations. The complementary hypothesis states that top...
Show moreI pursued two competing theories about insider stock holding levels and analyst recommendations. The complementary hypothesis states that top management and analysts conduct actions in a comparable manner; the contradicting hypothesis states that insiders and analysts exhibit opposite market actions (Hsieh and Ng, 2019). I examined insider stock holding levels and analyst recommendations. I analyzed a sample of S&P 500 firms from 2011-2020. In this sample, I found that the relationship between insider holding levels and analyst recommendations are opposite in concurrent time periods; thus, supporting the contradictory hypothesis. I also analyzed lagged insider holdings levels in a granger causality test. This test supports the idea that top management stock holdings increase when analysts downgrade stocks, and the opposite effect it true when analysts upgrade stocks. Using a sample of S&P 500 firms from 2011 – 2020, I provided support to my hypothesis that aggregated analyst recommendations forecast future aggregate equity returns. Furthermore, I conducted a test to support my conclusion that changes to insider holding levels should be used to forecast changes in future equity returns, beyond what is already explained by analyst recommendations. I argue two compelling additions that I make to the existing body of work regarding aggregate stock prediction. First, I build upon existing papers by using Bloomberg aggregate analyst recommendations as opposed to the IBES datasets. Second, I expand upon recent index forecasting papers by incorporating both aggregate analyst recommendations and aggregate insider holding levels into aggregate stock return models.
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Title: Understanding and Combating Filter Bubbles in News Recommender Systems
Creator: Liu, Ping
Date: 2022
Description: Algorithmic personalization of news and social media content aims to improve user experience. However, there is evidence that this filtering...
Show moreAlgorithmic personalization of news and social media content aims to improve user experience. However, there is evidence that this filtering can have the unintended side effect of creating homogeneous ``filter bubbles'' in which users are over-exposed to ideas that conform with their pre-existing perceptions and beliefs. In this thesis, I investigate this phenomenon in political news recommendation algorithms, which have important implications for civil discourse.I first collect and curate a collection of over 900K news articles from over 40 sources. The dataset was annotated in the topic and partisan leaning dimensions by conducting an initial pilot study and later via Amazon Mturk. This dataset is studied and used consistently throughout this thesis. In the first part of the thesis, I conduct simulation studies to investigate how different algorithmic strategies affect filter bubble formation. Drawing on Pew studies of political typologies, we identify heterogeneous effects based on the user's pre-existing preferences. For example, I find that i) users with more extreme preferences are shown less diverse content but have higher click-through rates than users with less extreme preferences, ii) content-based and collaborative-filtering recommenders result in markedly different filter bubbles, and iii) when users have divergent views on different topics, recommenders tend to have a homogenization effect.Secondly, I conduct a content analysis of the news to understand language usage among and across various topics and political stances. I examine words and phrases used by the liberal media and by the conservative media on each topic. I first study what differentiates the liberal media from the conservative media on each topic. I then study common phrases that are used by the liberals and the conservatives on different topics. For example, I examine which phrases are shared by the liberal articles on guns and conservative articles on abortion. Finally, I compare and visualize these words using different clustering algorithms and supervised classification methods.In the last chapter, I conduct an extensive user study to find possible solutions to combat the filter bubbles in the political news recommender systems. I designed a self-contained website that enables a content-based news recommender system and indexed 40,000 U.S.~political articles. I recruited over 800 U.S.~participants from Amazon Mechanical Turk (approved by IRB). The qualified participants are split into control and treatment groups. The users in the treatment group are provided transparency and interaction mechanisms, which grant them more control over the recommendations. Our results show that providing interaction and transparency a) increases click-through rates, b) has the potential to reduce the filter bubbles, and c) raises more awareness about filter bubbles.
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Title: An Experimental Investigation of Single Jet Heat Transfer with Surrounding Microjets
Creator: Ma, Weicong
Date: 2019
Description: An experimental investigation of a single main jet with surrounding microjets impinging on a flat heated surface was performed to understand...
Show moreAn experimental investigation of a single main jet with surrounding microjets impinging on a flat heated surface was performed to understand the role of the higher-speed microjets on the surface heat transfer. Eight microjets 45-degrees apart were fabricated on a circular disk mounted at the exit of the main jet axisymmetric. Heat transfer enhancement on the flat surface was evaluated by comparison with the results of a baseline single round jet with the same flow rate. The average Nusselt Number and the local Nusselt number in the radial direction are reported as functions of dimensionless nozzle-to-plate distance, dimensionless radial distance, and dimensionless mass flow rate ratio. Local Nusselt number contours are plotted as a function of radial position. The area-averaged Nusselt number and local Nusselt number beyond the near-field impingement jet region increases monotonically with increasing mass flow rate ratio and decreasing of nozzle-to-target distance. The local Nusselt number at the stagnation region shows a more complex behavior with the mass flow rate ratio and nozzle-to-target distance.
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Title: Thermoelectric Power Systems and the Energy-Water Nexus
Creator: Walker, Michael Edward
Date: 2012-04-26, 2012-05
Description: The goal of this Thesis is the development of a comprehensive methodology to evaluate the total cost of water use in the recirculating cooling...
Show moreThe goal of this Thesis is the development of a comprehensive methodology to evaluate the total cost of water use in the recirculating cooling loops of thermoelectric power plants. This methodology expands upon the work presented in the literature to improve estimations of the economic impact of condenser fouling. The methods developed in this Thesis are incorporated into a user friendly Combined Cost Model (CCM) interface that will allow future researchers, students and plant personnel to perform the same comparative analyses presented herein. The objective of this Thesis is the application of the CCM to determine the economic viability of treated municipal wastewater (MWW) use to replace freshwater for cooling in power plants with recirculating cooling systems. To accomplish this objective, a set of case study evaluations are included to (1) evaluate the sensitivity of the economic impact of fouling to condenser design and operation, (2) determine the cost of treated MWW use in pulverized coal power plants, and (3) compare the relative cost of degraded water use in advanced power systems such as IGCC and oxy-combustion. The results of these evaluations show that current freshwater prices do not provide an economic incentive to switch to the use of treated MWW water. However, results indicate that the breakeven differential price of freshwater, at which the total costs of using freshwater and treated MWW are equal, is only 0.52 $/1000Gal. (USD 2009). In addition, the use of treated MWW for cooling is shown to be a better economic alternative to dry air cooling technology (DACT) for the conservation of freshwater resources. Cost-to-conservation estimates of treated MWW use are 1.1 $/1000 Gal., in contrast to 5.6 $/1000 Gal. for DACT. This Thesis also presents a novel, hybrid coal conversion concept, the dry gasification oxy-combustion (DGOC) power cycle. This process is similar to oxycombustion, in that it maintains a concentrated CO2 flue stream and does not utilize a complex separation step. However, coal conversion and sulfur removal are performed within a gasification unit. It is estimated to achieve CCS goals with a higher efficiency than the leading alternative strategies.
Ph.D. in Chemical Engineering, May 2012
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Title: COMPUTATIONAL MODELLING OF FALLING FILM FLOW AND HEAT TRANSFER OVER HORIZONTAL TUBES
Creator: Karmakar, Avijit
Date: 2021
Description: In this study, numerical simulations based on the volume of fluid (VOF) method are conducted to investigate the hydrodynamic behavior,...
Show moreIn this study, numerical simulations based on the volume of fluid (VOF) method are conducted to investigate the hydrodynamic behavior, sensible heat transfer behavior, and tube surface wettability effects for a falling film over heated horizontal tubes encountered in falling film heat exchangers. The Reynolds number ranges from 15 - 210, covering the droplet, jet (inline and staggered), and sheet flow modes. To consider evaporation under liquid film waviness and gas (vapor and air) flow effects, a simplified case was studied for the wavy liquid film over a heated vertical surface with the surrounding gas flowing in either co-current or counter-current direction. The OpenFOAM CFD solver has been used to conduct the numerical simulations.For hydrodynamics, the liquid film thickness and interface velocity variation for all the flow modes are presented. In droplet mode, the movement of the liquid waves formed by the drop impact causes an over 350% change in film thickness. A dimple around the jet impingement region in the steady inline jet mode is formed with a relative change in film thickness by 40%. The base of the impinging jets possess ripples of wavelengths 0.3-1.0 times the capillary length. For the steady staggered jet mode, the neighboring jets interact to develop crest and stable segments with film thickness ratio of 1.7. Finally, for the sheet mode, interfacial waves are seen to travel along the tube periphery with amplitudes of about 20% of the nominal film thickness. A set of correlations have been presented to predict film thickness and interfacial velocity with RMSE = 0.2 for 80% of the data.The local Nusselt number (Nu) distribution depends on the flow features in each mode. In the droplet mode, the Nu value varies significantly as the droplet impinges and the remnant liquid-bridge retracts (peak instantaneous Nu = 6), followed by wave propagation with peak Nu = 0.25. For the jet modes, the local maximum in Nu occurs off-center to the impingement location with peak Nu = 3.1 for the inline jet mode and Nu = 2.7 for the staggered jet mode, while for other locations, Nu varies as inversely proportional to film thickness. Substantial variations in the Nu value are also recorded in the middle of the two impinging jets with Nu = 0.95 in the inline jet mode, and Nu = 0.60 in the crest region of the staggered jet mode. In the sheet mode, the Nu varies with the thickness of the traversing liquid waves. Lower Nu values were recorded beneath the crest location of the liquid waves, which increases (1.4 - 11.6%) abruptly at the advancing fronts of the waves. The temperature distribution in the liquid film in each of the modes was examined to evaluate the mechanism of heat transfer process. This study also compares the Nu distribution with the available analytical heat transfer models.The tube surface wettability results present the liquid film thickness, the wetted areas, and the Nusselt number (Nu) over the tube surface. The resistance imposed by the increasing contact angles inhibits the extent of the liquid spreading over the tube surface, and this, in turn, influences film thickness and wetted areas. A significant decrement in the heat transfer rate from the tube surfaces was observed as the equilibrium contact angle increased from 2 to 175 degrees. The local distributions of the Nu over the tube surface are strongly influenced by the flow recirculation in the liquid bulk.Finally, for wavy film evaporation under gas flow effects, the results show a 15% and 16% enhancement in time-averaged Sherwood number (Sh) due to film waviness (sinusoidal and solitary) with gas flow rate, Qg = +50 and Qg = -50, respectively. This enhancement in the Sh for both the waves further increases by 11% with Qg =+800 and by 196% with Qg = -800. Closer examination of the mass transfer process over a wave demonstrates that with Qg = +50, the concentration of the gas side streamlines at the trough locations of the wave leads to higher values of Sh than the rest of the locations. However, with Qg = +800, although the overall Sh increases, vortices appear at the wave trough locations, leading to decreased local Sh values than the surrounding locations.
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Title: Design of A Modern Hydrogen Production and Recovery Facility (Spring 2003) IPRO 304C
Creator: Mehta, Ankit, Ayobamidele, Bello, Barac, Predrag, Bartman, Alex, Ekelemu, Odemena, Gaicki, Richard, Gaydos, Celeste, Hardin, Kendra, Kittaneh, Marriam, Lawardi, Bernadette, Mckinney, Michelle, Malik, Maheen, Thomas, Tony, Trauscht, April
Date: 2003, 2003-05
Description: The objective of this project is to design and provide an economic assessment of new flue gas cleanup processes to meet new and future...
Show moreThe objective of this project is to design and provide an economic assessment of new flue gas cleanup processes to meet new and future environmental emissions standards. The issues to be considered in this project include technical viability, process integration, economic feasibility, and environmental disposal of waste streams. An economic assessment of the market-based prices of emissions allowances will be used to determine the best long-run strategy. An assessment will be made on the effects of implementation of new technologies on the cost of electricity for both low sulfur western coal, and high sulfur Illinois coal to determine if governmental incentives are needed to promote the use of Illinois coal. Students may focus on an existing power plant in Illinois which uses western coals and is not equipped with SOx/NOx/Hg control systems. Students are expected to use the principles of process design, to evaluate commercially available technologies for various pollutants or propose new approaches to the problem, integrate various technologies in the cleanup train, and perform an economic analysis of the overall processes.
Sponsorship: IIT Collaboratory for Interprofessional Studies
Project Plan for IPRO 304C: Design of A Modern Hydrogen Production and Recovery Facility for the Spring 2003 semester
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Title: Wastewater Reclamation (Spring 2002) IPRO 304C
Creator: Burkes, Danielle, Derrick, George, Dillard, Christy, Griffin, Ashanti, Gwozdz, Katie, Komatsu, Masami, Morken, Kelly, Patel, Anna, Sherman, Brian, Stachurski, Greg
Date: 2002, 2002-05
Description: The main aim of this project is Wastewater reclamation to save the fast depleting Groundwater resources
Sponsorship: NA
Project Plan for IPRO...
Show moreThe main aim of this project is Wastewater reclamation to save the fast depleting Groundwater resources
Sponsorship: NA
Project Plan for IPRO 304C: Wastewater Reclamation for the Spring 2002 semester
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Title: Devices for Removal of VOCs from Ground Water (Spring 2002) IPRO 304B
Creator: Brown, Nathaniel, Cacace, Benjamin, Kustwin, Brian, Ogunribido, Susan, Sarmiento, Melissa, Edwards Ii, Michael, Felfe, Kristina, Gundy, Justin Van, Hudalla, Greg, Keleko, Adenkunmi
Date: 2002, 2002-05
Description: Water in Wausau, Wisconsin is contaminated with VOCs posing hazardous health risks. As part of the IPRO project, we need to determine a unit...
Show moreWater in Wausau, Wisconsin is contaminated with VOCs posing hazardous health risks. As part of the IPRO project, we need to determine a unit operation that can remove VOCs effectively and cost efficiently.
Sponsorship: IIT Interprofessional Collaboratory
Project Plan for IPRO 304B: Devices for Removal of VOCs from Ground Water for the the Spring 2002 semester
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Title: A METHODOLOGY FOR UTILIZATION OF DEGRADED WATER IN THERMOELECTRIC POWER PLANT COOLING SYSTEMS
Creator: Safari, Iman
Date: 2013, 2013-12
Description: The overall objective of this study was to develop a comprehensive methodology to identify viable treatment strategies for utilization of...
Show moreThe overall objective of this study was to develop a comprehensive methodology to identify viable treatment strategies for utilization of degraded waters for cooling in thermoelectric power systems. To achieve this objective a process simulation model was developed using Aspen Plus® with the OLI (OLI System, Inc.) water chemistry model to predict water quality and the rate of fouling in the recirculating cooling loop utilizing secondary-treated municipal wastewater (MWW) and tertiary-treated municipal wastewater as the sources of makeup water. This process simulation model includes sub- models for pre-treatment units; the cooling tower with water, CO2, and NH3 evaporation; as well as the recirculating cooling system and condenser with salt precipitation and fouling. The input parameters of the model, including CO2 mass transfer coefficients in the cooling tower and kinetics of salts precipitation reactions, were determined by developing mathematical models and calibrating the models with the experimental data obtained from literature. The process simulation module was used to predict the water quality in the recirculating cooling loop and the results were compared with pilot-scale experimental data from literature on makeup water alkalinity, loop pH and ammonia evaporation. The effects of various parameters including makeup water quality, salt formation, NH3 and CO2 evaporation mass transfer coefficients, heat load and operating temperatures were investigated. The results indicate that stripping of CO2 and NH3 in the cooling tower can significantly affect the cooling loop pH. x viii The model was also used to determine the rate of fouling in the condenser. The results indicate that the fouling rate of MWW as makeup water is significantly higher than that expected with fresh water, and tertiary treatment of MWW such as nitrification and/or softening can significantly reduce the fouling potential. Finally, the rate of fouling obtained from this study was integrated into the existing cost model developed earlier (at Illinois Institute of Technology) to perform the overall economic analysis. The results show that the use of municipal wastewater (MWW) to replace freshwater as makeup for the recirculating cooling loops of thermoelectric power plants is economically viable when tertiary treatments such as nitrification or softening are applied. Among various treatment strategies studied, nitrification of MWW has the lowest cost of 0.29 $/m3 for utilization in a 550 MW power plant. Furthermore, it was concluded that utilization of secondary treated municipal wastewater (MWW) without tertiary treatments such as nitrification or softening is not economically viable due to its significant fouling costs.
PH.D in Chemical Engineering, December 2013
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Title: Modeling and Optimization of Power Plant Cooling Tower Systems Using Physics-Based and Neural-Network-Based Models
Creator: Salomon, Basile Clément Paul
Date: 2023
Description: Condensers and cooling towers are commonly used in steam power plants to condense the steam exiting the turbine and to recycle the condensed...
Show moreCondensers and cooling towers are commonly used in steam power plants to condense the steam exiting the turbine and to recycle the condensed-water into the boiler in a closed-loop system. These condensers typically use cooling water drawn from a water body (lake, river etc) to condense the steam. Cooling towers are used to lower the temperature of the warm water exiting the condenser. Since the steam condensation temperature plays an important role in the power plant efficiency, cool- ing tower performance which is limited by the wet-bulb temperature of the ambient air has been extensively studied. This work investigates the modeling of an enhanced cooling tower technology using a new pre-cooling and dehumidifying system (PDHS). This new system, based on a reversed Brayton cycle, is made out of a compressor, an air-cooled heat exchanger (HX), a heat and mass exchanger (HMX) and an expander. The goal of this PDHS concept is to pre-cool the air entering the cooling tower in order to improve its performance. In this work, a systems model has been developed. Thermodynamic models have been used for the compressor, the air-cooled heat exchanger and the expander. For the remaining components, i.e. the heat and mass exchanger, the cooling tower and the condenser, physics-based models have been developed and tested. Once tested and validated, each model can be integrated into the integrated PDHS-cooling tower-condenser system. Two different configurations of the PDHS have been considered in this thesis. In the open water loop configuration, the water in the HMX is obtained from the municipal water supply (or an alternate water source) and is released back to the source after exiting the HMX. In the closed water loop configuration, the water used to cool down the air in the HMX is being recirculated and cooled in the power plant cooling tower. The physics-based model of the PDHS developed in this work has been validated using results from an empirical model of the PDHS by GTI Energy. This first case study also shows how the PDHS can be used to save water in the cooling tower (CT). Indeed, when using the PDHS, a 37% reduction in the cooling tower evaporation rate can be observed when comparing to the baseline. This decrease in the CT evaporation rate is the main source of make-up water savings. Moreover, the water harvested by condensation in the PDHS can be redirected towards the CT, bringing another source of water savings. These two combined lead to an overall 46% decrease of the make-up water usage in the cooling tower. Another case study has been conducted on a 500 MW condenser unit. It shows that, under summer ambient conditions i.e. Ta,db = 35°C and φ = 47%, the PDHS can help the condenser restore its designed cooling load of 453 MW. Finally, using the physics-based model to create a dataset, an artificial neural network model of the PDHS has been developed to constitute a black box for the PDHS that would be able to predict with sufficient accuracy the condenser and HMX loads, the air conditions at the inlet of the CT and water temperature at both ends of the condenser and CT given the ambient air condition, the compressor pressure ratio and the water split between the condenser and the heat and mass exchanger.
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Title: COMPUTATIONAL FLUID DYNAMICS SIMULATION OF CARBON CAPTURE UNIT USING AN AMINE-BASED SOLID SORBENT
Creator: Esmaeili Rad, Farnaz
Date: 2021
Description: Carbon capture and sequestration (CCS) is one of the key technologies to reduce the emission of carbon dioxide, including that from exiting...
Show moreCarbon capture and sequestration (CCS) is one of the key technologies to reduce the emission of carbon dioxide, including that from exiting flue gas of fossil fuel-fired power plants. The goal of this project is the development of a computational fluid dynamics (CFD) model to predict the extent of CO2 capture in a circulating fluidized bed carbon capture unit using novel amine-based solid sorbents.In this study, first the hydrodynamics of the carbonation section of the carbon capture unit was investigated. Then, the performance of the amine-based solid sorbents toward capturing carbon dioxide from flue gas and the extent of CO2 adsorption in the carbonation section were studied. At the second stage of the study, the regeneration of the sorbents and desorption of carbon dioxide from carbonated solid sorbents in the regeneration section of the carbon capture unit was investigated. At the third stage of the study, the hydrodynamics of the entire loop of the integrated carbonation and regeneration sections were simulated. Two-dimensional non-reactive CFD simulations of the entire loop, including the carbonator, regenerator, and two loop-seal fluidized beds, were performed to study the details of the solid circulation in the system in a stable operational condition. At the fourth stage of the study, the effect of the carbonated solids’ residence time in the regeneration section was investigated by extending the regenerator fluidized bed height and adding to the volume of the system. Heated surfaces, which resembled heating coils in the regenerator cylinder, were also added to the system to investigate the effect of the temperature. The heated surface of the immersed coils in the bed provided sufficient energy for the endothermic regeneration reaction to keep the temperature of the bed at the desired temperature. Finally, the verified models of the carbonation section, the regenerations section, and non-reactive simulation of the CFB loop were used to simulate the entire circulating fluidized bed carbon capture unit, with an integrated carbonator and regenerator system using amine-based solid sorbents. The extent of CO2 capture in the carbonation section and desorption of carbon dioxide in the regeneration section were predicted. Our study showed the potential of continuous carbon capture by amine-based solid sorbents through the circulating fluidized bed CO2 capture unit.
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Title: Design and Evaluation of New Flue Gas Cleanup Processes to Meet New EPA Regulations (Spring 2003) IPRO 304
Creator: Amundsen, Cliff, Ash, Abigail, Lau, Wendy, Patel, Anup, Wickesberg, Tyler, Williams, Ben, Ahsan, Syed, Buchanan, Michael, Buresh, Rita, Kolev, Dimitre, Vaicekauskaite, Jotvinge, Wilson, Tristan, Zenfour, Ali
Date: 2003, 2003-05
Description: Students who join this IPRO team will gain experience in working with chemical and environmental engineering students on important issues that...
Show moreStudents who join this IPRO team will gain experience in working with chemical and environmental engineering students on important issues that relate to designing chemical and environmental engineering processes. Studens on this project will be split into three different subteams: (a) Design and Evaluation of New Flue Gas Cleanup processes to meet new Environmental Regulations: The objective of this project is to design and provide an economic assessment of new flue gas cleanup processes to meet new and future environmental emissions standards. The issues to be considered in this project include technical viability, process integration, economic feasibility, and environmental disposal of waste streams. An economic assessment of the market-based prices of emissions allowances will be used to determine the best long-run strategy. An assessment will be made on the effects of implementation of new technologies on the cost of electricity for both low sulfur western coal, and high sulfur Illinois coal to determine if governmental incentives are needed to promote the use of Illinois coal. (b) Design and evaluation of engineering systems to control VOCs from groundwater: The objective of this project is the design and cost estimation for various pollution control devices that can remove volatile organic chemicals (VOCs) from ground water. Effective and efficient treatment methods are needed to meet this clean up challenge. (c) Design of a Modern Hydrogen Production and Recovery Facility: The object of this project is to apply engineering principles of separation processes to recove pure hydrogen from mixed gases. This will include the availability and selection of a feed stream and an analysis of the feasibility and economics of commercial and innovative processed for the recovery operation.
Sponsorship: IIT Collaboratory for Interprofessional Studies
Project Plan for IPRO 304: Design and Evaluation of New Flue Gas Cleanup Processes to Meet New EPA Regulations for the Spring 2003 semester
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