Search results

(1 - 20 of 26)

Pages

Remarks to the Board of Trustees
Title
Remarks to the Board of Trustees
Creator
Mitchell, M. Ellen
Date
2009
Description
Presentation notes for remarks to the Board of Trustees regarding the Voices of the Holocaust project.
Influence of Injector Location on Part-Load Performance Characteristics of Natural Gas Direct-Injection in a Spark Ignition Engine
Title
Influence of Injector Location on Part-Load Performance Characteristics of Natural Gas Direct-Injection in a Spark Ignition Engine
Creator
Hall, Carrie, Sevik, James, Pamminger, Michael, Wallner, Thomas, Scarcelli, Riccardo, Boyer, Brad, Wooldridge, Steven, Miers, Scott
Date
2016
Publisher
SAE International
Doing physics : a festschrift for Thomas Erber
Title
Doing physics : a festschrift for Thomas Erber
Creator
Johnson, Porter Wear
Date
2010, 2010
Publisher
IIT Press, Chicago, IL
Description
Doing Physics is a festschrift (collection of articles, essays, and rememberances) published in honor of Illinois Tech Physics professor...
Show moreDoing Physics is a festschrift (collection of articles, essays, and rememberances) published in honor of Illinois Tech Physics professor Thomas Erber's 80th birthday. Selections were authored by Erber's colleagues, former stduents, and fellow scholars. This book was released in print form, this file was the original pdf assembled by editor Porter Johnson and submitted for printing with the front and rear covers added.
Show less
Using Peer Navigators to Address the Integrated Healthcare Needs of African Americans with Serious Mental Illness
Title
Using Peer Navigators to Address the Integrated Healthcare Needs of African Americans with Serious Mental Illness
Creator
Corrigan, Patrick
Date
2017, 2017
Publisher
American Psychiatric Association
Description
Objective...
Show moreObjective Impact of a peer navigator program (PNP) develop by a community based participatory research team was examined on African Americans with serious mental illness who were homeless. Methods Research participants were randomized to PNP or a treatment-as-usual control group for one year. Data on physical and mental health, recovery, and quality of life were collected at baseline, 4, 8 and 12 months. Results Findings from group by trial ANOVAs of omnibus measures of the four constructs showed significant impact over the one year for participants in PNP compared to control described by small to moderate effect sizes. These differences emerged even though both groups showed significant improvements in reduced homelessness and insurance coverage. Conclusions Implications for improving in-the-field health care for this population are discussed. Whether these results occurred because navigators were peers per se needs to be examined in future research.
Show less
Three agendas for changing the public stigma of mental illness.
Title
Three agendas for changing the public stigma of mental illness.
Creator
Corrigan, Patrick
Date
2018, 2017
Publisher
American Psychological Association
Description
OBJECTIVE:...
Show moreOBJECTIVE: Antistigma programs may be guided by 3 differing agendas: services (promote treatment engagement), rights (help people achieve rightful goals), and self-worth (facilitate self-worth and efficacy). This study examined the construct validity of this perspective by examining the factor structure of importance ratings of the 3 agendas. The study examined how importance might be viewed differently by the population as a whole versus a subsample of people who reported previous experience with mental health services and hence could be directly harmed by stigma. METHODS: 373 individuals recruited using Mechanical Turk completed importance ratings for each of the 3 agendas. Measures of public stigma were completed to examine concurrent validity of importance ratings. Those who reported taking medications for a psychiatric disorder were divided into a separate group and completed a measure of self-stigma. RESULTS: Outcomes seemed to confirm the factor structure of the 3 agendas model thereby offering partial support for the framework. Group analyses showed the services agenda was viewed as more important than rights or self-worth. People with mental health experience viewed the services agenda as more important than the other 2. However, dividing the mental health group into low and high self-stigma revealed that those with low self-stigma rated the rights agenda as more important. Conclusions and Implication for Practice: Participants with lower self-stigma identify the harm brought by stigma and thus endorse rights and self-worth more than those with higher self-stigma. Implications of these findings are discussed to assist to prioritize agendas for public health campaigns.
Show less
Systems and Systematic Design: Tracing the Evolution of Design Methodology at the Institute of Design, 1965-2010: Video documentation
Title
Systems and Systematic Design: Tracing the Evolution of Design Methodology at the Institute of Design, 1965-2010: Video documentation
Creator
Owen, Charles L.
Date
2010-10-28
Description
The 2010 IIT Archives annual lecture was scheduled on Thursday, October 28 from 3:30–5 p.m., with a reception immediately following. The...
Show moreThe 2010 IIT Archives annual lecture was scheduled on Thursday, October 28 from 3:30–5 p.m., with a reception immediately following. The lecture and reception was held in the McCloska Auditorium and Ballroom, located in The McCormick Tribune Campus Center.
Show less
Systems and Systematic Design: Tracing the Evolution of Design Methodology at the Institute of Design, 1965-2010
Title
Systems and Systematic Design: Tracing the Evolution of Design Methodology at the Institute of Design, 1965-2010
Creator
Owen, Charles L.
Date
2010-10-28
They Aren't Like Me, They are Bad, and They are to Blame: A Theoretically-Informed Study of Stigma of Hoarding Disorder and Obsessive-Compulsive Disorder
Title
They Aren't Like Me, They are Bad, and They are to Blame: A Theoretically-Informed Study of Stigma of Hoarding Disorder and Obsessive-Compulsive Disorder
Creator
Chasson, Gregory S., Guy, Arryn A., Bates, Sage, Corrigan, Patrick W.
Date
2018, 2018
Publisher
Elsevier
Transdiagnostic Emotional Vulnerabilities Linking Obsessive-Compulsive and Depressive Symptoms in a Community-Based Sample of Adolescents
Title
Transdiagnostic Emotional Vulnerabilities Linking Obsessive-Compulsive and Depressive Symptoms in a Community-Based Sample of Adolescents
Creator
Chasson, Gregory S., Bello, Mariel S., Luxon, Alexandria M., Graham, Trevor A. A., Leventhal, Adam M.
Date
2017, 2017
Publisher
Wiley Periodicals, Inc.
Description
Background: Transdiagnostic emotional vulnerabilities are suspected to underlie psychopathologic comorbidity but have received little...
Show moreBackground: Transdiagnostic emotional vulnerabilities are suspected to underlie psychopathologic comorbidity but have received little attention in adolescent emotional pathology literature. We examined distress tolerance, anxiety sensitivity, and anhedonia as concomitant transdiagnostic mechanisms that account for (i.e., statistically mediate) the covariance between adolescent obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) symptoms. Method: Data on MDD, OCD, and the three aforementioned transdiagnostic vulnerabilities were collected from a community-based sample of 3,094 9th graders in a large metropolitan area and analyzed using mixed effects modeling to evaluate mediation effects. Results: Individually and when controlling for each other, all three transdiagnostic vulnerabilities mediated the relation between OCD and MDD symptoms both before and after adjusting for demographics. Conclusions: Distress tolerance, anxiety sensitivity, and anhedonia may be unique mechanisms accounting for comorbidity between OCD and MDD symptoms in youth. Longitudinal evaluation of these candidate transdiagnostic emotional vulnerabilities in adolescent OCD-MDD comorbidity is warranted.
Sponsorship: Grant sponsor: National Institute on Drug Abuse; Contract grant number: R01?DA033296.
Show less
Conflict of Interest: What's to Worry?
Title
Conflict of Interest: What's to Worry?
Creator
Davis, Michael
Date
2008, 5/10/1994
Description
Michael Green's "Culture, Self, and Ethical Paradigms" is a daring paper. Though we must finally reject its argument and suspend judgement on...
Show moreMichael Green's "Culture, Self, and Ethical Paradigms" is a daring paper. Though we must finally reject its argument and suspend judgement on its conclusions, it has much to teach us about the possible relationships between business ethics and surrounding culture.
Show less
Machine Learning at the Bureau of Labor Statistics
Title
Machine Learning at the Bureau of Labor Statistics
Creator
Ellis, Robert, Kannan, Vinesh
Date
2019-11-21
Description
Vinesh Kannan (CS '19) shares his experiences working as a...
Show moreVinesh Kannan (CS '19) shares his experiences working as a data science fellow at the Bureau of Labor Statistics (BLS). Vinesh worked on the team that produces occupation and wage data used by policymakers, hiring staff, job seekers, and researchers across the country. He helped improve machine learning systems at the BLS: automatically identifying problematic training data and classifying rare jobs. Vinesh offers advice for students who may be interested in applying for the 2020 Civic Digital Fellowship, a program that recruits university students at all levels to spend a summer working on civic technology projects with various federal agencies.
Sponsorship: College of Science, Department of Computer Science, Department of Applied Mathematics, Machine Learning at IIT
Show less
Examining Partnership-Health Associations Among Lesbian Women and Gay Men Using Population-Level Data
Title
Examining Partnership-Health Associations Among Lesbian Women and Gay Men Using Population-Level Data
Creator
Du Bois, Steve N., Legate, Nicole, Kendall, Ashley D.
Date
2019
Description
Abstract...
Show moreAbstract Purpose: The aim was to provide the first broad assessment of partnership-health associations across partnership statuses among sexual minority individuals. Methods: Using population-level data from the 2016 U.S. Behavioral Risk Factor Surveillance System, specifically the 26 states/territories that assessed sexual orientation and gender identity, we ran analyses of covariance and logistic regressions to compare lesbian and gay individuals (N = 2963) of different partnership statuses in general health, physical health and health conditions, mental health, health behaviors, and healthcare access/utilization domains. Results: All omnibus and logistic regression models were significant (p < 0.001). Follow-up pairwise comparisons of mean differences across partnership groups revealed that in at least one variable in the general health, mental health, health behaviors, and healthcare access/utilization domains, married lesbian and gay individuals reported the best health, followed by partnered, single, and then divorced, separated, and widowed lesbian and gay individuals (p < 0.001). Exceptions included variables in the physical health and health conditions domain, the health behaviors of smoking and heavy drinking, and ever having an HIV test. When stratifying by sex, for both gay men and lesbian women being married or partnered related to the best health in at least one variable in each health domain, and in the majority of all outcome variables. Conclusion: This article provides the first evidence for partnership-health associations among gay and lesbian individuals based on a large-scale, multi-domain test of population-level data. Future research could examine temporal links between same-sex marriage legislation and health outcomes among sexual minority individuals.
Show less
Professionalism Among Chinese Engineers: An Empirical Study
Title
Professionalism Among Chinese Engineers: An Empirical Study
Creator
Wei, Lina, Davis, Michael
Date
2019
Description
Spreadsheet of answers from a questionnaire sent out in 2018-2019 to Chinese engineering students looking at their perceptions of professional...
Show moreSpreadsheet of answers from a questionnaire sent out in 2018-2019 to Chinese engineering students looking at their perceptions of professional and engineering ethics.
Show less
Collection
Center for the Study of Ethics in the Collection - "China's Unwritten Code of Ethics"
China's Unwritten Code of Engineering Ethics. English Final Data Set
Title
China's Unwritten Code of Engineering Ethics. English Final Data Set
Creator
Wei, Lina, Davis, Michael
Date
2020, 2020
Publisher
Springer
Description
This dataset contains the final results of a survey completed by several hundred engineers in China about what they think about engineering...
Show moreThis dataset contains the final results of a survey completed by several hundred engineers in China about what they think about engineering ethics, their awareness of ethics in their work, and how Chinese engineers' view of engineering ethics is not very different from those of American Engineers.
Show less
Optimizing Cell-Free Protein Synthesis for Increased Yield and Activity of Colicins
Title
Optimizing Cell-Free Protein Synthesis for Increased Yield and Activity of Colicins
Creator
Jin, Xing, Kightlinger, Weston, Hong, Seok Hoon
Date
2019
Publisher
MDPI
Description
Colicins are antimicrobial proteins produced by Escherichia coli that hold great promise as viable complements or alternatives to antibiotics....
Show moreColicins are antimicrobial proteins produced by Escherichia coli that hold great promise as viable complements or alternatives to antibiotics. Cell-free protein synthesis (CFPS) is a useful production platform for toxic proteins because it eliminates the need to maintain cell viability, a common problem in cell-based production. Previously, we demonstrated that colicins produced by CFPS based on crude Escherichia coli lysates are e?ective in eradicating antibiotic-tolerant bacteria known as persisters. However, we also found that some colicins have poor solubility or low cell-killing activity. In this study, we improved the solubility of colicin M from 16% to nearly 100% by producing it in chaperone-enriched E. coli extracts, resulting in enhanced cell-killing activity. We also improved the cytotoxicity of colicin E3 by adding or co-expressing the E3 immunity protein during the CFPS reaction, suggesting that the E3 immunity protein enhances colicin E3 activity in addition to protecting the host strain. Finally, we con?rmed our previous ?nding that active colicins can be rapidly synthesized by observing colicin E1 production over time in CFPS. Within three hours of CFPS incubation, colicin E1 reached its maximum production yield and maintained high cytotoxicity during longer incubations up to 20 h. Taken together, our ?ndings indicate that colicin production can be easily optimized for improved solubility and activity using the CFPS platform.
Sponsorship: NIH R15AI130988
Show less
Controlling biofilms using synthetic biology approaches
Title
Controlling biofilms using synthetic biology approaches
Creator
Fang, Kuili, Park, Oh-Jin, Hong, Seok Hoon
Date
2020
Description
Bacterial biofilms are formed by the complex but ordered regulation of intra- or inter-cellular communication, environmentally responsive gene...
Show moreBacterial biofilms are formed by the complex but ordered regulation of intra- or inter-cellular communication, environmentally responsive gene expression, and secretion of extracellular polymeric substances. Given the robust nature of bio?lms due to the non-growing nature of bio?lm bacteria and the physical barrier provided by the extracellular matrix, eradicating bio?lms is a very di?cult task to accomplish with conventional antibiotic or disinfectant treatments. Synthetic biology holds substantial promise for controlling bio?lms by improving and expanding existing biological tools, introducing novel functions to the system, and re-conceptualizing gene regulation. This review summarizes synthetic biology approaches used to eradicate bio?lms via protein engineering of bio?lm-related enzymes, utilization of synthetic genetic circuits, and the development of functional living agents. Synthetic biology also enables bene?cial applications of bio?lms through the production of biomaterials and patterning bio?lms with speci?c temporal and spatial structures. Advances in synthetic biology will add novel bio?lm functionalities for future therapeutic, biomanufacturing, and environmental applications.
Sponsorship: NIH-R15AI130988, NSF CBET-1917130
Show less
Engineering Escherichia coli to produce and secrete colicins for rapid and selective biofilm cell killing
Title
Engineering Escherichia coli to produce and secrete colicins for rapid and selective biofilm cell killing
Creator
Jin, Xing, An, Sungjun, Kightlinger, Weston, Zhou, Jiacheng, Hong, Seok Hoon
Date
2021
Description
Bacterial biofilms are associated with chronic infectious diseases and are highly resistant to conventional antibiotics. Antimicrobial...
Show moreBacterial biofilms are associated with chronic infectious diseases and are highly resistant to conventional antibiotics. Antimicrobial bacteriocins are alternatives to conventional antibiotics and are characterized by unique cell-killing mechanisms, including pore formation on cell membranes, nuclease activity, and cell wall synthesis inhibition. Here, we used cell-free protein synthesis to rapidly evaluate the antibiofilm activities of colicins E1, E2, and E3. We found that E2 (with DNase activity) most effectively killed target biofilm cells (i.e., the K361 strain) while leaving nontargeted biofilms intact. We then engineered probiotic Escherichia coli microorganisms with genetic circuits to controllably synthesize and secrete colicin E2, which successfully inhibited biofilms and killed preformed indicator biofilms. Our findings suggest that colicins rapidly and selectively kill target biofilm cells in multispecies biofilms and demonstrate the potential of using microorganisms engineered to produce antimicrobial colicin proteins as live therapeutic strategies to treat biofilm-associated infections.
Sponsorship: NIH-R15AI130988
Show less
Editorial, "Cell-Free Synthetic Biology": Synthetic Biology Meets Cell-Free Protein Synthesis
Title
Editorial, "Cell-Free Synthetic Biology": Synthetic Biology Meets Cell-Free Protein Synthesis
Creator
Hong, Seok Hoon
Date
2019
Publisher
MDPI
Description
Sponsorship: NIH R15AI130988
Incorporation of non-standard amino acids into proteins: challenges, recent achievements, and emerging applications
Title
Incorporation of non-standard amino acids into proteins: challenges, recent achievements, and emerging applications
Creator
Jin, Xing, Park Oh-Jin, Hong, Seok Hoon
Date
2019
Description
The natural genetic code only allows for 20 standard amino acids in protein translation, but genetic code reprogramming enables the...
Show moreThe natural genetic code only allows for 20 standard amino acids in protein translation, but genetic code reprogramming enables the incorporation of non-standard amino acids (NSAAs). Proteins containing NSAAs provide enhanced or novel properties and open diverse applications. With increased attention to the recent advancements in synthetic biology, various improved and novel methods have been developed to incorporate single and multiple distinct NSAAs into proteins. However, various challenges remain in regard to NSAA incorporation, such as low yield and misincorporation. In this review, we summarize the recent efforts to improve NSAA incorporation by utilizing orthogonal translational system optimization, cell-free protein synthesis, genomically recoded organisms, artificial codon boxes, quadruplet codons, and orthogonal ribosomes, before closing with a discussion of the emerging applications of NSAA incorporation.
Sponsorship: NIH R15AI130988
Show less
Undecanoic Acid, Lauric Acid, and N-Tridecanoic Acid Inhibit Escherichia coli Persistence and Biofilm Formation
Title
Undecanoic Acid, Lauric Acid, and N-Tridecanoic Acid Inhibit Escherichia coli Persistence and Biofilm Formation
Creator
Jin, Xing, Zhou, Jiacheng, Richey, Gabriella, Wang, Mengya, Hong, Sung Min Choi, Hong, Seok Hoon
Date
2021
Description
Persister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating...
Show morePersister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating persister cells is challenging, owing to their tolerance to conventional antibiotics, which cannot kill cells in a metabolically dormant state. A high frequency of persisters in biofilms makes inactivating biofilm cells more difficult, because the biofilm matrix inhibits antibiotic penetration. Fatty acids may be promising candidates as antipersister or antibiofilm agents, because some fatty acids exhibit antimicrobial effects. We previously reported that fatty acid ethyl esters effectively inhibit Escherichia coli persister formation by regulating an antitoxin. In this study, we screened a fatty acid library consisting of 65 different fatty acid molecules for altered persister formation. We found that undecanoic acid, lauric acid, and N-tridecanoic acid inhibited E. coli BW25113 persister cell formation by 25-, 58-, and 44-fold, respectively. Similarly, these fatty acids repressed persisters of enterohemorrhagic E. coli EDL933. These fatty acids were all medium-chain saturated forms. Furthermore, the fatty acids repressed Enterohemorrhagic E. coli (EHEC) biofilm formation (for example, by 8-fold for lauric acid) without having antimicrobial activity. This study demonstrates that medium-chain saturated fatty acids can serve as antipersister and antibiofilm agents that may be applied to treat bacterial infections.
Sponsorship: NIH-R15AI130988; NSF REU-1757989
Show less

Pages