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Title: The Voderettes: Gender, Labor, and Techno-Utopia at the 1939 New York World's Fair
Creator: Simon, Sara M. B.
Date: 2024
Description: This thesis explores the labor demands of the Voder, the electrical speech synthesis machine developed by Bell Labs to be a major component of...
Show moreThis thesis explores the labor demands of the Voder, the electrical speech synthesis machine developed by Bell Labs to be a major component of AT&T's 1939 New York World's Fair exhibit. With the United States emerging from the Great Depression, and with political tensions escalating across the globe, the paper situates the Voder's labor demands within the historical context of the fair. Specifically, I explore the decision to have young women operate the Voder, the intricacies of the machine cloaked by the warm presence of its highly-skilled female operator. Using archival records from Bell Labs engineers, the paper exposes the previously unacknowledged engineering contributions of Voder operators in the years before the fair. These young women not only influenced major decisions about the Voder's mechanics but also gave early credence to the notion that developing a performance with the machine could make for a thrilling fair exhibit. Moreover, the paper argues that at the fair itself, AT&T and Bell Labs executives used the Voder operators to normalize a new vision of a technological utopia that relied heavily and conspicuously on the infrastructural labor of women. Given the Voder's legacy, as a tool that laid critical groundwork for voice encryption technology, the paper adds important context to the historical record, highlighting the young women at the heart of the machine.
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Title: Design and Synthesis of New Sulfur Cathodes Containing Polysulfide Adsorbing Materials
Creator: Suzanowicz, Artur M
Date: 2023
Description: Lithium-sulfur battery (LSB) technology has tremendous prospects to substitute lithium-ion battery (LIB) technology due to its high...
Show moreLithium-sulfur battery (LSB) technology has tremendous prospects to substitute lithium-ion battery (LIB) technology due to its high theoretical specific capacity and energy density. However, escaping polysulfide intermediates (produced during the redox reaction process) from the cathode structure is the primary reason for rapid capacity fading. Suppressing the polysulfide shuttle (PSS) is a viable solution for this technology to move closer to commercialization and supersede the established LIB technology. In this dissertation, I have analyzed the challenges faced by LSBs and selected methods and materials to address these problems. I have concluded that in order to further pioneer LSBs, it is necessary to address these essential features of the sulfur cathode: superior electrical conductivity to ensure faster redox reaction kinetics and high discharge capacity, high pore volume of the cathode host to maximize sulfur loading/utilization, and polar polysulfide-resistive materials to anchor and suppress the migration of lithium polysulfides.Furthermore, a versatile, low-cost, and practical scalable synthesis method is essential for translating bench-level development to large-scale production. This dissertation covers designing and synthesizing new scalable cathode structures for lithium-sulfur batteries that are inexpensive and highly functional. The rationally chosen cathode components accommodate sulfur, suppress the migration of polysulfide intermediates via chemical interactions, enhance redox kinetics, and provide electrical conductivity to sulfur, rendering excellent electrochemical performance in terms of high initial specific capacity and good long-term cycling performance. TiO2, Ni12P5, and g-C3N4 as polysulfide adsorbing materials (PAMs) have been fully studied in this thesis along with three distinct types of host structures for lithium-sulfur batteries: Polymer, Carbon Cloth, and Reduced Graphene Oxide. I have created adaptable bulk synthesis techniques that are inexpensive, easily scalable, and suitable for bench-level research as well as large-scale manufacturing. The exceptional performance and scalability of these materials make my cathodes attractive options for the commercialization of lithium-sulfur batteries.
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Title: In situ EXAFS studies of novel Palladium-based anode catalysts for direct ethanol and formic acid fuel cells
Creator: Su, Ning
Date: 2024
Description: In this work we made nanoscale uniform deposition of Pd based anode catalyst on the transition metal Au (with atomic ratio Pd:Au=1:10) support...
Show moreIn this work we made nanoscale uniform deposition of Pd based anode catalyst on the transition metal Au (with atomic ratio Pd:Au=1:10) support of direct liquid ethanol fuel cells (DLEFCs) and direct liquid formic acid fuel cells (DLFAFCs). Synthesizing with uniform dispersion and catalyst nanoparticle dimensions understand the role of Pd reaction on its support in the direct EOR (ethanol oxidation reaction) and FOR (formic acid reaction) pathways, we performed in situ Pd K-edge X-ray absorption spectroscopy measurements as a function of potential using a custom-designed flow cell with the catalyst deposited on the glassy carbon window. We did in-situ EXAFS to better understand the reaction mechanism of Pd1@Au10 anode catalyst with EOR and AOR in nanoscale. Compared EOR with FOR electrochemical performance showed Pd@Au&C played better in ethanol than HCOOH and more stable which the the current density can reach up to 1216.25 mA·mg-1 Pd of EOR with Pd1@Au10&C in 1M KOH+1M EtOH (CH3CH2OH) on the ethanol fuel cells (DLEFCs), and 3.56 times higher of the EOR current compared with commercial Pd@C
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Title: Agency and Pathway Thinking as Mediators of The Relationship Between Caregiver Burden And Life Satisfaction Among Family Caregivers Of People With Parkinson’s Disease: An Application Of Snyder’s Hope Theory
Creator: Springer, Jessica Gabrielle
Date: 2024
Description: In the United States, there are 47.9 million caregivers providing care to family members with disabilities. Those providing care to someone...
Show moreIn the United States, there are 47.9 million caregivers providing care to family members with disabilities. Those providing care to someone who has Parkinson’s Disease (PD), a complex degenerative movement disorder, may have a unique caregiving experience, given that disease-related factors (e.g. motor and non-motor symptoms) can contribute to worsening caregiver burden and life satisfactions (LS). PD has an increasing incidence of 90,000 new cases per year, likely resulting in an increased need for caregivers. Caregiving research frequently focuses on the mediators between caregiver burden and LS including social support, coping skills, and appraisals. Research that has specifically focused on caregivers of people with PD (Pw/PD) is significantly limited. Hope is a “positive motivational characteristic comprised of agency and pathways thinking that can help facilitate drive towards one’s goal while also serving as a buffer against negative events” (Snyder et al.,1991). The goal of this study is to understand Snyder’s hope theory as it relates to caregiver burden and LS for caregivers of Pw/PD. Specifically, we hypothesized that (a) caregiver burden will be negatively correlated with agency thinking, pathways thinking, and LS among caregivers of Pw/PD. In addition, pathways thinking, and agency thinking will be positively associated with LS, and (b) agency thinking, and pathways thinking will mediate the relationship between caregiver burden and LS among caregivers of Pw/PD. The study sample consisted of 249 caregivers of Pw/PD who completed an online anonymous questionnaire. Correlations between agency and pathways thinking, LS, caregiver burden, and sociodemographic factors were evaluated. A parallel mediation analysis was run to evaluate the mediating roles of pathways and agency thinking in the relationship between caregiver burden and LS. Results indicated that LS was significantly and negatively correlated with caregiver burden. LS was significantly and positively correlated with both pathways and agency thinking. Pathways thinking had no indirect effect on the relationship of caregiver burden on LS. Agency thinking had a negative, indirect effect on the relationship suggesting that agency thinking partially mediated the relationship between caregiver burden and LS. Clinical implications and future directions are discussed.
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Title: Three-Dimensional Co-Culture Systems for Vascularization of Cardiac Tissue
Creator: Rodriguez Arias, Jessica A.
Date: 2023
Description: Myocardial Infarction (MI) is the partial or complete blockage of blood flow to the myocardial tissue resulting in damage and therefore loss...
Show moreMyocardial Infarction (MI) is the partial or complete blockage of blood flow to the myocardial tissue resulting in damage and therefore loss of heart function. In the U.S. every 40 seconds, someone will suffer from MI and the only available treatment is medication to treat the symptoms of heart function loss, but do not treat the underlying cause. Some attempts to treat the underlying cause have arisen in the last decades including cell-based therapies or tissue engineering therapies such as spheroid-based cardiac patches that have shown to be promising. Improvement in the mechanical properties to create suturable engineered tissues remain to be improved for ease of implantation purposes. Cell-laden hydrogel scaffolds can provide improved mechanical properties compared to biomaterial free cell-based therapies but need to allow for vascularization of the engineered tissue. Thus, the goal of this thesis is to provide preliminary studies for the use of a cell adhesive, proteolytically degradable PEG hydrogel scaffold that eventually would be used as an invitro model to evaluate engineered tissue vascularization for cardiac tissue engineering. To construct this model, important cell spheroid parameters on vascular invasion in 3D culture were investigated including the total number of cells/spheroid, the supporting cell for endothelial cells. In order to scale-up scaffolds to size of clinically relevant dimensions, a multilayered hydrogel construct visible light free-radical polymerization approach encapsulating vascular spheroids in multiple layers was also investigated. Results indicate that a total cell number of 5000 cells/spheroid aggregate were feasible due to cell sourcing. In addition, co-cultures of endothelial and mesenchymal stem cells led to maximized vascular invasion of the spheroids compared to fibroblast/endothelial co-culture and endothelial monoculture of spheroids in the hydrogel. Finally, the extent of vascularization of spheroids in each layer of the multilayered hydrogel constructs varied due to the observed differences in mechanical properties and swelling ratio of each layer due to incomplete polymerization of layers. This study demonstrated the importance of support cells and hydrogel mechanical properties in promoting vascularization of spheroid which serves as basis for building cell-laden hydrogel scaffolds for vascularization for cardiac tissues.
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Title: UTILIZING BACTERIAL INTERACTIONS TO CONTROL PATHOGENIC BIOFILM FORMATION
Creator: Fang, Kuili
Date: 2020
Description: Many chronic infections involve bacterial biofilms, which are difficult to eliminate using conventional antibiotic treatments. Biofilm...
Show moreMany chronic infections involve bacterial biofilms, which are difficult to eliminate using conventional antibiotic treatments. Biofilm formation is a result of dynamic intra- or inter-species interactions. However, the nature of molecular interactions between bacteria in multi-species biofilms are not well understood compared to those in mono-species biofilms. The first project (Chapter 3) investigated the ability of probiotic Escherichia coli Nissle 1917 (EcN) to outcompete the biofilm formation of pathogens including enterohemorrhagic E. coli (EHEC), Pseudomonas aeruginosa, Staphylococcus aureus, and S. epidermidis. When dual-species biofilms were formed, EcN inhibited the EHEC biofilm population by 14-fold compared to EHEC mono-species biofilms. This figure was 1,100-fold for S. aureus and 8,300-fold for S. epidermidis; however, EcN did not inhibit P. aeruginosa biofilms. In contrast, commensal E. coli did not exhibit any inhibitory effect toward other bacterial biofilms. We identified that EcN secretes DegP, a bifunctional (protease and chaperone) periplasmic protein, outside the cells and controls other biofilms. Although three E. coli strains tested in this study expressed degP, only the EcN strain secreted DegP outside the cells. The deletion of degP disabled the activity of EcN in inhibiting EHEC biofilms, and purified DegP directly repressed EHEC biofilm formation. Hence, probiotic E. coli outcompetes pathogenic biofilms via extracellular DegP activity during dual-species biofilm formation. Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a pathogen causing the outbreaks of hemorrhagic colitis. Conventional antibiotics treatment is not recommended for EHEC infection as antibiotics trigger Shiga toxin production of EHEC and aggravate hemolytic-uremic syndrome. EHEC biofilm formation is closely associated with its virulence expression. Previously, we identified that probiotic E. coli Nissle 1917 (EcN) secretes DegP resulting in the inhibition of EHEC biofilm formation in a dual culture. DegP is a serine protease exhibiting both proteolytic and chaperone functions and binds to outer membrane proteins (OMPs) of target cells. However, the extracellular function of DegP is not clear. We hypothesized that binding of DegP to OMPs of EHEC might inhibit EHEC biofilm formation by affecting the adhesion ability or changing biofilm-related gene regulations of EHEC. We constructed EHEC mutants lacking ompA, ompC, or ompF individually and in combination and assessed their biofilm formation in the presence of DegP-secreting EcN in the co-culture or by adding purified DegP. It was found that both ompA and ompC double deletion decreased EHEC single species biofilm, and also caused that DegP inhibited more EHEC biofilm (about 25 fold inhibition) than DegP inhibited EHEC wt biofilm (about 10 fold), indicating that OmpA and OmpC are more related to EHEC biofilm than OmpF, and OmpA and OmpC might deplete DegP inhibitory functions. On the other hand, DegP S210A, a DegP mutant lacking protease function, inhibited EHEC wt biofilm, indicating that DegP’s biofilm inhibition function is not from its protease activity. Additionally, EHEC transcription profiles in the presence of DegP showed that DegP up-regulated expressions of cellulose production related genes (csgD and bcsA) and motility related genes (flhD, qseB), which were all involved in EHEC biofilm inhibition, and down-regulated Shiga toxin 2 virulence gene (stx2). Besdies, DegP promoted EHEC cellulose production and motility, which is consistent with transcription profile, and Shiga toxin 2 production will be further tested. This study reveals a new function of DegP secreted by EcN in controlling biofilms and leads us to develop an alternative strategy to control biofilm-related infections. Foodborne pathogen Listeria monocytogenes biofilm formation renders these cells highly resistant to current sanitation methods, and probiotics may be a promising approach to the efficient inhibition of Listeria biofilms. In the Chapter 5 study, three Leuconostoc mesenteroides strains of lactic acid bacteria isolated from kimchi were shown to be effective probiotics for inhibiting Listeria biofilm formation. Biofilms of two L. monocytogenes serotypes, 1/2a (ATCC15313) and 4b (ATCC19115), in dual-species culture with each probiotic strain were decreased by more than 40-fold as compared with single-species Listeria biofilms; for instance, a reduction from 5.4 times 10^6 CFU/cm2 L. monocytogenes ATCC19115 in single-species biofilms to 1.1 times 10^5 CFU/cm2 in dual-species biofilms. Most likely, one of the Leuconostoc strains, L. mesenteroides W51, led to the highest Listeria biofilm inhibition without affecting the growth of L. monocytogenes. The cell-free supernatant from the L. mesenteroides W51 culture containing large protein molecules (> 30 kDa) also inhibited Listeria biofilms. These data indicate that Leuconostoc probiotics can be used to repress L. monocytogenes biofilm contamination on surfaces at food processing facilities.
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Title: A MICROFLUIDIC INTESTINAL-MICROBIOTA PLATFORM TO STUDY DRUG METABOLISM
Creator: Wang, Chengyao
Date: 2020
Description: The intestine is the main site that orally administered drugs are primarily metabolized, absorbed, and distributed. The trillions of bacteria...
Show moreThe intestine is the main site that orally administered drugs are primarily metabolized, absorbed, and distributed. The trillions of bacteria that inhabit the intestine influence health and regulate important biochemical factors, such as the activity of enzymes pertinent to drug metabolism. However, this has not been systematically studied partly due to the challenges of recapitulating the unique and complex intestinal microenvironment that includes (1) the presence of mammalian and microbial cells and (2) a unique partitioned oxygenation proﬁle across the lumen to the subepithelial mucosa from anaerobic to the richly vascularized oxygenated. This thesis reports the development of a microfluidic device in which is integrated a membrane synthesized from a key element of mucosal basal lamina, collagen, and precisely controlled partitioned oxygen environment. The device enabled excellent cell viability and long-term function. More importantly, it enabled the coculture of intestinal epithelial cells and aerobic and anaerobic bacteria in the partitioned oxygen environment. These experiments on one hand allowed the measurement of cellular oxygen consumption rate under perfusion, which could be used to study microbial regulation of oxidative metabolism in epithelial cells. On the other hand, the device allowed a systematic examination of the role of different gut bacteria strains on the regulation of factors that are important in drug metabolism, namely, transporters and phase I enzymes. Our studies highlighted the importance of direct communication between the intestinal cells and the gut bacteria with major findings being that species-specific differences exist in the regulation of drug metabolism. This work will be useful for (1) the discovery of novel regulators of drug metabolizing enzymes, (2) developing new pharmacokinetic models, and (3) advancing precision medicine models for patients.
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Title: Technology News, January 10, 1944
Creator: Illinois Institute of Technology
Date: 1944-01-10, 1944-01-10
Collection: Technology News Microfilm collection, 1928-1981

Title: Population Dynamics of Listeria monocytogenes in Nut, Seed and Legume Butters
Creator: Zhang, Xinyuan
Date: 2020
Description: Nut, seed, and legume butters are low water activity foods and do not support the growth of foodborne pathogens. Research has determined that...
Show moreNut, seed, and legume butters are low water activity foods and do not support the growth of foodborne pathogens. Research has determined that some pathogens, such as Listeria monocytogenes, can survive for long periods of time in butters, such as almond butter. However, information on the persistence of L. monocytogenes in butters is lacking. The purpose of this study was to determine the population dynamics of L. monocytogenes in butters stored at 5 and 25°C. Nut (almond, hazelnut, pecan), seed (pumpkin, sesame, sunflower), legume (peanut and soy) and butters containing chocolate (hazelnut and peanut) were inoculated with a 4-strain cocktail of rifampicin-resistant L. monocytogenes at 4 (high inoculation) or 1 log CFU/g (low inoculation). High inoculation butters were mixed by hand for 15 min and 100-g portions were weighed into deli-style containers with lids and stored at 5 or 25°C for 12 mo (370 d). Low inoculation butters were stored in 25- g portions in stomacher bags at 25°C for 6 mo (180 d). During storage, 25 g from the 100- g high inoculation portion or 25 g from the low inoculation samples, in triplicate, were homogenized with 225 mL BPB (or BLEB for FDA BAM enrichments when necessary) and serial dilutions of the homogenate were plated onto BHIA with rifampicin for enumeration of L. monocytogenes. Data were statistically analyzed using Student’s t-test (α=0.05). The average initial population of L. monocytogenes in the butters was 3.58±0.25 log CFU/g for the high inoculation butters; L. monocytogenes was detected through enrichments for all low inoculation butters. After 12 mo storage at 5°C, the population of L. monocytogenes decreased by 1.34, 1.27, 1.72, 2.04 and 0.93 log CFU/g in almond, hazelnut, peanut with chocolate, hazelnut with chocolate and pecan butter, respectively, when inoculated at the higher level. Significantly less population reduction was observed in pumpkin, sesame, soy, peanut and sunflower butters (1.08, 0.61, 0.84, 0.05 and 0.40 log CFU/g, respectively). After 12 mo storage at 25°C, the L. monocytogenes population in all butters, with the exception of sunflower butter, decreased to below the limit of enumeration (1.67 log CFU/g), but the pathogen was still present via enrichment. For low inoculation butters, L. monocytogenes was present as determined by enrichment in all butters in at least one of two trials after 6 mo. The results of this study provide information on the survival of L. monocytogenes in different butter types when stored at different temperatures.
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Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Modernism art fair, including Mary Henry's Quasar, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar....
Show morePhotograph of the Aaron Galleries Booth at the Modernism exhibition, at Park Place Armory in 2006, including Mary Henry's painting Quasar. Aaron Brothers, a Chicago gallery, included Mary Henry's work in two art shows at Park Place Armory in 2006, Modernism and Art20. Inscription on verso: "Modernism - Park Avenue Armory 2006 Mary Henry 'Quasar' in booth center Aaron Galleries, Exhibitor." Photographer unknown.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Photograph of the Aaron Galleries booth at the Art 20 art fair, including Mary Henry's The Chelsea Way, New York, New York, 2006
Date: 2006
Description: Photograph of the Aaron Galleries Booth at the Art 20 exhibition, at Park Place Armory in 2006, including Mary Henry's painting The Chelsea...
Show morePhotograph of the Aaron Galleries Booth at the Art 20 exhibition, at Park Place Armory in 2006, including Mary Henry's painting The Chelsea Way visible at right. Inscription on verso: "Art 20 - Park Ave. Armory 2006 Mary Henry 'The Chelsea Way' on the aisle Aaron Galleries Booth."
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Collection: Mary Dill Henry Papers, 1913-2021

Title: TechNews, March 29, 2011
Creator: Illinois Institute of Technology
Date: 2011-03-29, 2011-03-29
Collection: Technology News print collection, 1940-2019

Title: Intraoperative Assessment of Surgical Margins in Head And Neck Cancer Resection Using Time-Domain Fluorescence Imaging
Creator: Cleary, Brandon M.
Date: 2023
Description: Rapid and accurate determination of surgical margin depth in fluorescence guided surgery has been a difficult issue to overcome, leading to...
Show moreRapid and accurate determination of surgical margin depth in fluorescence guided surgery has been a difficult issue to overcome, leading to over- or under-resection of cancerous tissues and follow-up treatments such as ‘call-back’ surgery and chemotherapy. Current techniques utilizing direct measurement of tumor margins in frozen section pathology are slow, which can prevent surgeons from acting on information before a patient is sent home. Other fluorescence techniques require the measurement of margins via captured images that are overlayed with fluorescent data. This method is flawed, as measuring depth from captured images loses spatial information. Intensity-based fluorescence techniques utilizing tumor-to-background ratios do not decouple the effects of concentration from the depth information acquired. Thus, it is necessary to perform an objective measurement to determine depths of surgical margins. This thesis focuses on the theory, device design, simulation development, and overall viability of time-domain fluorescence imaging as an alternative method of determining surgical margin depths. Characteristic regressions were generated using a thresholding method on acquired time-domain fluorescence signals, which were used to convert time-domain data to a depth value. These were applied to an image space to generate a depth map of a modelled tissue sample. All modeling was performed on homogeneous media using Monte Carlo simulations, providing high accuracy at the cost of increased computational time. In practice, the imaging process should be completed within a span of under 20 minutes for a full tissue sample, rather than 20 minutes for a single slice of the sample. This thesis also explores the effects of different thresholding levels on the accuracy of depth determination, as well as the precautions to be taken regarding hardware limitations and signal noise.
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