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- Title
- Evaluation of Bridge Abutment Slope Protection at Stream Crossings
- Creator
- Wang, Peng
- Date
- 2023
- Description
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Extensive research has revealed that scour and flooding contribute to over 50% of bridge failures in the United States, with scour-induced...
Show moreExtensive research has revealed that scour and flooding contribute to over 50% of bridge failures in the United States, with scour-induced failures alone causing the collapse of 20-100 over-water bridges annually out of a total population of approximately 504,000 bridges. Within Wisconsin, a significant number of bridges, specifically over 1200, have been identified as scour-critical, with 200 of them experiencing slope instability issues.This study focuses on the problematic bridge sites in Wisconsin, particularly examining the underperformance of abutment slopes. To identify and document these problematic bridges, a comprehensive survey was conducted, followed by site visits. Subsequently, a thorough Limit Equilibrium Method (LEM) simulation was carried out based on an investigated bridge. The simulation results indicate that the infiltration of water into the slope berm areas significantly decreases slope stability due to seepage forces. Furthermore, the absence of riprap toe protection can result in overall slope failure. The implementation of concrete pouring to address riprap scoring has proven unreliable, leading to frequent failures.Additionally, simulations were performed for grouted riprap, slope walls, grouted tiebacks, and piles. The results demonstrate their potential to enhance slope safety, with their suitability requiring careful evaluation. Notably, a simulation comparing a 1:2 slope design with a 1:1.5 slope inclination reveals that the former significantly improves slope safety.In Chapter 5, a comprehensive life cycle cost analysis is conducted, comparing the 1:2 slope design to the 1:1.5 design. The analysis reveals that the 1:2 design method is more cost-effective over a 60-year study period.In conclusion, this research provides valuable insights into the assessment and mitigation of abutment slope protection issues in Wisconsin. The findings emphasize the importance of considering seepage forces, appropriate riprap installation, and alternative stabilization measures together with a comprehensive life cycle cost analysis. The research contributes to enhancing slope safety and informs decision-making processes for bridge design and maintenance.
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- Title
- Certified Rehabilitation Counselors' Knowledge, Stigma, and Self-Efficacy in Working with Non-Suicidal Self-Injury
- Creator
- Tseng, Yen Chun
- Date
- 2023
- Description
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Certified Rehabilitation Counselors (CRCs) are professionals who are responsible for supporting the rights and independence of people with...
Show moreCertified Rehabilitation Counselors (CRCs) are professionals who are responsible for supporting the rights and independence of people with disabilities. They provide services such as mental health counseling, vocational counseling, advocacy, and psychoeducation to people with disabilities. Suicide prevention and safety education are within the scope of services provided by CRCs as well. Non-suicidal self-injury (NSSI), one of the strongest risk factors for suicide attempts (Franklin et al., 2017; Kiekens et al., 2018), has received more attention as people with disabilities have elevated risk to engage in such behaviors (Coduti et al., 2016). NSSI refers to the socially unacceptable behavior causing intentional and direct injury to one’s own body tissue without conscious suicidal intent (Nock & Favazza, 2009). As the prevalence of NSSI increases, it is likely that in their professional tenure, CRCs will interact with clients who have engaged in NSSI. It is within CRCs scope of practice to advocate at individual, group, institutional, and societal levels to promote opportunity and access, improve quality of life for individuals with disabilities (Commission on Rehabilitation Counselor Certification, [CRCC], 2023). However, few studies have explored CRCs’ training, stigma, and self- efficacy when working with NSSI. The purpose of this study was to explore the nature and extent of NSSI training received by CRCs, CRCs’ stigma towards individuals engaging in NSSI, and factors associated with CRCs’ self-efficacy for working with clients with NSSI. CRCs practicing in the United States participated in the study (N = 91). Less than half of the participants reported that they received NSSI training in the past. In addition, they demonstrated some knowledge of NSSI while holding some misconceptions of NSSI at the same time. In addition, CRCs reported generally positive attitudes toward NSSI. Predictors examined in the study included training, knowledge, familiarity, and attitudes toward individuals engaged in NSSI while controlling for participants’ age and gender. Hierarchical regression analysis was used to analyze whether these factors were associated with self-efficacy to work with clients with NSSI. Results indicated that training and stigma (helping attitude) were significant predictors of CRCs’ self-efficacy for working with clients experiencing NSSI. Additionally, the variance in self-efficacy was accounted for by NSSI training and stigma. CRCs who received NSSI training in the past reported more positive attitudes and perceived themselves as more capable to work with clients who engaged in NSSI. This study is among the few to examine specific factors impacting CRCs’ self-efficacy in working NSSI. Implications for practice and research are discussed.
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- Title
- Self-Stigma, Disclosure, and Care-Seeking in People with Self-Reported Mental Illness
- Creator
- Shah, Binoy Biren
- Date
- 2023
- Description
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Objective: The longstanding mental illness treatment gap has only been exacerbated by the COVID-19 pandemic. One reason for this is the self...
Show moreObjective: The longstanding mental illness treatment gap has only been exacerbated by the COVID-19 pandemic. One reason for this is the self-stigma of mental illness, which has been shown to decrease care-seeking. This study aims to better understand the relationships between self-stigma and care-seeking by identifying novel mediators of this relationship. Method: A sample of 125 individuals with mental health difficulties, obtained from MTurk, completed measures of self-stigma, disclosure, care-seeking. Self-stigma was conceptualized as a distal antecedent to disclosure, and novel proximal antecedents of disclosure (i.e., approach goals, avoidance goals, and the “Why Try?” effect) were unpacked. Hypotheses were tested in steps via path analysis. Results: We found partial evidence to support our model of self-stigma. Disclosure did not mediate the relationship between self-stigma and care-seeking. Findings regarding proximal antecedents of disclosure were mixed. Conclusion: Results should be interpreted with caution due to data quality concerns. Additional research is needed to better understand how self-stigma impacts disclosure. This line of inquiry has noteworthy implications for research, policy, and clinical practice.
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- Title
- Shared Authentic Leadership and Team Attitudes: The Role of Social Support and Team Diversity
- Creator
- Shu, Frank
- Date
- 2023
- Description
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Across 15 weeks, data from 48 interdisciplinary teams were collected to test the direct and indirect effects of shared authentic leadership on...
Show moreAcross 15 weeks, data from 48 interdisciplinary teams were collected to test the direct and indirect effects of shared authentic leadership on team attitudes (i.e., team work engagement & team satisfaction). Under the conservation of resources (COR) theory, team social support was considered a team resource, mediating the relationship between shared authentic leadership and team attitudes respectively. Functional diversity was also examined as a moderator between team social support and team attitudes. Results revealed that shared authentic leadership was a significant and positive predictor of team attitudes. However, team social support was not found to be a significant mediator. On the other hand, functional diversity was able to partially moderate the relationship between socio-emotional social support and team work engagement. A discussion of the results, strengths, and limitations of this study will be provided at the end of this manuscript.
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- Title
- First-principles study on the stability, electrochemical property, and degradation mechanism of ceramic electrode materials
- Creator
- Wei, Jialiang
- Date
- 2023
- Description
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First-principles studies demonstrate the capability to rapidly and accurately calculate desired properties in battery materials. This thesis...
Show moreFirst-principles studies demonstrate the capability to rapidly and accurately calculate desired properties in battery materials. This thesis focuses on the examination of layered NaCrO2 as a case study to assess the impact of various calculation methods. Additionally, a microscopic analysis is conducted to investigate the failure mode of NaCrO2. Lastly, a successful first-principles based high-throughput screening of electrode materials is performed to identify stable compounds that enable easy Li migration.The layered O3 NaCrO2 compound exhibits promising characteristics as a Na-ion cathode material, including good thermal stability and specific capacity. However, it suffers from poor rate capability. To address this limitation and develop high-rate Na-ion cathodes, we conducted a first-principles study that focused on the stability and Na diffusion in pure and doped NaCrO2. The study utilized various functionals, including those explicitly incorporating van der Waals (vdW) interactions. By including vdW interactions, we observed a significant reduction in interlayer distances within partially desodiated NaCrO2, which directly impacted the prediction of Na diffusion barriers. We established a linear relationship between interlayer distance and diffusion barrier using different functionals. Notably, the increased diffusion barriers were mainly due to the reduced interlayer distances predicted by the vdW-inclusive functionals, rather than the inclusion of vdW interactions in the transition state calculations. Other factors, such as the charge density change introduced by different dopants, also influenced the Na diffusion barriers. Metal doping (Al, Zn, Mn, and Co) at low concentrations in NaCrO2 had minor effects on its thermodynamic stability but significantly promoted Na diffusivity. Among the doped NaCrO2 compounds, Co-doped NaCrO2 exhibited the lowest Na diffusion barriers and emerged as a potential candidate for high-rate Na-ion cathode materials. This study highlights the significance of vdW interactions in layered transition metal oxides and provides strategies to enhance first-principles predictions for such structures.Then, TM migration usually occurs at highly charged states in layered Na transition metal oxide, leading to a deterioration in capacity and reversibility. Furthermore, the formation of hybrid phases, characterized by the intergrowth of octahedral and prismatic Na layers, is known to take place at highly charged states. These hybrid phases often exhibit greater stability compared to simple O3 or P3 stacking configurations. However, there is limited understanding regarding the mechanism and impact of TM migration in these hybrid phases. To address this gap, we conducted a comparative first-principles study to elucidate the connection between structural changes and Cr migration in layered O3 and hybrid-phased NaCrO2. We observed that the hybrid-phased NaCrO2 experienced more significant layer shrinkage than the O3 phase after Cr migration. Three factors were found to affect the Cr migration energy: the Na concentration, local 3D configuration, and 2D in-plane geometry. Low Na concentration and specific 3D configurations facilitated Cr migration. Furthermore, the Cr migration barriers in both O3 and hybrid-phased NaCrO2 were found to be positively correlated with Cr migration energy. Lastly, we surveyed the Cr migration of 17 doped O3 and hybrid-phased NaCrO2 compounds. A uniform distribution of Cr-O bond length usually indicated suppressed Cr migration. We identified optimal dopants for Cr migration suppression by considering both Cr and dopant migration energy. This comparative study on Cr migration in O3 and hybrid-phased NaCrO2 highlights the significant role of hybrid phases in the application of layered cathode materials.Moving from the calculations of single material system, we last conduct a first-principles high-throughput screening of multicomponent transition metal sulfides (TMS) as fast Li-ion intercalation compounds. We compared two representative TMS frameworks, pyrite and spinel, with regard to their selectivity in forming stable disordered TMS. To quantify the ability to form entropy stabilized disordered TMS, we examined the effects of cation permutation on the formation enthalpy range. Although low energy-above-hull (Ehull) is a preliminary requirement for the formation of stable TMS, a narrow formation enthalpy range can also lead to entropy stabilized TMS, as only a small amount of excess energy is required to stabilize the metastable configurations. Among the 70 pyrite and spinel frameworks studied, we selected 13 spinel compounds based on their low Ehull and narrow Ef range. Additionally, these spinel compounds exhibited greater stability compared to their pyrite counterparts. We found that early transition metal elements such as Ti and V were less favorable for the formation of pyrite TMS, while late TM elements, especially Cu, strongly destabilized spinel TMS. The spinel (CrMnCoNi)S2 TMS demonstrated the most promising characteristics with a narrow Ef range. Finally, we calculated and ranked the Li migration barriers in the 13 stable spinel TMS using a bond valence-based method, which allowed for quick screening of ion migration. High oxidation state TM elements, such as Mn4+ and Cr3+, located nearest to the Li migration path, increased the Li migration barrier. (CrMnCoNi)S2 exhibited the lowest Li migration barrier, positioning it as a promising entropy-stabilized spinel intercalation compound.
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- Title
- An Alternative Approach for the Jefferson Lab Electron-Ion Collider Ion Accelerator Complex
- Creator
- Martinez Marin, Jose Luis
- Date
- 2020
- Description
-
An assessment by the National Academy of Sciences (NAS) of the scientific merit for a future Electron Ion Collider (EIC) in the US concluded...
Show moreAn assessment by the National Academy of Sciences (NAS) of the scientific merit for a future Electron Ion Collider (EIC) in the US concluded that such a facility would be unique in the world and enable indispensable research on current and compelling scientific questions. This assessment confirmed the recommendations of the 2015 Nuclear Science Advisory Committee (NSAC) for an EIC with highly polarized beams of electrons and ions, sufficient luminosity and sufficient, variable center-of-mass energy. Proposals were requested for a cost-effective design that uses existing accelerator infrastructure to reduce the risk; one of two major proposals submitted for consideration originated from the Thomas Jefferson National Accelerator Facility (JLab). The Jefferson Laboratory Electron-Ion Collider (JLEIC) would use the Continuous Electron Beam Accelerator Facility (CEBAF) at JLab as a full-energy electron injector. The primary accelerator challenges are twofold: producing and maintaining a high degree of polarization for both beams, and achieving high luminosity. This thesis project was part of an effort to produce an alternative, low-risk and cost- effective design for the JLEIC ion complex. The primary goal was not to find a replacement for the JLEIC ion complex design, but rather to investigate alternative options for the different components of the ion complex that could lower the overall cost, reduce its footprint, mitigate risk, and identify possible staging or future upgrades of the project. The platform for this thesis was the alternative design for the JLEIC ion complex that included (1) a more compact ion linac, (2) two staged ion boosters instead of one before injection to the collider ring, with a more compact and lower energy Pre-Booster ring as the first stage, and (3) the dual use of the electron storage ring (e-ring) as a second stage ion Large Booster.The alternative design was first investigated for medium energy (65-GeV center-of-mass), and was then upgraded following the National Academy of Sciences (NAS) review to higher energy (100-GeV center-of-mass). Developing a more cost-effective design and meeting all the requirements is challenging due to several constraints imposed on the alternative approach -- for example, the use of only room-temperature magnets for both ion boosters. There are also space limitations, the need to keep the shape and crossing angle of the ion Large Booster the same as the collider ring, ensuring reasonable length and aperture requirements for the magnets, and avoiding transition crossing for all the rings, which can cause beam dilution and instabilities.Development of both the Medium-Energy and the High-Energy options is presented. The Medium-Energy option consists of a 135 MeV injector linac, a 3 GeV octagonally-shaped Pre-Booster ring and a 11 GeV Large Booster. The High-Energy option consists of a 150 MeV (~ 40 MeV/u for Pb) injector linac, a 8 GeV (~ 2.04 GeV/u for Pb) non figure-8 Pre-Booster ring and a 40 GeV proton (~ 16 GeV/u for Pb) Large Booster, which would also serve as the electron storage ring (e-ring). The figure-8 shape of the Large Booster helps to maintain high polarization. High luminosity is achieved following a strategy to have a high bunch repetition rate of the colliding beams, very short bunch lengths, and small transverse emittances; the main concern here is to provide a lattice that is consistent with these requirements. The main results reported are the lattice design optimization and consolidation, benchmarking of the beam optics with different codes such as ELEGANT, COSY-Infinity, MAD-X, TRACE-3D, and Zgoubi, and spin resonance simulation results. Spin dynamics studies were performed for the linac and the Pre-Booster, and mechanisms to preserve the polarization are proposed. Beam formation and non-linear effects such as chromaticity, space charge, and intra-beam scattering were also studied to gain understanding of how the alternative approach could affect the baseline beam formation scheme and to ensure that the beam requirements are met through the injector chain with this alternative approach. It was shown that the polarization can be preserved through the alternative ion complex even with the more compact linac and a Pre-Booster that does not have a figure-8 shape by using a sufficiently long spin correction solenoid in the linac and a partial Siberian snake in the Pre-Booster. The baseline beam formation scheme could still be used to reach the required beam characteristics for collider injection. Cooling is not needed in the more compact Pre-Booster, and the large, higher energy booster helps to avoid space charge effects at extraction. This study has confirmed the effectiveness of the alternative approach as concerns the optics, acceleration, polarization, and beam formation. The ion injectors are sufficiently compact, and the ion Large Booster size and shape are consistent with the e-ring requirements, enabling the desired dual functionality of that machine. This work created a basis for design discussions during the JLEIC design process. The final High-Energy design for the JLEIC ion complex adopted design features that came from the alternative design studies, which were derived in part from this work—in particular, the shorter, lower-energy linac, the use of two boosters in the injection chain before the collider ring, and the ability to have only room-temperature magnets in the boosters, with superconducting magnets used only in for the collider ring.
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- Title
- NON-DESTRUCTIVE CANCER DETECTION IN LYMPH NODE USING PAIRED-AGENT MOLECULAR IMAGING
- Creator
- Li, Chengyue
- Date
- 2020
- Description
-
Identification of cancer spread to tumor-draining lymph nodes through lymph node dissection and histology offers critical information for...
Show moreIdentification of cancer spread to tumor-draining lymph nodes through lymph node dissection and histology offers critical information for guiding treatment in many cancer types, including breast, melanoma, head and neck, lung and gynecologic cancers, as the lymphatic system serves as the primary route for metastasis. Lymph node biopsy involves localization of tumor-draining lymph nodes, followed by their surgical removal and histological assessment. However, the procedure is associated with overtreatment concerns and some considerable morbidity, including lymphedema, seroma formation, and restricted arm movement. Moreover, conventional histological analyses are time-consuming and laborious, yet pathologists generally examine less than 1% of the volume of each lymph node, leading to undetected micrometastasis (tumor clusters 0.2-2mm in diameter) in 30-60% of cases. In response to these limitations in standard lymph node dissection protocol, there is a significant need for the development of lymph node imaging strategies that are capable of identifying metastatic cancer as a means of staging a patient’s cancer without the need for invasive and time-intensive conventional pathology. Paired-agent imaging molecular imaging protocols have been spearheaded by our group and entail co-administration of a control imaging agent with a molecular targeted agent as a way to account for nonspecific uptake and retention. The overall goal of my thesis was to methodically design, optimize and evaluate the clinical utility of a paired-agent lymph node imaging protocol to achieve levels of sensitivity and specificity in nodal staging not possible with current conventional methods, less invasively and at a fraction of the time and cost.
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- Title
- Effect of Phosphorus Additions on Polycrystalline Ni-base Superalloys
- Creator
- Li, Linhan
- Date
- 2020
- Description
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In recent years, advanced polycrystalline Ni-base superalloys have been developed with elevated levels of γ′ forming elements and high level...
Show moreIn recent years, advanced polycrystalline Ni-base superalloys have been developed with elevated levels of γ′ forming elements and high level of refractory elements as solid-solution strengtheners in an effort to extend the temperature capability. Moreover, the properties of the grain boundaries become more important and this necessitates the need to study of effects of minor additions of interstitial P for grain structure optimization. Due to the increased level of refractory elements employed, powder-processed Ni-base superalloys tend to have a high propensity to form Topologically Close-Packed (TCP) phases, which was found to be further promoted by the addition of P. A systematic study of the phase stability of high refractory content powder-processed Ni-base superalloys with three levels of P additions revealed an increased tendency to form Laves phase as a function of P additions. Additions of P were discovered to not only depress the incipient melting temperature to stabilize the eutectic Laves phase, but also promote Laves phase formation during the aging heat treatment and the following isothermal exposure. During the thermal exposure, excessive formation of Laves phase promoted the formation of a basket-weave structure comprised of an intertwined mixture of Laves and Sigma phase. The stabilization of the Laves phase structure due to P additions was found to be consistent with Density Functional Theory (DFT) calculations and could be rationalized through structure maps that relate the valence electron concentration and relative size differences. Additionally, a variation of grain structure obtained via either a sub-solvus or super-solvus solution heat treatment was noted to some extent vary the P segregation level at high-angle grain boundaries, thereby affecting the phase stability. For a sub-solvus solutioned grain structure that possessed a high length density of high-angle grain boundaries, the Laves phase formation was depressed for alloys with a low level of P addition. However, the phase stability variation associated with Laves phase formation was moderate when high concentrations of P were present. The effect of P addition on the γ′ microstructure variation is limited, which was confirmed by microstructure observations as well as through the short-term 0.6%-strain stress relaxation tests at high temperature. Heat treatment variations to modify the secondary and tertiary γ′ microstructures were discovered to exert a much more significant influence on the 0.6%-strain stress relaxation behavior. When a higher initial strain of 2% was applied, the stress relaxation behavior of the powder-processed Ni-base superalloys was found to be microstructure independent. The creep ductility of Waspaloy was determined to be notably reduced by the P additions due to the enhanced precipitation of M23C6 carbide at the grain boundaries. Excessive precipitation of M23C6 carbide increased the likelihood of brittle fracture when tested under low temperature/high stress creep conditions. However, the P addition as well as the excessive precipitation of M23C6 carbide did not impact the creep behavior as the dominant deformation was transgranular in nature when tested under high temperature/low stress conditions.
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- Title
- ATOMIC LAYER DEPOSITION STUDIES OF GOLD AND TUNGSTEN DISULFIDE
- Creator
- Liu, Pengfei
- Date
- 2020
- Description
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In the last few decades, atomic layer deposition (ALD), as a vapor deposition technique and a powerful thin film fabrication method, has...
Show moreIn the last few decades, atomic layer deposition (ALD), as a vapor deposition technique and a powerful thin film fabrication method, has received more and more attention in many fields. A variety of materials can be made by ALD; however, the progress of ALD application is still necessary. Meanwhile, in the process of film fabrication by ALD, the interfacial chemistry is interesting and well worth studying. This dissertation mainly described the process of exploring two materials, gold and tungsten disulfide, fabrication and related content.For the portion of applying ALD in gold thin film deposition, a relatively comprehensive process was explored, studied, analyzed and discussed. Start with the synthesis of the gold precursor, Me2Au(S2CNEt2), the synthetic reaction was explored. By modified the conditions, such as solvent system, twice the yield as previously reported in the literature were achieved. Next, the application of in situ microbalance and infrared spectroscopic technique illuminate the organometallic chemistry during the gold thermal ALD process with Me2Au(S2CNEt2) and ozone. In situ quartz crystal microbalance (QCM) studies give an explanation for the nucleation delay and island growth of gold on a freshly prepared aluminum oxide surface. In situ infrared spectroscopy provides insight to study the surface chemistry during the process, which supports an oxidized gold surface mechanism. The epitaxy of gold thin film was explored by X-ray diffraction. The thermal ALD gold on various substrates reveals out-of-plane orientation, however, in-plane orientation was only existed in the gold film on mica. For the portion of applying ALD in tungsten disulfide fabrication, the early work started with studying the effect of interfaces upon crystallinity. The sulfuration of indium thin film with different interface was explored. Then the idea of “interfaces” was brought into the process of tungsten compounds fabrication. Due to this “indirect” method which made tungsten disulfide by sulfurizing ALD made tungsten compounds (eg. tungsten oxide and tungsten nitride) could not reduce the reaction temperature of tungsten disulfide synthesis to less than 400 °C. Sequently, the “direct” way of tungsten disulfide fabrication which directly utilized tungsten precursor and H2S in ALD system was tested and explored. With the tungsten precursors developed by our group, finally, tungsten disulfide could be fabricated at the temperature as low as 125 °C.
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- Title
- The role of fibrillar collagen in tissue function
- Creator
- Ma, Yin
- Date
- 2020
- Description
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Fibrillar collagen plays an important role in maintaining soft tissue integrity and providing chemical and physical cues for cell fate...
Show moreFibrillar collagen plays an important role in maintaining soft tissue integrity and providing chemical and physical cues for cell fate decisions. Collagen remodeling, which alternates the amount, distribution, and biomechanics of collagen, primarily type I (COLI) and type III (COLIII), can change tissue properties. This process is essential not only in biological developments but also in pathological processes. Thus, it is meaningful to understand the correlation between collagen remodeling and tissue dysfunction and investigate the cells' response to fibrous protein matrices. However, current studies in biochemical analysis of collagen and biomechanical study of tissues were carried out at different scales. So it is hard to correlate the data to draw solid conclusions. In this thesis research, we used two collagen disorder associated pathological conditions, pelvic organ prolapse (POP) and micropapillary serous carcinoma (MPSC) of the fallopian tube, as models to unravel the correlation between tissue dysfunctions and the impaired microenvironment relevant to the composition, nanostructure, and biomechanics of a collagen fibril. In the case of POP, we found the collagen fibers in tissues of POP patients were less abundant but stiffer than those of non-POP individuals, implying a loose and fragile matrix that is weakly integrated with other components of the connective tissue to provide adequate support of the pelvic organs. On the other hand, the collagen D-period, the characteristic banding feature which signals the proper assembly of collagen molecules, decreased in POP tissues. We surmised that the molecular level changes of collagen in POP were accountable for the weak matrix mechanics, verified by a systematic in vitro study. We also examined the collagen matrix alternation in MPSC of the fallopian tube, which is thought to cause ovarian cancer via metastasis. Since cancer metastasis is often related to collagen remodeling, we examined the collagen matrix alternation in this disease. We observed the heterogeneous distribution of COLI and COLIII in the papillae of the tumor tissue. Noticeably, COLI was accumulated at the papillae tip, whereas COLIII was dominant at the papillae base. We also observed the absence of collagen matrix between the micropapillary tip and the fibrosis base. Such an uneven collagen distribution implies that the matrix exerted distinctive forces on the tumor cells to regulate their behaviors, including cell migration, directional growth, and shedding from the primary tumor to initiate metastasis. These conclusions have been supported by the results of our in vitro experiments. In investigating the effect of the microenvironment on cell behavior, we established and validated an AFM-based method to collect and quantitatively analyze the mRNA samples from targeted live cells at the single-cell level. This method overcomes issues, such as severe cell damage or even cell death, the capability of time-dependent and in situ analyses, in current methods. The application of the method in studying heterogeneous gene expression in single cells and the interaction between cancer cells and cancer-associated fibroblasts was demonstrated. We also demonstrated that this method can be potentially used to quantitatively analyze the gene expression level changes in a targeted cell in response to the microenvironment.
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- Title
- FEARING FORGETTING? DEVELOPMENT OF A SCALE TO ASSESS ATTITUDES ABOUT DEMENTIA IN THE LAY POPULATION
- Creator
- Ogu, Precious N
- Date
- 2020
- Description
-
Individuals with dementia show a progressive decline in cognitive functioning which results in an inability to complete activities of daily...
Show moreIndividuals with dementia show a progressive decline in cognitive functioning which results in an inability to complete activities of daily living (American Psychiatric Association, 2013). Early diagnosis of dementia is a positive prognostic indicator (World Alzheimer Report, 2011) and is widely regarded as an important pre-condition for improving dementia care (Kim et al., 2015; Vernooij-Dassen et al., 2005). However, negative attitudes and stigma towards dementia could possibly interfere with an individual’s willingness to recognize or accept the idea of themselves having the disease through label avoidance. The goal of the present study was to contribute to understanding the perception of dementia by developing a quantitatively derived and psychometrically validated measure that encompasses the positive and negative attitudes towards dementia held by people without dementia. This study also explored the potential association between negative attitudes about dementia and lack of familiarity with dementia as familiarity with individuals with mental illness is related to stigmatizing attitudes towards mental illness. These goals were achieved by a principal components analysis (PCA) of 56 modified items from extant and well-validated mental illness attitude scales (Community Attitudes to Mental Illness, CAMI, Taylor & Dear, 1981; Social Distance Scale, SDS, Link, 1986; Depression Stigma Scale, DSS, Griffiths et al., 2004). Convergent validity was assessed by examining the relationship between the final derived measure and a construct associated with negative attitudes about mental illness (Mental Retardation Attitude Inventory-Revised, MRAI-R). Discriminant validity was assessed by examining the relationship between the final measure and a construct that should be unrelated to negative attitudes about mental illness (Belief in a Just World Scale, BJW). Finally, exploratory analyses were conducted to assess if attitudes measured by the newly created scale are related to participants’ familiarity with dementia (Level of Familiarity Scale, LoFS, Corrigan et al., 2001). 400 adults with no history of dementia were recruited through Amazon’s MTurk. Participants were compensated by a credit to their Amazon account upon completion of the survey. The PCA supported 2 conceptually different (not method variance) latent components titled Negative Attitudes and Positive Attitudes. These 2 components comprise the Attitudes to Dementia Inventory (ADI). Construct validity was partially supported for each component of the ADI. Degree of familiarity with dementia was not associated with negative or positive attitudes about dementia. Overall, this study is an important contribution to dementia attitudes research. Given the identification of Negative Attitudes and Positive Attitudes have been identified as distinct dimensions of dementia attitudes, the ADI can be used to further investigate how negative reactions towards dementia might cause delays in initiating medical intervention and treatment, and also to examine whether positive attitudes provide any protections against the probable effects of negative attitudes on stigma and help-seeking behaviors. Since the early recognition and diagnosis of dementia is widely regarded as an important condition for improving dementia care (Kim et al., 2015; Vernooij-Dassen, et al., 2005), the ADI can be used to inform stigma-prevention, which hopefully translates into improved help-seeking behaviors.
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- Title
- IMPACT OF DATA SHAPE, FIDELITY, AND INTER-OBSERVER REPRODUCIBILITY ON CARDIAC MAGNETIC RESONANCE IMAGE PIPELINES
- Creator
- Obioma, Blessing Ngozi
- Date
- 2020
- Description
-
Artificial Intelligence (AI) holds a great promise in the healthcare. It provides a variety of advantages with its application in clinical...
Show moreArtificial Intelligence (AI) holds a great promise in the healthcare. It provides a variety of advantages with its application in clinical diagnosis, disease prediction, and treatment, with such interests intensifying in the medical image field. AI can automate various cumbersome data processing techniques in medical imaging such as segmentation of left ventricular chambers and image-based classification of diseases. However, full clinical implementation and adaptation of emerging AI-based tools face challenges due to the inherently opaque nature of such AI algorithms based on Deep Neural Networks (DNN), for which computer-trained bias is not only difficult to detect by physician users but is also difficult to safely design in software development. In this work, we examine AI application in Cardiac Magnetic Resonance (CMR) using an automated image classification task, and thereby propose an AI quality control framework design that differentially evaluates the black-box DNN via carefully prepared input data with shape and fidelity variations to probe system responses to these variations. Two variants of the Visual Geometric Graphics with 19 neural layers (VGG19) was used for classification, with a total of 60,000 CMR images. Findings from this work provides insights on the importance of quality training data preparation and demonstrates the importance of data shape variability. It also provides gateway for computation performance optimization in training and validation time.
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- Title
- LOW-COVERAGE GENOMES AS AN EFFECTIVE AND ECONOMICAL APPROACH FOR LEPIDOPTERAN MICROSATELLITE ISOLATION
- Creator
- Liang, Huijia
- Date
- 2020
- Description
-
This study aimed to verify that whether a low-coverage genome can work as an effective approach to isolate Lepidopteran microsatellites. As...
Show moreThis study aimed to verify that whether a low-coverage genome can work as an effective approach to isolate Lepidopteran microsatellites. As microsatellites are useful tool to study population genetics, and there are many Lepidopteran agriculture pests which can cause huge economic damages every year, additionally, Lepidoptera have abundant similar flanking sequences making it difficult to develop reliable microsatellites. However, there are not enough published genomes of Lepidoptera species. If low-coverage Lepidopteran genomes can be used to isolate reliable microsatellites, the low-coverage genomes would be an effective and economical approach for microsatellites isolation, because low-coverage genome sequencing is much cheaper and less time-consuming than the published genome sequencing.
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- Title
- Testing actor and partner mediation effects of the mindfulness-relationship satisfaction association in long-distance relationships
- Creator
- Manser, Kelly A.
- Date
- 2023
- Description
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Long-distance romantic relationships (LDR) have become increasingly common as technology and sociocultural norms have evolved. Individuals in...
Show moreLong-distance romantic relationships (LDR) have become increasingly common as technology and sociocultural norms have evolved. Individuals in LDR, many of whom are post-secondary students, report LDR-specific experiences and stressors. Nonetheless, romantic relationship satisfaction (RS) nonetheless appears comparable between LDR and non-LDR relationships, although the underlying mechanisms are not well-understood. Mindfulness, which relates positively to RS and negatively to stress, is minimally studied in LDR. Moreover, despite empirical and theoretical support, few studies have tested stress as a mediator of associations between mindfulness and RS at the within-person level (termed actor effects) or between-person level (partner effects). This study tested a theoretically-grounded, empirically-supported Actor-Partner Interdependence Mediation Model (APIMeM) in a sample (N = 150; 75 dyads) of post-secondary students and their LDR romantic partners. As hypothesized, an partner-actor indirect effect emerged of T1 actor mindfulness on T2 partner RS through decreased T2 partner stress. Unexpectedly, no direct, total, or indirect effects of T1 actor mindfulness on T2 actor stress or T2 actor RS emerged. Findings suggest that within- and between-person associations between mindfulness, stress, and RS may present uniquely in LDR, with implications for research, clinical practice, and policy.
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- Title
- Associations between subjective cognitive decline, neurodegeneration, and vascular neuroimaging markers: Findings from a multiethnic cohort
- Creator
- Gonzalez, Christopher
- Date
- 2023
- Description
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Mounting evidence suggests that subjective cognitive decline (SCD) may provide a unique target to identify the earliest changes in cognitive...
Show moreMounting evidence suggests that subjective cognitive decline (SCD) may provide a unique target to identify the earliest changes in cognitive function in Alzheimer’s disease (AD). In addition, vascular-related risk factors are also linked to increase the risk of clinical expression of AD, and independently increase the risk for vascular dementia (VaD). However, most investigations have not explored SCD across a multiethnic population. The study investigated 1) the associations between white matter hyperintensities (WMH) and targeted neuroimaging AD markers (hippocampal volume, cortical thickness of AD regions) with SCD amongst a multiethnic cohort, and 2) whether race moderated the relationship between them. A total of 871 older adults ages from 62-96 years old with a mean age of 74.48 (SD = 6.11), mean education of 12.79 years (SD = 4.53), and with 62% identifying as female were recruited from preexisting data from the Washington Heights Inwood Columbia Aging Project (WHICAP). Linear regression model revealed a significant association between WMH and both AD targeted neuroimaging markers across the total sample. Secondary analyses revealed that race did not moderate the relationship between WMH and AD cortical thickness with SCD but did in fact moderate the relationship between hippocampal volume and SCD. Results suggest that cultural biological differences exist in the Hispanic/Latine individuals compared to non-Hispanic White and non-Hispanic Black individuals.
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- Title
- Design for Equivalence: Mutual Learning and Participant Gains in Participatory Design Processes
- Creator
- Geppert, Amanda Anne
- Date
- 2023
- Description
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The ways in which people are or are not—aware, eligible, able, invited, required, supported, willing, and/or forced, among other conditions—to...
Show moreThe ways in which people are or are not—aware, eligible, able, invited, required, supported, willing, and/or forced, among other conditions—to participate in the procedures or experiences that constitute world-making activities—from voting, policymaking, or designing algorithms, technologies, products, programs, services, interventions, infrastructures, or systems, among other things—that affect their lives—is a central issue of our time. It demands careful consideration and is of great consequence as to whether or not the worlds we create are equitable, sustainable, and just, so that all people have free and equal standing and a real opportunity to belong and flourish. This study took up this issue in the context of participatory design practice and research and the making of sexual and reproductive health interventions with and for adolescents who are marginalized by race, class, ethnicity, gender, and sexuality, in Lucknow, Uttar Pradesh, India, and Chicago, Illinois, United States. The study advances knowledge in design by exploring how problem-focused, front-end participatory design processes expand or constrain the epistemic authority of less powerful actors, more specifically, systematically excluded individuals and groups. The study was conducted in two parallel phases. First, through a theoretical elaboration and critical analysis, it examined the application of Mouffean agonism in recent formulations of participatory design processes to address complex social and political issues with marginalized individuals and groups. The analysis demonstrated that a key construct—the chain of equivalence—is absent and resulted in the failure of these processes to achieve the collective, counter-hegemonic, and emancipatory responses strong enough to counter power as imagined by Chantal Mouffe. Second, an explanatory embedded multiple case study was conducted on two front-end participatory design workshops to understand what less powerful actors gain by engaging in collaborative processes of design and how practices and processes do or do not support their epistemic authority and matters of care. Thematic analysis suggested how the practices of collective information sharing and gathering—mutual learning and learning— affect participant gains and design process outputs. Additionally, thematic analysis informed a theoretical, conceptual, and practical move to expand beyond the original scope of the Mouffean chain of equivalence to include collaborating actors who may not be equivalently disadvantaged by current power relations, but who are committed to participatory design processes that prioritize the issues and matters of care of less powerful actors. When considered together, findings from both research phases inform the development of design for equivalence, at once a theoretical stance and a methodological framework to inform the selection of approaches, theories, processes, methods, practices, and tools for participatory design processes that support the epistemic authority of participants in challenging social and structural inequalities and creating articulations of the common good strong enough to counter dominant paradigms.
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- Title
- Development of Metal Oxide-Based Phosphors for Luminescence Thermometry
- Creator
- Jahanbazi, Forough
- Date
- 2023
- Description
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Temperature is both a thermodynamic property and a fundamental unit of measurement; one of the seven base quantities of the international...
Show moreTemperature is both a thermodynamic property and a fundamental unit of measurement; one of the seven base quantities of the international system of units (SI). It can be seen simply as the degree of hotness or coldness, a qualitative definition built on the bodily sensation of heat and cold. Today it is readily defined from the principles of classical thermodynamics as the parameter of state that has the same value for any systems which are in thermal equilibrium, and from statistical mechanics as a direct measure of the average kinetic energy of noninteracting particles. Temperature is an intensive quantity, meaning that its value does not depend on the amount of the substance for which it is measured. It is important because it is something we feel and because it influences the smallest aspects of our daily life, from how to adjust our housing and clothing to what we eat for supper. It affects the life cycles of plants and animals, governs rates of chemical reactions, influences tides and so on. For these reasons, it is by far the most measured physical quantity; sensors of temperature account for 80% of all sensors worldwide at present and they are used across a broad spectrum of human activities, such as in medicine, home appliances, meteorology, agriculture, and industrial and military contexts, to mention some of the most significant areas. Thus, the market demand for temperature sensors is increasing due to their extending applications in human activities. Traditional “contact” temperature measurements, which are mainly based on the expansion and contraction of an employed material, encounter difficulties when used in some emerging technologies and environments, such as nanotechnology and biomedicine. Today, an immediate need exists for the “non-contact” thermometry of moving or contact-sensitive objects, difficult to access pieces, bodies in hazardous locations, objects of nano-size dimensions, or living cells and organisms. However, the properties of existing thermometers and sensor platforms limit their use in such environments. Non-contact sensors measure object temperature without the need for physical contact between sensors and objects. Therefore, they have been considered as a great interest for hardly accessible objects. As non-contact thermometry methods, besides pyrometers and radiation thermometers, optical thermometers have drawn extensive attention nowadays. Specifically, among all the optical based thermometry methods, including Raman scattering, optical interferometry, and near field optical scanning microscopy, the one having drawn the most attention is luminescence thermometry in which the temperature detection is based on the luminescent signal accompanied with acceptable spatial resolution.In luminescence thermometry method, temperature can be determined from different features of luminescence using luminescence thermometers. Depending on the temporal nature of these features, the principles of their measurements are classified as either time-integrated (steady-state) or time-resolved ones. The temperature measurement based on the excitation and emission band positions and bandwidths, emission band intensities, luminescence/fluorescent intensity ratio (LIR or FIR, the ratio of the intensities of two emission bands) are classified as time-integrated methods. The temperature measurements based on the emission decay- or rise-times are classified as time-resolved ones. Temperature readouts from LIR and emission lifetime are by far the most exploited methods. Both readouts are self-referenced, so they are not affected by fluctuations in excitation and signal detection. Moreover, thermal sensing ability of many lanthanide-based luminescent materials is not limited to only one read-out method. Some of them can be used as dual/multiple modes via utilizing a combination of two or more read-out methods for temperature measurement. Non-contact luminescence thermometry based on LIR read-out method has attracted much attention due to its excellent accuracy and sensitivity. The intensity ratio is independent of undesirable factors that makes this luminescence thermometry more appropriate. Moreover, the method is self- referencing which removes the need for a temperature standard. In principle, it can be realized with any combinations of the emission lines from lanthanides and transition metallic ions with different temperature dependencies, either from single or multiple luminescent centers. It is the most reported luminescence thermometric read-out method in the past few years. In the past years, researchers have done a lot of work on developing high-efficient LIR thermometers by employing a single center emitting. This ratiometric method is mainly performed based on the principle that governs thermally coupled energy level of the luminescent ions. The electronic distribution between electronic states of closely separated excited levels of the doped element follows the Boltzmann equation. The two excited levels of ions are thermally coupled with a maximum energy gap of 2000 cm-1, which is sufficiently small to allow electrons to transit to high energy level upon thermal excitation and at the same time large enough to have different electronic populations and high sensitivity value. In this case, both high and low excited states share the electronic population according to Boltzmann’s distribution. Therefore, the ratio of the number of electrons between the high and the low excited levels can be defined as follows for LIR-based thermometry utilizing single emitting centers. In addition to LIR between two thermally coupled energy levels of the luminescent ion, in some ions LIR between two other energy levels which are not coupled thermally were employed to reach to a high-sensitive thermometry. The quantitative evaluation of the thermometric performance of a temperature probe is defined by its absolute and relative thermal sensitivities, temperature resolution, and repeatability. The rate of change in thermometric parameters (indicated by Δ) over a temperature changing process (∂T) is defined as absolute thermal sensitivity (Sa). However, absolute sensitivity is not appropriate to compare the performance among thermometers with different employed materials or physical principles. The relative thermal sensitivity (Sr) is defined to eliminate the problem associated with comparison between the performance of thermometers with different natures. Sr of a luminescent thermometer is one of the most important factors which determine its temperature readout accuracy. The smallest temperature change resolvable by a thermometer is defined as temperature resolution or temperature uncertainty (indicated by δT) which is expressed in Kelvin and depends on the characteristic of measuring systems such as the experimental detection setup and the signal-to noise ratio: The reproducibility is defined as the change of the same measurement performed under different conditions such as different methods or devices. The repeatability (indicated by R) is the ability of a thermometer to provide the same result under different conditions. Regarding temperature resolution, most light detection systems, including thermometry systems, suffer from low resolution because of the scattering at both excitation and emission wavelengths. Light scattering of thermometric phosphors is induced by their grain size, shape, and surface roughness. This is a problem particularly associated with conventional phosphors which typically have micrometer grain size. On the other hand, the light scattering by nanoparticles (NPs) is close to zero, which leads to better resolution of luminescence thermometers using NPs. Consequently, nanothermometry has emerged as a hot research area of thermometers for new technological applications with high resolution. Accordingly, below in chapter 1, we discussed a host material, pyrochlore compound of La2Zr2O7, doped with Tb3+ and Eu3+, synthesized in nanoscale (~15 nm) that showed a great potential for LIR temperature sensing with a high resolution based on dual emitting centers. In chapter 2, another sample of this nano powder host, La2Zr2O7 doped with Pr3+, is discovered and discussed for LIR temperature sensing based on single emitting center. Beside the high-resolution thermometry by La2Zr2O7: Pr3+ nano powder, a broad-temperature sensing range was achieved using it. The broad temperature sensing range obtained only by using one LIR-read out mode originated from high-lying charge transfer states with slow thermal-quenching that will be elaborated in chapter 2. Multiple materials employed for luminescence thermometry application, such as organic dyes, quantum dots, metal–organic complexes and frameworks, among which lanthanide or transition metal ion-based phosphors, are most promising. The electronic states of lanthanides are characterized by partially filled 4f orbitals as they are gradually filling up from 4f0 for La3+ to 4f14 for Lu3+. Their luminescence emission occurs due to interconfigurational f-f transitions except some ions like Eu2+ and Ce3+ which have f-d allowed transition emissions. The partially filled 4f orbitals of lanthanide ions are shielded by 5s and 5p subshells from surrounding environment that leads to long lifetime and narrowband emission characteristics. Once excited with UV light, lanthanide-doped materials mostly emit light in visible/near infrared (NIR) range in a downshift (DS) photoluminescence (PL) mechanism. In DS emission, high energy photons are converted into phonons with lower energy. Overall, having excellent repeatability, reproducibility and photostability with thermally and chemically stable structures makes the lanthanide-based materials the most favorite choices for luminescent thermometry applications. Their luminescence is easy to identify and differentiate from other materials. Multiplexing is possible due to their narrow emission bands which are easily identifiable. Host materials also play a crucial role in thermal sensing properties of thermometric phosphors. Various hosts such as fluorides, ceramic oxides, nitrides, chalcogenides, and phosphides have been employed for luminescence thermometry. Ceramic hosts are composed of different elements, thus often require complex synthesis processes which would limit their applicability. Fluoride hosts have a level of toxicity which is harmful for living systems, so they are not environmentally friendly. Nitride compounds are commonly prepared in oxygen/water-free glove boxes and synthesized in harsh synthesis conditions under high pressure/temperature which restrict their large-scale production. Chalcogenides and phosphides may not be sufficiently stable. On the other hand, metal oxide phosphors possess the advantages of convenient preparation, non-toxicity, excellent chemical stability (capable of withstanding sustained exposure to high temperature), and low cost. Moreover, they are preferable in biomedical luminescence thermometry as applications for measuring long-wavelength emissions where tissues are optically transparent and are less affected by scattering and background luminescence. Considering all these aspects, metal oxide-based phosphors are more favorable for luminescent thermometry. One of the goals of research in luminescence thermometry field has been to push the limit of temperature measurement capability to higher temperatures. However, the development of luminescent phosphors with high thermal stability of emission and high sensing efficiency still is a paramount challenge. Thermal stability of photoluminescence (PL) is a property related to the chemical composition, electronic structure, and crystal structure rigidity of phosphors. It is commonly referred to as positive thermal quenching (TQ), that is, the loss of light emission with rising temperature. Most phosphors indicate positive TQ which stems from high non-radiative transition probability at elevating temperatures. This phenomenon severely limits the applications of luminescent phosphors and degrades their devices’ performance. To compensate for the thermally induced emission loss of phosphors, several strategies have been reported, while as will be discussed in chapter 3, mostly have negative impacts on their inherent luminescence properties. From the structural perspective, TQ caused by nonradiative relaxations is closely related to the crystal structure stability. A rigid structural framework with high lattice symmetry has reduced nonradiative transitions at elevated temperatures. As one of the rigid-type hosts, materials possessing a negative thermal expansion (NTE) property have been explored as suitable hosts for anti-TQ phosphors doped with lanthanides. NTE refers to the unique property of some unique and rare materials with their volume abnormally contracting with increasing temperature. Among various reported NTE families, compounds with the general formula of A2M3O12, where A is a trivalent rare earth ion and M stands for W6+ or Mo6+, are well-known with a broad range of compositions and have been explored for anti-TQ in the recent years. Some earlier works reported employing A2M3O12 host to obtain thermally enhanced upconversion (UC) emission. However, the upconversion emission is not the type of widely used emission as they produce weaker emissions mostly limited to a higher wavelength range than most-applicable visible range. Thus, NTE phosphors and thermally enhanced stronger downshift (DS) emissions on visible range are not yet high enough to fulfill their practical application. To explore the applicability of NTE idea for down-shift (DS) emitting phosphors, we reported the anti-TQ performance of single and co-doped samples of Sc2Mo3O12: Eu3+ and Sc2Mo3O12: Tb3+, Eu3+ in chapter 3 and 4, respectively. Specifically, we took advantage of the existence of interionic energy transfer in our NTE host, to achieve superior anti-TQ performance for DS luminescence that can be employed for efficient thermometry at high temperatures range. The structural shrinkage with rising temperature shortens the distance between the host and activator dopant ions, which enhances the host to activator ET and consequently the final emission intensity as will be elaborated in two last chapters. As a highly promising strategy, there is an urgent need to obtain more evidence on how NTE property, associates with the anti-TQ of luminescence that we tried to discover in our works. We explored these compound’s potential for high temperature luminescence thermometry. We tested both LIR and lifetime-based temperature sensing and revealed their great potential for an efficient temperature sensing at high temperature ranges. This study opens a new design strategy and perspective to obtain phosphors with thermally boosted luminescence based on NTE host materials to meet the serious demands for their broad applications at elevated temperatures and harsh conditions.
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- Title
- Application of Blockchain and Artificial Intelligence Methods in Power System Operation and Control
- Creator
- Farhoumandi, Matin
- Date
- 2023
- Description
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The proliferation of distributed energy resources (DERs) and the large-scale electrification of transportation infrastructure are driving...
Show moreThe proliferation of distributed energy resources (DERs) and the large-scale electrification of transportation infrastructure are driving forces behind the ongoing evolution for transforming traditionally passive consumers into prosumers (both consumers and producers) in a coordinated system of power distribution network (PDN) and urban transportation network (UTN). In this new paradigm, peer-to-peer (P2P) energy trading is a promising energy management strategy for dynamically balancing the supply and demand in electricity markets. In this thesis, we propose the applications of artificial intelligence technology to power system operation and control. First, blockchain (BC) is applied to electric vehicle charging station (EVCS) operations to optimally transact energy in a hierarchical P2P framework. In the proposed framework, a decentralized privacy-preserving clearing mechanism is implemented in the transactive energy market (TEM) in which BC’s smart contracts are applied in a coordinated PDN and UTN operation. The effectiveness of the proposed TEM and its solution approach are validated via numerical simulations which are performed on a modified IEEE 123-bus PDN and a modified Sioux Falls UTN. Second, machine learning and deep learning methods are applied to short-term forecasting of non-conforming net load (STFNL). STFNL plays a vital role in enhancing the secure and efficient operation and control of power systems. However, power system consumption is affected by a variety of external factors and thus includes high levels of variations. These variations cause STFNL to be a challenging task as more DERs are integrated into the power grid. This thesis proposes two commonly used machine learning and deep learning methods, i.e., ensemble bagged and long short-term memory, for STFNL. The advantages, features and applications of these methods are expanded in a proposed fusion forecasting model that improves the STFNL accuracy. Additionally, data engineering and preprocessing options are used to increase the accuracy of the proposed fusion model. A comparative study based on practical load data is performed to demonstrate that the proposed fusion methodology can reach a relatively higher forecasting accuracy with lower error indices. Index Terms—Blockchain, deep learning and machine learning, electric vehicle charging stations, non-conforming net load forecasting, peer-to-peer transactive energy, power distribution and transportation networks, distributed energy resources, behind-the-meter supply resources.
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- Title
- Dynamic Risk and Dynamic Performance Measures Generated by Distortion Functions and Diversification Benefits Optimization
- Creator
- Liu, Hao
- Date
- 2023
- Description
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This thesis consists of two major parts, and it contributes to the fields of risk management and optimization.One contribution to risk...
Show moreThis thesis consists of two major parts, and it contributes to the fields of risk management and optimization.One contribution to risk management is made via developing dynamic risk measures and dynamic acceptability indices that can be characterized by distortion functions. In particular, we proved a representation theorem illustrating that the class of dynamic coherent risk measures generated by distortion functions coincides with a specific type of dynamic risk measures, the dynamic WV@R. We also investigate thoroughly various types of time consistencies for dynamic risk measures and dynamic acceptability indices in terms of distortion functions. Another contribution to risk management is proving strong consistency and asymptotic normality of two estimators of dynamic WV@R. In contrast to the exist- ing literature, our results do not rely on the assumptions of distribution of random variables. Instead, we investigate the asymptotic normality of estimators in terms of the generating distortion functions. Last but not least, we give counterexample to show that a sufficient condition of asymptotic normality is not necessary. The contribution to optimization is twofold. On the one hand, we formulate the (scalar) diversification optimization problem as a vector optimization problem (VOP), and show that a set-valued Bellman principle is satisfied by this VOP. On the other hand, we derive explicit policy gradient formula and implement the deep neural network to solve diversification optimization problem numerically. This deep learning technique allows to overcome computation difficulty caused by the non-convexity of VOP.
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- Title
- Toward a Network Model of Executive Functioning
- Creator
- Fuller, Jordan S.
- Date
- 2023
- Description
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The executive functions are the higher-order mental processes that are responsible for organized, strategic behavior. These functions have...
Show moreThe executive functions are the higher-order mental processes that are responsible for organized, strategic behavior. These functions have been a source of significant controversy since their initial introduction. This study sought to create a model of the executive functions utilizing psychological network analysis. Participants completed six measures reflecting inhibition, task switching, and working memory updating, as well as a fluid intelligence measure. A processing speed index was calculated from non-executive trials of various measures. Four networks were generated, including an executive functions network, an executive functions and intelligence network, an executive functions and processing speed network, and a network with all variables included. The resulting networks contained no stable edges between the executive functioning tasks. Stable edges were identified between the intelligence node and the two nodes reflecting working memory updating. There was an additional edge identified between processing speed and one measure of task switching. Results of the study may indicate that there is relative independence among executive functions. However, the management of task impurity in a psychological network analysis also merits further investigation.
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