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- Title
- EFFECT OF STRAWBERRY ANTIOXIDANTS ON OXIDATIVE STRESS IN INSULIN RESISTANT INDIVIDUALS: A DOSE RESPONSE STUDY
- Creator
- Vijayakumar, Lakshmi Prabha
- Date
- 2014, 2014-05
- Description
-
Oxidative and inflammatory stress is associated with chronic disease development and progression. Recent studies suggest that consumption of...
Show moreOxidative and inflammatory stress is associated with chronic disease development and progression. Recent studies suggest that consumption of fruits and vegetables rich in antioxidant compounds attenuate oxidative stress and inflammation. Strawberries are abundant in polyphenolic compounds with antioxidant properties, which have attracted research attention for their possible health benefits. The aim of the project was to determine whether the antioxidant properties of strawberries formulated in a beverage would dose-dependently restore oxidative stress induced by a high fat/ high carbohydrate meal in insulin resistant individuals. Plasma was collected from insulin resistant individuals (n=25) every 30-60 min over 6 h after ingestion after a 650 kcal high fat/ high carbohydrate meal accompanied with a beverage containing 0, 10, 20 or 40 g freeze-dried strawberry powder. The antioxidant capacity of test beverages containing 10, 20 and 40 g strawberry powder were 9.31± 0.66, 19.10 ± 0.60 and 33.57 ± 1.75 μmol Trolox equivalents/mL based on the Oxygen Radical Absorbance Capacity (ORAC) assay. The ORAC value for the placebo (0 g) was below the detectable limits. Biologically relevant oxidative stress was determined using the ORAC assay to estimate antioxidant capacity of the plasma and oxidation of low density lipoprotein (ox-LDL) using an ELISA assay to determine the oxidative damage. Assessment of ox-LDL over 6 hr revealed a significant effect of time (p<0.0001), however no significant difference between the treatment dosages was evident (p>0.05). A marginal treatment by time interaction suggested possible time specific differences between treatments. The evaluation of antioxidant capacity of the plasma was split into assessment of the hydrophilic and lipophilic fractions. Hydrophilic ORAC results showed ix no significant differences between test beverages over 6 hr (p>0.05), including effects of time or treatment by time interactions (p>0.05). The lipophilic ORAC also did not reveal significant differences between treatments (p>0.05). Overall, it appears that beverages with different “doses” of antioxidant capacity did not result in dose-dependent changes in oxidative stress in insulin resistant individuals. There was a trend for protection of ox-LDL by the 20 g strawberry beverage revealed by differences among treatments at 240 min compared to the placebo/0 g strawberry beverage. The findings suggest that antioxidant food properties do not translate directly to plasma antioxidant capacity as measured by ORAC and alternative mechanisms are likely responsible for biological antioxidant effects of strawberry.
M.S. in Mechanical and Aerospace Engineering, May 2014
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- Title
- A COMPRHENSIVE MECHANISTIC STUDY OF PEPTIDOMIMETICS ON MODEL MEMBRANE SYSTEMS
- Creator
- Bianchi, Christopher P.
- Date
- 2014, 2014-12
- Description
-
Peptidomimetics are a broad class of structural variant synthetic mimics of antimicrobial peptides (AMPs). AMPs are natural antibiotics found...
Show morePeptidomimetics are a broad class of structural variant synthetic mimics of antimicrobial peptides (AMPs). AMPs are natural antibiotics found in almost entirety throughout all living organisms. Although, AMPs were once thought of as promising therapeutics to combat infectious bacteria, key shortcomings such as low bioavailability, as well as high manufacturing costs have prevented them from reaching a clinical market. Peptidomimetics capitalize on the characteristics of AMPs thought to be responsible for their antibacterial activity, such as net cationic charge and amphiphilicity, while introducing key structural differences. The principal mode of antibacterial activity of AMPs is causing disruption to the bacteria cell membrane of both Gram-positive and Gram-negative bacteria types. The complexities of cell membranes with their various lipid molecule species and proteins makes it difficult to determine mechanistic details of AMPs. It is for this reason model membrane systems such as Langmuir monolayers and supported bilayers composed of the lipid species found in that of actual cell membrane are used. In the present work we have investigated the mechanism of action of different types of peptidomimetics such as N-substituted glycines (peptoids) and oligomers of acylated-lysines (OAKs) on model bacteria and cancer cell membrane systems using various experimental techniques, such as epifluorescence microscopy (EFM), atomic force microscopy (AFM), X-ray reflectivity, and grazing incidence X-ray diffraction (GIXD). From these studies structure function relationships can be obtained, which help aid in the design of new and more effective peptidomimetics. Through these investigations it was found that the substitution of hydrogen atoms for fluorine atoms in the phenyl side chains of cyclic peptoids increases antibacterial on both Gram-positive and Gram-negative model membrane systems, guanidino containing side chains compared to amino containing side chains in α-peptide-β-peptoid chimeras show greater activity on model membrane systems mimicking the cytoplasmic membrane of both Gram-positive and Gram negative bacteria. In addition, insights were gained on the anticancer mechanisms of the naturally occurring AMP magainin-2 and OAK C12K-7α8. The significance of the model membrane system being used cannot be overstated, when the overall arching goal is to bring these peptidomimetics to a clinical market. Thus, the biological relevance of the model membrane system is of great importance. It is this motivation that has lead our research group to develop a floating planar lipid bilayer that is bound to a lipid monolayer functionalized with polyethylene glycol, which to our knowledge has not been previously done. This system and the planar Langmuir monolayer that were used in this work are ideal systems for the use of high energy X-rays that are produced from synchrotron radiation facilities. From such measurements as X-ray reflectivity (XR) and grazing incidence X-ray diffraction (GIXD) molecular scale resolution of the peptidomimetic interactions with the model membrane systems can be achieved.
Ph.D. in Physics, December 2014
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- Title
- Impacts of Sulfur Capture Technology in Coal Power Plants (sequence unknown), IPRO 302 - Deliverables
- Creator
- Contreras, Abraham, Dickman, Justin, Enadeghe, Gregory, Garcia Rodriguez, Hector, Haddad, Michael, Kyle, Ryan, Mongillo, Michael, Murphy, Ryan, Shonubi, Oluwaseun, Swillum, Bryce, Wolber, Brian, Worthon, Terrika
- Date
- 2009-12
- Description
-
The IPRO team was investigating the net impact of sulfur capture technologies used in current and next generation power plants in the United...
Show moreThe IPRO team was investigating the net impact of sulfur capture technologies used in current and next generation power plants in the United States. It planned to use this knowledge to determine which sulfur capture technologies produce the greatest benefit for industry and society and to find the marketability of the sulfur byproducts created in these power plants.
Sponsorship: Sargent & Lundy, LLC
These are the deliverables for IPRO 302: Impacts of Sulfur Capture Technology in Coal Power Plants from the Fall 2009 semester.
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- Title
- Oil Rig Eco Hotel: OilRigEcoHotel_Poster
- Creator
- Marcan, Stephanie
- Date
- 2011, 2011-05
- Description
-
By refashioning the design and programmatic use of an offshore oil rig into a luxury hotel for ecotourists, a new age of responsible travel...
Show moreBy refashioning the design and programmatic use of an offshore oil rig into a luxury hotel for ecotourists, a new age of responsible travel may emerge. By twisting the symbol of oil dependency into an ecologically preserved, environmentally accountable and revenue-producing prototype, the ideals of reuse, energy and environment can be viewed through a new lens. This design creates interesting and innovative living spaces and environments aided by sustainable integrations to create a “living machine” that establishes connections between all building systems as well as inhabitant inputs and outputs resulting in an energy independent habitat.
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- Title
- Green Building Design Concept & Integration (sequence unknown), IPRO 335 - Deliverables: IPRO 335 Brochure F09
- Creator
- Avanessian, Aris, Banda, Justine, Bergerson, Joshua, Burke, Jeffrey, Christo, Robert, Dexter, Eric, Kim, Kibum, Mey, Andrew, Okunaga, Jonathan, Razeq, Ali, Schaefer, Jacqueline, Thovar Leon, Adrian, Um, Hye
- Date
- 2009-12
- Description
-
The scope of this IPRO project spans structural, architectural, foundation, HVAC, lighting and electric system designs, as well as building...
Show moreThe scope of this IPRO project spans structural, architectural, foundation, HVAC, lighting and electric system designs, as well as building cost estimating and professional ethics. The IPRO team will become informed about and apply principles associated with green design concepts, energy sustainability, post occupancy comfort, acoustic design issues, smart building concepts, health issues (abatement of mold- and allergy-causing agents), and safety considerations.
Deliverables for IPRO 335: Green Building Design Concept & Integration for the fall 2009 semester
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- Title
- SYSTEMATIC FINANCE: ESSAYS ON ETHICS, METHODOLOGY AND QUALITY CONTROL IN HIGH FREQUENCY TRADING
- Creator
- Van Vliet, Benjamin Edward
- Date
- 2012-04-18, 2012-05
- Description
-
A firm is in a state of strategic competitiveness if it has a plan that it rationally and responsibly believes is capable of success. In the...
Show moreA firm is in a state of strategic competitiveness if it has a plan that it rationally and responsibly believes is capable of success. In the age of automation, what justifies a trading firm’s belief in its strategic competitiveness has changed. Rational and responsible belief in the capability of the firm’s trading strategies can be justified by a prudent process that defines conditions for both initial and sustained belief. The process of developing trading systems is itself systematic and a source of competitive advantage. In this thesis, I present three chapters that address strategic competitiveness in automated trading—ethics, methodology and quality control. These chapters examine responsibility, and develop processes for both initial and sustained belief in the competitiveness of trading systems and the trading firm.
Ph.D. in Management Science, May 2012
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- Title
- Resonant interaction of a linear array of supersonic rectangular jets: An experimental study
- Creator
- Raman, G, Taghavi, R
- Date
- 1996-02-25
- Publisher
- CAMBRIDGE UNIV PRESS
- Description
-
This paper examines a supersonic multi-jet interaction problem that we believe is likely to be important for mixing enhancement and noise...
Show moreThis paper examines a supersonic multi-jet interaction problem that we believe is likely to be important for mixing enhancement and noise reduction in supersonic mixer-ejector nozzles. We demonstrate that it is possible to synchronize the screech instability of four rectangular jets by precisely adjusting the inter-jet spacing. Our experimental data agree with a theory that assumes that the phase-locking of adjacent jets occurs through a coupling at the jet lip. Although synchronization does not change the frequency of the screech tone, its amplitude is augmented. The synchronized multi-jets exhibit higher spreading than the unsynchronized jets, with the single jet spreading the least. We compare the near-field noise of the four jets with synchronized screech to the noise of the sum of four jets operated individually. Our noise measurements reveal that the more rapid mixing of the synchronized multi-jets causes the peak jet noise source to move upstream and to radiate noise at larger angles to the flow direction. Based on our results, we have grounds to believe that screech synchronization is advantageous for noise reduction internal to a mixer-ejector nozzle, since the noise can now be suppressed by a shorter acoustically lined ejector.
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- Title
- Laboratory Notebook 9
- Creator
- Sadler, George, Koutchma, Tatiana
- Date
- 2010-03-03T22:55:05Z
- Description
-
This laboratory notebook relates to the Combat Ration Network (Coranet) project which is connected with High Pressure Processing (HPP) on O2...
Show moreThis laboratory notebook relates to the Combat Ration Network (Coranet) project which is connected with High Pressure Processing (HPP) on O2 permeation with Tatiana Koutchma as the Principle Investigator.
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- Title
- Developing a Collaborative On-line Student Research Forum (sequence unknown), IPRO 321 - Deliverables: IPRO 321 Final Report F09
- Creator
- Abhay, Anandha, Cornelius, Zachary, Corsus, Tom, De Courten-myers, Maximilian, Eberlin, Adam, Kapaldo, James, Nicholson, Bethany, Sizyuk, Yuriy, Sundberg, Stephen
- Date
- 2009-12
- Description
-
ResearchWeb is meant to broaden IIT undergraduate participation beyond the existing mechanisms such as fellowships, research and reading...
Show moreResearchWeb is meant to broaden IIT undergraduate participation beyond the existing mechanisms such as fellowships, research and reading courses, and departmental projects. There is also the possibility of broadening this program to other scholarly individuals outside of the IIT undergraduate community. These individuals include IIT graduate students, students from other universities, and promising high school students. ResearchWeb is also meant to improve the transition, and perhaps promote if need be, the transition from undergraduate education to graduate education. This would be fulfilled through practical research experience.
Deliverables for IPRO 321:Developing a Collaborative On-line Student Research Forum for Fall 2009
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- Title
- Nibakure Children's Village School: Final Presentation Board
- Creator
- May, Bryan
- Date
- 2010-07-13
- Title
- Color reconnection and its effects on precise measurements at the LHC, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
- Creator
- Sjöstrand, Torbjörn
- Date
- 2013-09-15, 2013-09-15
- Publisher
- IIT Press
- Description
-
There is experimental evidence for the occurrence of color reconnection, but the mechanisms involved are far from understood. Previous...
Show moreThere is experimental evidence for the occurrence of color reconnection, but the mechanisms involved are far from understood. Previous reconnection studies are briefly summarized, and some potential implications for LHC physics are outlined.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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- Title
- LIVE LOAD FACTORS FOR CONTINUOUS GIRDER BRIDGES
- Creator
- Wang, Qing
- Date
- 2016, 2016-07
- Description
-
Live load factors of Strength I limit state for continuous girder highway bridges are calibrated based on reliability concept adopted by...
Show moreLive load factors of Strength I limit state for continuous girder highway bridges are calibrated based on reliability concept adopted by AASHTO LRFD and LRFR specifications. A uniform reliability is maintained for multi-girder highway bridges with various span lengths. WIM data, gathered by California, Michigan, New York, Oregon, and Illinois State Department of Transportation are analyzed. Live load effects produced by WIM data are calculated using influence lines. Expected maximum live load effects in given periods are modeled and extrapolated by Gumbel distribution. A relativecalibration formula is developed in order to derive live load correction factors for designing/evaluating continuous highway bridges at a reliability level that is in consistent with simply supported highway bridges. Computer programming is conducted for data sorting and traffic statistical analysis.
Ph.D. in Civil Engineering, July 2016
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- Title
- Church & School Energy Efficiency and Financing Program (sequence unknown), IPRO 328 - Deliverables: IPRO 328 Midterm Presentation F09
- Creator
- Ciuffini, Kathryn, Kim, Ja Young, Knapczyk, Robert, Mckinley, Matthew, O'brien, Patrick, Maddamma, Todd, Schafer, Michael, Soderling, Philip, Wedster, Bonnie
- Date
- 2009-12
- Description
-
The Fall 2009 IPRO 328 team envisions the development and ultimately execution of a volunteer program which would facilitate the...
Show moreThe Fall 2009 IPRO 328 team envisions the development and ultimately execution of a volunteer program which would facilitate the implementation of energy saving improvements in a church and/or parochial school within the surrounding neighborhoods of IIT campus.
Sponsorship: Vince Cushing of Clean Urban Energy
Deliverables for IPRO 328: Church & School Energy Efficiency and Financing Program for the fall 2009 semester
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- Title
- Design of a Large Scale Structure (sequence 315), IPRO 315 - Deliverables: IPRO 315 Brochure F09
- Creator
- Aguilar-wedge, Carmen, Animashaun, Oladipo, Baur, Alex, Cullen, Michael, Hadi, Shuaib, Hedge, Namrata, Kuo, Steve, Lee, Christopher, Lee, Yongdoo, Rybaltowski, Karol, Scully, Dawveed, Shen, Jie-hua, Yousef, Shadi
- Date
- 2009-12
- Description
-
Located in Oakbrook, IL the architects and engineers of IPRO 315 will design a 22 story hotel. Together architects and engineers will modify...
Show moreLocated in Oakbrook, IL the architects and engineers of IPRO 315 will design a 22 story hotel. Together architects and engineers will modify and re analyze a structure created by pervious designers, and select any new materials for construction. In creating the hotel students will be responsible for the structural analysis of columns, beams, foundation, steel, and concrete design required to insure all serviceability requirements. The students will be required to follow the 2006 International Building Code, and secure the safety of all possible occupants. Management, leadership, ethics, and teamwork will be an integral part of building a large scale structure as students learn to work together on a “real life” project.
Deliverables for IPRO 315: Design of a Large Scale Structure for the fall 2009 semester
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- Title
- Re-Inventing the IIT Tower: Re-inventing the IIT Tower
- Creator
- Baharani, Aarzoo
- Date
- 2011, 2011-05
- Description
-
The building systems, envelope performance and building use efficiency of the IIT Tower will be analyzed for evaluation of the current...
Show moreThe building systems, envelope performance and building use efficiency of the IIT Tower will be analyzed for evaluation of the current building energy use and occupant comfort levels. Energy modeling tools will be used to demonstrate the achievement of superior building performance and better occupant comfort levels through proposed design interventions. The transformative design will also result in a holistic improvement in building performance.
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- Title
- Modeling, monitoring and control strategies for high temperature short time pasteurization systems - 3. Statistical monitoring of product lethality and process sensor reliability
- Creator
- Negiz, A., Ramanauskas, P., Cinar, A., Schlesser, J. E., Armstrong, D. J.
- Date
- 1998-02
- Publisher
- ELSEVIER SCI LTD
- Description
-
Statistical process monitoring (SPM) is used in food processing industries to improve productivity and product quality. SPM can also provide...
Show moreStatistical process monitoring (SPM) is used in food processing industries to improve productivity and product quality. SPM can also provide information to operators on how close a process is to non-compliance to product safety limits, and carry out periodic checks of sensor accuracy at high frequency. Traditional SPM tools such as Shewhart charts are not appropriate for continuous food processes because of autocorrelation in data. Four alternative SPM techniques are presented and applied to high temperature short time (HTST) dairy pasteurization. The study attempted to achieve compliance of the HTST process operation with the recommended Pasteurized Milk Ordinance by providing a margin between the alarm limits of the monitoring chart and the safety limits. Monitoring of residuals and parameter change detection techniques ave used for monitoring processes with autocorrelated variables. Hotelling's T-2 and residuals of canonical variates techniques are used for monitoring multivariable processes.
Endnote format citation
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- Title
- Washington Park Center for Improvisational Music: Kellen White_FINAL 34x44 BOARD_01
- Creator
- White, Kellen
- Date
- 2010-07-30
- Title
- Hadronic final states in high-pT QCD at CDF, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
- Creator
- Matera, Keith
- Date
- 2013-09-15, 2013-09-15
- Publisher
- IIT Press
- Description
-
The heavy quark content associated with gauge boson production is of great interest to studies of QCD. These events probe the gluon and heavy...
Show moreThe heavy quark content associated with gauge boson production is of great interest to studies of QCD. These events probe the gluon and heavy-quark parton distribution functions of the proton, and also provide a measurement of the rate of final state gluon splitting to heavy favor. In addition, gauge boson plus heavy quark events are representative of backgrounds to Higgs, single top, and supersymmetric particle searches. Recent work with the CDF II detector at the Fermilab Tevatron has measured the cross-section of several gauge boson plus heavy flavor production processes, including the first Tevatron observation of specific charm process p͞p → W + c. Results are found to be in agreement with NLO predictions that include an enhanced rate of g → c͞c =b͞b splitting. Lastly, a new analysis promises to probe a lower pT (c) region than has yet been explored, by fully reconstructing D* → D^0 (Kπ)π decays in the full CDF dataset (9:7 fb^1).
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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- Title
- EVALUATING DYNAMIC JOB PERFORMANCE: A FIELD STUDY OF DYNAMIC PERFORMANCE CHARACTERISTICS AND PERFORMANCE RATINGS
- Creator
- Hall, Rachael
- Date
- 2012-12-17, 2012-12
- Description
-
Previous research has established that job performance changes over time, yet the implications of this dynamism for performance evaluations...
Show morePrevious research has established that job performance changes over time, yet the implications of this dynamism for performance evaluations remain unclear. Studies that have examined the implications of different dynamic performance characteristics have mostly been laboratory based and have included a variety of performance measures, except for supervisor ratings of performance. Therefore, the present study integrates and builds on the literature on dynamic performance and performance ratings by examining its effects in an applied setting. Predictions were made about how the patterns in objective performance over a 12-month performance period would relate to annual performance appraisal ratings. Based on the monthly performance of 1,100 troopers working for a state law enforcement agency, main effects were found on supervisor ratings for the mean and trend in objective performance. However, the performance trend unexpectedly had a negative association with performance ratings. An interaction between the performance trend and variability also provided new information about how dynamic performance characteristics may interact to have an influence on ratings. Findings from the current study add to the existing research on dynamic performance characteristics and performance ratings, but more research is needed to understand the implications for different jobs and contexts.
M.S. in in Psychology, December 2012
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- Title
- ADULTS WITH SICKLE CELL DISEASE: THE DISEASE'S IMPACT ON PAIN NEUROPSYCHOLOGICAL DYSFUNCTION AND QUALITY OF LIFE
- Creator
- Vernale Iii, Michael A.
- Date
- 2013, 2013-07
- Description
-
The primary aim of this study is to address the neuropsychological functioning of adults with Sickle Cell Disease (SCD) by examining the...
Show moreThe primary aim of this study is to address the neuropsychological functioning of adults with Sickle Cell Disease (SCD) by examining the association of illness-related and psychosocial factors with cognition. The neuropsychological functioning of adults with SCD will be compared to that of controls matched on gender, race, and age. There is considerable evidence for neuropsychological complications associated with SCD (Anie, 2005; Schatz, 2004). Much of the cognitive deficits are thought to be the result of cerebrovascular accidents commonly suffered by this population. Studies of cognition in children with SCD suggest that cognitive complications tend to increase with age. Particularly implicated are deficits in attention, concentration, and executive functioning. Although the specific neuropsychological morbidity is not as clearly understood for adults with SCD as it is for children, global cognitive impairment within this population has been documented. In addition, pain negatively affects cognitive functioning in both children and adults (Libon et al., 2010). The pattern of impairment was suggested to be the result of additional demands on attentional capacity. However, the relationship between pain and cognitive performance in adults with sickle cell disease is less clear. As a result of frequent pain, individuals with SCD often report a low evaluation of quality of life particularly as a result of health complaints (Anie, 2005). Thus, the inter-dynamic of health -related quality of life, pain , and cognitive dysfunction is not entirely clear within the sickle cell population and therefore warrants examination.
PH.D in Psychology, July 2013
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