Positron emission tomography (PET) is a molecular imaging technology that can be used to detect various diseases including cancer. Zirconium... Show morePositron emission tomography (PET) is a molecular imaging technology that can be used to detect various diseases including cancer. Zirconium-89 (t1/2 = 78.4 h) is one of the positron-emitting radionuclides that has been widely explored for PET imaging because its half-life matches the long biological half-life of antibody. Research efforts have been devoted to the development of chelation chemistry for 89Zr, a bone-seeking radionuclide. Deferoxamine (DFO) is the most frequently used chelator for 89Zr in both clinical and preclinical trials. DFO can rapidly sequester 89Zr to form 89Zr-DFO complex. However, DFO is not an ideal ligand for 89Zr because 89Zr-labeled DFO-antibody conjugate showed high bone uptake in mice. We wanted to develop novel small molecule donors and novel chelators for 89Zr. We discovered N-methyl-N-(pyridin-2-yl)hydroxylamine (Py-HA) and 2,6-bis(N-methylhydroxylamino)pyridine (Py-BHA) as small molecule donors for 89Zr. Based on the new small molecule donors (Py-HA and Py-BHA), we have designed and synthesized a series of novel macrocyclic chelators containing TACN (1,4,7-triazacyclononane), CYCLEN (1,4,7,10-tetraazacyclododecane), and a diaza-crown ether backbone for 89Zr-based PET imaging applications. Moreover, bifunctional chelators (BFCs) structured on TACN and diaza-18-crown-6 were synthesized for conjugation to antibody. Theranostics contains a diagnostic agent and a therapeutic drug that can be used for simultaneous therapy and imaging of diseases. Radiotheranostics includes radiometal complexes for both therapy and imaging. 177Lu is a promising radiotheranostic metal because it can emit gamma radiation for single photon emission computed tomography (SPECT) imaging and emit β radiation for radiotherapy. A radioisotope pair with complementary emission such as 64Cu/67Cu and 86Y/90Y, can be used for PET imaging and radiotherapy. In this study, we synthesized nonfunctional TACN and diaza crown ether-backboned chelators containing different donor groups for 177Lu, 64Cu/67Cu, and 86Y/90Y. Finally, two bifunctional chelators were synthesized for coupling with hydroxamic acid-based small molecule as a potential histone deacetylase (HDAC) inhibitor to generate a small molecule ligand-chelator conjugate (SMLC) for theranostic applications. Show less
This report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software... Show moreThis report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software architecture patterns. This report provides additional examples of using C-Saw, supplementary evaluation details, and it defines the formal semantics of the language. Show less
Photograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date... Show morePhotograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant. Show less
Photograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title... Show morePhotograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant. Show less
Digitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title... Show moreDigitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant. Show less
Digitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title... Show moreDigitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant. Show less
Color slide depicting the intersection of 35th Street and South State Street, looking northeast. Photographer unknown, possibly a member of... Show moreColor slide depicting the intersection of 35th Street and South State Street, looking northeast. Photographer unknown, possibly a member of the university's Department of Public Relations. Show less
Two photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of... Show moreTwo photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of Technology Campus. The Chicago Land Clearance Commission acquired the land on which the junkyard stood in 1958, and demolition occurred in 1959, after which the land was sold to Illinois Tech. Photographer unknown. Show less
Photograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham,... Show morePhotograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham, and were demolished in 1952. Originally constructed as a hotel for the World's Columbian Exposition of 1893, the 96-unit Mecca building became an apartment building after the fair. The building was acquired by Illinois Tech around 1941, and was demolished in 1952 to make way for the construction of S.R. Crown Hall. The building was also known as Mecca Apartments, and The Mecca. Show less
Photograph of László Moholy-Nagy with hand sculptures. Photographer unknown. Date of photograph unknown. Date listed is approximate, based on... Show morePhotograph of László Moholy-Nagy with hand sculptures. Photographer unknown. Date of photograph unknown. Date listed is approximate, based on notation found adjacent to photograph. Show less
"New Priorities|New Directions" Print advertisement created by photographer Howard LeVant/LeVant Photography (other contributors unknown) for... Show more"New Priorities|New Directions" Print advertisement created by photographer Howard LeVant/LeVant Photography (other contributors unknown) for Amoco Chemicals Corporation, featuring fiberglass windmills created to look like Chicago buildings. Date of advertisement is unknown. Date range listed (1969-1968) is approximate. Title supplied by Howard LeVant. Show less
Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to... Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni. Show less
Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to... Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni. Show less
Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to... Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni. Show less
Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to... Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni. Show less