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Title: Novel Chelating Agents for Positron Emission Tomography Imaging and Theranostic Applications
Creator: Zhang, Shuyuan
Date: 2022
Description: Positron emission tomography (PET) is a molecular imaging technology that can be used to detect various diseases including cancer. Zirconium...
Show morePositron emission tomography (PET) is a molecular imaging technology that can be used to detect various diseases including cancer. Zirconium-89 (t1/2 = 78.4 h) is one of the positron-emitting radionuclides that has been widely explored for PET imaging because its half-life matches the long biological half-life of antibody. Research efforts have been devoted to the development of chelation chemistry for 89Zr, a bone-seeking radionuclide. Deferoxamine (DFO) is the most frequently used chelator for 89Zr in both clinical and preclinical trials. DFO can rapidly sequester 89Zr to form 89Zr-DFO complex. However, DFO is not an ideal ligand for 89Zr because 89Zr-labeled DFO-antibody conjugate showed high bone uptake in mice. We wanted to develop novel small molecule donors and novel chelators for 89Zr. We discovered N-methyl-N-(pyridin-2-yl)hydroxylamine (Py-HA) and 2,6-bis(N-methylhydroxylamino)pyridine (Py-BHA) as small molecule donors for 89Zr. Based on the new small molecule donors (Py-HA and Py-BHA), we have designed and synthesized a series of novel macrocyclic chelators containing TACN (1,4,7-triazacyclononane), CYCLEN (1,4,7,10-tetraazacyclododecane), and a diaza-crown ether backbone for 89Zr-based PET imaging applications. Moreover, bifunctional chelators (BFCs) structured on TACN and diaza-18-crown-6 were synthesized for conjugation to antibody. Theranostics contains a diagnostic agent and a therapeutic drug that can be used for simultaneous therapy and imaging of diseases. Radiotheranostics includes radiometal complexes for both therapy and imaging. 177Lu is a promising radiotheranostic metal because it can emit gamma radiation for single photon emission computed tomography (SPECT) imaging and emit β radiation for radiotherapy. A radioisotope pair with complementary emission such as 64Cu/67Cu and 86Y/90Y, can be used for PET imaging and radiotherapy. In this study, we synthesized nonfunctional TACN and diaza crown ether-backboned chelators containing different donor groups for 177Lu, 64Cu/67Cu, and 86Y/90Y. Finally, two bifunctional chelators were synthesized for coupling with hydroxamic acid-based small molecule as a potential histone deacetylase (HDAC) inhibitor to generate a small molecule ligand-chelator conjugate (SMLC) for theranostic applications.
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Title: Semantics and further Use-Cases and Evaluation of the C-Saw language
Creator: Zhu, Henry, Zhao, Junyong, Sultana, Nik
Date: 2023-03-09
Description: This report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software...
Show moreThis report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software architecture patterns. This report provides additional examples of using C-Saw, supplementary evaluation details, and it defines the formal semantics of the language.
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Title: Hooker on Wells Street
Creator: LeVant, Howard
Date: 1966-1969
Description: Date of photograph is unknown. Date range listed (1966-1969) is approximate. Title supplied by Howard LeVant.
Collection: Howard LeVant papers, 1950-2020

Title: Picasso statue
Creator: LeVant, Howard
Date: 1970-1978
Description: Photograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date...
Show morePhotograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Nuns picnicking
Creator: LeVant, Howard
Date: 1967-1969
Description: Photograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title...
Show morePhotograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Rabbi writing a new Torah
Creator: LeVant, Howard
Date: 1977
Description: Title supplied by Howard LeVant, labeled as personal/historical photo.
Collection: Howard LeVant papers, 1950-2020

Title: Norwegian Landscape
Creator: LeVant, Howard
Date: 1986
Description: Digitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title...
Show moreDigitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Bungalow - Alternate front elevations for wide or narrow lots
Creator: Gordon, Robert Philip
Date: 1990
Description: Hand-colored laser print.
Collection: Robert Philip Gordon papers, 1963-2010

Title: English Hill Street
Creator: LeVant, Howard
Date: 1976
Description: Digitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title...
Show moreDigitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Northeast corner of 35th Street and State Street, Chicago, Illinois, January 24, 1954
Date: 1954-01-24
Description: Color slide depicting the intersection of 35th Street and South State Street, looking northeast. Photographer unknown, possibly a member of...
Show moreColor slide depicting the intersection of 35th Street and South State Street, looking northeast. Photographer unknown, possibly a member of the university's Department of Public Relations.
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Collection: Dan Ryan collection, 1954-1980

Title: Kaplan's Junkyard, Chicago, Illinois, 1959
Date: 1959
Description: Two photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of...
Show moreTwo photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of Technology Campus. The Chicago Land Clearance Commission acquired the land on which the junkyard stood in 1958, and demolition occurred in 1959, after which the land was sold to Illinois Tech. Photographer unknown.
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Collection: Office of Communications and Marketing photographs, 1905-1999

Title: Mecca Flats, Chicago, Illinois, ca. 1951
Creator: Yuskaitis, Robert J
Date: 1951
Description: Photograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham,...
Show morePhotograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham, and were demolished in 1952. Originally constructed as a hotel for the World's Columbian Exposition of 1893, the 96-unit Mecca building became an apartment building after the fair. The building was acquired by Illinois Tech around 1941, and was demolished in 1952 to make way for the construction of S.R. Crown Hall. The building was also known as Mecca Apartments, and The Mecca.
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Collection: Office of Communications and Marketing photographs, 1905-1999

Title: László Moholy-Nagy with hand sculptures, ca. 1945
Date: 1945
Description: Photograph of László Moholy-Nagy with hand sculptures. Photographer unknown. Date of photograph unknown. Date listed is approximate, based on...
Show morePhotograph of László Moholy-Nagy with hand sculptures. Photographer unknown. Date of photograph unknown. Date listed is approximate, based on notation found adjacent to photograph.
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Collection: Institute of Design records, 1937-ca. 1962

Title: László Moholy-Nagy
Description: Photograph of László Moholy-Nagy in profile. Photographer unknown. Date of photograph is unknown.
Collection: Institute of Design records, 1937-ca. 1962

Title: Blue skyline ad
Creator: LeVant, Howard, LeVant Photography
Date: 1969-1978
Description: "New Priorities|New Directions" Print advertisement created by photographer Howard LeVant/LeVant Photography (other contributors unknown) for...
Show more"New Priorities|New Directions" Print advertisement created by photographer Howard LeVant/LeVant Photography (other contributors unknown) for Amoco Chemicals Corporation, featuring fiberglass windmills created to look like Chicago buildings. Date of advertisement is unknown. Date range listed (1969-1968) is approximate. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: World Languages and Cultures Club
Creator: Muhammad, Ahmad, Petkov, Kamen, Converse, Christopher, Youssef, Nikhil, Honda, Julia, Watatani, Allen, Brown, Jacob
Date: 2022
Description: Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to...
Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni.
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Title: Analysis on the Persisting Effects of Redlining in Chicago Neighborhoods as it relates to Green Infrastructure
Creator: Meyer, Joel, Brizzolara, Gemma
Date: 2022
Description: Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to...
Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni.
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Title: Camras Scholars Website
Creator: Wong, Jocelyn, Melchor, Jovany, Zainedin, Hazim, Robbins, Hayley, Wrobel, Katherine, Patel, Pooja
Date: 2022
Description: Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to...
Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni.
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Title: Beyond the Sole: Where Human Performance Meets Data Analytics
Creator: Muhammad, Ahmad
Date: 2022
Description: Presentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to...
Show morePresentation describing a Pillar project completed as part of the Camras Scholars Program at Illinois Tech. Camras scholars are expected to make meaningful contributions to the campus and the Illinois Tech community in three focus areas known as the Camras Pillars: leadership, research, and service. The Camras Scholars Program (CSP) is a student-led organization that oversees and runs the program for current Camras scholarship recipients and alumni.
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