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Title: EMBEDDED SYSTEM DESIGN FOR TRAFFIC SIGN RECOGNITION USING MACHINE LEARNING ALGORITHMS
Creator: Han, Yan
Date: 2016, 2016-12
Description: Traffic sign recognition system, taken as an important component of an intelligent vehicle system, has been an active research area and it has...
Show moreTraffic sign recognition system, taken as an important component of an intelligent vehicle system, has been an active research area and it has been investigated vigorously in the last decade. It is an important step for introducing intelligent vehicles into the current road transportation systems. Based on image processing and machine learning technologies, TSR systems are being developed cautiously by many manufacturers and have been set up on vehicles as part of a driving assistant system in recent years. Traffic signs are designed and placed in locations to be easily identified from its surroundings by human eyes. Hence, an intelligent system that can identify these signs as good as a human, needs to address a lot of challenges. Here, ―good‖ can be interpreted as accurate and fast. Therefore, developing a reliable, real-time and robust TSR system is the main motivation for this dissertation. Multiple TSR system approaches based on computer vision and machine learning technologies are introduced and they are implemented on different hardware platforms. Proposed TSR algorithms are comprised of two parts: sign detection based on color and shape analysis and sign classification based on machine learning technologies including nearest neighbor search, support vector machine and deep neural networks. Target hardware platforms include Xilinx ZedBoard FPGA and NVIDIA Jetson TX1 that provides GPU acceleration. Overall, based on a well-known benchmark suite, 96% detection accuracy is achieved while executing at 1.6 frames per seconds on the GPU board.
Ph.D. in Computer Engineering, December 2016
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Title: INFLUENCE OF OWNER-ORGANIZATION IMPRESSION AND CONTRACT FRAMING ON CONSTRUCTION CONTRACTORS' RISK PERCEPTIONS
Creator: Hanioglu, Mehmet Nihat
Date: 2014, 2014-12
Description: In a construction project, it is generally accepted that the contractor's perceived risk is the main factor in determining what is to be...
Show moreIn a construction project, it is generally accepted that the contractor's perceived risk is the main factor in determining what is to be proposed as the project cost and duration. Both the owner-organization and the contractor are aware of the existing risks and the owner-organizations tend to mitigate the existing risks by using the construction contract. It is hypothesized that the contractor’s initial impression of the owner-organization is a factor in the contractor’s perception of risk. It is further hypothesized that the initial impression is influenced by the content and context of the construction bid documents, which further influences the perceived risk and the bid strategy. The goal is to investigate the factors that influence contractors' impression of the owner-organization and to study the effects of contract document language and content in the impression formation process and subsequent development of a bid strategy. By better understanding the factors and relationships that influence impression formation and risk perceptions, it is expected that substantial time, money and unnecessary contention between these parties can be eliminated.
Ph.D. in Civil Engineering, December 2014
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Title: CYCLIC THERMAL TREATMENT
Creator: Gu, Sijie
Date: 2015, 2015-12
Description: Cyclic thermal treatment has the potential to improve energy efficiency of thermal processing. It has been shown that in some cases, the...
Show moreCyclic thermal treatment has the potential to improve energy efficiency of thermal processing. It has been shown that in some cases, the productivity was enhanced by the cyclic thermal treatment operation. In order to investigate the cyclic thermal treatment effect, Copper-Nickel interdiffusion couples were investigated. When the Cu-Ni interdiffusion couple showed positive results, the cyclic thermal treatment was applied to pack carburization and gas carburization of steel. The Cu-Ni interdiffusion couples were annealed with different time-temperature profiles for 5 days. There are three types of time-temperature profile; isothermal, symmetric, and asymmetric cyclic thermal treatment. After thermal treatment, concentration-distance profiles were. Based on the concentration-distance profile, the interdiffusion coefficients of different time-temperature profiles were calculated. The interdiffusion coefficient of the diffusion couple with a ramp rate of 1°C/min had a higher diffusion coefficient than that of the diffusion couple annealed isothermally at the equivalent temperature, 863°C, which means that cyclic thermal treatment has the effect of accelerating diffusion. When the ramp rate was 5ºC/min interdiffusion coefficients were higher than that of the diffusion couple annealed isothermally at the maximum temperature. However, when the ramp rate was increased to 10°C/min, the diffusion coefficient decreased to almost the same as the interdiffusion coefficient of the diffusion couple at the equivalent temperature. After achieving a promising result for the Cu-Ni diffusion couples, we expanded the cyclic thermal treatment to carburizing. The temperature range for cyclic pack carburization was 850° to 950°C. Increasing the cyclic ramp rate resulted in an increase in the case depth. Due to the setup of the pack carburization, the maximum cooling rate achievable is 5°C/min. In order to reach a higher ramp rate, an induction heating gas carburization system was setup. The temperature range for the cyclic induction heat gas carburization was 850°C to 950°C. For the cyclic induction heat gas carburization with increase in ramp rate, the case depth increased. The sample induction gas carburized at a ramp rate of 20°C/min had a deeper case depth than the sample induction gas carburized isothermally at 904.4°C, the equivalent temperature. The first test showed the sample induction gas carburized with a ramp rate of 20°C/min had a deeper case depth than the sample induction gas carburized isothermally at 950° C. With this we draw the conclusion that the cyclic induction gas carburization can achieve a deeper case depth than the isothermal at equivalent temperature induction gas carburization.
Ph.D. in Materials Science and Engineering, December 2015
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Title: POWER GRID VERIFICATION ON CLOUD
Creator: Gupte, Naval
Date: 2016, 2016-05
Description: Reliability and performance of modern ICs is becoming increasingly susceptible to supply voltage variations. Increased demand for low voltage...
Show moreReliability and performance of modern ICs is becoming increasingly susceptible to supply voltage variations. Increased demand for low voltage integrated circuits has made power grid analysis extremely critical and indispensable in modern design flows. Efficient validation of on-chip power distribution network is computationally demanding because of increasing grid sizes. Power grid simulation is critical for analysis and verification of power supply noises for robust and reliable IC designs. Computational demands to simulate power grids for ICs with increasing complexity is never-ending. Cloud computing platforms can be leveraged to mitigate costs associated with making these resources available. However, since simulation data usually contains sensitive design information, simulating on third-party platforms lead to major security concerns. In this study, we propose a framework for secure power grid simulation on Cloud. A transformation algorithm to hide current excitations is presented, while still allowing a majority of computations to be completed on Cloud. We employ multiple compression strategies to significantly reduce communication and storage overheads. Experiments show that our framework can achieve similar turn-around time as an insecure simulator on Cloud, while securing current excitations and output voltage vectors with reasonable communication and computational overheads. Vectorless technique to grid verification estimates worst-case voltage noises without detailed enumeration of load current excitations. We study voltage noise assessment in RLC models of VDD and GND networks in integrated power grids. Abstract grid model is utilized to abbreviate runtime, while transient constraints capture transitory circuit behaviour. Heuristics are employed to extract constraints that restrict power consumption profiles to realistic scenarios. Multiple linear programming problems are formulated to evaluate bounds on voltage overshoots and undershoots. We propose ways to mitigate storage and computational requirements on processing resources, enabling users to deploy computations on economical Cloud Computing platforms. Recommended solution is parallelizable, thereby reducing the overall verification time. Data compression is applied to fully exploit the compute capabilities of contemporary processors for higher throughputs. Experimental results suggest that the proposed technique is practical and scalable for industrial grids.
Ph.D. in Electrical Engineering, May 2016
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Title: PERFECTIONISM AS A MODERATOR OF ASSOCIATIONS BETWEEN BODY DISSATISFACATION AND DISORDERED EATING: AN ECOLOGICAL MOMENTARY ASSESSMENT STUDY
Creator: Hansen, Meghan A.
Date: 2017, 2017-07
Description: Disordered eating attitudes and behavioral urges are prevalent in community samples and contribute to numerous negative physical and...
Show moreDisordered eating attitudes and behavioral urges are prevalent in community samples and contribute to numerous negative physical and psychological outcomes. Using an ecological momentary assessment, this study examines how body dissatisfaction, perfectionism, and disordered eating relate to one another. Over the course of one week, women (n=49) with disordered eating completed multiple daily ratings of body dissatisfaction and disordered eating attitudes, urges and behaviors. Multilevel model analyses were used to test study hypotheses that; (1) body dissatisfaction prospectively predicts disordered eating attitudes and urges; and (2) perfectionism moderates the associations between body dissatisfaction and subsequent disordered eating attitudes and behaviors, such that individuals higher in perfectionism will report stronger associations between these variables. Results indicate that, in this sample, greater body dissatisfaction does not predict disordered eating attitudes, urges or behaviors. However, the interaction between increased body dissatisfaction and perfectionism predicted subsequent disordered eating attitudes and behavioral urges, but did not predict engagement in eating disorder behaviors. Results have important clinical and treatment implications for including perfectionism in the treatment of eating disorders.
Ph.D. in Psychology, July 2017
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Title: DEPRESSION AND ATTRIBUTIONS FOR DISTRESS
Creator: Hanson, Bjorn J.
Date: 2013, 2013-07
Description: Distress caused by depressive symptoms includes both direct and mediated pathways. Attributions for distress in individuals suffering from...
Show moreDistress caused by depressive symptoms includes both direct and mediated pathways. Attributions for distress in individuals suffering from depressive symptoms represent indirect pathways that have a high potential to be modified by psychotherapeutic interventions; however, little research has focused on the content of these attributions. This study provides the first quantitative measurement of this reasons-for-distress paradigm. Specifically, we aim to describe the frequencies, intensities, and co-occurrence patterns of attributions for distress, as well as distinguish the attributions for distress paradigm from previous attributions for depression research. Furthermore, we seek to demonstrate the accuracy of an illness behavior model for conceptualizing distress caused by depressive symptoms by differentiating symptom severity from symptom distress. In addition to quantifying attributions for distress, this study also extends previous research regarding rumination, the severity of distress caused by cognitive and vegetative symptoms of depression, and the co-occurrence of specific symptoms and specific reasons for distress. Individuals currently suffering from depressive symptoms were recruited from web-based advertisements to participate in this cross-sectional, online self-report study. A total of 204 individuals qualified for the study and completed some portion of the Reasons for Distress Questionnaire-Depression (RDQ-D). Results demonstrated that all reasons provided as part of the RDQ-D represented common attributions for distress in depressed individuals. Reasons related to personalized reasons for distress (Other), long-term outcomes (Long-term Consequences), productivity impairment (Work and Productivity Impairment), and x existential distress (Lack of Purpose or Meaning) were rated as significantly more distressing when compared with all reasons for distress. Cluster analysis suggested that certain reasons tended to co-occur and that some attributions for distress are nearly universal amongst individuals suffering from significant depressive symptoms. The reason-for-distress paradigm was demonstrated to be related to, yet distinct from, the reason-for-depression paradigm (Addis, Truax, & Jacobson, 1995). Distress ratings were also found to be moderately positively correlated with some depressive symptoms, but not others, providing support for an illness behavior conceptualization of distress severity in depression. Expanding on prior research, results showed that rumination was equally distressing and frequent across gender. Also, cognitive/affective symptoms of depression were rated as more distressing than vegetative symptoms of depression. Additionally, participants demonstrated the capacity to endorse specific reasons for distress in association with specific symptoms. As predicted, the existential reason for distress Lack of Purpose or Meaning was endorsed more frequently in relation to cognitive/affective symptoms of depression as compared to vegetative symptoms of depression. By focusing on specific symptoms of depression, the RDQ-D provides a clinical assessment that has the ability to identify specific unhelpful responses to symptoms that may be causing distress in addition to that inherent in the experience of the symptom. These unhelpful responses can then be included in case conceptualization, treatment planning, and intervention selection.
PH.D in Psychology, July 2013
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Title: COMPUTER AIDED DIAGNOSIS IN MAMMOGRAPHY WITH CONTENT-BASED IMAGE RETRIEVAL
Creator: Jing, Hao
Date: 2011-11, 2011-12
Description: Computer-aided diagnosis (CAD) for breast cancer, a common form of cancer in women, has been an active research area. This work aims to...
Show moreComputer-aided diagnosis (CAD) for breast cancer, a common form of cancer in women, has been an active research area. This work aims to investigate and develop CAD techniques for clustered microcalcifications (MCCs), which can be an important early sign of breast cancer. The contributions of this work include development of a database of cancer cases and algorithms for detection and classification of MCCs. First, a database consisting of a large number of cases is built from different sources. To support the merging of cases from different data sources, a feature comparison study is conducted between mammograms from screen film and full field digital mammography (FFDM) systems. It is demonstrated that the features extracted from film and FFDM are highly correlated and there is no adverse effect on a CAD task of classification when used together. Second, a spatial point process (SPP) approach is proposed to exploit the spatial distribution among different MCs in a mammogram directly during the detection process. This is different from the conventional approach in which detection algorithms are employed to first identify individual MCs in a mammogram, which are subsequently grouped into clusters by a clustering algorithm. The performance of the proposed approach is demonstrated to be superior to an existing method based on the support vector machine (SVM). Third, in observation of the emerging of large databases from the picture archiving and communication (PAC) systems in the clinics, a retrieval driven approach is proposed for classification of MCCs. In this approach, for a case to be diagnosed (i.e., query), a set of similar cases is retrieved from a database and subsequently is used to train xii an adaptive classifier specifically for the query case using the technique of logistic regression. The proposed approach is demonstrated to lead to significant improvement in classification accuracy. Moreover, the proposed adaptive classification approach is further developed using regularization techniques, where a prior is first derived from a baseline classifier and then used to regularize the adaptive classifier trained with the retrieved cases. The regularized adaptive classifier can be more computationally efficient, and is demonstrated to achieve further improvement in performance.
Ph.D. in Electrical Engineering, December 2011
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Title: MEASUREMENT OF INTRARETINAL NITRIC OXIDE IN EARLY DIABETIC RETINOPATHY
Creator: Guthrie, Micah
Date: 2014, 2014-12
Description: Diabetic retinopathy (DR) is the most frequent cause of new cases of blindness among adults aged 20-74 years. Nearly all patients with Type 1...
Show moreDiabetic retinopathy (DR) is the most frequent cause of new cases of blindness among adults aged 20-74 years. Nearly all patients with Type 1 diabetes and greater than 60% of patients with Type 2 diabetes will develop retinopathy within the rst two decades of the disease. Nitric oxide (NO) has been shown to play a role in the progression of DR, contributing to neuronal dysfunction and the breakdown of the blood-retina barrier early stages of the disease. The objective of the current study was to investigate the changes in intraretinal NO levels in early DR. To accomplish this, a dual NO/electroretinogram (ERG) electrode was developed to make the rst direct measurements of NO concentration throughout the in vivo retina. These electrodes were validated in an in vivo animal model by comparing control recordings to those taken after injection of the broad spectrum nitric oxide synthase (NOS) inhibitor L-NG-Nitroarginine methyl ester (L-NAME). Control NO pro les showed high levels of NO in the photoreceptor layer with localized areas of increased NO in the amacrine/ganglion cell layer. L-NAME NO pro les showed substantially reduced NO in the retina, indicating that the electrodes were measuring actual NO. The electrodes were then used to record NO pro les from the retinas of rats made diabetic with streptozotocin (STZ). The recordings were obtained three weeks after injection of STZ. Blood glucose levels were also monitored in order to correlate the blood glucose level with intraretinal NO concentration. It was found that mild diabetic rats (blood glucose 250-400 mg/dL) had higherthan- control levels of NO throughout their retinas. Severe diabetics (500-600 mg/dL) had lower-than-control levels, while moderate diabetics (400-500 mg/dL) did not have signi cantly di erent NO levels than controls. The NO pro les from the severe diabetics were very similar to L-NAME pro les, indicating that NOS production may be abnormal in severe diabetics. It was also found that intraretinal NO concentration was inversely correlated with the blood glucose of diabetic rats. To determine if the changes in NO seen in diabetic rats were due to direct tissue exposure to high glucose, NO pro les were also recorded from rats acutely injected with glucose solution to achieve similar levels of hyperglycemia. No changes in NO levels were seen in the retinas of these acute hyperglycemic rats, indicating that there are other factors besides high glucose contributing to the NO changes in DR. The results show that there is not a simple increase in NO as severity of diabetes increases and highlight the importance of being able to make measurements of bioavailable NO in retinal tissue. The electrodes were able to detect clear di erences in experimental DR, indicating their utility in investigating NO changes in the early stages of the disease. Future work with the electrodes needs to be performed to investigate the mechanisms of NO changes in DR in order to develop potential treatments which could mitigate the damage at an early stage before vision loss occurs.
M.S. in Biomedical Engineering, December 2014
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Title: TOWARD A NATURAL GENETIC/EVOLUTIONARY ALGORITHM FOR MULTIOBJECTIVE OPTIMIZATION
Creator: Ramasamy, Hariharane
Date: 2013, 2013-05
Description: Practical optimization problems often have multiple objectives, which are likely to conflict with each other, and have more than one optimal...
Show morePractical optimization problems often have multiple objectives, which are likely to conflict with each other, and have more than one optimal solution representing the best trade-offs among the competing objectives. Genetic algorithms, which optimize by repeatedly applying genetic operators to a population of possible solutions, have been used recently in multiobjective optimization, but often converge to a single solution that is not necessarily optimal due to lack of diversity in the population. Current multiobjective genetic and other evolutionary methods prevent this premature convergence by promoting new members that are dissimilar in parameter or objective space. A distance measure, which calculates similarities among the members in either objective or parameter space, is used to degrade the fitness of solutions when they are crowded in a small region. This process forces the algorithm to find new but distinct trade-off points in the objective or parameter space, but is computationally expensive. As the number of objectives or parameters increases, the methods fail to scale up and they deviate from the motivating concept of the genetic algorithm—natural evolution. We extend the standard genetic algorithm through two simple, yet powerful, changes motivated by natural evolution. In the first method, the algorithm, at each step, randomly or sequentially chooses one of the objectives for optimization; hence the method is called sequential extended genetic algorithm (SEGA). In the second method, a population is maintained for each objective, and crossover is performed selecting parents from across populations. This method is called parallel extended genetic algorithm (PEGA). We applied these methods to test problems from the literature, and to two well known problems, protein folding and multiple knapsack. We discovered our methods found better trade-off solutions than current multiobjective methods, without increasing computational complexity of genetic algorithms.
PH.D in Computer Science, May 2013
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Title: POLARIZATION COUPLING IN SEMICONDUCTOR NANO-DIMERS IN THE TERAHERTZ RANGE
Creator: Hu, Zhijing
Date: 2017, 2017-05
Description: Surface plasmon resonance (SPR) occurs at the interface of a semiconductor and a dielectric when certain conditions are satisfied. SPR is...
Show moreSurface plasmon resonance (SPR) occurs at the interface of a semiconductor and a dielectric when certain conditions are satisfied. SPR is impetus to new sensor and device development in the optical range, with nanoparticles of noble metals taking up major roles. Typical conduction band electron concentrations in semiconductors lead to resonance frequencies in the terahertz and infrared bands. While the response strength is weaker than those exhibited by metals, it can be made up for by the formation of aggregates. The added degree of freedom by doping or carrier injection further enhances the versatility of semiconductor nanoclusters. To obtain a first principle solution to the coupled set of equations for charge carrier transport and electrodynamics in a conductive cluster is a formidable task with a high computational cost. Employing a finite-element based tool, the COMSOL Multiphysics Simulation Software, the interaction inside and outside some elementary semiconductor structures such as slab and sphere have been solved, which revealed the screening of the internal field while displaying dispersion and absorptions effects. The study of semiconductor dimer also showed a significant field enhancement and frequency shift. Under strong applied field, asymmetric polarization within the particles is revealed. The accompanying nonlinear polarization response can be employed to develop new devices. These model structures can serve to provide insight to the analysis and synthesis more complex structures.
Ph.D. in Electrical Engineering, May 2017
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Title: A NANO-STRUCTURED CERAMIC/POLYMER COMPOSITE FILM FOR ELECTRONIC INTERCONNECTIONS
Creator: Harwath, Frank
Date: 2016, 2016-05
Description: Separable electrical interconnections are a ubiquitous part of modern life and for technical reasons are currently based on the use of gold....
Show moreSeparable electrical interconnections are a ubiquitous part of modern life and for technical reasons are currently based on the use of gold. Since gold is a commodity and subject to significant price fluctuations there is a need for separable interconnects not based on gold. Polymer/ceramic films were produced from various polymer precursors with loadings of multi-wall nanotubes (MWNT) and inert fillers. A variety of applications means were employed with the best success being achieved by means of a modified doctor blade. Pyrolysis was conducted in an inert atmosphere at 1 bar at a range of temperatures in a tube furnace. Pyrolysis was also conducted using a fiber laser. The modulus of the film is estimated to be 71.8 MPa with an ultimate tensile strength of 179 MPa based on hardness tests and anisotropic crack dimensions which developed as a result of uniaxial stress induced during application of the precursor. Uniaxial stress improved film adhesion regardless of filler type or level. Modification of film characteristics after pyrolysis was attempted using spark plasma sintering (SPS). Electrical testing displayed a percolation threshold above loadings of 1% (wt) of MWNTs where there is a significant drop in electrical resistivity. Further reductions in contact resistance were demonstrated up to 2% loading of MWNTs. The level of contact resistance achieved (<10) for a separable contact, in conjunction with a gold plated contact representative of most electronic connectors, indicates that an acceptable level of contact resistance may be achieved using these materials. Characterization of the film using attenuated total reflectance (ATR), xray diffraction (XRD), x-ray photoelectron spectroscopy (XPS), and Raman spectroscopy point to a morphology which is dominated by crystallites joined by regions of aliphatic carbon chains. Work function measurements were consistent with highly ordered pyrolytic graphite. (HOPG)
Ph.D. in Materials Science and Engineering, May 2016
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Title: CRITICISM, HEALTH FUNCTIONING, AND MARITAL ADJUSTMENT IN COUPLES WITH CARDIOVASCULAR DISEASE
Creator: Hicks, R. Elliott Iii
Date: 2017, 2017-07
Description: Destructive communication and hostile interactions between spouses are associated with poor behavior maintenance and can elicit substantial...
Show moreDestructive communication and hostile interactions between spouses are associated with poor behavior maintenance and can elicit substantial increases in systolic blood pressure, heart rate, and cardiac output in patients (Broadwell, & Light, 2005; Nealey-Moore et al., 2007; Ryan & Deci, 2000). This negatively impacts the cardiovascular health of the targeted partner (Nealey-Moore et al., 2007; Ryan & Deci, 2000; Smith et al., 2009). Constructive, non-hostile criticism between partners may bolster behavior change and maintenance (Zinbarg, 2007). The present study assesses the relationship between forms of criticism and reports of marital adjustment, autonomous support, health functioning, and health behavior change in a sample of couples participating in a cardiac risk reduction intervention. Results indicate that Hostile Criticism predicted Physical Health Functioning. Further, there were no significant moderating relationships. Interpretation of results and future directions are discussed.
Ph.D. in Psychology, July 2017
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Title: FROM EXPLORATION TO RATIONAL DESIGN OF SELECTIVE PROPANE DEHYDROGENATION CATALYSTS
Creator: Hu, Bo
Date: 2015, 2015-12
Description: Light olefins, e.g., ethene and propene, are important building blocks of chemical industry for the production of fuels, polymers, lubricants...
Show moreLight olefins, e.g., ethene and propene, are important building blocks of chemical industry for the production of fuels, polymers, lubricants and other fine chemicals. Due to the rapidly increasing production of shale gas, conversion of small alkanes in the shale gas, e.g., ethane and propane, to their corresponding olefins via alkane dehydrogenation could be an important industrial process. This thesis has focused on exploring the novel single site heterogeneous catalysts for selective alkane dehydrogenation and investigating the general principles of rational catalyst design to achieve a better performing (e.g., more active, more stable, highly selective) dehydrogenation catalyst. Based on the observed reactivity of ZnO for olefin hydrogenation and activity of Zn-ZSM-5 catalysts for alkane activation, catalytic properties of isolated Zn2+ were first explored for propane dehydrogenation. The 3-coordinate Zn in single site Zn/SiO2 catalyst was demonstrated to be the catalytically active species that was highly selective for the generation of propene by propane dehydrogenation. DFT calculations revealed that slow β-hydride elimination of alkyl intermediates limited the overall activity of single site Zn/SiO2 catalyst. Thus, single site Co/SiO2 was also prepared in order to take the advantage of fast β-hydride elimination. The higher activity of single site Co/SiO2 emphasized the potential of transition metals for alkane dehydrogenation, and propane dehydrogenation reactivity of transition metals was further explored by investigating single site Fe/SiO2 catalyst. By comparing with metallic Fe nanoparticles and bulk phase Fe oxides catalysts, the 3-coordinate single site Fe2+ was also suggested to be the catalytically active species for selective propane dehydrogenation. However, the catalytic activity of single site Fe/SiO2 catalyst was lower than that of Zn/SiO2. Such result suggested heterolytic cleavage of C-H bonds was slow for transition metals, e.g., Co and Fe, due to their weak Lewis acidity, and it may mitigate the advantages gained in rapid β-hydride elimination. An exploration of ligand effects for improving heterolytic cleavage over single site heterogeneous catalysts was performed. The strength of metal oxygen bond governed by ligand electron donating effects and ligand basicity were found to be the critical chemical descriptors for a facile heterolytic cleavage. Those observed principles of ligand effects would lead to a new strategy of rational catalyst design for a superior dehydrogenation catalyst.
Ph.D. in Chemistry, December 2015
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Title: TEXT MESSAGE REMINDERS AND TREATMENT ADHERENCE IN A TYPE II DIABETES POPULATION: A FEASIBILITY STUDY
Creator: Kramer, Alexis J.
Date: 2014, 2014-05
Description: Type II Diabetes (T2DM) is a chronic disease effecting millions of people worldwide. It is well documented that lifestyle changes including...
Show moreType II Diabetes (T2DM) is a chronic disease effecting millions of people worldwide. It is well documented that lifestyle changes including adherence to treatment regimens (e.g. glucose monitoring) can be very effective in reducing the onset and progression of T2DM. The literature suggests that individuals within this population are often non-compliant with treatment recommendations, for a variety of reasons (e.g. psychological factors, availability of resources, co-morbid conditions). The purpose of this study was to investigate the suitability, recruitment and retention feasibility, and preliminary outcomes of a text message reminder system on treatment adherence within a type 2 diabetic population, as measured by blood glucose levels (HbA1c). A total of 28 participants were randomized into experimental or no-treatment conditions. Participants in the experimental group received text message reminders on either a fixed or variable schedule; with either neutral or calming test message content. They also completed a qualitative feedback measure, to assess participant satisfaction with the proposed intervention. Participants in the no-treatment condition did not receive any text message reminders. All participants completed the Diabetes Care Profile (DCP) and Short Form-36 Health Form Survey, Version 2 (SF-36v2) at baseline and three months later (time 2). Preliminary analyses show that frequency of text message reminder significantly impacted glucose levels over time. The content of the text message was not shown to have a significant effect on glucose levels. Participant perception of the proposed intervention was mixed. Despite diverse recruitment efforts, recruitment was low, however, retention was high.
PH.D in Psychology, May 2014
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Title: THE EFFECT OF NANOPARTICLE SELF-STRUCTURING ON WETTING AND SPREADING OF NANOFLUIDS ON SOLID SURFACES
Creator: Kondiparty, Kirtiprakash
Date: 2011-11, 2011-12
Description: Nanofluids are suspensions of nanometer-sized particles in liquids. The nanoparticles self-structure at the three-phase contact region...
Show moreNanofluids are suspensions of nanometer-sized particles in liquids. The nanoparticles self-structure at the three-phase contact region resulting in the structural disjoining pressure gradient which causes enhanced the spreading of nanofluids compared to simple fluids without nanoparticles. In this thesis, we attempt to understand the effect of the structural disjoining pressure on the spreading dynamics of nanofluids on solid surfaces. We observed nanoparticle self-structuring phenomena during film thinning on a smooth hydrophilic glass surface using a silica-nanoparticle aqueous suspension and reflected light interferometry. Our experiments revealed that film formed from small drop is thicker and contains more particle layers than a film formed from large drop. The data for the film-meniscus contact angle verses film thickness were obtained and used to calculate the structural energy isotherm of an asymmetric film. We studied the effect of structural disjoining pressure on the wedge meniscus profile formed by an oil drop on solid surface surrounded by nanofluid using Laplace Equation augmented with the structural disjoining pressure. Our analyses indicate that a suitable combination of the nanoparticle concentration, nanoparticle size, contact angle, and capillary pressure can result not only in the displacement of the three-phase contact line, but also in the spontaneous spreading of the nanofluid as a film on solid surface. We validated our theoretical predictions using experiments where we observed spreading of nanofluid on glass surface displacing a sessile drop of canola oil. The dynamic spreading of the nanofluid on a solid surface between a sessile oil drop on solid surface was experimentally measured using reflected light microscopy. We xiv obtained the rate of nanofluid spreading by plotting the position of the inner contact line with time. The nanofluid film was found to spread at a constant velocity. We modeled the spreading dynamics of the nanofluid film using the lubrication approximation of the Navier-Stokes Equation, taking into consideration the structural disjoining pressure in the over-all pressure balance. The model was evaluated by estimating the rate of nanofluid spreading for the 10v% nanofluid. The rate of spreading thus predicted by the dynamics model for 10v% nanofluid was in good agreement with the experimental observations.
Ph.D. in Chemical Engineering, December 2011
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Title: INVESTIGATING THE IMPACT OF EDUCATION AND CONTACT-BASED ANTI-STIGMA INTERVENTIONS ON THE STIGMA OF MENTAL ILLNESS IN THE COLLEGE POPULATION
Creator: Kosyluk, Kristin
Date: 2014, 2014-12
Description: Approximately one in four college students screen positive for a mental illness, however many who might benefit from mental health care do not...
Show moreApproximately one in four college students screen positive for a mental illness, however many who might benefit from mental health care do not seek treatment. Amongst both the general adult population and college students, stigma has been shown to be a predictor of treatment engagement, with higher levels of stigma with regard to mental illness predicting lower levels of treatment utilization. It has been demonstrated in the general adult population that contact-based anti-stigma programs are the most effective approach to stigma change, followed by education-based programs. This study aimed to investigate the impact of contact- and education-based anti-stigma interventions, relative to a control condition, on mental illness stigma, affirming attitudes towards individuals with mental illness, discrimination towards individuals with mental illness, and treatment seeking amongst college students. Both contact- and education-based interventions were found to have a significant impact on personal stigma, perceptions of empowerment, desired social distance from individuals with mental illness (a proxy of discrimination), attitudes towards treatment seeking, and intentions to seek treatment from formal sources of support. No difference in effect was demonstrated between the contact- and education-based conditions. These findings suggest that these two approaches may be equally effective for challenging stigma amongst college students.
Ph.D. in Psychology, December 2014
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Title: NEUROPATHOLOGIC CORRELATES OF BRAIN MACROSTRUCTURE
Creator: Kotrotsou, Aikaterini
Date: 2014, 2014-07
Description: Alzheimer’s disease, the most common form of dementia, is a degenerative disorder of the brain that leads to memory loss. Clinical diagnostic...
Show moreAlzheimer’s disease, the most common form of dementia, is a degenerative disorder of the brain that leads to memory loss. Clinical diagnostic techniques in use today rely on mental and behavioral tests and physical examinations and only provide diagnoses of possible or probable Alzheimer’s disease. However, lately it has become clear that clinical-pathological correspondence is not always consistent. A definitive diagnosis of Alzheimer’s disease is only possible via histology, when the density of neurofibrillary tangles and amyloid plaques is measured. Therefore, the development of a reliable neuroimaging technique that allows detection of Alzheimer’s pathology during life is needed. This method would be noninvasive, and could allow the detection of Alzheimer’s disease in the early stages, and could be also used to monitor the progression of the disease through time. The purpose of this work was to investigate the use of magnetic resonance imaging (MRI) as diagnostic tool for Alzheimer’s pathology and other age-related neurodegenerative pathologies that are common in older persons. To uncover the anatomical origins and determine the macrostructural signatures of age-related neuropathologies, it is necessary to link MRI findings with pathologic information on the same individuals. In this work, we focused on imaging cerebral hemispheres ex-vivo, when a complete pathology report was available from a board-certified neuropathologist. The main difference between this work and any other study is the abundance of postmortem imaging data paired with neuropathology data in a relatively large pool of subjects. First, we developed and validated a protocol to perform ex-vivo MR volumetry. By using this protocol we observed the longitudinal behavior of the volume of different brain regions. Furthermore, we tested the hypothesis that volumetric measurements performed ex-vivo are associated with in-vivo measurements. It was shown that: (a) regional brain volumes measured with this approach for ex-vivo MR volumetry remain relatively unchanged for a period of 6 months postmortem, and (b) a linear correspondence was detected between in-vivo and ex-vivo measurements, suggesting that this approach captures information linked to antemortem macrostructural brain characteristics. Using the approach for ex-vivo MR volumetry, we combined ex-vivo MR volumetry with pathology on the same adults. AD pathology was significantly negatively correlated with volumes of cortical gray matter regions, mainly in the temporal, frontal, parietal and cingulate cortices, subcortical gray matter, and whole-hemisphere white matter. A significant negative correlation was shown between hippocampal sclerosis and volumes of the hippocampus, as well as other temporal and frontal gray matter regions. Finally, we performed a morphometric MRI study to investigate associations of brain volumes with pathology using voxel-based analysis. This technique allows the assessment of gray and white matter volumes in subjects with different pathologies compared with controls in an automated fashion, across the whole brain. AD pathology was negatively associated with regions of gray matter and white matter located in temporal and frontal lobes, and orbitofrontal cortex. This work examined the associations of brain volumes with Alzheimer’s pathology and other typed of age-related neurodegenerative pathologies. Combining histological result with MR images requires that the time elapsed between imaging and histology is minimal. Ex-vivo MRI provides images at essentially the same time-point as histological examination of the tissue, and this study is unique in that it involves a large number of cadaveric brain hemispheres. The findings of this ex-vivo study could allow for future standardization of MRI as a biomarker of neurodegenerative diseases, and also allow in identification and classification of subjects in groups for tests of new drugs.
Ph.D. in Biomedical Engineering, July 2014
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Title: DEVELOPMENT OF ADVANCED PACKAGING, FABRICATION AND RELIABILITY METHODS FOR SUBMINIATURE IMPLANTABLE NEURAL PROSTHESES
Creator: Kim, Taehyung
Date: 2011-08, 2011-07
Description: The main purpose of the present thesis is to study the critical reliability issues of polymeric encapsulated electronic devices for visual...
Show moreThe main purpose of the present thesis is to study the critical reliability issues of polymeric encapsulated electronic devices for visual prosthesis. Visual prosthesis has been compatibly studied over twenty years in many professional research labs. The electric design of circuit for the visual prosthesis has been well studied so far. However, the device packaging design and reliability have been not studied extensively. In particular, failure analysis and reliability using non-hermetic packaging for long lifetime visual prosthesis have been poorly studied. The first step of the research for this thesis was to create a mechanical design of a visual prosthesis prototype. The prototype device was created by fabricate a multi-layer structure consisting of electrodes, substrate, and integrated circuit chip with silicone encapsulated packaging. The interconnection between the chip and electrodes used Au wire and Al bonding pad. The prototype devices were tested in a liquid water. This water environment is not a common reliability test for commercial electronic packaging. Relative humidity testing is a common and widely used testing methods, but the visual prosthesis device cannot be applied to gas phase relative humidity testing due to the environment condition. Water absorption in polymeric material in the liquid water is higher than in the vapor water. After water penetrated interconnection interface, the Au-Al intermetallic compound becomes oxidized and generates bonding die open failure. From these unusual testing results, we were conformed the failure mechanism and predicted the lifetime using Au-Al imtermetallic growth pattern and oxidation. Additional discussions include transition metal ions in CSF to expect the other failure mechanisms. Wafer and packaging level xiii failure mechanisms by Cu and Fe ions are also discussed in this thesis. The end of this thesis discuss possible fabrication processing to protect overall external environment effects for polymeric packaging visual prosthesis. Overall this thesis study, which uses polymeric packaging electronic devices for bio-implant research, concluded that devices may not make good reliability devices in the CSF environment. The corrosion, oxidation and metallization on or in metal surfaces and interconnection interfaces should continually be studied to produce longer lasting electronic devices over 30 years. The reliability of the visual prosthesis has not been well studied in any other professional research labs, so this thesis may give or address some initial guidelines to help save time for the project decision in the future to develop advanced hermetic packaging for bioimplantable electronic devices.
Ph.D. in Materials Science and Engineering, July 2011
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Title: BLADE PITCH OPTIMIZATION METHODS FOR VERTICAL-AXIS WIND TURBINES
Creator: Kozak, Peter
Date: 2016, 2016-07
Description: Vertical-axis wind turbines (VAWTs) offer an inherently simpler design than horizontal-axis machines, while their lower blade speed mitigates...
Show moreVertical-axis wind turbines (VAWTs) offer an inherently simpler design than horizontal-axis machines, while their lower blade speed mitigates safety and noise concerns, potentially allowing for installation closer to populated and ecologically sensitive areas. While VAWTs do offer significant operational advantages, develop- ment has been hampered by the difficulty of modeling the aerodynamics involved, further complicated by their rotating geometry. This thesis presents results from a simulation of a baseline VAWT computed using Star-CCM+, a commercial nite volume (FVM) code. VAWT aerodynamics are shown to be dominated at low tip- speed ratios by dynamic stall phenomena and at high tip-speed ratios by wake-blade interactions. Several optimization techniques have been developed for the adjustment of blade pitch based on finite-volume simulations and streamtube models. The effectiveness of the optimization procedure is evaluated and the basic architecture for a feedback control system is proposed. Implementation of variable blade pitch is shown to increase a baseline turbine's power output between 40%-100%, depending on the optimization technique, improving the turbine's competitiveness when compared with a commercially-available horizontal-axis turbine.
Ph.D. in Aerospace and Mechanical Engineering, July 2016
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Title: LIPID-LIPID AND LIPID-DRUG INTERACTIONS IN BIOLOGICAL MEMBRANES
Creator: Martynowycz, Michael W.
Date: 2016, 2016-07
Description: Interactions between lipids and drug molecules in biological membranes help govern proper biological function in organisms. The mechanisms...
Show moreInteractions between lipids and drug molecules in biological membranes help govern proper biological function in organisms. The mechanisms responsible for hydrophobic drug permeation remain elusive. Many small molecule drugs are hydrophobic. These drugs inhibit proteins in the cellular interior. The rise of antibiotic resistance in bacteria is thought to be caused by mutations in protein structure, changing drug kinetics to favor growth. However, small molecule drugs have been shown to have different mechanisms depending in the structure of the lipid membrane of the target cell. Biological membranes are investigated using Langmuir monolayers at the airliquid interface. These offer the highest level of control in the mimetic system and allow them to be investigated using complementary techniques. Langmuir isotherms and insertion assays are used to determine the area occupied by each lipid in the membrane and the change in area caused by the introduction of a drug molecule, respectively. Specular X-ray re ectivity is used to determine the electron density of the monolayer, and grazing incidence X-ray diffraction is used to determine the inplane order of the monolayer. These methods determine the affinity of the drug and the mechanism of action. Studies are presented on hydrophobic drugs with mammalian membrane mimics using warfarin along with modified analogues, called superwarfarins. Data shows that toxicity of these modified drugs are modulated by the membrane cholesterol content in cells; explaining several previously unexplained effects of the drugs. Membrane mimics of bacteria are investigated along with their interactions with a hydrophobic antibiotic, novobiocin. Data suggests that permeation of the drug is mediated by modifications to the membrane lipids, and completely ceases translocation under certain circumstances.
Ph.D. in Physics, July 2016
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