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Title: Integrated Design Framework For Electric Motor Drive Systems
Creator: Salameh, Mohamad
Date: 2020
Description: This thesis aims to develop a flexible and time-efficient framework for machine design optimization that considers driving cycles,...
Show moreThis thesis aims to develop a flexible and time-efficient framework for machine design optimization that considers driving cycles, multiphysics domains and current design. The proposed development of the framework is based on the enhancement of three key aspects in the machine design process. A data mining algorithm – the X-means – is employed in the driving cycle analysis, to establish a trade-off between the optimization objectives and the computational intensity. A novel vibration surrogate model is proposed to evaluate the vibroacoustic behavior of the machine in an accurate and time-efficient way. In the identification process, the time effectiveness of the model is attained with a minimized number of finite element simulations. Furthermore, the principle of simultaneous coupled optimization is considered in the framework, where current design variables are included in the optimization environment to allow identifying design candidates with improved performance.
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Title: IDENTIFICATION OF BAX∆2 FRAMESHIFTING REGION VIA DUAL LUCIFERASE ANALYSIS
Creator: Reiner, Katherine
Date: 2020
Description: The antitumor protein Bax is susceptible to microsatellite instability (MSI) mutations that alter its open reading frame by changing Baxs’...
Show moreThe antitumor protein Bax is susceptible to microsatellite instability (MSI) mutations that alter its open reading frame by changing Baxs’ microsatellite of eight guanines (G8) to seven guanines (G7). This mutation results in a frameshift that is corrected by alternative splicing, making Bax∆2. Evidence shows that non-MSI mutated full length Bax∆2 (Bax∆2 G8) can be found in tissue. However, the extra guanine in Bax∆2 should result in premature termination of protein synthesis. Therefore, we believe that Bax∆2 is capable of +1 frameshifting to correct the out of frame sequence caused by splicing. The dual luciferase assay system is a useful tool for measuring frameshifting and in this study, we cloned full length Bax∆2 G8 into a dual luciferase vector to analyze frameshifting. Using this method, we found that the full length Bax∆2 G8 sequence has 3.5% frameshifting activity. To further determine whether the frameshifting occurs in or near the G8 microsatellite, we focused on several truncated constructs containing the first three exons. The results from dual luciferase assay showed that frameshifting activity was high in the constructs containing the G8 microsatellite but diminished when the G8 microsatellite region was removed. Surprisingly, constructs containing exon 4 and 5, which are away from the predicted frameshifting region, also showed frameshifting activity. One possibility to explain these results is that mRNA structures, which are critical to frameshifting, could be altered by construct truncation and consequently lead to artificial frameshifting. Thus, using truncated constructs may not be a viable option for testing frameshifting activity. To maintain mRNA integrity, point mutations within the full sequence, could be a better option to identify the frameshifting site.
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Title: MULTIYEAR AUTOMATED ANALYSIS OF AURORAL IMAGES TO CATEGORIZE IONOSPHERE IRREGULARITY LAYER
Creator: Stuart, David Jacques
Date: 2020
Description: This thesis presents a method of automated analysis of auroral all-sky images (ASIs) to determine the ionospheric layer of plasma...
Show moreThis thesis presents a method of automated analysis of auroral all-sky images (ASIs) to determine the ionospheric layer of plasma irregularities. These irregularities can perturb radio signals in an effect called scintillation, degrading and at worst preventing signal reception. One key question about scintillation-causing irregularities is whether they occur in the E or F layer of the ionosphere, whose dynamics differ.Previous studies have shown Global Positioning System (GPS) scintillation to be correlated with aurorae. The Scintillation Auroral GPS Array (SAGA) at Poker Flat Research Range, Alaska, was used to detect thousands of GPS L1 and L2C scintillation events over 2014-2015. Collocated auroral images of emissions are recorded nightly by both a keogram spectrograph (measuring intensity along a single longitude vs time) and an ASI filtered at 630.0 nm (red), 557.7 nm (green), and 427.8 nm (blue) wavelengths.In this work scattering layers are hypothesized based on optical measurements, through automated filtering of keograms followed by spectral analysis of aurorae, which tend to occur with these irregularities. A cloud detection method using the North-South keogram is implemented, where a time-averaged, intensity-corrected characteristic snapshot of cloudy times was built as a baseline response, and used as the gain in a flat field correction-like step to normalize the cloudy sky appearance. The coefficient of variation Cv is used as the test statistic to determine cloudy times. Cloud-free ASIs have the location of scintillating PRNs identified, and the ratio of red oxygen 630 nm to blue nitrogen 428 nm emissions in that direction. With an auroral model of characteristic energy, ratios above 0.5 are categorized E-Layer and ratios below F-Layer.Multiyear ASI irregularity layer determinations are used to categorize 364 of the initial 4174 SAGA scintillation events. A 77% majority of the events are hypothesized to be F-Layer based on ASI spectral classification. This disagrees with prior PFISR categorizations, which found scintillation events to be majority E-layer. This presents an outstanding question as to the possible reasons for the difference.
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Title: Scale and Scope Economies Drive Asymmetric Competition in Tech Industries
Creator: Ryali, Balajirao
Date: 2020
Description: This research is motivated by my industry experience of working with small manufacturers in the high technology industry market space and ...
Show moreThis research is motivated by my industry experience of working with small manufacturers in the high technology industry market space and large manufacturers in the telecom and healthcare industry market spaces. In these industries, small manufacturers thrive on specialization and focus on breakthrough innovation to maintain product differentiation and premium positioning and to sustain competition. In contrast, large manufacturers enjoy the benefits of economies of scale that provide cost efficiencies and use price as major differentiating factor. This research work endeavors to model asymmetric competition that emerges endogenously in industries where scale and scope economies interact to force firms to adopt specialized strategies and address the below research questions:1. How does the cost structure shaped by scope and scale economies in engineering, sales and service drive asymmetric product line choices?2. What channel coordination problems arise in this context?3. How can manufacturers redesign their operating mechanism and sales force to optimize the channel?
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Title: ANALYSIS AND OPTIMIZATION OF VIBRATION AND ACOUSTIC NOISE IN SWITCHED RELUCTANCE MACHINES
Creator: Yaman, Selin
Date: 2019
Description: One of the main drawbacks of switched reluctance machines (SRM) is the vibration and high acoustic noise compared to other electrical motors....
Show moreOne of the main drawbacks of switched reluctance machines (SRM) is the vibration and high acoustic noise compared to other electrical motors. The root cause of the high level of acoustic noise is radial forces with high harmonic content. These harmonics may trigger resonant modes in the stator and cause the machine to create high vibration and acoustic noise. To better understand the factors influencing vibration and acoustic noise in an SRM, this dissertation first develops a multi-physics model in ANSYS Workbench environment and carries out a comprehensive analysis of multiple variations in stator and rotor geometries. Based on this understanding, this dissertation identifies distinct factors affecting noise in the machine, which are affected by electromagnetic design and power electronic control. From the electromagnetic perspective, geometrical optimizations in the stator and rotor structures are evaluated to understand the impact on NVH (noise, vibration and harshness) performance. This background is used to develop a fast geometry-sensitive analytical approach to reduce acoustic noise in the machine. While optimizing the geometry for a silent machine design, different design of experiments (DoE) methods and response surface (RS) optimization methods are also compared and presented. Furthermore, material analysis is included in structural design, where high flux material effect on vibration and acoustic noise is observed. The second topic of the NVH analysis is power electronic and switching solutions. In this study, multiple basic and advanced switching techniques have been considered and optimized to reduce acoustic noise under a preset efficiency constraint. Further, a time efficient model of SRM is introduced with vibro-acoustic noise perspective by developing a computationally cost effective SRM modeling. By using this analytical time-efficient NVH model, a current shape optimization is implemented, and results are discussed. Finally, experimental validations are provided for NVH and psychoacoustics analysis for different operating conditions and current control methods.
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Title: COMMUNICATION-BASED DISTRIBUTED CONTROL IN MICROGRIDS AND NETWORKED MICROGRIDS
Creator: Zhou, Quan
Date: 2019
Description: Microgrids representing localized small-scale power systems are capable of operating as self-controlled entities, which cluster and manage...
Show moreMicrogrids representing localized small-scale power systems are capable of operating as self-controlled entities, which cluster and manage distributed energy resources (DERs) and other smart devices within a defined electrical boundary. By utilizing locally available resources, microgrids reduce their dependencies on the utility grid, which provide more reliable, resilient, and economic power services to local customers. Geographically close microgrids can be connected for forming a networked microgrid system, which provides additional operational flexibility and further enhances the system reliability and resilience by sharing available DERs.Considering variable and controllable characteristics of DERs, locally available DERs need to be appropriately coordinated and controlled to respond to changing loads. The proliferation of microgrids will make it inevitable to rely on communication systems among microgrids for realizing the coordinated control of participating DERs in networked microgrid systems. The networked microgrid system is considered as a cyber-physical system (CPS) which requires sophisticated network technologies to cope with the massive adaption of communication, computation and control devices. Conventionally, a networked system has been managed by a centralized master controller, which processes the data collected from participating DERs and sends operational set points to each participant.Compared with the centralized control strategies, distributed control is more advantageous for connecting participating DERs. The connectivity of distributed control system (i.e., meshed network) is higher than that of a centralized structure (i.e., star network), in particular when critical circumstances are encountered in which some of the network connections are lost. Also, the distributed control system enables parallel data processing and control, which speeds up the networked system response to variable DERs and loads and promote economic merits. The communication-based distributed control strategies have proven to demonstrate higher reliability, resilience, and scalability while possessing lower implementation costs as compared with centralized control strategies.We have proposed several communication-based distributed control strategies for realizing the coordinated operation of participating microgrids and DERs, which can be applied to achieve various operational objectives, including proportional active power sharing, DER plug-and-play capability, seamless microgrid islanding, and resynchronization operations, and optimal economic operations. The benefits and challenges of communication-based distributed control strategies in networked microgrid systems are discussed and addressed in our work. Extensive case studies have been conducted in this thesis to validate the effectiveness of the proposed communication-based distributed controller design.
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Title: Environmental Monitoring of University Archives and Special Collections
Creator: Strohm, Adam
Date: 2020
Description: This is the final report and analysis of activities conducted as part of Environmental Monitoring of University Archives and Special...
Show moreThis is the final report and analysis of activities conducted as part of Environmental Monitoring of University Archives and Special Collections, a project funded by a Preservation Assistance Grant from the National Endowment of the Humanities (PG-263471-19). This grant was awarded to support the first evercsystematic environmental monitoring of the UASC spaces. This report includes a summary of the collected data, analysis of the data, and potential future activities to be undertaken as a result of the grant activities and the data collected.
Sponsorship: National Endowment For The Humanities, Preservation Assistance Grants for Smaller Institutions
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Title: Novel Chelating Agents for Positron Emission Tomography Imaging and Theranostic Applications
Creator: Zhang, Shuyuan
Date: 2022
Description: Positron emission tomography (PET) is a molecular imaging technology that can be used to detect various diseases including cancer. Zirconium...
Show morePositron emission tomography (PET) is a molecular imaging technology that can be used to detect various diseases including cancer. Zirconium-89 (t1/2 = 78.4 h) is one of the positron-emitting radionuclides that has been widely explored for PET imaging because its half-life matches the long biological half-life of antibody. Research efforts have been devoted to the development of chelation chemistry for 89Zr, a bone-seeking radionuclide. Deferoxamine (DFO) is the most frequently used chelator for 89Zr in both clinical and preclinical trials. DFO can rapidly sequester 89Zr to form 89Zr-DFO complex. However, DFO is not an ideal ligand for 89Zr because 89Zr-labeled DFO-antibody conjugate showed high bone uptake in mice. We wanted to develop novel small molecule donors and novel chelators for 89Zr. We discovered N-methyl-N-(pyridin-2-yl)hydroxylamine (Py-HA) and 2,6-bis(N-methylhydroxylamino)pyridine (Py-BHA) as small molecule donors for 89Zr. Based on the new small molecule donors (Py-HA and Py-BHA), we have designed and synthesized a series of novel macrocyclic chelators containing TACN (1,4,7-triazacyclononane), CYCLEN (1,4,7,10-tetraazacyclododecane), and a diaza-crown ether backbone for 89Zr-based PET imaging applications. Moreover, bifunctional chelators (BFCs) structured on TACN and diaza-18-crown-6 were synthesized for conjugation to antibody. Theranostics contains a diagnostic agent and a therapeutic drug that can be used for simultaneous therapy and imaging of diseases. Radiotheranostics includes radiometal complexes for both therapy and imaging. 177Lu is a promising radiotheranostic metal because it can emit gamma radiation for single photon emission computed tomography (SPECT) imaging and emit β radiation for radiotherapy. A radioisotope pair with complementary emission such as 64Cu/67Cu and 86Y/90Y, can be used for PET imaging and radiotherapy. In this study, we synthesized nonfunctional TACN and diaza crown ether-backboned chelators containing different donor groups for 177Lu, 64Cu/67Cu, and 86Y/90Y. Finally, two bifunctional chelators were synthesized for coupling with hydroxamic acid-based small molecule as a potential histone deacetylase (HDAC) inhibitor to generate a small molecule ligand-chelator conjugate (SMLC) for theranostic applications.
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Title: Semantics and further Use-Cases and Evaluation of the C-Saw language
Creator: Zhu, Henry, Zhao, Junyong, Sultana, Nik
Date: 2023-03-09
Description: This report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software...
Show moreThis report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software architecture patterns. This report provides additional examples of using C-Saw, supplementary evaluation details, and it defines the formal semantics of the language.
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Title: Hooker on Wells Street
Creator: LeVant, Howard
Date: 1966-1969
Description: Date of photograph is unknown. Date range listed (1966-1969) is approximate. Title supplied by Howard LeVant.
Collection: Howard LeVant papers, 1950-2020

Title: Picasso statue
Creator: LeVant, Howard
Date: 1970-1978
Description: Photograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date...
Show morePhotograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Nuns picnicking
Creator: LeVant, Howard
Date: 1967-1969
Description: Photograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title...
Show morePhotograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Rabbi writing a new Torah
Creator: LeVant, Howard
Date: 1977
Description: Title supplied by Howard LeVant, labeled as personal/historical photo.
Collection: Howard LeVant papers, 1950-2020

Title: Norwegian Landscape
Creator: LeVant, Howard
Date: 1986
Description: Digitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title...
Show moreDigitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Bungalow - Alternate front elevations for wide or narrow lots
Creator: Gordon, Robert Philip
Date: 1990
Description: Hand-colored laser print.
Collection: Robert Philip Gordon papers, 1963-2010

Title: English Hill Street
Creator: LeVant, Howard
Date: 1976
Description: Digitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title...
Show moreDigitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant.
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Collection: Howard LeVant papers, 1950-2020

Title: Northeast corner of 35th Street and State Street, Chicago, Illinois, January 24, 1954
Date: 1954-01-24
Description: Color slide depicting the intersection of 35th Street and South State Street, looking northeast. Photographer unknown, possibly a member of...
Show moreColor slide depicting the intersection of 35th Street and South State Street, looking northeast. Photographer unknown, possibly a member of the university's Department of Public Relations.
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Collection: Dan Ryan collection, 1954-1980

Title: Kaplan's Junkyard, Chicago, Illinois, 1959
Date: 1959
Description: Two photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of...
Show moreTwo photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of Technology Campus. The Chicago Land Clearance Commission acquired the land on which the junkyard stood in 1958, and demolition occurred in 1959, after which the land was sold to Illinois Tech. Photographer unknown.
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Collection: Office of Communications and Marketing photographs, 1905-1999

Title: Mecca Flats, Chicago, Illinois, ca. 1951
Creator: Yuskaitis, Robert J
Date: 1951
Description: Photograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham,...
Show morePhotograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham, and were demolished in 1952. Originally constructed as a hotel for the World's Columbian Exposition of 1893, the 96-unit Mecca building became an apartment building after the fair. The building was acquired by Illinois Tech around 1941, and was demolished in 1952 to make way for the construction of S.R. Crown Hall. The building was also known as Mecca Apartments, and The Mecca.
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Collection: Office of Communications and Marketing photographs, 1905-1999

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