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Title: Efficiency of Carbon Fiber Composite Structural Systems for Tall Buildings: A Parametric Simulation Based Framework for Finite Element Analysis
Creator: Khairnar, Piyush Rajendra
Date: 2022
Description: The rate of global urban migration has increased drastically over the last century. With increasing population, the need for dense urban...
Show moreThe rate of global urban migration has increased drastically over the last century. With increasing population, the need for dense urban habitats is growing. Tall buildings are at the forefront of this growth and changing skyline of different cities around the globe is evident. The Structural system is an important and critical component of any tall building. Structural material can significantly impact the performance of a structural system as well as the way it is constructed. Carbon composite is known for its high strength and stiffness, also it is a lightweight structural material. Current industrial techniques allow for manufacturing of structural components made of carbon composite to be used in building structures. Carbon composite as a structural material shows potential to be used in tall buildings where strength and stiffness requirements are a key parameter.This research focuses on applications of Carbon Composite, also known as Carbon Fiber Reinforced Polymer (CFRP), as a structural material for tall buildings. The research aims to study the properties of carbon composite as a structural material and to explore its application in the structural system for tall buildings. Mechanical properties of CFRP such as strength, stiffness, etc. are studied with available literature to assess the potential of the material to be used in the design of structural system for tall buildings. Manufacturing processes along with fabrication methods are also studied to investigate the constructability using CFRP. The research draws attention on the issues of connectivity within CFRP structural components as well as performance of CFRP as a structural material in tall building structural systems. Computer based simulations are utilized to develop digital models and analyze the performance of the material in structural systems of tall buildings. Current applications of the material in building and construction sector are addressed in the literature review. This research evaluates the performance of the structural systems for tall buildings using carbon composite as the primary structural material. Connection level simulations presented in this research provide insights on the significance of fiber orientation in the fabrication of structures. Other challenges in the widespread use of CFRP material in tall buildings are addressed in the research but focus of the research is on the structural applications of the material in tall buildings. The research provides information about the use of CFRP as a structural material in tall buildings. The results of this study offer significant insights about the issues of connectivity and constructability related to use of CFRP in tall buildings. This research also provides a parametric framework for architects and designers to evaluate and study the performance of a structural materials to be used in tall building structural systems using finite element analysis.
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Title: Evaluating the Impact of Residential Indoor Air Quality and Ventilation and Filtration Interventions on Adult Asthma-Related Health Outcomes in Chicago, IL
Creator: Kang, Insung
Date: 2022
Description: Human exposure to a variety of airborne pollutants is associated with various adverse health effects, ranging from respiratory symptoms to...
Show moreHuman exposure to a variety of airborne pollutants is associated with various adverse health effects, ranging from respiratory symptoms to exacerbation of chronic diseases to cardiovascular disease and cancer. While most of our knowledge of the adverse impacts of air pollution comes from studies utilizing outdoor air pollutants as surrogates for exposure, people spend most of their time indoors, especially at home, where pollutant concentrations are often higher than outdoors. And within homes, mechanical ventilation systems and filtration are increasingly recommended to provide fresh air for ventilation and dilute indoor pollutant sources. There are a variety of ventilation system types that can be used for home retrofits; however, there is limited information on how they affect indoor air quality (IAQ) from both indoor and outdoor sources and how they influence occupant health and well-being. Therefore, to fill some of these knowledge gaps, this research aims to evaluate the effects of indoor air quality broadly, as well as interventions with three common types of residential mechanical ventilation system retrofits (i.e., continuous exhaust-only, intermittent fan-integrated supply, and continuous balanced systems with energy recovery ventilators), on asthma-related health outcomes in a cohort of adults in Chicago, IL. The key findings of this dissertation indicate that exposures to indoor NO2 and PM, higher indoor temperature, and mold/dampness were associated with poorer asthma control. The home ventilation and air filtration interventions, regardless of ventilation system type, significantly improved asthma control of the study population (~4% increase in ACT score; p < 0.001), and led to reductions in indoor concentrations of formaldehyde (HCHO) (-19.5 ppb; -63%; p < 0.001), carbon dioxide (CO2) (-120 ppm; -15%; p < 0.001), nitrogen dioxide (NO2) (-1.8 ppb; -3%; p = 0.035), and particulate matter (PM), including PM1 (-4.9 µg/m3; -43%; p = 0.001), PM2.5 (-4.9 µg/m3; -39%; p = 0.003), and PM10 (-6.2 µg/m3; -41%; p = 0.003). Additionally, asthma control was significantly improved in all subgroups: participants who received both ventilation and filtration interventions (~6% increase in ACT score; p < 0.001); continuous exhaust-only systems (~3% increase in ACT score; p = 0.033); intermittent central-fan-integrated-supply (CFIS) systems (~3% increase in ACT score; p = 0.018); and continuous balanced systems with an energy recovery ventilator (ERV) (~7% increase in ACT score; p < 0.001). Indoor CO2 concentrations were significantly reduced in homes with continuous ventilation systems, including exhaust-only (-165 ppm, -20%; p = 0.005) and balanced ERV systems (-186 ppm, -23%; p = 0.004), while indoor particulate matter (PM1, PM2.5, and PM10) concentrations were significantly reduced in homes with ventilation systems with filtration upgrades, including CFIS (PM1: -5.3 µg/m3, -46%; PM2.5: -5.0 µg/m3, -39%; and PM10: -6.2 µg/m3, -41%; all p < 0.05) and balanced ERV systems (PM1: -7.5 µg/m3, -59%; PM2.5: -8.3 µg/m3, -58%; and PM10: -10.4 µg/m3, -61%; all p < 0.05). Last, results of a cost-benefit analysis (CBA) of the three types of mechanical ventilation systems over an assumed 10-year life span, which predicted impacts on mortality and asthma outcomes based on measured impacts on two indoor pollutants – PM2.5 and NO2 – relative to initial and operational costs, as well as filtration upgrade costs, suggest that the intermittent CFIS system with improved MERV 10 filtration was the most beneficial approach, with the central benefit-cost ratio (BCR) of 6.0, followed by the continuous balanced ERV system (central BCR = 3.7) and exhaust-only system (central BCR = 3.2). This dissertation provides the first known empirical data in the U.S. on asthma outcomes associated with different types of mechanical ventilation systems that have highly varying impacts on indoor pollutant concentrations of both indoor and outdoor origin and environmental conditions. Results are also expected to provide much-needed guidance to homeowners, contractors, builders, and agencies on the advantages and disadvantages of different types of residential mechanical ventilation systems.
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Title: Self-Reconfigurable Soft Robots Based on Boundary-Constrained Granular Swarms
Creator: Karimi, Mohammad Amin
Date: 2022
Description: Unlike conventional robots, which consist of rigid bodies and linkages, soft robots are composed of compliant and flexible components and...
Show moreUnlike conventional robots, which consist of rigid bodies and linkages, soft robots are composed of compliant and flexible components and actuators. This distinction enables adaptive behaviors in response to unpredictable environments, like manipulating objects with a variety of shapes. As such, soft robots afford greater potential over traditional robots for safe human interaction.Despite these advantages, there remain obstacles due to the challenges in modeling, controlling, and fabricating soft materials. For example, soft robots that rely on thermal or electrical actuation are typically slow to respond and unable to apply large forces as compared to traditional robots. Pneumatically actuated soft robots, while more responsive and capable of applying larger forces, generally need to be tethered to external control mechanisms, which becomes limiting in tasks that require lightweight, autonomous functionality.In contrast, this thesis describes a new type of robot that exhibits those same characteristics, but achieves them via a boundary-constrained swarm.The robotic structure consists of passive granular material surrounded by an active membrane that is composed of a swarm of interconnected robotic sub-units. The internal components are important for overall function, but their relative configuration is not. This allows for an effectively random, unstructured placement of the internal components, which in turn creates excellent morphability. Collectively, the subunits determine the overall shape of the robot and enable locomotion through interaction with external surfaces.The constrained swarm embodies the continuum, compliant, and configurable properties found in soft robots, but in this state the robot is limited in its ability to manipulate objects due to the relatively low force it can apply to external objects.To address this issue, the unique ability to execute a jamming phase transition is added to the robot. Importantly, jamming is controlled by the degree by which the passive particles are spatially confined by the membrane, and this in turn is controlled by the active sub-unit robots using different jamming mechanisms. The robot exploits its ability to transition between soft (unjammed) and rigid (jammed) states to induce fluid-like flexibility or solid-like rigidity in response to objects and features in the environment.In order to investigate this design concept, I have studied different prototype designs for the robot that varied in terms of the locomotion and jamming mechanisms. I also present a simulation framework in which I model the design and study the scalability of this class of robots. The simulation framework uses the Project Chrono platform, which is a multi-body dynamics library that allows for physics-driven collision and contact modeling.
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Title: Workload Interference Analysis and Mitigation on Dragonfly Class Networks
Creator: Kang, Yao
Date: 2022
Description: Dragonfly class of networks are promising interconnect topologies that support current and next-generation high-performance computing (HPC)...
Show moreDragonfly class of networks are promising interconnect topologies that support current and next-generation high-performance computing (HPC) systems. Serving as the "central nervous system", Dragonfly tightly couples tens of thousands of compute nodes together by providing high-bandwidth, low-latency data exchange for exascale computing capability. Dragonfly can support unprecedented system scale at a reasonable cost thanks to its hierarchical architecture. In Dragonfly systems, network resources such as routers and links are arranged into identical groups.Groups are all-to-all connected through global links, and routers within groups are connected via local links. In contrast to the fully connected inter-group topology, connections for the routers within groups are designed according to the system requirement. For example, the one-dimensional all-to-all connection is favored for higher network bandwidth, a two-dimensional grid arrangement can be constructed to support larger system size, and a tree structure router connection is built for the extreme system scale. The hierarchical design with groups enables the topology to support unprecedented system size while maintaining a low-diameter network. Packets can be minimally delivered by simply traversing the network hierarchy between groups through global links and reaching their destinations through local links. In case of network congestion, packets can be non-minimally forwarded through any intermediate group to increase the system throughput. As a result, all network resources are shared such that links and routers are not dedicated to any node pair. While link utilization is increased, shared network resources lead to inevitable network contention among different traffic flows, especially for the systems that hold multiple workloads at the same time. This network contention is observed as the workload interference that causes degraded system performance with delayed workload execution time. In this thesis, we first model and analyze the workload interference effect on Dragonfly+ topology through extensive system simulation.Based on the comprehensive interference study, we propose Q-adaptive routing, a multi-agent reinforcement learning based solution for Dragonfly systems. Compared with the existing routing solutions, the proposed Q-adaptive routing can learn to forward packets more efficiently with smaller packet latency and higher system throughput. Next, we demonstrate that intelligent routing algorithms such as Q-adaptive routing can greatly mitigate workload interference and optimize the overall system performance. Subsequently, we propose a dynamic job placement strategy for workload interference prevention. When combined with Q-adaptive routing, dynamic job placement gives users the flexibility to either reduce workload interference from communication intensive applications or protect target applications for higher performance stability.
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Title: Intelligent Battery Switching Module for Hybrid Electric Aircraft
Creator: Kamal, Ahmad
Date: 2022
Description: The growth in world economics, tourism and international cooperation has resulted in significant growth of civil aviation industry. This...
Show moreThe growth in world economics, tourism and international cooperation has resulted in significant growth of civil aviation industry. This growing number of fossil fuel reliant aircrafts will significantly increase waste gas emissions with detrimental impact on the environment. The system efficiency of the aircraft must be substantially improved to reduce the fuel burn and thus waste gas emissions. Therefore, the aircraft industry is pushing towards higher electrification of future aircrafts to increase system efficiency, reduce fuel burn and to lower emissions as well as operational costs. The more electric aircraft (MEA) design concept, commercially realized by Boeing 787 and Airbus A380, increases system efficiency by replacing the mechanical, pneumatic, and hydraulic systems with electrical systems. However, global regulation authorities demand further reduction in waste gas emissions and fuel burn. To meet these stringent demands, the aircraft industry is exploring hybrid electric aircrafts which can significantly reduce fuel burn by electrifying the propulsion train of the aircraft. This higher penetration of electrical energy in the aircraft warrants smart short-circuit protection with ultrafast response time. However, current hybrid aircrafts still use outdated mechanical and thermal short-circuit protection which have historically proven to cause numerous tragedies. Solid-state power controller (SSPC) is an alternate solution which uses semiconductor devices to offer faster response. However, the main drawbacks of SSPCs are their need for active cooling due to higher conduction loss and the use of foldback current limiting approach to limit the inrush current of DC-link capacitor of the powertrain. The foldback current limiting approach degrades the power semiconductor devices used due to excessive heat loss by driving the device near the safe operating area (SOA) limits of the device. This thesis presents a 750V/250A intelligent Li-ion battery switching module (BSM) for hybrid electric aircraft propulsion application. The BSM uses commercially available 1200 V SiC JFET power modules with ultra-low RDSON in parallel to achieve sub-mΩ total on-resistance, comparable to the incumbent mechanical contactor solution. This allows the total nominal conduction power loss of the BSM to be less than merely 23 W, permitting maintenance-free passive cooling. In contrast to the incumbent contactor solution, the BSM has ultrafast response (µs-level) to a fault condition. Which, in conjunction with the reduced fault current stress, significantly improves the operation lifetime of the entire system. The BSM incorporates various intelligent features by implementing a tri-mode operation concept, which allows to pre-charge the DC-link capacitor with a limited charging current in PWM mode. To mitigate single-point failures, several design redundancy measures are implemented to ensure reliability and safety for the aircraft. Design considerations of the circuit and physical design of the BSM are discussed in detail including the design of the custom laminated busbar and thermal analysis. Furthermore, the inherent uncontrolled oscillation phenomenon of the JFET cascode structure is explored and addressed. Finally, the experimental results obtained from the built and tested prototype of the BSM are reported.
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Title: Examining Associations Between Discrimination, Social Cohesion, and Health among White and POC LGBT Chicagoans
Creator: Kannout, Lynn
Date: 2022
Description: Consistent with the minority stress perspective, lesbian/gay, bisexual, and transgender (LGBT) individuals on average report worse health than...
Show moreConsistent with the minority stress perspective, lesbian/gay, bisexual, and transgender (LGBT) individuals on average report worse health than heterosexual individuals in several domains, e.g., general health, mental health, physical health, and health care access. Intersectionality-based research shows that LGBT-POC are, on average, at even greater risk for adverse health outcomes compared to their White LGBT counterparts. Discrimination and social cohesion may be two mechanisms underlying these between- and within-group disparities, given their broader relations to health and their relatively high frequency within marginalized populations. This study used data from the Chicago Department of Public Health to examine broad health differences between LGBT White and LGBT-POC individuals, and to test specific mediations models in which social cohesion mediated links between discrimination and health. LGBT-POC reported experiencing worse general health, lower access to health care, more experiences of discrimination, and lower feelings of social cohesion than did White LGBT individuals. No mediation effects emerged, however there was a direct effect of experiencing discrimination on mental health distress. Further, discrimination exposure related inversely to feelings of social cohesion. Study strengths, limitations, and implications are discussed.
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Title: Advanced methods for storage ring nonlinear beam dynamics design and implementation
Creator: Song, Minghao
Date: 2022
Description: To meet the increasing demands of scientific researchers for brighter photonbeams, storage ring beam emittance is continually pushed down to a...
Show moreTo meet the increasing demands of scientific researchers for brighter photonbeams, storage ring beam emittance is continually pushed down to a new ultra-low level. It, therefore, becomes correspondingly more challenging to ensure such storage rings have good nonlinear beam dynamics performance. This thesis work is focused on developing advanced methods for low emittance storage ring nonlinear beam dynamics design and implementation.Nonlinear beam dynamics optimization is essential to low emittance storagering design. A highly efficient multi-objective optimization algorithm is needed to simultaneously achieve a large dynamic aperture and a large local momentum aperture. Work was done to improve and test a machine learning-based algorithm called multi-generation Gaussian process optimizer (MG-GPO). This advanced method uses constructed GP models to pre-select solutions, and benchmarking of results on toy problems shows that MG-GPO converges significantly faster than traditional algorithms. The MG-GPO algorithm was successfully applied to nonlinear lattice design optimization, for example, to the SPEAR3 upgrade 7-nm lattice, and it was demonstrated to converge faster than NSGA-II and MOPSO. This was due to its capability of selecting candidates that tend to have better performance. This algorithm will help accelerate nonlinear lattice studies.Correction of nonlinear beam dynamics is also important for low emittancestorage ring commissioning and operation. In order to measure and correct features relevant to the nonlinear beam dynamics, an effective method is needed to excite sustained beam oscillations to large amplitude. A method based on the concept of autoresonance was proposed. This advanced technique excites nonlinear transverse beam motion in storage rings by sweeping the drive frequency. The theory for the autoresonance threshold was derived for the nonlinear optics systems in storage rings, both with and without damping effects, using Hamiltonian dynamics. The theoretical predictions for the drive amplitude threshold were found to agree well with simulations for a simple storage ring model, as well as for simulations with the actual SPEAR3 and APS lattices. The theory was also compared favorably to historical data from experiments on SPEAR3. Simulations verified that an oscillation driven by autoresonant excitation matches the character of a free oscillation, so that beam oscillation data taken during the ramping process can confidently be used to characterize the nonlinear beam dynamics performance. The precision of measurements can be improved by using autoresonant excitation since large amplitude beam oscillations are sustained significantly longer. Simulations of autoresonant excitation demonstrated the measurements of the detuning coefficients and resonance driving terms. The use of autoresonant excitation for the detection of faulty magnets and correction of resonance driving terms was also demonstrated.Online optimization is an alternative way to effectively improve nonlinear beamdynamics performance in a real storage ring. The greater efficiency of an advanced optimization algorithm is also needed to find globally optimal solutions in the limited experimental time that is typically available. The MG-GPO algorithm was implemented for SPEAR3 vertical emittance minimization and injection efficiency optimization. Again, the optimized solutions demonstrate that MG-GPO is more efficient than the commonly used PSO algorithm. SPEAR3 performance was successfully improved during the online optimization runs with MG-GPO.
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Title: SYSTEMATIC ANALYSIS OF THE MCENTER BEAMLINE AT THE FERMILAB TEST BEAM FACILITY FOR THE NOVA TEST BEAM EXPERIMENT
Creator: Temizel, Buse Naz
Date: 2021
Description: This thesis presents a systematic analysis of the MCenter beamline at the Fermilab Test Beam Facility to help to generate improved beam...
Show moreThis thesis presents a systematic analysis of the MCenter beamline at the Fermilab Test Beam Facility to help to generate improved beam profiles for the NOvA Test Beam Experiment. Several studies were carried out to understand beam transport to the experiment, including optics calculations and computer simulations using a novel procedure for incorporating the acceptance of the channel. Data from beam profile monitors was used to trace the beam phase space and compared to simulation results. Detailed analysis revealed that the beam sizes on the NOvA target were large compared to its transverse size. New tunes were proposed for a detailed beam optics study. Analysis of the new tunes shows that the new optics produce two components corresponding to two different peaks at different energies in the horizontal profile at the NOvA target.
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Title: Predictive Energy Management of Connected Hybrid Electric Vehicles in the Presence of Uncertainty
Creator: Sotoudeh, Seyedeh Mahsa
Date: 2022
Description: Energy efficiency improvements brought by electrification of the powertrain in Hybrid Electric Vehicles (HEVs) highly depend on their...
Show moreEnergy efficiency improvements brought by electrification of the powertrain in Hybrid Electric Vehicles (HEVs) highly depend on their powertrain Energy Management Strategy (EMS) that determines optimal power allocation between powertrain components.Eco-driving based EMS seeks further energy efficiency improvements through optimizing vehicle's driving cycle (velocity and hence torque demand), in addition to the powertrain's EMS. A novel hierarchical EMS is developed in this thesis for connected human-driven HEVs and then extended to automated HEVs that effectively addresses some of the major challenges of the energy management problem. At its high-level, a computationally-tractable Pseudospectral Optimal Controller (PSOC) with discounted cost is employed to approximately solve the powertrain's energy management problem over driving cycle previews of the entire trip. The high-level's approximate solution is then used as a reference by the low-level tube-based Model Predictive Controller (MPC) that solves the problem over higher-quality, short-horizon driving cycles in a real-time applicable fashion. For human-driven HEVs, a Long Short-Term Memory (LSTM) neural network predicts the human driver's velocity profile over low-level's short horizons. A velocity optimizer is added to the low-level for automated HEVs that optimizes the vehicle's driving cycle by effectively utilizing regenerative braking capability of the HEV. At the low-level, the tube-based MPC controller solves the powertrain's energy management problem over either predicted (human-driven HEV) or optimized (automated HEV) driving cycles by accounting for driving cycle's uncertainty, due to uncertain future information, and hence ensures robust constraints satisfaction. A novel cost-to-go approximation method is developed that uses the optimal costate trajectories obtained from the high-level PSOC controller to generate terminal costs for the low-level controller. This improves suboptimality of the short-horizon solutions and ensures charge balance constraint satisfaction at the end of the trip without having to impose conservative constraints. A novel learning-based framework is also proposed to jointly optimize the automated HEV's driving cycle and its powertrain's power split. A Deep Neural Network (DNN)-based MPC controller is developed for the low-level that jointly optimizes the HEV's driving cycle and powertrain energy management in a real-time applicable manner. To ensure constraints satisfaction, a novel Quadratic Programming (QP)-based projection of the DNN-based approximate control laws is proposed that can be efficiently solved in real-time. Simulation results over standard and real-world driving cycles demonstrate efficacy of the proposed control frameworks in terms of suboptimality (fuel efficiency) improvement, potential real-time applicability, and constraints (especially charge balance constraint) satisfaction in the presence of driving cycle uncertainty.
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Title: Thermal Effects in Fluid Dynamics
Creator: Sulzbach, Jan-Eric
Date: 2021
Description: In this thesis we propose a mathematical framework modeling non-isothermal fluids.The framework is based on a coupling between non-equilibrium...
Show moreIn this thesis we propose a mathematical framework modeling non-isothermal fluids.The framework is based on a coupling between non-equilibrium thermodynamics and an energetic variational approach for the mechanical parts of the system. From this general model we derive and analyze three separate systems.The first application is the Brinkman-Fourier model. This is related to the ideal gas system, where the pressure and internal energy depend linearly on the product of density and temperature. This is a subsystem to the general Navier-Stokes-Fourier system. We prove the existence of local-in-time weak solutions via compensated compactness arguments.The next model we study is a non-isothermal diffusion system involving chemical reactions. For a system close to chemical equilibrium we show the well-posedness of classical solution using a fixed-point argument involving theory of homogeneous Besov spaces.The third application of the general theory is for another general diffusion system with a Cahn-Hilliard energy. In this framework, we study in detail how the temperature can affect the system on different scales, leading to different models. For the analysis, we focus on one case and show the well-posedness of classical solutions. The proof relies on methods from the theory of Besov spaces and paradifferential calculus.
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Title: Technological Consciousness in Midwestern American Farming: From Party Lines to Autonomous Tractors
Creator: Sziron, Mónika
Date: 2022
Description: This dissertation is primarily concerned with understanding the current conceptions, perceptions, and ethical concerns of artificial...
Show moreThis dissertation is primarily concerned with understanding the current conceptions, perceptions, and ethical concerns of artificial intelligence in Midwestern agriculture. Using the theory of technological consciousness as a backdrop for understanding the relationship between Midwestern agriculture and technology, in chapter two this dissertation first provides a narrative review of major technological developments throughout history in Midwestern farming and how the human experience in farming is influenced by technology throughout history. This history provides context for the current state of Midwestern agriculture, which is now increasingly entangled with artificial intelligence. The theory behind artificial intelligence ethics and general trends in artificial intelligence are discussed in chapter three. To understand present conceptions, perceptions, and ethical concerns of artificial intelligence for Midwestern farmers, a pilot survey was dispersed to farmers and pilot media content analysis was conducted on Midwestern agriculture publications. The results from this pilot survey and pilot media content analysis are discussed in chapter four. Chapter five delves into theory and how the human experience with technology has evolved over time and its effects on the human experience today. This chapter also provides theoretical insights for the future of farming with artificial intelligence. The dissertation concludes with reviewing the ethical concerns relating to artificial intelligence in agriculture for Midwestern farmers, provides recommendations for developers of agriculture technology, and highlights the new partnership between farmers and computer scientists and how this partnership will lead the way in the future of Midwestern farming.
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Title: Biophysical and Computational Characterization of CinDel Edits of Dystrophin
Creator: Stojkovic, Vladimir
Date: 2022
Description: Duchenne muscular dystrophy (DMD) is a degenerative genetic disease caused by a genetic defect that results in the absence of dystrophin, a...
Show moreDuchenne muscular dystrophy (DMD) is a degenerative genetic disease caused by a genetic defect that results in the absence of dystrophin, a protein with an important stabilizing role in muscle cells. DMD causes progressive muscle degeneration leading to the loss of ambulation, and typically results in death before the third decade of life. Treatments for DMD aim to restore dystrophin expression and typically do so by producing edited or modified dystrophins. The only FDA approved therapy, exon skipping, produces dystrophin edits at exon boundaries but emerging therapeutic approaches like gene replacement therapy and CRISPR-Cas9-based gene editing techniques like CinDel allow for greater flexibility and are not constrained to exon boundary edits. However, understanding of what makes a “good”, functional edit is limited so it is not clear how to make use of this increased flexibility to produce optimal edits which are believed to be necessary for robust treatment. In an effort to improve understanding of the biophysics of these non-exon edits, we have embarked on a mixed experimental and computational study of a set of CinDel edits in the D19-D21 region of the dystrophin central rod domain. First, we have conducted an Alphafold structure prediction-based screen of a subset of possible edits in this region and selected one edit for follow-up characterization. We then compared this computationally-selected edit to three other heuristically designed edits experimentally and computationally by molecular dynamics simulations. We found that the computationally selected edit is significantly more thermodynamically stable than the other edits in the cohort. This edit also generally exhibited more favorable properties in MD simulations across multiple measures such as helicity, STR-junction unwinding and conformational variability.
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Title: Health Information Seeking, Depression, and Satisfaction with Life in Racial/ethnic Minority vs. White individuals with Spinal Cord Injuries
Creator: Stipp, Kelsey
Date: 2022
Description: Health information is available both traditionally by conversations with health care professionals, and non-traditionally via use of the...
Show moreHealth information is available both traditionally by conversations with health care professionals, and non-traditionally via use of the Internet and other media sources. Health information is crucial to individuals with chronic health conditions and/or disabilities, such as spinal cord injury (SCI), to promote health, minimize comorbidities, and improve quality of life (QOL). Methods of health information seeking have been shown to differ between individuals who are racial/ethnic minority individuals and individuals who are White. Existing research appears to show health information seeking may increase QOL in populations with chronic health conditions and/or disabilities. However, it is unclear how aspects of QOL differ between individuals within the SCI population by race/ethnicity. The present study used Chi Square analyses to test racial/ethnic group differences in health information seeking and multiple analysis of covariance (MANCOVA) to test whether method of health information seeking and aspects of QOL, specifically depression and satisfaction with life, were moderated by race/ethnicity. An adult sample of 9,403 individuals with SCI who completed a survey on their injury, health, and QOL between 2011 and 2016 was used. Participants identified their source of health information as traditional (i.e., conversations with health care professionals) or non-traditional (e.g., newspaper, television, radio, etc.). Results indicated non-traditional sources of health information were utilized more frequently regardless of race/ethnicity. Unexpectedly, moderation results suggested that associations between source of health information and depression and satisfaction with life did not differ by race/ethnicity. However, source of health information was associated with satisfaction with life and depression for the entire sample. Study findings demonstrate the shift towards non-traditional (e.g., newspaper, television, radio, etc.) health information seeking within the SCI population. Further, findings support previous empirical work demonstrating the association between method of health information seeking and depression and satisfaction with life. These findings can be used to improve dissemination of accurate health information to the SCI population via non-traditional sources. Further research should include more diverse samples of individuals to better understand health information seeking as well as depression and satisfaction with life within the SCI population.
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Title: A Functionalized 2D Boron Nitride Electrode for Rechargeable Batteries
Creator: Tatagari, Vignyatha Reddy
Date: 2021
Description: Motivated by the great performance of the graphene oxide battery and its poor safety, in the present work, an attempt is made to fabricate an...
Show moreMotivated by the great performance of the graphene oxide battery and its poor safety, in the present work, an attempt is made to fabricate an alternative battery from functionalized 2-dimensional (2D) boron nitride. The expectation is that functionalized boron nitride can exhibit the same great electrochemical performance as graphene oxide while it would be much more thermally stable. Toward this goal, synthetic opportunities were explored to realize -OBF3 functionalized hexagonal boron nitride. Both top-down and bottom-up synthetic approaches were considered and implemented. In the top-down methods, commercially available bulk hexagonal boron nitride (h-BN) is reacted with functionalization agents such as LiOBF3 and LiOH.BF3. Synthesis of these functionalization agents and their reactions with h-BN were carried out in several different ways. Bottom-up synthetic approach using Boric Acid and Urea was utilized to synthesize turbostratic boron nitride (t-BN), which is an intermedier in the commercial synthesis of hexagonal boron nitride. Turbostratic boron nitride contains exfoliated and -OH functionalized monolayers of boron nitride. An attempt is made to esterify the -OH groups of turbostratic boron nitride to obtain the desired -OBF3 functionalized monolayers of h-BN. Initial electrochemical tests on turbostratic boron nitride and its esterified form are carried out along with ionic conductivity measurements. Only a very limited electrochemical activity was observed due to a low degree of functionalization in these materials, indicating the need for improved synthetic procedures to achieve the desired target materials.
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Title: PIMMINER: A HIGH-PERFORMANCE PIM ARCHITECTURE-AWARE GRAPH MINING FRAMEWORK
Creator: Su, Jiya
Date: 2022
Description: Graph mining applications, such as subgraph pattern matching and mining, are widely used in real-world domains such as bioinformatics, social...
Show moreGraph mining applications, such as subgraph pattern matching and mining, are widely used in real-world domains such as bioinformatics, social network analysis, and computer vision. Such applications are considered as a new class of data-intensive applications that generate massive irregular computation workloads and memory accesses, which degrade the performance and scalability significantly. Leveraging emerging hardware, such as process-in-memory (PIM) technology, could potentially accelerate such applications. In this paper, we propose PIMMiner, a high-performance PIM architecture graph mining framework. We first identify that current PIM architecture cannot be fully utilized by graph mining applications. Next, we propose a set of optimizations that enhance the locality, and internal bandwidth utilization and reduce remote bank accesses and load imbalance through cohesive algorithm and architecture co-designs. We compare PIMMiner with several state-of-the-art graph mining frameworks and show that PIMMiner is able to outperform all of them significantly.
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Title: DO ACT CONSTRUCTS MODERATE ASSOCIATIONS BETWEEN SOCIAL MEDIA AND EATING PATHOLOGY?
Creator: Badillo Regan , Krystal E
Date: 2022
Description: Limited research has assessed individuals with disordered eating and their social media use. Additionally, there has been limited...
Show moreLimited research has assessed individuals with disordered eating and their social media use. Additionally, there has been limited investigation into psychotherapy constructs that could be used when addressing social media use in those with eating pathology. This study aims to improve the existing literature on social media and eating pathology by recruiting a sample of probable eating disorders and assessing if Acceptance and Commitment Therapy (ACT) constructs moderate the relation between social media and eating pathology. It is anticipated that 1) eating disorder pathology severity will be positively correlated with photo-based social media behavior; 2) eating disorder symptom severity will be positively associated with importance of social media; and 3) those who score higher in mindful eating, body image flexibility, and body image acceptance will have a weaker positive association between ED pathology and importance of social media and those who score lower in body image cognitive fusion will have a weaker positive association between ED pathology and importance of social media mindful eating, body image flexibility, body image acceptance, and body image cognitive fusion will moderate the relation between eating disorder symptom severity and social media use. To test the hypotheses women with a probable eating disorder (N=121) completed online questionnaires via prolific. The majority of participants identified as non-Hispanic (81%) and White (45.5%). Results suggest that there are associations between ED pathology, ACT constructs, Importance of Twitter and Instagram, and photo-based behaviors but not Importance of Facebook. Additionally, the moderation models examined were not statistically significant. Implications of these findings are discussed as well as future direction for research and clinical work.
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Title: OPTIMUM WEIGHT STIFFNESS STRUCTURAL DESIGN
Creator: Barnett, Ralph L.
Date: 2021
Description: My adventures with flexible structures began on the IIT campus with an extracurricular undergraduate project to design an “Open House Exhibit”...
Show moreMy adventures with flexible structures began on the IIT campus with an extracurricular undergraduate project to design an “Open House Exhibit” for the Civil Engineering Department. I chose to display a reinforced concrete diving board together with a prestressed concrete diving board. Visitors enthusiastically pounced on the reinforced concrete structure whose rigid response disappointed one and all. Their indignation was transferred to the prestressed cantilever which thrust them upward from six to ten feet into the air. This unexpected response from a diving board became so dangerous that the Exhibit was unceremoniously closed. I still have the display sign, “More Bounce to the Ounce.”While still an undergraduate, I secured a part-time job at Armour Research Foundation where I responded to a bid request from Rock Island Arsenal to design the 26 foot Honest John Rocket Launcher Rail at minimum weight. This tactical weapon was transported by helicopter. I basked in the fantasy that I was Leonardo da Vinci without his artistic proclivity. Rocket launchers that droop during operation are similar in concept to a circular firing squad. So began my research into minimum weight beams based on deflection rather than strength. I searched for the shoulders of Giants. I found them in the form of mathematicians not structural engineers. I achieved a 26.5% weight savings in the 1126 pound rail by optimizing the geometry. When I developed an optimum prestressed and segmented Kentanium cermet rail, the weight savings became 89%. The right material provides a bigger bang for the buck. When my journey into optimum design began, I was armed only with analysis tools: strength, stability, and stiffness. This thesis begins with an outline of my present toolbox which contains eight design concepts: 1. Establish the Geometry, 2. Select a material from a finite number of candidates, 3. Prestress and Prestrain, 4. Statistical Screening (Proof Testing), 5. Manipulation of Boundary Conditions, 6. Energized Systems, 7. Counterweights, 8. Self-Healing and Self-Reinforcing. Four of these are used through this review which focuses on stiffness. Beginning with beams, deflection control examples are described where prestraining and prestressing techniques are used to produce both a zero-deflection beam and a method for pushing with a chain. The calculus of variations made it possible to establish optimum tapers for the flanges and webs of I-beams that minimize beam weight for a specified deflection or, because of reciprocity, minimize beam deflection for a specified beam weight. An anomaly is encountered that enables one to achieve an upward, downward, or zero deflection with a set of beams of vanishing weight. In addition, special circumstances are defined where a uniform strength design is identical to the minimum weight design based on a specific deflection. Closed form solutions are obtained for a variety of loading scenarios. One problem is presented for self-weight that leads to a nonlinear integral equation. The optimum stiffness-weight design of trusses is undertaken where the area distribution of the truss members is optimized using Lagrange’s method of undetermined multipliers. Once again, we obtain a degenerate case where upward, downward, and zero deflection conditions can be met with an infinite set of trusses of vanishing weight. We photograph a simply supported truss under a downward load that leads to an upward deflection at one of the joints. Special loading conditions are identified that lead to uniform stress designs that are identical to the minimum weight designs based on deflections. This study provides a Segway into the world of minimum weight strength design of trusses. The resulting Maxwell and Michell trusses sometimes display the optimum distribution of bar areas from the point of view of stiffness. Many practitioners are under the mistaken impression that Michell structures, when they exist, provide the optimum truss profile for stiffness. Unfortunately, the optimum array of truss joints based on deflection does not exist. For both trusses and beams the optimum distribution of mass is shown to be necessary and sufficient; the sufficiency is established using well-known inequalities. The role of stiffness in the design of columns is explored in our final chapter. This cringe-worthy history of column analysis begins our study as a warning to practitioners who use analysis as their basis for design and especially optimum design. Conventional elastic and inelastic buckling theories provide little insight into the design of columns. The fundamentals of minimum weight column design are presented to show the power of design theory in contrast to analysis. Both prismatic and tapered columns are studied with one surprise result; the optimum taper gives rise to a uniform bending stress (without axial stresses). It was fun to see that in 1733 Lagrange made a mistake in calculus of variations that led to the incorrect solution for the optimum tapered column. It took 78 years before Clausen obtained the correct solution. The problem has been revisited by William Prager and again by the author who used dynamic programming. Of course, we all got the same result which is a dreadful solid circular tapered column that is heavier than any ordinary waterpipe. The best of a class is not necessarily the best possible design. Under the heading, “Intuition is a good servant but a bad master,” we introduce the notions of tension members that buckle, columns constructed from spherical beads, optimum rigging of crane booms, and deflection reversal of beam-columns. In several places we observe that the weight of optimum columns is proportional to P^α where P is the axial load and α is less than unity. We fail to tell the reader that this implies that minimum weight columns require putting all your eggs in one basket; one column under load P is lighter than two columns each under load P/2. On the other hand, we expose the solid circular column as the least efficient shape among all regular polygons, the equilateral triangle is the best. Indeed, there is a family of rectangles that are superior to the circular cross-section. Finally, the author’s prestressed tubular column is introduced that is pressurized to eliminate local buckling. Euler’s buckling can always be eliminated with a thin-wall section of sufficient width without a weight penalty. The weight of the balloon-like member is proportional to (PL) which implies that at last we have a compressive member that meets the requirement of a Michell structure. Bundling of pressurized gas columns are possible without a weight penalty. Further, the column is insensitive to most imperfections. It is the lightest known column for small structural indices (P/L^2 ). When coupled with circulating cryogenic liquid as a prestressing system, a limiting column has a vanishing weight.
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Title: A Network Analysis of the Six Core Processes Associated with Acceptance and Commitment Therapy
Creator: Bailey, Jennifer Rose
Date: 2022
Description: According to the theoretical model of Acceptance and Commitment Therapy, six core processes comprise a latent factor of psychological...
Show moreAccording to the theoretical model of Acceptance and Commitment Therapy, six core processes comprise a latent factor of psychological flexibility: present moment, chosen values, committed action, self as context, cognitive defusion, and acceptance. Little research has directly examined the unique relations among the processes. The present study extended our knowledge of the structure and relations between these processes by examining the relative importance and influence of a single process to the system of processes as a whole utilizing network analysis with a sample of 277 adult, non-clinical participants. Committed action was the most central of all the processes, demonstrating the highest strength centrality and most number of edges. Cognitive defusion and present moment also showed high strength centrality, suggesting that these processes exert the greatest influence on other processes in the network based on partial correlations controlling for all other constructs. Results provided support for the conceptualization of the three response styles (i.e., open, centered, and engaged). The addition of neuroticism to the core processes network showed little effect on the number of edges present between the six core processes. Neuroticism was strongly related to cognitive defusion and more weakly related to committed action. Results not only increased our understanding of the relations between processes and provided knowledge that may be useful to our understanding of the ACT theoretical model, but it also may have potential clinical implications, such as aiding in the identification of treatment targets to enhance psychological flexibility.
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Title: DESIGN FOR COMFORT: DESIGN BUILDING ENVELOPE TO IMPROVE THERMAL COMFORT FOR RESIDENTIAL BUILDINGS IN AL-MUKALA, YEMEN
Creator: Bakarmom, Aamena Mubarak Saeed
Date: 2021
Description: This thesis is about the research into the design of building envelopes to reduce energy consumption and moderate thermal performance of the...
Show moreThis thesis is about the research into the design of building envelopes to reduce energy consumption and moderate thermal performance of the residential buildings in Yemen, which is in an arid climate. A suitable building envelope is important because of the building occupants’ thermal comfort. The most important question is how architects could implement high-performance envelope technologies in their designs, especially in residential buildings. These technologies have some basic principles which are applied differently from one region to another. One of the most promising strategies applied to house envelopes in a hot-dry climate is the passive cooling design. This thesis reviews the results of other research in the same region that discuss proper parameters of building envelopes such as form, width, climate, walls, materials, and windows design. Passive cooling strategies will be the key to providing potential design building envelopes that provide thermal comfort and reduce energy use. This study applies the natural ventilation principle (single-sided, cross- or stack ventilation), thermal mass, and shaded devices. The research methods were to collect data and create quantitative models to analyze the data. From this analysis, I suggest specific architecture guidelines for design in residential buildings which could improve comfort in indoor spaces for occupants.
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Title: SEPARATING NOBLE GASES SUCH AS KRYPTON AND XENON FROM NUCLEAR POWER PLANTS OFF-GAS USING DD3R ZEOLITIC MEMBRANES: A COMPUTATIONAL MOLECULAR DYNAMICS STUDY
Creator: BASHMMAKH, BANDAR JAMAL S.
Date: 2021
Description: Noble gas fission products generated within nuclear power reactors, such as Kr and Xe, are currently discharged into the atmosphere. This...
Show moreNoble gas fission products generated within nuclear power reactors, such as Kr and Xe, are currently discharged into the atmosphere. This practice has a major economic drawback because of the high value associated with some of these gases. Zeolites, nanoporous materials suitable for gas separation processes, have become of major interest due to the potentially high selectivity for such separations. We have used nonequilibrium molecular dynamics to investigate the separation performance of DD3R framework zeolitic membranes (using LAMMPS software package) for such separations. Our studies have shown that the DD3R membrane shows promise for high selectivity ratios of Kr over Xe. The effects of pressure, temperature and pure vs. mixture gas feed conditions are studied in this work to understand at the molecular level the mechanisms of these (Kr/Xe) separations. MD runs show an agreement with most experimental trends in the permeation of Kr/Xe pure and mixed gases using DD3R zeolite with high separation factor, despite the absence of Xe complete permeation through the membrane because of MD timescale limitation, signaling much slower diffusion in comparison to Kr which is a desired trend in looking for high separation factors.
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