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- Title
- STUDIES ON SYNTHETIC APPLICATIONS OF STEREOSELECTIVE AND REGIOSELECTIVE RING OPENING REACTIONS OF AZIRIDINIUM IONS
- Creator
- Chen, Yunwei
- Date
- 2014, 2014-12
- Description
-
Aziridinium ions are valuable reactive intermediates in organic synthesis. Regioselective and stereoselective ring opening reactions of...
Show moreAziridinium ions are valuable reactive intermediates in organic synthesis. Regioselective and stereoselective ring opening reactions of aziridinium ions can provide various useful building blocks including optically active vincinal amines, amino alcohols and amino esters. Aziridinium ions are also involved in the biological process of anti-cancer agents. However, aziridinium ions are under-utilized in organic synthesis. In this thesis, we utilize stereoselective and regioselective ring opening reactions of aziridinium ions for synthesis of enantiomerically enriched compounds. Ring opening reactions of aziridinium ions were utilized in intramolecular Friedel-Crafts (FC) reactions for stereoselective and regioselective synthesis of 4-substituted tetrahydroisoquinoline. A series of β-haloamine were prepared as precuresors of aziridinium ions. The reaction conditions for ring opening of aziridinium ions for the FC reactions including temperature, catalysts, and solvents were optimized. Further, the reaction mechanism was studied to prove that the aziridinium ions were formed as the key intermediates during the intramolecular FC reaction. Intermolecular nucleophilic ring opening reaction of aziridinium ions was studied as a convenient method of carbon-carbon formation. Regioselective and stereoselective nucleophilic substitution reactions of aziridinium ions with indole analogues were carried out for the synthesis of optically active tryptamine analogues. The reactions proceeded smoothly to provide the tryptamine analogues in high yield in the presence of halo-sequestering agents, while the reaction provided the tryptamine products in significantly low yield in the absence of halo-sequestering agents. Ring opening reactions of aziridinium ions with malonic esters and Grignard reagents were carried out for the respective synthesis of optically active tryptamine analogues, γ-aminobuyric acid (GABA), and α-amine derivatives. The regiospecific ring opening reactions of aziridinium ions was directly applied for the synthesis of bifunctional ligands which have a potential use in targeted therapy and imaging of cancers. The novel bifunctional chelates with a shorter alkyl spacer C-NETA and 2E-C-NETA as well as the chelates with a longer alkyl spacer 5p-C-NETA were prepared. 5p-C-NETA was conjugated to a cyclic peptide c(RGDyK) as a targeting moiety for use in targeted radiation therapy. In addition, 2E-C-NETA was conjugated to a fluorescent dye Cy5.5 for theranostic applications. The experimental results indicated that the new bifunctional ligands have promising applications in the biomedical field. In summary, stereoselective and regioselective ring opening reactions of aziridinium ions have been successfully applied for the synthesis of optically active compounds such as 4-substituted tetrahydroisoquinolines, tryptamines, γ-aminobuyric acid, α-amine derivatives and the bifunctional chelators. We demonstrated that ring opening of versatile aziridinium intermediates is a strightforward and convenient method for the synthesis of various optically active compounds.
Ph.D. in Chemistry, December 2014
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- Title
- Test of slender wooden struts for aeroplanes
- Creator
- Smith, M. A,, Kellener, W. A., Stevens, W. A.
- Date
- 2009, 1910
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/testofslenderwoo00smit
Thesis (B.S.)--Armour Institute of Technology
- Title
- Inclusive measurements at HERA from low to high x, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
- Creator
- Behnke, Olaf
- Date
- 2013-09-15, 2013-09-15
- Publisher
- IIT Press
- Description
-
New inclusive Deep Inelastic Scattering (DIS) measurements are presented, obtained with the H1 and ZEUS detectors at HERA. The results...
Show moreNew inclusive Deep Inelastic Scattering (DIS) measurements are presented, obtained with the H1 and ZEUS detectors at HERA. The results comprise (flavour) inclusive DIS cross sections as well as inclusive charm production. In the area of inclusive DIS, both H1 and ZEUS completed last year their high Q2 Neutral and Charged current measurements exploiting the large statistics from the HERA II running period. For inclusive charm production, H1 and ZEUS published a combination of numerous existing measurements based on various tagging methods. Among other things a precise determination of the running charm quark mass mc(mc) was obtained from the combined data.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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- Title
- Hierarchical Structured Data Organization System
- Creator
- Frieder, Ophir, Kapoor, Sanjiv
- Date
- 2015-09-09, 2015-09-08
- Description
-
A method in a data processing system and apparatus for organizing files or web pages, structured or unstructured, of multiple users stored...
Show moreA method in a data processing system and apparatus for organizing files or web pages, structured or unstructured, of multiple users stored across one or more server computers into hierarchical file structures on a recordable medium of a data processing system. A user-defined metalabel is assigned to each of the electronic files or web pages. The electronic files or web pages are organized as a function of the metalabels into the hierarchical file structures.
Sponsorship: Illinois Institute of Technology
United States Patent
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- Title
- A CONCEPTUAL SOLAR CHIMNEY PLANT AND FLORAL FARM USING ETFE AND BAMBOO
- Creator
- De Vita, Niels
- Date
- 2012-11-20, 2012-12
- Description
-
Motivated by a desire to create an architectural response to the environmental and social challenges of today, the following thesis project...
Show moreMotivated by a desire to create an architectural response to the environmental and social challenges of today, the following thesis project attempts to offer new paths for the future development of the solar chimney energy plant concept originally developed by the German engineer Jӧrg Schlaich in the early 1980s. The starting point of this thesis was to analyze the solar chimney prototype completed in the Manzanares desert in 1982 in order to understand the parameters guiding the design. The analysis allowed me to better understand the potential of the concept and to recognize the opportunity that existed to push the technological boundaries to craft a new design that reflects the current socio-political, economical and environmental context we live in. In the following pages, I attempt to demonstrate that the concept could be made even more appealing through the use of technology and locally available resources. By doing this, I seek to reinvigorate the idea, opening paths for a new conversation about the potential of the project as a social agent for progress. Throughout this thesis, I remain respectful and aware of the accomplishments of the pioneers before me, simply taking cues from their work to suggest new alternatives and solutions to a problem that has been made even more pressing due to the world’s energy crisis and economic uncertainty.
M.S. in Architecture, December 2012
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- Title
- Constant Speed Drive for Magnetic Recorders
- Creator
- Camras, Marvin
- Date
- 1945-04-03
- Description
-
Sponsorship: Armour Research Foundation
United States Patent
- Title
- THE CHANGE OF KURTOSIS IN IMPORTANCE SAMPLING FOR MONTE CARLO
- Creator
- Zhang, Xiaodong
- Date
- 2013, 2013-12
- Description
-
The Mont e Carlo (II IC) Method is commonly used to approximat e mult ivariat e integrals, which can be interpreted as means of random variab...
Show moreThe Mont e Carlo (II IC) Method is commonly used to approximat e mult ivariat e integrals, which can be interpreted as means of random variab les. The IIIC method uses th e sample mean to estimate the tr ue mean. In this thesis, we focus on minimizing th e sample size in MC simulat ion needed to sat isfy the specified error tolerance. Based on t he algorithm proposed by [5], we explain that t he cost of reliable IIIe est imat ion depends not only on variance but also on kurtosis. T herefore, when we try to improve th e efficiency of MC simulation by reducing variance, such as with Importance Sampling (IS), we need also look into the change of kurtosis. We analyze the change of cost in terms of the change of kur tosis and the change of variance. For a special case of IS we explore how to find th e optimal density in order to reduce variance.
M.S. in Applied Mathematics, December 2013
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- Title
- Wellness and Education
- Creator
- Mason, Laurie
- Date
- 2012, 2012-05
- Description
-
What if the school were more like a playground; a laboratory for exploration and discovery? What if the place itself actually inspired the...
Show moreWhat if the school were more like a playground; a laboratory for exploration and discovery? What if the place itself actually inspired the students within it? My proposal for a new primary school in Chicago attempts to become such a place. With an emphasis on wellness and ecologically based practices the school becomes a teaching tool. Featuring a diverse range of flexible interior and exterior spaces, the building supports different learning environments. The school also encourages community involvement through shared resources and volunteer opportunities. The project becomes more than a school; an integral part of the neighborhood and place to experience learning.
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- Title
- Method and Apparatus for Detecting Collisions on and Controlling Access to a Communications Channel
- Creator
- Campbell, Graham M., Wu, Chien-ting
- Date
- 2009-05-14, 2002-06-18
- Description
-
A nodal apparatus for sending and receiving digital data in multiple data slots has a transmitter for transmitting a request for multiple data...
Show moreA nodal apparatus for sending and receiving digital data in multiple data slots has a transmitter for transmitting a request for multiple data slots during a control minislot. A conflict resolution queue representative of nodal apparatus sending substantially simultaneous requests for transmission resulting in a collision in a minislot is maintained and stored in a memory. A transmission queue representative of nodal apparatus that have successfully transmitted in a minislot and can be queued for data slot transmission is stored in memory. The transmitter sends multiple data slots signals comprising multiple slots of digital data in response to the transmission queue. A receiver receives multiple data slots signals comprising digital data. A high priority transmission queue may also be stored in memory.
Sponsorship: Illinois Institute of Technology
United States Patent
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- Title
- Juvenile Treatment Center
- Creator
- Cueva, Hernan
- Date
- 2010-07-29
- Title
- Safety Timing Mechanism for Magnetic Recorders
- Creator
- Camras, Marvin
- Date
- 1945-08-07
- Description
-
Sponsorship: Armour Research Foundation
United States Patent
- Title
- ELIASHBERG ANALYSIS OF CUPRATE OXIDE SUPERCONDUCTORS
- Creator
- Ahmadi, Omid
- Date
- 2011-11, 2011-12
- Description
-
In this thesis, evidence for antiferromagnetic spin uctuations as the pairing glue in high temperature superconductors is presented through a...
Show moreIn this thesis, evidence for antiferromagnetic spin uctuations as the pairing glue in high temperature superconductors is presented through a modi ed Eliashberg analysis of experimental tunneling data of Bi2212 over a wide range of doping. In particular, the normalized conductance data of the junctions, from optimal to overdoped, will be tted at T=0K using d-wave Eliashberg equations where the spectral function is modeled after spin uctuation spectra seen in experiments. The corresponding real and imaginary diagonal and anomalous self-energy curves are extracted and compare well to photoemission experiments. This is followed by a temperature dependent Eliashberg analysis where the spectral function is now temperature dependent, based on trends seen in inelastic neutron scattering experiments. New results for temperature dependent self energy curves are also compared to experiment with slight deviations. Finally, the Josephson product is calculated as an independent check of the tunneling matrix used in tting the data.
Ph.D. in Physics, December 2011
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- Title
- Reel Lock
- Creator
- Camras, Marvin, Galus, Stanley A.
- Date
- 4/23/2009, 1966-10-11
- Description
-
Sponsorship: IIT Research Institute
United States Patent
- Title
- Hafnium Base Alloy (CR-Al)
- Creator
- Hill, Vernon L., Nichols, Harry R.
- Date
- 2009-04-27, 1971-07-27
- Description
-
Sponsorship: IIT Research Institute
United States Patent
- Title
- Design of the Stadium (semester?), IPRO 335
- Creator
- Johnson, Drew, Clemens, Natalie, Jarog, Arkadiusz, Leingang, Sarah, Uchanski, Artur, Medina, Jorge, Ramirez, Julio, Sanchez, Gerardo, Tam, Chi Hang, Wang, Nathan, Dantapalli, Sushma, Kuyken, Scott, Campbell, Keith, Griffin, Timothy, Kennedy, Thomas, Marcus, Zander, Parikh, Harshill
- Date
- 2006-12, 2006-12
- Description
-
This semester IPRO 335, Capstone Design, continues placing its efforts in designing the most innovative and creative architectural and...
Show moreThis semester IPRO 335, Capstone Design, continues placing its efforts in designing the most innovative and creative architectural and structural design from senior undergraduate and graduate students. The same project from last semester, the New United Center, will be analyzed, explored, and redesigned in detail to meet new requirements. The primary goal in this semester long project is to implement the knowledge and new techniques learned at IIT along with the experience from individual members in order to create a unique and superior product. Most of the basic design was completed last semester; nevertheless there are many areas that must be designed or some portions that will be modified.
Deliverables for IPRO 335: Design of the Stadium for the Fall 2006 semester
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- Title
- Investigation of Fresh Produce Washing on E. Coli O157:H7 and Murine Norovirus with Peroxyacetic Acid and High Power Ultrasound
- Creator
- Yuan, Wen
- Date
- 2011-12-05, 2011-12
- Description
-
E. coli O157:H7 and norovirus have each been responsible for outbreaks of foodborne illness involving fresh leafy green vegetables....
Show moreE. coli O157:H7 and norovirus have each been responsible for outbreaks of foodborne illness involving fresh leafy green vegetables. Peroxyacetic acid (POAA) has the potential to be an effective sanitizer during commercial fresh-cut produce washing. The addition of high power ultrasound (HPU) to the washing system may enhance the POAA efficacy. The purpose of this study was to reduce E. coli O157:H7 and norovirus contamination during commercial fresh-cut lettuce washing using POAA and HPU. Fresh-cut romaine lettuce leaves were inoculated with E. coli O157:H7 or murine norovirus (MNV, a surrogate for the human norovirus) and washed by POAA and HPU. Cross-contamination was tested by washing clean leaves in contaminated processing water where pre-inoculated leaves were washed previously. A high level of cross-contamination (4.5-log CFU/g E. coli) occurred after uninoculated leaves were rinsed in contaminated wash water for 2 min. A subsequent 2 min wash in POAA alone or in combination with HPU reduced counts by approximately 1.2-log and 2.3-log, respectively. More than 2-log norovirus was removed from washing 2 min in either DI water or POAA. However infectious MNV washed from leaves was not detected in wash water containing POAA. Those results implied a high possibility of cross-contamination during freshproduce washing, and indicate that adding POAA and HPU in addition to washing water in wash water can reduce cross-contamination rate.
M.S. in Food Safety and Technology, December 2011
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- Title
- Video Recording System and Method
- Creator
- Camras, Marvin
- Date
- 2009-04-27, 1971-06-28
- Description
-
Sponsorship: IIT Research Institute
United States Patent
- Title
- Integration of Process Improvements (Semester Unknown) IPRO 304
- Creator
- Bauer, Jessie, Bergeron, Tony, Campen, Matt, Gruchalski, Erik, Ki Choi, Tae, Marx, Ryan, Murti, Chaitanya, Robbins, Brian, Pal Sohal, Atinder, Stenson, Amanda, Taboada, Alejandro, Zhang, Bingjian
- Date
- 2009, 2009-12
- Description
-
The goal and mission this semester is to create a procedure that can show a technician when a carbide insert breaks off of a face mill during...
Show moreThe goal and mission this semester is to create a procedure that can show a technician when a carbide insert breaks off of a face mill during operation. Completing this task will increase productivity for A. Finkl and Sons.
Deliverables
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- Title
- Sustainable Water distribution System for Pignon, Haiti (semester?), IPRO 327
- Creator
- George, Alayna, Kircher, Alex, Sissala, Amy, Mohammed, Ashfaq, Susek, Ben, Tam, Chi, Chung, Chun Pong, Durra, David, Williams, David, Radloff, Eric, Skrebo, Ermin, Forkan, Garret, Rajic, Ivan, Sullivan, Joshua, Tailor, Kinjal, Rokita, Mark, Ballog, Matt, Hollister, Nathaniel, Sawulski, Piotr, Shoulders, Shawn, Ratmani, Shoaib
- Date
- 2007-05, 2007-05
- Description
-
Our objectives for the semester are: Produce or procure a topographical map of Pignon, Haiti Map the current structures on a topographical...
Show moreOur objectives for the semester are: Produce or procure a topographical map of Pignon, Haiti Map the current structures on a topographical map Design a preliminary water distribution system Work with Haiti Outreach to foster relations between IIT, the organization, and the community of Haiti Raise funds to cover partial costs of trips to Haiti to gather data
Deliverables for IPRO 327: Sustainable Water distribution System for Pignon, Haiti for the Spring 2007 semester
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- Title
- Highrise
- Creator
- Ma, Shasha
- Date
- 5/4/2011, 2011-05
- Description
-
Highrise structure study
Sponsorship: Land, Peter