Search results

Title: A SYSTEMATIC APPROACH TO UNDERSTANDING ALIGNMENT BETWEEN THE EXISTING AND SELF-ADOPTED ENVIRONMENTAL EDUCATION STANDARDS: UNITED STATES SIXTH TO TWELFTH GRADE ENVIRONMENTAL SCIENCE STANDARDS
Creator: Connell, Margaretann Grace
Date: 2019
Description: The purpose of this thesis was to conduct a systematic approach to determine the alignment between the existing and self-adopted science 6th...
Show moreThe purpose of this thesis was to conduct a systematic approach to determine the alignment between the existing and self-adopted science 6th-12th grade EE science standards for 10 U.S. National States (6th-8th [AZ; ID; MA; WY]) and (9th-12th [NE; NYS; OH; PA; SC; TX]). The criteria for States’ selection were based on States with SASS (non-NGSS adoption) and 2) demographics - random selection from the 10 U.S. EPA Regions. The Existing Environmental Education Standards (EEES) (GCDEE, Hungerford et al., 1980; NAAEE Guidelines, Simmons, 2010a; Tbilisi, UNESCO, 1978) were aligned with the 10 States. The investigation was conducted by a DCA (Mayring, 2002). Data were analyzed using MAXQDA 2018.1(VERBI, 2017), judged by a Content Match (La Marca et al., 2000), and measured by the adapted criteria for Categorical Concurrence and Range of Knowledge Correspondence (Webb, 1999). Instruments to score the output were: 1). CEEI – Tbilisi/GCDEE (K-12), and EEI – NAAEE Guidelines (6-8; 9-12). Results for the Content Match of the EEES revealed that 50% of the States were Partly Aligned and other 50% were Not Aligned with the NAAEE Guidelines Code Coverage. Additionally, the Content Match with Tbilisi/GCDEE revealed that 20% of the States (OH, PA) were Fully Aligned and the other 80% Partly Aligned . The States’ science standards ability to reach appropriate levels of alignment was due to the scientific specificity of those States with implicit EE standards. Moreover, it was difficult to come to a common ground to expect complete alignment based on the socioecological approaches and interdisciplinary nature (Kyburz-Graber, 2013; Simmons, 2010a) of the EEES. Therefore, it is now left up to the policymakers at the State levels to work with stakeholders and come to a consensus in support of EE standards that are relevant, fair, and balanced with multidisciplinary, socioecological approaches to promote of an environmentally literate citizenry.
Show less

Title: KINETIC MODEL FRAMEWORKS OF ANIMAL CELL CULTURES FOR CONTROL AND OPTIMIZATION
Creator: Yilmaz, Denizhan
Date: 2019
Description: This dissertation proposes four different kinetic model frameworks that havebeen developed for optimization and control of monoclonal antibody...
Show moreThis dissertation proposes four different kinetic model frameworks that havebeen developed for optimization and control of monoclonal antibody producing mammalian cell cultures to improve biopharmaceutical production by decreasing the costof trial and error experimentation. The developed models mainly describe the transient metabolic behavior of mammalian cell culture under different culture conditionsand predicts cell growth and death, cell metabolism, and monoclonal antibody synthesis, and production. These models are developed via ordinary differential equationsbased on the assumption of well-mixing reactor. All developed models were calibrated, and their predictive capabilities were tested with experimental reports published in the literature. Good agreement was obtained between model predictions and experimental data. The presented results illustrate that the developed models successfully describe and predict the transient behavior of mammalian cell cultures and can be a useful tool for biopharmaceutical production.
Show less

Title: STRATEGIES TO MAXIMIZE DOSE REDUCTION IN SPECT MYOCARDIAL PERFUSION IMAGING
Creator: Juan Ramon, Albert
Date: 2019
Description: Radiation exposure in medical imaging has become a topic of major concern, gaining intense attention within the clinical and research...
Show moreRadiation exposure in medical imaging has become a topic of major concern, gaining intense attention within the clinical and research communities. In 2009, the National Council on Radiation Protection and Measurements (NCRP) announced radiation exposure of patients via medical imaging increased more than sixfold between the 1980s and 2006, with cardiac nuclear medicine, specifically myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) being the second biggest culprit. The goal of this work is to evaluate several strategies to enable radiation dose to be minimized while maintaining current levels of diagnostic accuracy in the clinic. We achieve dose reduction through optimization of advanced image reconstruction strategies, to obtain higher-quality images at a given dose (noise) level, through a machine learning approach to predict the optimal dose for each patient, and through advanced deep learning (DL) algorithms to improve the quality of reconstructed images. Our ultimate objective is to provide the nuclear cardiology field with a new set of algorithms and guidelines for selecting administered activity levels and image reconstruction procedures in the clinic. The project is based on a clinical study in which imaging and various other data are being collected for a set of patients. The project has the following components. First, we investigate a global dose-reduction approach (i.e., reducing dose by a uniform proportion across all patients) via optimization of image reconstruction strategies. Specifically, we maximize perfusion-defect detection (diagnostic accuracy) over a range of simulated dose levels using clinical data into which we have introduced simulated defects. We measure diagnostic performance using clinically validated model observers from the Quantitative Perfusion SPECT (QPS) software package. We investigate the diagnostic accuracy over a range of dose levels ranging from those currently used in the clinic down to one-eighth of this level. We consider the following image-reconstruction: filtered-backprojection (FBP) with no correction for physics effects, and ordered-subsets expectation-maximization (OS-EM) with several combinations of attenuation correction (AC), scatter correction (SC), and resolution correction (RC).Second, we propose a patient-specific ("personalized") dose reduction approach based on machine learning that aims to predict the minimum radiation dose needed to obtain consistent perfusion-defect detection accuracy for each individual patient. This prediction is based on patient attributes, especially body measurements, and various clinical variables. We compare the diagnostic accuracy produced by predicted personalized doses to that produced by standard clinical dose levels to validate the predictive models.Third, we verify that the dose minimization results obtained in the context of perfusion-defect detection also maintain diagnostic accuracy in evaluating cardiac function, as characterized by myocardial motion.Finally, we propose a deep learning (DL) method to denoise SPECT-MPI reconstructed images. The method is a 3D convolutional neural network trained to predict standard-dose images from low-dose images. We quantify the extent to which dose reduction can be achieved using the proposed DL structure when dose is reduced uniformly across patients or by means of our patient-specific approach.
Show less

Title: SI NANOSTRUCTURED COMPOSITE AS HIGH PERFORMANCE ANODE MATERIAL FOR NEXT GENERATION LITHIUM-ION BATTERIES
Creator: He, Qianran
Date: 2019
Description: Silicon has attracted huge attention in the last decade as the anode material for Li-ion batteries because it has a theoretical capacity ∼10...
Show moreSilicon has attracted huge attention in the last decade as the anode material for Li-ion batteries because it has a theoretical capacity ∼10 times that of graphite. However, the practical application of Si is hindered by three major challenges: large volume expansion during cycling (∼300%), low electrical conductivity, and instability of the SEI layer caused by repeated volume changes of the Si material. Our study focused on novel design and synthesis of Si anodes that can solve all the key problems of Si anodes simultaneously. The Si micro-reactors we designed and synthesized contain well-designed internal structures, including (i) nanoscale Si building blocks, (ii) the engineered void space, and (iii) a conductive carbon shell. Because of these internal structures and nitrogen doped carbon shell, these sub micrometer-sized Si particles are termed as Si micro-reactors and denoted as Si@void@C(N). According to our electrochemical results, the as-synthesized Si micro-reactors could live up to 1000 charge/discharge cycles at high current densities (up to 8 A/g) while still providing a higher specific capacity than the state-of-the-art carbonaceous anodes. Our investigation shows that the unique design of Si@void@C(N) has a relatively low specific surface area (SSA) which significantly reduces the undesired surface side reactions and increases ICE to 91%, while the engineered voids with nano-channel shape inside the structure can accommodate Si volume expansion and keep the structure and SEI layer stable. Furthermore, the porous N-doped carbon shell along with nano-channeled voids allows rapid lithiation of the Si micro-reactor without Li plating during ultrafast charging. As a result, Si@void@C(N) exhibits ultrafast charging capability with high ICE, superior specific capacity and long cycle life.
Show less

Title: HETEROGENEOUS CATALYST FOR ALKANE DEHYDYGENATION AND IMPLEMENTING TO SOLID OXIDE FUEL CELL
Creator: Xu, Yunjie
Date: 2019
Description: In the past decade, shale gas has become the most import source of natural gas in the United States. Large amounts of light alkanes in shale...
Show moreIn the past decade, shale gas has become the most import source of natural gas in the United States. Large amounts of light alkanes in shale gas, such as methane, ethane, and propane are available as an industrial source of chemicals through the catalyzed, on-purpose light alkane dehydrogenation to olefins. Therefore, it is obvious there is a benefit to developing catalysts to directly convert shale gas to olefins. However, alkane dehydrogenation and non-oxidative methane coupling are thermodynamically unfavorable reactions at low temperatures. The energy requirements make these reactions less attractive for shale gas utilization. In principle, consuming the hydrogen product with a fuel cell can drive the thermodynamically unfavorable reaction by reducing the hydrogen partial pressure in the anode and by heat generating by the fuel cell, while also generating electricity in the process. Moreover, catalyst integration with fuel cell can facilitate the transfer of charge in anode which is rate determine step in the fuel cell. This thesis will focus on catalyst development for alkane dehydrogenation and exploring a way to integrate these catalysts with fuel cells.Chapters 2, 3 and 4 focus on designing, characterizing, and studying catalysts for non-oxidative coupling of methane (NOCM) and propane dehydrogenation (PDH). PtM (M is a transition metal) alloys were found to efficiently decrease the desorption energy of olefin products and avoid deeper C-H bond activation compared to metallic Pt. Based on the previous study of single cobalt on silica, a novel synthesis of PtCo3 was developed to further increase the activity of the PDH reaction. The Pt bimetallic catalyst made by novel synthesis route was proven to be one of several types of alloy. It was observed that extremely high conversion of PDH and high selectivity of target olefin were catalyzed by PtCo3/SiO2. Ga, as another promotor to replace Co, was also investigated. As expected, PtGa3 alloy was formed by a similar synthesis, and it showed extraordinary stability and activity for propane dehydrogenation. A Mo-Pt dual-metal catalyst was found to catalyze methane coupling even though Pt-Mo bimetallic alloys do not form. We hypothesize that Pt catalyzed C-H bond cleavage of CH4 to form methyl radical, and a MoOC species, formed by MoO3 reacting with CH4, could effectively facilitate methyl radical coupling to form larger alkanes and alkenes. Pt-Mo dual-metal catalyst had higher catalytic activity for methane coupling than a physical mixture of Pt and Mo and genuine PtMo alloy. Chapter 5 details our efforts to transplant PtM catalysts from silica support to target fuel cell material--(La,Sr)(Cr,Fe)O3 as a support. Different catalyst structures were observed, and, in this case, second transition metals become a barrier to prevent Pt aggregation. When using propane as fuel for fuel cell, we observed electrochemical redox reactions occurred via electrochemical analysis. However, the resistance of cell is comparatively high and limited overall system performance. Chapter 6 details a study of the impact of the electrode oxide phase on overall cell performance. In this case, we conducted a fundamental study of degradation of cathode material, (La,Sr)(Co,Fe)O3. We found that raw material and cells can degrade even under room temperature. Thus, the storage of raw powder and fabricated cells is critical for performance studies. This also indicates that our high cell resistance in previous electrochemical measurements could come from the insulating compound formation during storage. Some directions for future research on catalyst integration and electrochemical testing are outlined.
Show less

Title: DOPING OF SODIUM CHROMIUM OXIDE CATHODE MATERIALS TO ENHANCE ELECTROCHEMICAL PERFORMANCE FOR SODIUM-ION BATTERIES
Creator: wang, ziyong
Date: 2019
Description: In this project, we investigated the effects of doping several types of metals to NaCrO2 on its electrochemical performance. The doping method...
Show moreIn this project, we investigated the effects of doping several types of metals to NaCrO2 on its electrochemical performance. The doping method is aiming to stabilize the O3-type structure by partial substituting some of Cr with other metals during intercalation/deintercalation by suppressing Cr6+ migration to alkaline slab, and thus facilitate long-term cycle performance and reversible capacity. All doped NaCrO2 powders were hereby denoted to NaMe0.1Cr0.9O2 (Me=Al, Co, Ni, Mn). To achieve metal-doped NaCrO2 powders, sodium, chromium and dopant sources were mixed with various metal oxides and then subjected to 6-hour high energy ball milling, followed by heating in flow-Ar tube at 900℃ for 1 hour. Pristine NaCrO2 powder synthesized in the same process was to make comparisons with doped ones. To understand the mechanism of doping, field emission scanning microscopy (FESM) and energy Disperse Spectroscopy (EDS), as well as X-ray diffractometer (XRD), were employed to analyze the morphology and composition of final products. Benefiting from Ni doping, NaNi0.1Cr0.9O2 cell exhibited a high reversible capacity of 132 mAh g-1 at the initial cycle in a potential region between 2.0 and 3.6 V vs. Na/Na+, and 78 % of capacity retention over 70 cycles. For NaMn0.1Cr0.9O2, reversible capacity at first discharge is about 30 mAh g-1, lower than that of Ni-doped and pristine NaCrO2, while the cycle retention stays at nearly 100% after 100 cycles. The opposite charge/discharge behaviors from Ni- and Mn-doped NaCrO2 provide us a potential method for the optimization of cathode materials with the best electrochemical performance in the future.
Show less

Title: Multi-function multi-modality sensing and communication system: a designer's perspective
Creator: Fepeussi, Tonmo Vanessa Carine
Date: 2019
Description: The combination of sensing and communication functionalities on the same electronic device is the key to autonomous sensing applications in...
Show moreThe combination of sensing and communication functionalities on the same electronic device is the key to autonomous sensing applications in the transportation industry, including driverless vehicles and structural health monitoring (SHM) of aero-vehicles. Due to the limited availability of spectral and hardware resources, there is a need for resource sharing between sensing and communication systems. This is achieved by the efficient integration of sensing and communication functions through a unified design of both systems into smart sensors. To that end, a multi-modality approach is employed in this research to design multi-functional systems at two different bands of the frequency spectrum, namely radio and acoustic frequencies.First, a radio-frequency (RF) software-defined system capable to support radar sensing and RF communication is proposed for use in modern interconnected automotive applications such as driverless vehicles. The proposed RF radar is designed on a software-defined homodyne transceiver prototype capable of radio communication. The system is implemented in the S band over a narrow frequency bandwidth of 34 MHz between 3.550 GHz and 3.584 GHz. Experimental measurements show that the designed radar sensor can measure short-range targets with a range accuracy of less than 21 cm.An acoustic sensing and communication system is developed in parallel for use in autonomous SHM monitoring of aero-vehicles. The proposed communication system uses M-ary time-reversal pulse position modulation (M-TRPPM) as the modulation scheme for dispersion compensated wireless communication across the elastic channel. The time reversal based time division multiple access (TR-TDMA) protocol is introduced to regulate channel access by multiple sensors. Simulation and experimental validation demonstrate that the designed system, using an excitation signal generated by a PZT sensor disc at 300 kHz resonant frequency, is capable of reliable data transmission with a bit error rate (BER) approximating zero at low data rates of a few kilobits per seconds.
Show less

Title: Kinetic and Structural Characterization of the Vibrio cholerae Flavin Transferase ApbE
Creator: Fang, Xuan
Date: 2019
Description: Cholera has long been a global concern and in the past decades traditional antibiotic treatments have failed due to the emergence of the...
Show moreCholera has long been a global concern and in the past decades traditional antibiotic treatments have failed due to the emergence of the antibiotic-resistance of its causative agent, V. cholerae. The resistance is mainly supported by a transmembrane electrochemical gradient of Na+ produced by the respiratory complex Na+-NQR coupled with an internal electron transfer pathway. The assembly and function of Na+-NQR is fulfilled by ApbE, the only known flavin transferase which covalently attaches two FMN molecules to the complex as part of its electron transport chain. Hence, ApbE is closely associated with the cause of antibiotic resistance. Because it does not have any human homologues, ApbE becomes an excellent drug target. In this work, we have investigated the physical properties of the enzyme and clarified its substrate specificity and pH dependence. For instance, our experiments indicate that divalent cations are essential for ApbE function, and that the selectivity depends largely on the size and the coordination sphere of the cation. Our data also show that ApbE regulation by pH, ADP and potassium is an important mechanism that enhances the adaptation, survival and colonization of V. cholerae in the small intestine. Moreover, pH dependence, mutagenesis, and steady-state kinetic studies have led us to identify the conserved His257 as a residue with dual roles: substrate binding and catalysis. Furthermore, bi-substrate kinetic studies have also revealed that ApbE follows a random Bi Bi mechanism. Together with structural studies, we propose a reaction mechanism where His257 functions as a base, shedding light into the understanding of the ApbE family.
Show less

Title: Scale and Scope Economies Drive Asymmetric Competition in Tech Industries
Creator: Ryali, Balajirao
Date: 2020
Description: This research is motivated by my industry experience of working with small manufacturers in the high technology industry market space and ...
Show moreThis research is motivated by my industry experience of working with small manufacturers in the high technology industry market space and large manufacturers in the telecom and healthcare industry market spaces. In these industries, small manufacturers thrive on specialization and focus on breakthrough innovation to maintain product differentiation and premium positioning and to sustain competition. In contrast, large manufacturers enjoy the benefits of economies of scale that provide cost efficiencies and use price as major differentiating factor. This research work endeavors to model asymmetric competition that emerges endogenously in industries where scale and scope economies interact to force firms to adopt specialized strategies and address the below research questions:1. How does the cost structure shaped by scope and scale economies in engineering, sales and service drive asymmetric product line choices?2. What channel coordination problems arise in this context?3. How can manufacturers redesign their operating mechanism and sales force to optimize the channel?
Show less

Title: Simulation and Experimental Testing of High-Gradient Dielectric Disk Accelerating Cavities
Creator: Weatherly, Sarah K.
Date: 2022
Description: Structure-based wakefield acceleration can be accomplished using either Collinear Wakefield Acceleration (CWA) where the drive beam and the...
Show moreStructure-based wakefield acceleration can be accomplished using either Collinear Wakefield Acceleration (CWA) where the drive beam and the witness beam are located on the same beamline or Two Beam Acceleration (TBA) where the RF power generated by the drive beam is extracted and transferred to the witness beam line. A Dielectric Disk Accelerator (DDA) is an accelerating structure that is utilized by TBA that uses dielectric disks to improve the structure's shunt impedance and accelerate the witness beam. Dielectric based accelerators studied in this thesis are X-Band structures (have a working frequency between 8 and 12 GHz) that can use any pulse length but in this study utilize short (<20 ns) traveling wave pulses. Short pulse lengths are used to decrease breakdown probability and allow for a large gradient. DDAs have a higher group velocity and a larger shunt impedance compared to traditional metallic accelerating structures while maintaining a large accelerating gradient. DDAs are a strong candidate for use in the Argonne Wakefield Accelerator’s 500 MeV Demonstrator. Recent experimental results of a clamped single cell structure demonstrated a >100 MV/m accelerating gradient with no evidence of breakdown in the RF volume. Additional structures, including a brazed single cell model and a multicell structure, have been designed and are now being fabricated for high power testing.
Show less

Title: ESTIMATING PM2.5 INFILTRATION FACTORS FROM REAL-TIME OPTICAL PARTICLE COUNTERS DEPLOYED IN CHICAGO HOMES BEFORE AND AFTER MECHANICAL VENTILATION RETROFITS
Creator: Wang, Mingyu
Date: 2021
Description: PM2.5 are fine inhalable particles that are 2.5 micrometers or smaller in size. Indoor PM2.5 consists of outdoor PM2.5 (ambient PM2.5) that is...
Show morePM2.5 are fine inhalable particles that are 2.5 micrometers or smaller in size. Indoor PM2.5 consists of outdoor PM2.5 (ambient PM2.5) that is infiltrated into the indoor environment and indoor generated PM2.5 (non-ambient PM2.5). As people spend nearly 90% of their lifetimes indoors, with most of that time in their homes, PM2.5 exposure in homes results in severe health effects such as asthma. One strategy increasingly being used to dilute air pollutants generated indoors and improve indoor air quality (IAQ) in homes is the introduction of mechanical ventilation systems. However, mechanical ventilation systems also have the potential to introduce more ambient PM2.5 than relying on infiltration alone, although limited data exist to demonstrate the magnitude of impacts in occupied homes. The objective of this paper is to estimate the infiltration factor (Finf) of PM2.5 before and after installing mechanical ventilation systems in a subset of occupied homes. The data source utilized comes from the Breathe Easy Project, a more than 2-year-long study conducted in 40 existing homes in Chicago, IL aiming to explore the effects of three different types of mechanical ventilation system retrofits on IAQ and asthma. An automated algorithm was developed to remove indoor PM2.5 peaks in time-series data collected from optical particle counters deployed inside and outside of each home. The Finf was estimated using the resulting indoor/outdoor ratio with indoor peaks removed. Before mechanical ventilation retrofits, the weekly median Finf was 0.29 (summer median = 0.41, fall median = 0.26, winter median = 0.29, spring median = 0.30); after mechanical ventilation retrofits, the median Finf was 0.34 (winter median= 0.28, spring median = 0.45, summer median = 0.54, fall median = 0.20). Differences in Finf between pre- and post-intervention periods were not statistically significant (p = 0.23 from Wilcoxon signed rank tests). The median PM2.5 infiltration factor increased ~22% (from 0.27 to 0.33) with the installation of balanced ventilation systems with energy recovery ventilators (ERV), although differences were not statistically significant (Wilcoxon signed rank p = 0.35). The median PM2.5 infiltration factor decreased ~4% (from 0.28 to 0.27) after installing intermittent CFIS systems, which intermittently supply ventilation air through the existing central air handling units and associated filters (which were upgraded to a minimum of MERV 10 in all CFIS homes), although differences were not statistically significant (Wilcoxon signed rank p = 0.24). The median PM2.5 infiltration factor increased ~26% (from 0.35 to 0.44) with the installation of continuous exhaust-only systems, and differences were significant (Wilcoxon signed rank p = 0.04). These results suggest that the filtration mechanisms used on the CFIS and balanced systems were adequate for maintaining similar distributions of Finf values pre- and post-interventions whereas the increased delivery of outdoor air via the building envelope by exhaust-only systems significantly increased Finf following retrofits.
Show less

Title: A New Control and Decision Support Framework To Avoid Fast-Evolving System Collapse and Cascading Failure
Creator: Guha, Bikiran
Date: 2022
Description: The modern power system is a vast and incredibly complex network with a very large number of equipment operating round the clock to reliably...
Show moreThe modern power system is a vast and incredibly complex network with a very large number of equipment operating round the clock to reliably transport electricity from generators to consumers. However, factors such as aging and faulty equipment, extreme and unpredictable weather, cyber attacks and increasing amounts of unpredictable renewable generation have made it increasingly vulnerable to cascading failure and wide-area collapse. Therefore, a lot of work has been done over the years on cascading failure vulnerability analysis and mitigation. However, to the best of our knowledge, the existing literature on this topic focus on preventive analysis and mitigation, mostly from a planning perspective. There is a lack of decision support schemes which can take real-time preventive action when the system becomes vulnerable to cascading failure, while taking into account the various dynamics and uncertainties involved in these types of failures. The only defense under these situations are pre-designed emergency control schemes. However, they are only effective against known vulnerabilities and can make matters worse if not accurately designed and calibrated.This research work has proposed a novel wide-area monitoring protection and control (N-WAMPAC-20) framework designed to make decisions in real-time to assess the vulnerabilities of the system (when a disturbance happens) and to implement mitigation actions, if necessary. The main contributions of this dissertation focus on the disturbance monitoring, real-time control and decision making aspects of this framework. The proposed framework has been divided into two major parts: an offline part and an online part. The offline part continuously runs extreme contingency analysis in the background (using combined dynamics and protection simulators) to generate elements which can assess system vulnerabilities and suggest suitable mitigation actions, if necessary. In this regard, a novel load shedding adjustment scheme is also proposed, which has been shown to be effective against a variety of fast-evolving cascading failure scenarios. The online part consists of real-time disturbance monitoring and decision-making components. The disturbance monitoring component focuses on real-time fault detection and location. If a fault has been identified and located, the real-time decision making component determines the vulnerability of the system, by consulting with the elements designed offline. If vulnerabilities are identified, targeted mitigation actions are implemented. The design and applicability of a prototype of N-WAMPAC-20 has been presented using a case of voltage collapse and a case of wide-area loss of synchronization on a synthetic model of the Texas grid.
Show less

Title: Distinctive Categorization Deficits in Repeated Sorting of Common Household Objects in Hoarding Disorder
Creator: Hamilton, Catharine Elizabeth
Date: 2022
Description: The present study examines sorting techniques and deficits among individuals with hoarding disorder (n = 34) compared to age- and gender...
Show moreThe present study examines sorting techniques and deficits among individuals with hoarding disorder (n = 34) compared to age- and gender-matched adults (n = 35) in the general population. Performance was compared on the Booklet Category Test (BCT), selected other neuropsychological measures, and an ecologically valid sorting task designed for the study to model the Delis-Kaplan Executive Function System (D-KEFS) Sorting subtest but with common household objects as stimuli. Contrary to predictions, individuals with hoarding disorder did not perform significantly worse than controls on the BCT or the sorting task designed for the present study. Also contrary to predictions, the hoarding group performed significantly better when initiating their own sorts of the objects than when tasked with naming categories grouped by the researcher. These findings are discussed as well as exploratory analyses suggesting participants with hoarding put forth more mental effort sorting the household objects (shoes and mail). They provided significantly more individual responses on the task with significantly more description errors. IQ and performance on other selected neuropsychological measures were not significantly different between groups. These findings provide preliminary evidence there may be specific types of real-life sorting difficulties associated with hoarding disorder that are subtle and beyond what existing neuropsychological tests can measure. Given that current CBT treatments for hoarding presuppose a certain level of competency in sorting (e.g., recognizing and naming different categories of household items to complete a personal organizing plan), it is important to clarify potential sorting and categorization deficits in this group as one possible avenue to help improve treatment response among individuals struggling with hoarding disorder.
Show less

Title: Machine Learning On Graphs
Creator: He, Jia
Date: 2022
Description: Deep learning has revolutionized many machine learning tasks in recent years.Successful applications range from computer vision, natural...
Show moreDeep learning has revolutionized many machine learning tasks in recent years.Successful applications range from computer vision, natural language processing to speech recognition, etc. The success is partially due to the availability of large amounts of data and fast growing computing resources (i.e., GPU and TPU), and partially due to the recent advances in deep learning technology. Neural networks, in particular, have been successfully used to process regular data such as images and videos. However, for many applications with graph-structured data, due to the irregular structure of graphs, many powerful operations in deep learning can not be readily applied. In recent years, there is a growing interest in extending deep learning to graphs. We first propose graph convolutional networks (GCNs) for the task of classification or regression on time-varying graph signals, where the signal at each vertex is given as a time series. An important element of the GCN design is filter design. We consider filtering signals in either the vertex (spatial) domain, or the frequency (spectral) domain. Two basic architectures are proposed. In the spatial GCN architecture, the GCN uses a graph shift operator as the basic building block to incorporate the underlying graph structure into the convolution layer. The spatial filter directly utilizes the graph connectivity information. It defines the filter to be a polynomial in the graph shift operator to obtain the convolved features that aggregate neighborhood information of each node. In the spectral GCN architecture, a frequency filter is used instead. A graph Fourier transform operator or a graph wavelet transform operator first transforms the raw graph signal to the spectral domain, then the spectral GCN uses the coe"cients from the graph Fourier transform or graph wavelet transform to compute the convolved features. The spectral filter is defined using the graph’s spectral parameters. There are additional challenges to process time-varying graph signals as the signal value at each vertex changes over time. The GCNs are designed to recognize di↵erent spatiotemporal patterns from high-dimensional data defined on a graph. The proposed models have been tested on simulation data and real data for graph signal classification and regression. For the classification problem, we consider the power line outage identification problem using simulation data. The experiment results show that the proposed models can successfully classify abnormal signal patterns and identify the outage location. For the regression problem, we use the New York city bike-sharing demand dataset to predict the station-level hourly demand. The prediction accuracy is superior to other models. We next study graph neural network (GNN) models, which have been widely used for learning graph-structured data. Due to the permutation-invariant requirement of graph learning tasks, a basic element in graph neural networks is the invariant and equivariant linear layers. Previous work by Maron et al. (2019) provided a maximal collection of invariant and equivariant linear layers and a simple deep neural network model, called k-IGN, for graph data defined on k-tuples of nodes. It is shown that the expressive power of k-IGN is equivalent to k-Weisfeiler-Lehman (WL) algorithm in graph isomorphism tests. However, the dimension of the invariant layer and equivariant layer is the k-th and 2k-th bell numbers, respectively. Such high complexity makes it computationally infeasible for k-IGNs with k > 3. We show that a much smaller dimension for the linear layers is su"cient to achieve the same expressive power. We provide two sets of orthogonal bases for the linear layers, each with only 3(2k & 1) & k basis elements. Based on these linear layers, we develop neural network models GNN-a and GNN-b, and show that for the graph data defined on k-tuples of data, GNN-a and GNN-b achieve the expressive power of the k-WL algorithm and the (k + 1)-WL algorithm in graph isomorphism tests, respectively. In molecular prediction tasks on benchmark datasets, we demonstrate that low-order neural network models consisting of the proposed linear layers achieve better performance than other neural network models. In particular, order-2 GNN-b and order-3 GNN-a both have 3-WL expressive power, but use a much smaller basis and hence much less computation time than known neural network models. Finally, we study generative neural network models for graphs. Generative models are often used in semi-supervised learning or unsupervised learning. We address two types of generative tasks. In the first task, we try to generate a component of a large graph, such as predicting if a link exists between a pair of selected nodes, or predicting the label of a selected node/edge. The encoder embeds the input graph to a latent vector space via vertex embedding, and the decoder uses the vertex embedding to compute the probability of a link or node label. In the second task, we try to generate an entire graph. The encoder embeds each input graph to a point in the latent space. This is called graph embedding. The generative model then generates a graph from a sampled point in the latent space. Di↵erent from the previous work, we use the proposed equivariant and invariant layers in the inference model for all tasks. The inference model is used to learn vertex/graph embeddings and the generative model is used to learn the generative distributions. Experiments on benchmark datasets have been performed for a range of tasks, including link prediction, node classification, and molecule generation. Experiment results show that the high expressive power of the inference model directly improves latent space embedding, and hence the generated samples.
Show less

$X-Ray Diffraction Studies of Activation and Relaxation In Fast and Slow Rat Skeletal Muscle$

Title: X-Ray Diffraction Studies of Activation and Relaxation In Fast and Slow Rat Skeletal Muscle
Creator: Gong, Henry M.
Date: 2022
Description: The contractile properties of fast-twitch and slow-twitch skeletal muscles are primarily determined by the myosin isoform content and...
Show moreThe contractile properties of fast-twitch and slow-twitch skeletal muscles are primarily determined by the myosin isoform content and modulated by a variety of sarcomere proteins. X-ray diffraction studies of regulatory mechanisms in muscle contraction have focused predominately on fast- or mixed-fiber muscle with slow muscle being much less studied. Here, we used time-resolved x-ray diffraction to investigate the dynamic behavior of the myofilament proteins in relatively pure slow fiber rat soleus (SOL) and pure fast fiber rat extensor digitorum longus (EDL) muscle during twitch and tetanic contractions at optimal lengths (Lo), 95% Lo, and 90% Lo. Before the delivery of stimulation, reduction in muscle length led to decrease in passive tension. The x-ray reflections upon reduction in length showed no transition in the myosin heads from ordered OFF state, where heads are held close to the thick filament backbone, to disordered ON states, where heads are free to bind to thin filament, in both muscles. When stimulation was delivered to both muscles for twitch contractions at Lo, x-ray signatures indicating the transition of myosin heads to ON states were observed in EDL but not in soleus muscle. During tetanic contractions, changes in the disposition of myosin heads as active tension develops is a cooperative process in EDL muscle whereas in soleus muscle this relationship is less cooperative. Moreover, this high cooperativity was maintained in EDL at all lengths tested here, but cooperativity decreased upon reduction in lengths in soleus. The observed reduced extensibility of the thick filaments in soleus muscles as compared to EDL muscles indicate a molecular basis for this behavior. These data indicate that for the EDL thick filament activation is a cooperative strain-induced mechano-sensing mechanism, whereas for the soleus thick filament xiii activation has a more graded response. Lastly, x-ray data collected at different lengths demonstrated that the effect of length on soleus is more pronounce compared to EDL, particularly noticeable in the thick filament during relaxation phase after stimulation ceased. These observations indicate that soleus is more length-dependent than EDL. These different approaches to thick filament regulation in fast- and slow-twitch muscles may be designed to allow for short duration, strong contractions versus sustained finely controlled contractions, respectively.
Show less

Title: Pressure Feedback Control on a UCAS Model in Random Gusts
Creator: He, Xiaowei
Date: 2021
Description: This research focuses on efficient active flow control (AFC) of the aerodynamic loads on a generic tailless delta wing in various flow/flight...
Show moreThis research focuses on efficient active flow control (AFC) of the aerodynamic loads on a generic tailless delta wing in various flow/flight conditions, such as, flying through atmosphere gusts, fast pitching, and other rapid maneuvers that would cause the aircraft to experience unsteady aerodynamic effects. A feedback control scheme that uses the surface pressure measurements to estimate the actual aerodynamic loads that act on the aircraft is put forward, with the hypothesis that a pressure surrogate can replace the inertia-based sensors to provide the controller with faster and/or more accurate feedback signals of the real-time aerodynamic load. The control performance of the AFC actuation and conventional elevons were evaluated. Results showed that the AFC with a momentum coefficient input of 2% was equivalent to 27-deg elevon deflection in terms of roll moment change and the control derivative of the AFC is at least doubled than that of the elevons.Streamwise and cross-flow gusts were simulated in the Andrew Fejer Unsteady Wind Tunnel at IIT. A spectral feedback approach was tested by generating the horizontal velocity components of the von Karman and the Dryden turbulence spectra. The velocity components in the test section were controlled temporally and spatially to generate transverse cross-flow gusts with designated wavelengths and frequencies. Sparse surface pressure measurements on the aircraft surface were used to develop lower-order models to estimate the instantaneous aerodynamic loads using the Sparse Identification of Nonlinear Dynamics (SINDy) algorithm. The pressure-based models acted as surrogates of the aerodynamic loads to provide feedback signals to the closed-loop controller to alleviate the gust effects on the wing. The control results showed that the pressure feedback scheme was sufficient to provide feedback signals to the controller to reduce the roll moment fluctuations caused by the dynamic perturbations down to 20% comparing to 30% to 50% in previous studies.
Show less

Title: Fault Detection and Localization in Flying Capacitor Multilevel Converters
Creator: Hekmati, Parham
Date: 2021
Description: This dissertation addresses fault detection, fault localization, and recovery in different topologies of the flying capacitor multilevel...
Show moreThis dissertation addresses fault detection, fault localization, and recovery in different topologies of the flying capacitor multilevel converters to guarantee the safe post-fault operation of the system and maintain load supply. There are multiple contributions of this dissertation, including techniques for device open-circuit fault (OCF) detection in stacked multicell converters (SMCs), a windows detector circuit to track the output terminal voltage levels and current directions, a fast and straightforward active power device OC fault detection and localization technique for the family of flying capacitor multilevel converters (FCMCs), a model-based open circuit fault detection and localization technique for the Buck-FCMC, a new estimator for tracking the voltage of flying capacitors, and fault detection and localization for interleaved converters. Each of these contributions is summarized below.The first contribution of this dissertation proposes a fast and straightforward technique for power device OCF detection in SMCs. The fault detection concept only needs to sense the converter's output terminal voltage and current. The sensed output terminal voltage is compared to a predicted one to detect and localize the OCF. A front-end routing circuit is then added to the SMC to maintain the operation of the converter post fault. The second contribution proposes a window detector circuit to track the output terminal voltage levels and current directions. The window detector circuit detects output terminal voltage level and current direction instead of requiring high sample rates and interrupt loops in the controller.The third contribution proposes a fast and straightforward active power device OCF detection and localization technique for the family of FCMCs, including DC to DC FCMCs, single or multi-phase H-bridge FCMCs, and cascaded H-bridge multilevel converters. This technique only needs to sense voltage and direction of current at the output terminals of the converters to detect and localize the fault. The method compares the measured and the expected terminal voltage while considering the commanded switch states and the terminal current direction. As switches transition to different states, healthy switches are excluded from the set of possible faulty switches until only one faulty switch remains. Coordination of the asynchronous operation of FPGA, DSP, and sensors is addressed for practical implementation. The fourth contribution is a model-based OCF detection and localization technique for the Buck-FCMC using model predictive control. In this technique, state-space equations of the system are developed. Comparison of the measured output inductor with the predicted one from the state-space model is used for the OCF detection and localization. This technique can potentially be used for other converters of the FCMC family. The fifth contribution is a new estimator for tracking the voltage of flying capacitors as the internal states of the FCMC. Using the proposed flying capacitor voltage estimator reduces the number of required sensors compared to the conventional model-based methods. At the same time, the overall technique's robustness to dynamic changes, including startup and load changes, is maintained. The last contribution is open and short circuit switch fault detection and localization for interleaved converters using the harmonic analysis of the output terminal parameters. With this method, monitoring electrical parameters of each leg of the interleaves converters is no longer required for fault detection and localization purposes.
Show less

Title: ROBUST AND EXPLAINABLE RESULTS UTILIZING NEW METHODS AND NON-LINEAR MODELS
Creator: Onallah, Amir
Date: 2022
Description: This research focuses on robustness and explainability of new methods, and nonlinear analysis compared to traditional methods and linear...
Show moreThis research focuses on robustness and explainability of new methods, and nonlinear analysis compared to traditional methods and linear analysis. Further, it demonstrates that making assumptions, reducing the data, or simplifying the problem results in negative effect on the outcomes. This study utilizes the U.S. Patent Inventor database and the Medical Innovation dataset. Initially, we employ time-series models to enhance the quality of the results for event history analysis (EHA), add insights, and infer meanings, explanations, and conclusions. Then, we introduce newer algorithms of machine learning and machine learning with a time-to-event element to offer more robust methods than previous papers and reach optimal solutions by removing assumptions or simplifications of the problem, combine all data that encompasses the maximum knowledge, and provide nonlinear analysis.
Show less

Title: How Does Self-Stigma Influence Functionality in People with Serious Mental Illness? A Multiple Mediation Model of "Why-Try" Effect, Coping Resources, and Personal Recovery
Creator: Qin, Sang
Date: 2022
Description: People with serious mental illness (SMI) face self-stigma effects that often undermine their functionality. Functionality herein refers to a...
Show morePeople with serious mental illness (SMI) face self-stigma effects that often undermine their functionality. Functionality herein refers to a person's execution of tasks (i.e., activities) and engagement in life situations (i.e., participation). This study used a path model to examine three mediating factors between self-stigma and functionality: The "why-try" effect, coping resources, and personal recovery. Specifically, the “why-try” effect was viewed as an extension of self-stigma harm that occurred when people suffered from a loss of self-esteem and self-efficacy. Coping resources were conceptualized as individuals’ strengths and the support they had to overcome negative stigma outcomes, particularly stigma stress. Endorsement of personal recovery, namely pursuing self-defined life goals despite illness—had a buffering effect reducing self-stigma. These three mediators were examined simultaneously using an archival dataset. Due to poor internal consistency, coping resources were eventually removed from the model; the subsequent, revised model achieved a good model fit. Results showed that people with SMI experiencing self-stigma were found to have an enhanced "why-try" effect as well as reduced personal recovery, leading to a decline in functionality. Implications of the results and future research directions are discussed.
Show less

Title: Decreasing Body Dissatisfaction in Male College Athletes: A Pilot Study of the Male Athlete Body Project
Creator: Perelman, Hayley
Date: 2020
Description: Body dissatisfaction is associated with marked distress and often precipitates disordered eating symptomology. Body dissatisfaction in male...
Show moreBody dissatisfaction is associated with marked distress and often precipitates disordered eating symptomology. Body dissatisfaction in male athletes is an important area to explore, as research in this field often focuses on eating disorders in female athletes. The current body of literature regarding male college athletes suggests that they experience pressures associated with both societal muscular ideals and sport performance. While there is a clear association between drive for muscularity and body dissatisfaction in college male athletes, no study to date has evaluated the efficacy of a body dissatisfaction intervention for this population. Therefore, the present study sought to investigate the efficacy and feasibility of a pilot intervention program that targeted body dissatisfaction in male college athletes. Participants were randomized into an adapted version of the Female Athlete Body Project (i.e., the Male Athlete Body Project) or an assessment-only control condition. A total of 79 male college athletes (39 in treatment condition) completed this study for a retention rate of 84.9%. Participants in the experimental group attended three 80-minute group sessions once a week for three weeks. All participants completed measures of body dissatisfaction, internalization of the body ideal, drive for muscularity, negative affect, and sport confidence at three time points: baseline, post-treatment (three weeks after baseline for the control condition), and one-month follow-up. Hierarchical Linear Modeling was used to assess differences between conditions across time. Participation in the MABP improved men’s satisfaction with specific body parts, drive for muscularity, and body-ideal internalization at post-treatment. Men in the MABP also reported improvements in appearance evaluation and overweight preoccupation at post-treatment and one-month follow-up, and in negative affect at one-month follow-up only. Improvements in drive for muscularity were retained at one-month follow-up. This study provides preliminary evidence for the feasibility and efficacy of the Male Athlete Body Project.
Show less

repository.iit

Search the repository

Pages

Pages