Institutional Repository
Array
Pages
-
- Fix it: Mending Workshop
- Book chapter from The Sustainable Library's Cookbook
-
- Engineering Escherichia coli to produce and secrete colicins for rapid and selective biofilm cell killing
- Bacterial biofilms are associated with chronic infectious diseases and are highly resistant to conventional antibiotics. Antimicrobial bacteriocins are alternatives to conventional antibiotics and are characterized by unique cell-killing mechanisms, including pore formation on cell membranes, nuclease activity, and cell wall synthesis inhibition. Here, we used cell-free protein synthesis to rapidly evaluate the antibiofilm activities of colicins E1, E2, and E3. We found that E2 (with DNase activity) most effectively killed target biofilm cells (i.e., the K361 strain) while leaving nontargeted biofilms intact. We then engineered probiotic Escherichia coli microorganisms with genetic circuits to controllably synthesize and secrete colicin E2, which successfully inhibited biofilms and killed preformed indicator biofilms. Our findings suggest that colicins rapidly and selectively kill target biofilm cells in multispecies biofilms and demonstrate the potential of using microorganisms engineered to produce antimicrobial colicin proteins as live therapeutic strategies to treat biofilm-associated infections., Sponsorship: NIH-R15AI130988
-
- Empirical Modeling of Public Safety to Voice Traffic to Aid Emergency Capacity
- An RF measurement system with high time resolution is implemented to determine the statistical characteristics of various channels in the Land Mobile Radio bands. The applicability of simple statistical models to the observed data is investigated, as well as their validity over short and long periods of time. The results show that the statistics of the idle and holding times of communication on these channels vary significantly over time and demonstrate daily periodicity, requiring non-stationary models to accurately represent them. Over short durations of time however, conventional distributions such as the exponential and lognormal may adequately characterize the properties of these quantities, allowing convenient and compact representations of the data. Results based on empirical data are presented to quantify the probability of stationarity for voice traffic within a time span of given length. The findings are useful for network planning or streamlining, network simulation and modeling, and investigation of dynamic spectrum access., Sponsorship: National Science Foundation, Federal Communications Commission, Motorola, Cleversafe, Roberson & Associates LLC
-
- Replacement as a Problem for Justification of Preventative Detention
- What makes Don E. Scheid’s article on indefinite detention interesting is that he thinks through many of the moral issues inherent in attempting to prevent (or, rather, keep to a minimum) certain kinds of violent crime, an attempt we have come to call (however unwisely) ‘‘the war on terror.’’ Scheid takes ‘‘war’’ as literally as possible, while making the reasonable assumption that this war, unlike wars generally, is not a temporary expedient responding to a moral emergency but an institution that must operate at full power for a long time, decades at least. Scheid’s argument yields a long list of preconditions for justified indefinite preventive detention: a high standard of dangerousness (‘‘mega-terrorism’’), a reasonable standard of proof of dangerousness, as good an investigation as conditions will allow, adequate resources for the defense, a hearing before a fair and independent tribunal, detention under the most comfortable conditions practical, and periodic review of the detainee’s supposed dangerousness. To these preconditions one more should be added: that detaining the persons in question will reduce the danger posed. I take this additional precondition to follow from Scheid’s own defense of indefinite detention, not from an independent argument. Scheid limits his argument to megaterrorists because the scale of destruction they have already achieved (for example, destruction of the World Trade Center) shows them to be dangerous on a scale ordinary crime is not and so to invite measures of prevention beyond what seems necessary (or proper) for ordinary criminals. Scheid explicitly declines to consider the non-consequentialist argument that preventive detention is what a mega-terrorist deserves for his character or for what he has already done. Scheid’s argument for preventive detention is consequentialist throughout: we may, and should, detain to prevent (or at least substantially reduce the probability of) the large-scale destruction of life that mega-terrorists aim at. We may justifiably deny a few, including some innocent persons, their freedom because, and only because, it makes the rest of us, the great majority, considerably safer. My additional precondition can be defended in the same way: where there is no danger posed, any detention is (all else equal) a net loss in happiness, well being, or whatever reasonable measure of consequences we adopt. A precondition of preventative detention must be a net reduction in danger posed. Where what is proposed is an institution of preventative detention, the institution must have that effect overall. What I shall argue here is that preventive detention generally fails to satisfy this condition and Scheid’s indefinite preventive detention of mega-terrorists always does. An institution to prevent terrorism by detaining terrorists cannot, in practice, significantly reduce the danger terrorism poses., Criminal Justice Ethics. Vol. 30, No. 1, April 2011, 90-97.
-
- Learning the Lingo? Gender, Prestige and Linguistic Adaptation in Review Communities
- Women and men communicate differently in both face-to- face and computer-mediated environments. We study linguistic patterns considered gendered in reviews contributed to the Internet Movie Database. IMDb has been described as a male-majority community, in which females contribute fewer reviews and enjoy less prestige than males. Analyzing reviews posted by prolific males and females, we hypothesize that females adjust their communication styles to be in sync with their male counterparts. We find evidence that while certain characteristics of “female language” persevere over time (e.g., frequent use of pronouns) others (e.g., hedging) decrease with time. Surprisingly, we also find that males often increase their use of “female” features. Our results indicate, that even when they resemble men’s reviews linguistically, women’s reviews still enjoy less prestige and smaller audiences.
-
- Tweet Acts: How Constituents Lobby Congress via Twitter
- Twitter is increasingly becoming a medium through which constituents can lobby their elected representatives in Congress about issues that matter to them. Past research has focused on how citizens communicate with each other or how members of Congress (MOCs) use social media in general; our research examines how citizens communicate with MOCs. We contribute to existing literature through the careful examination of hundreds of citizen-authored tweets and the development of a categorization scheme to describe common strategies of lobbying on Twitter. Our findings show that contrary to past research that assumed citizens used Twitter to merely shout out their opinions on issues, citizens utilize a variety of sophisticated techniques to impact political outcomes.
-
- 'Ain't No One Here But Us Social Forces' : Constructing the Social Responsibility of Engineers.
- There are many ways to avoid responsibility, for example, explaining what happens as the work of the gods, fate, society, or the system. For engineers, “technology” or “the organization” will serve this purpose quite well. We may distinguish at least nine (related) senses of “responsibility”, the most important of which are: (a) responsibility-as-causation (the storm is responsible for flooding), (b) responsibility-as-liability (he is the person responsible and will have to pay), (c) responsibility-as-competency (he’s a responsible person, that is, he’s rational), (d) responsibility-as-office (he’s the responsible person, that is, the person in charge), and (e) a responsibility-as-domain-of-tasks (these are her responsibilities, that is, the things she is supposed to do). For all but the causal sense of responsibility, responsibility may be taken (in a relatively straightforward sense)—and generally is. Why then would anyone want to claim that certain technologies make it impossible to attribute responsibility to engineers (or anyone else)? In this paper, I identify seven arguments for that claim and explain why each is fallacious. The most important are: (1) the argument from “many hands”, (2) the argument from individual ignorance, and (3) the argument from blind forces. Each of these arguments makes the same fundamental mistake, the assumption that a certain factual situation, being fixed, settles responsibility, that is, that individuals, either individually or by some group decision, cannot take responsibility. I conclude by pointing out the sort of decisions (and consequences) engineers have explicitly taken responsibility for and why taking responsibility for them is rational, all things considered. There is no technological bar to such responsibility., Science and Engineering Ethics.
-
- Transdiagnostic Emotional Vulnerabilities Linking Obsessive-Compulsive and Depressive Symptoms in a Community-Based Sample of Adolescents
- Background: Transdiagnostic emotional vulnerabilities are suspected to underlie psychopathologic comorbidity but have received little attention in adolescent emotional pathology literature. We examined distress tolerance, anxiety sensitivity, and anhedonia as concomitant transdiagnostic mechanisms that account for (i.e., statistically mediate) the covariance between adolescent obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) symptoms. Method: Data on MDD, OCD, and the three aforementioned transdiagnostic vulnerabilities were collected from a community-based sample of 3,094 9th graders in a large metropolitan area and analyzed using mixed effects modeling to evaluate mediation effects. Results: Individually and when controlling for each other, all three transdiagnostic vulnerabilities mediated the relation between OCD and MDD symptoms both before and after adjusting for demographics. Conclusions: Distress tolerance, anxiety sensitivity, and anhedonia may be unique mechanisms accounting for comorbidity between OCD and MDD symptoms in youth. Longitudinal evaluation of these candidate transdiagnostic emotional vulnerabilities in adolescent OCD-MDD comorbidity is warranted., Sponsorship: Grant sponsor: National Institute on Drug Abuse; Contract grant number: R01?DA033296.
-
- Machine Learning at the Bureau of Labor Statistics
- Vinesh Kannan (CS '19) shares his experiences working as a data science fellow at the Bureau of Labor Statistics (BLS). Vinesh worked on the team that produces occupation and wage data used by policymakers, hiring staff, job seekers, and researchers across the country. He helped improve machine learning systems at the BLS: automatically identifying problematic training data and classifying rare jobs. Vinesh offers advice for students who may be interested in applying for the 2020 Civic Digital Fellowship, a program that recruits university students at all levels to spend a summer working on civic technology projects with various federal agencies., Sponsorship: College of Science, Department of Computer Science, Department of Applied Mathematics, Machine Learning at IIT
-
- Examining Partnership-Health Associations Among Lesbian Women and Gay Men Using Population-Level Data
- Abstract Purpose: The aim was to provide the first broad assessment of partnership-health associations across partnership statuses among sexual minority individuals. Methods: Using population-level data from the 2016 U.S. Behavioral Risk Factor Surveillance System, specifically the 26 states/territories that assessed sexual orientation and gender identity, we ran analyses of covariance and logistic regressions to compare lesbian and gay individuals (N = 2963) of different partnership statuses in general health, physical health and health conditions, mental health, health behaviors, and healthcare access/utilization domains. Results: All omnibus and logistic regression models were significant (p < 0.001). Follow-up pairwise comparisons of mean differences across partnership groups revealed that in at least one variable in the general health, mental health, health behaviors, and healthcare access/utilization domains, married lesbian and gay individuals reported the best health, followed by partnered, single, and then divorced, separated, and widowed lesbian and gay individuals (p < 0.001). Exceptions included variables in the physical health and health conditions domain, the health behaviors of smoking and heavy drinking, and ever having an HIV test. When stratifying by sex, for both gay men and lesbian women being married or partnered related to the best health in at least one variable in each health domain, and in the majority of all outcome variables. Conclusion: This article provides the first evidence for partnership-health associations among gay and lesbian individuals based on a large-scale, multi-domain test of population-level data. Future research could examine temporal links between same-sex marriage legislation and health outcomes among sexual minority individuals.
-
- Three agendas for changing the public stigma of mental illness.
- OBJECTIVE: Antistigma programs may be guided by 3 differing agendas: services (promote treatment engagement), rights (help people achieve rightful goals), and self-worth (facilitate self-worth and efficacy). This study examined the construct validity of this perspective by examining the factor structure of importance ratings of the 3 agendas. The study examined how importance might be viewed differently by the population as a whole versus a subsample of people who reported previous experience with mental health services and hence could be directly harmed by stigma. METHODS: 373 individuals recruited using Mechanical Turk completed importance ratings for each of the 3 agendas. Measures of public stigma were completed to examine concurrent validity of importance ratings. Those who reported taking medications for a psychiatric disorder were divided into a separate group and completed a measure of self-stigma. RESULTS: Outcomes seemed to confirm the factor structure of the 3 agendas model thereby offering partial support for the framework. Group analyses showed the services agenda was viewed as more important than rights or self-worth. People with mental health experience viewed the services agenda as more important than the other 2. However, dividing the mental health group into low and high self-stigma revealed that those with low self-stigma rated the rights agenda as more important. Conclusions and Implication for Practice: Participants with lower self-stigma identify the harm brought by stigma and thus endorse rights and self-worth more than those with higher self-stigma. Implications of these findings are discussed to assist to prioritize agendas for public health campaigns.
-
- Using Peer Navigators to Address the Integrated Healthcare Needs of African Americans with Serious Mental Illness
- Objective Impact of a peer navigator program (PNP) develop by a community based participatory research team was examined on African Americans with serious mental illness who were homeless. Methods Research participants were randomized to PNP or a treatment-as-usual control group for one year. Data on physical and mental health, recovery, and quality of life were collected at baseline, 4, 8 and 12 months. Results Findings from group by trial ANOVAs of omnibus measures of the four constructs showed significant impact over the one year for participants in PNP compared to control described by small to moderate effect sizes. These differences emerged even though both groups showed significant improvements in reduced homelessness and insurance coverage. Conclusions Implications for improving in-the-field health care for this population are discussed. Whether these results occurred because navigators were peers per se needs to be examined in future research.
-
- Making the cut: Collaborative Decision Making in Collection Management
- Presented at the CARLI Collection Management Forum. Making collaborative collection management decisions making using a decision tree.
-
- Creating partnerships and mapping events
- Presentation at ALA Annual 2019.
-
- Building accessibility partnerships
- Presented at LibUX Chicago From Accessibility to Inclusion. Describes the importance of developing partnerships for supporting diverse user needs, including in the design of accessible learning objects.
-
- From in-person to webinar
- Slides used at the IIT Libraries 2019 Mini Conference.
-
- Collaborative Collection Development: Increasing Equity in Times of Austerity
- Presentation at ALA Annual, 2018. Libraries have long participated in cooperative collection development as a strategic way of spending funds and sharing resources. Using established best practices for collaborative collection development as a foundation, this session will describe updated strategies for initiating and assessing simple but effective cooperative collection development projects that increase the number of unique titles that can be shared among libraries with minimal commitment. The strategies are applicable to any library setting. Co-sponsored by RUSA CODES and the Social Responsibilities Round Table (SRRT)