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Title: IN VITRO ASSAYS FOR ASSESSING THE IMPACT OF PROCESSING ON THE ALLERGENIC POTENTIAL OF MILK ALLERGENS
Creator: Zhao, Yuhui
Date: 2014, 2014-07
Description: A better understanding of how processing may affect the allergenicity of proteins will allow a more accurate allergen risk assessment and...
Show moreA better understanding of how processing may affect the allergenicity of proteins will allow a more accurate allergen risk assessment and achieve a greater success in food allergy management. To determine whether food processing can affect the allergenic potential of proteins, immunochemical methods are commonly used, however, these methods are not able to determine changes in the proteins’ ability to elicit allergic reactions. Although food challenge studies are the gold standard for determining the allergenicity of proteins, such studies are seldom performed due to ethical reasons and the difficulty in recruiting a sufficient number of study participants. In recent years, a number of mediator release assays have been developed to measure the allergenic potential of food proteins in vitro. How these cell-based assays can be used to assess the impact of thermal or other processing conditions on the allergenic potential of proteins remains to be determined. This study evaluated the use of sensitized rat basophilic leukemia (RBL) cells for assessing the impact of boiling on the allergenic potential of milk allergens by measuring changes in the proteins’ ability to induce cell degranulation and the release of β-hexosaminidase. RBL-2H3 cells sensitized with rat IgEs that were specifically raised against NIST non-fat milk standard reference material, β-lactoglobulin (BLG), α-lactalbumin (ALA) and α-casein (αCAS) were challenged with various concentrations of each allergen in its native and processed (boiled in PBS for 10 min) forms. Cell degranulation caused by the allergen was monitored by measuring the release of β-hexosaminidase. All allergens (NIST milk, BLG, ALA, and αCAS) were able to induce the release of β-hexosaminidase, up to 43.1%. A decrease in % release of β-hexosaminidase was observed when cells were challenged with a decreasing concenration xi of the ALA and milk allergens. Boiling of nonfat milk, ALA, BLG and αCAS caused an increase in the % release of β-hexosaminidase from sensitized cells across antigen concentrations from 10-6 mg/mL to 1 mg/mL. In conclusion, this study demonstrated that the in vitro mediator release assay method may serve as a useful model to evaluate the impact of thermal processing on the allergenic potential of milk allergens.
M.S. in Food Safety and Technology, July 2014
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Title: FINFET BASED STANDARD CELL LIBRARY CHARACTERIZATION
Creator: Yuan, Yu
Date: 2015, 2015-07
Description: In this work, four standard cell libraries based on FinFET technology have been characterized and implemented. The first library uses the BSIM...
Show moreIn this work, four standard cell libraries based on FinFET technology have been characterized and implemented. The first library uses the BSIM-CMG and PTM-MG models, which represents the common multi-gate devices. Two libraries are based on the BSIM-IMG model, operating in short-gate (corresponding to low-Vt) mode and lowpower (corresponding to high-Vt) mode separately. Synthesis and simulation of BSIMCMG based library is presented and compared to the conventional 45nm CMOS library, FreePDK45. The results show acceptable accuracy of the library based on BSIM-CMG model. For the libraries based on BSIM-IMG model, Short-Gate (SG) mode, Low-Power (LP) mode and the mixed-mode (combining both SG and LP modes) have been analyzed. The results proved that the low-power independent multi-gate FinFET can be used for leakage power reduction, just like the bulk CMOS high-Vt devices. At the end of this work, another library based on CCS model was characterized and verified, which show far better accuracy in terms of both timing and power modeling.
M.S. in Electrical Engineering, July 2015
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Title: PREPARATION FOR IMPLANTATION OF AN INTRACORTICAL VISUAL PROSTTIESIS IN A HUMAN: WORKING TOWARDS SATURATION
Creator: Troyk, Melissa J
Date: 2017, 2017-07
Description: The research focused on restoring visual perception via a vision prosthetic is progressing at a rapidly advancing rate. Previous research on...
Show moreThe research focused on restoring visual perception via a vision prosthetic is progressing at a rapidly advancing rate. Previous research on the experiences and perspectives of past, current, and potential vision prosthesis users has demonstrated that the decision to obtain a vision prosthetic is driven by a variety of unique factors and variables that merge with one another during the process of deciding to participate in clinical vision prosthesis research (Lane, Huyck, Troyk, & Schug, 2012; Lane, Nitsch, Huyck, Troyk, & Schug, 2014; Lane, Nitsch, & Troyk, 2015). The purpose of the current study was twofold: 1) to determine if our understanding of the experiences and perspectives of potential vision prosthesis users was nearing saturation, and 2) to understand the perspectives of potential vision prosthesis users who are veterans. Data were analyzed in accordance with qualitative analysis procedures. Results identified several new themes and subthemes that were determined to be important to our understanding of potential users’ perspectives of an intracortical vision prosthesis device. A preliminary framework is proposed for understanding how the identified themes and subthemes merge during the process of deciding to participate in an experimental vision prosthesis human clinical trial. The results demonstrated that while progress has been made, there is still more to learn about blind individuals’ perspectives of vision prostheses and how they would decide to participate in vision prosthesis research.
M.S. in Psychology, July 2017
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Title: PROPOSITION AND EVALUATION OF A NEW DAMPER, CALLED ROTATIONAL CYLINDRICAL FRICTION DAMPER (RCFD)
Creator: Divani, Abbass
Date: 2013, 2013-12
Description: The objective of this study is to propose and evaluate an innovative frictional damper for structural systems, called Rotational Cylindrical...
Show moreThe objective of this study is to propose and evaluate an innovative frictional damper for structural systems, called Rotational Cylindrical Friction Damper (RCFD), which does not bear limitation of previously proposed systems and yet maintains their advantages. Different kinds of energy dissipaters have been studied and used in structural systems in recent years. They perform more effectively compared to structures without any energy dissipater. Each of previously employed devices has its advantages and limitations. In this report, applicability of previous energy dissipaters will be investigated; then the proposed damper, RCFD, will be introduced, and the performance of RCFD will be evaluated under lateral load using ABAQUS software. RCFD consists of a shaft, a cylinder and proper assembly of braces so that the bracing members make the cylinder and shaft move in opposite circular directions under defined load. The assemblage of braces depends on type of bracing system that is employed. When load in bracing member exceeds the buckling load of the member, it overcomes the friction between the shaft and inner surface of the cylinder and while providing the ductility demand of the structure, it absorbs the energy of the seismic load, and it will work like a safety valve to protect main structural members from inelastic deformation. In spite of other types of frictional dampers, RCFD does not use and reduces the construction cost of high strength bolts. There is no limitation for the size and fitness of the bracing members more than that is for conventional design of braced frames. When we prove the performance of RCFD, some of the requirements of conventional design such as requirement of section F2 of Seismic Provisions for Structural Steel Buildings, AISC 341-10, will be eliminated. The pressure needed for developing friction is provided by heating the shaft and placing it into the cylinder with slightly smaller xiii diameter. It is simple to design and construct and does not have the limitation of other kinds of frictional damper systems. It can also be installed with little or no modification on any kind of Braced Frames or to retrofit Moment Frames. In this study, RCFD will be installed and evaluated on an Inverted V Concentrically Braced Frame, although installation of the RCFD on X Braced frame will be illustrated.
M.S. in Civil Engineering, December 2013
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Title: Functionalized Polyoxovanadates: Synthesis, Characterization and Properties
Creator: Zheng, Yujuan
Date: 2012-04-30, 2011-12
Description: The compound [NaVIV6O6{(OCH2CH2)2NCH2CH2OH}6]Cl.H20, designated C0 in this report, an Anderson type structure, contains a single nitrogen atom...
Show moreThe compound [NaVIV6O6{(OCH2CH2)2NCH2CH2OH}6]Cl.H20, designated C0 in this report, an Anderson type structure, contains a single nitrogen atom in place of a single oxygen atom in each of the six vanadium-oxygen octahedra. Attached to each nitrogen are two alkoxide arms (-O-C-C-) which terminate on separate oxygen atoms of the octahedra. A third ethoxy group (-CH2-CH2-OH) dangles freely from each nitrogen atom. The functionalized cationic core [NaVIV6O6{(OCH2CH2)2NCH2CH2OH}6]+ is generated in situ and is cationic with a charge of +1. Chloride is the counteranion. Each vanadium addenda atom is the +4 oxidation state, and the six unpaired electrons result in interesting magnetic properties. C0 is obtained by reaction of a vanadium oxide source triethanolamine. The purpose of the research described here was to adapt the synthetic protocol associated with triethanolamine to other similar ligands. Ligand choice was motivated by the broader goal of this research group to form (extended) hybrid electronic and magnetic materials by chemically bonding POM cores to chemically interesting ligands, such as dyes or other POM cores. In this regard, the original triethanolamine derivative has a number of shortcomings; chief among them is the inaccessibility of the alcoholic functional group chemistry---due to its low pH---that otherwise might have been used to form linkages through the dangling alkoxy arms. Additionally, linkages containing paraffinic carbon (-C-C-), which is not a good conduit of electronic interaction, are chemically undesirable where the synthetic goal is hybrid structures with interesting electronic and magnetic properties. The results associated with the three ligands, diethanolamine, N,N'-Bis(2-hydroxyethyl)ethylenediamine, and N,N-Bis(2-hydroxyethy) ethylenediamine, are described herein. Diethanolamine was chosen because---based on a structural comparison to triethanolamine---it was expected to produce a structure having a hydrogen atom in place of the dangling ethoxy arms, which was indeed the result. We considered this structure highly desirable becasue of the potential lability of the hydrogen atom (-N-H), which would allow us to functionalist the core directly. The resulting compounds are characterized by single-crystal X-ray diffraction, elemental analysis, mass spectroscopy, thermogravimetric analysis, FT-IR and UV-Vis spectroscopy, maganometric titration, temperature-dependent magnetic susceptibility measurements, and cyclic voltammetry. The results of the cyclicvoltammetric investigation are consistent with the labile hydrogen atom (-N-H).
M.S. in Chemistry, December 2011
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Title: MULTIPLE-INPUT MULTIPLE-OUTPUT NONLINEAR CONTROL OF SELECTIVE CATALYTIC REDUCTION SYSTEMS
Creator: Dong, Siwei
Date: 2015, 2015-05
Description: Selective catalytic reduction (SCR) is one of the most promising solutions to meet the future nitrogen oxides (NOx) emissions regulations for...
Show moreSelective catalytic reduction (SCR) is one of the most promising solutions to meet the future nitrogen oxides (NOx) emissions regulations for heavy-duty diesel vehicles. However, such vehicles often operate in highly transient operations in which mobile selective catalytic reduction systems encounter significant efficiency challenges, especially when the engine is under a low load. A detailed simulation model of the SCR system was developed in the Gamma Technologies simulation suite and a baseline model of feedback control on SCR was constructed. Experiment data for the exhaust gas composition and conditions from a Cummins ISB engine was used to provide the input parameters for the SCR model. The results reveal that in the low-load conditions, the efficiency of NOx reduction in the SCR system is very low, and the level NOx concentration exiting the vehicle could be over 5 times than the limitation set by the US Environmental Protection Agency (EPA). However, these issues are encountered in part due to the fact that current SCR controls focus solely on the aftertreatment components and treat the incoming engine output conditions as system disturbances. To address the low NOx conversion problems encountered in low load conditions, a new integrated engine and aftertreatment control model was designed. This integrated approach improves the SCR system efficiency by using available feedback and modulating the upstream air/fuel ratio to provide more favorable SCR inlet conditions. From experiment data analysis, the engine’s air/fuel ratio is shown to have a critical impact on exhaust gas temperature and exhaust oxygen fraction, which highly affect the SCR reactions. In order to integrate the engine and aftertreatment system, a model of the SCR dynamics was created and validated and a simple model of the relationship between the engine’s air/fuel ratio and resulting exhaust temperature and composition is leveraged. The new model-based control strategy is proven to be effective to improve SCR system performance at low-load operations. With a small value shift in air/fuel ratio, the efficiency of low-load SCR system can increase from 40% to 85% at low load operating conditions.
M.S. in Mechanical and Aerospace Engineering, May 2015
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Title: LINEAR AND NONLINEAR BEHAVIOR OF TRANSIENT LIFT RESPONSE TO PULSE-ACTUATION
Creator: An, Xuanhong
Date: 2014, 2014-07
Description: The transient lift coe cient for a NACA0009 airfoil with pulsed jet actuation type of active ow control at stall conditions is investigated....
Show moreThe transient lift coe cient for a NACA0009 airfoil with pulsed jet actuation type of active ow control at stall conditions is investigated. The experimental mea- surements show the lift coe cient dependence to a single-pulse with di erent pulse widths and amplitudes. Based on the single-pulse with optimal parameters, multi- pulse and continuous pulse actuation cases are studied, which indicate that the pulse interval is the major factor of the active ow control system capability. Linear and nonlinear model are used to predict the lift coe cient variation for di erent input signals to the actuators. A combined nonlinear model is introduced to predict lift coe cient change due to arbitrary unsteady pitching motion with active ow control.
M.S. in Mechanical and Aerospace Engineering, July 2014
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Title: Some commutation phenomena of direct current machinery
Creator: Clark, F. C.
Date: 2009, 1905
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/somecommutationp00clar
Thesis (B.S.)--Armour Institute of Technology

Title: OPTIMIZATION OF POWER TRENCH MOSFETS FOR HIGH EFFICIENCY SYNCHRONOUS BUCK CONVERTERS
Creator: Wang, Wendi
Date: 2016, 2016-05
Description: Synchronous buck converter might be one of the most widely used and fabricated circuitry in the world for its favorable trade-off on many...
Show moreSynchronous buck converter might be one of the most widely used and fabricated circuitry in the world for its favorable trade-off on many subjects. However, the ever higher operation frequency has lead to increasing power loss in power switches and imposed new challenge to MOSFET engineering. One promising alternative for the traditionally used trench MOSFET is the shield gate MOSFET. Shield gate MOSFET has superior conduction performance as well as fast switching transient response due to its Reduced Surface Electric Field (RESURF) effect. In recent years, characterization of power MOSFET has developed along with MOSFET technology itself. New Figure of Merits (FOMs) have come into people's sight as they serve as better standards to fully describe MOSFET's overall performance. Being the same case for many other device structures, this new characterizing system also puts advanced requirements to shield gate MOSFET. And one of the most crucial problems is the rather large output capacitance this structure is having. To improve the property of shield gate MOSFET and meet the requirements of new standards, several ways of structure refinement have been proposed in this work. Both shield gate MOSFET and conventional MOSFET rated at 40V have been designed and simulated in the second chapter. The outcome shows that shield gate MOSFET has superior performance in almost every respect except for its large output charge. Then new structure for COSS reduction has been introduced in the following section, with decrement of about 50% in QQS-1 being achieved. Finally, another issue that has been tackled with is the shoot through of synchronous buck converter. Equivalent circuit model for shoot through analysis is built in this section to study the effect of each parasitic element. And a p type pillar added structure has been verified as an effective way to suppress shoot through gate bounce.
M.S. in Electrical Engineering, May 2016
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Title: Some features of a modern overhead distributing system
Creator: Redman, A. R.
Date: 2009, 1916
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/somefeaturesofmo00redm
Thesis (B.S.)--Armour Institute of Technology

Title: ISOGEOMETRIC ANALYSIS VIA TRIANGULATION
Creator: Jaxon, Noah
Date: 2013-05-15, 2013-05
Description: We present a method for isogeometric analysis on a triangulation of a domain bounded by NURBS curves. In this method, both the geometry and...
Show moreWe present a method for isogeometric analysis on a triangulation of a domain bounded by NURBS curves. In this method, both the geometry and the physical eld are represented by bivariate splines in Bernstein B ezier form over the triangulation. We describe a set of procedures to construct a parametric domain and its triangulation from a given physical domain, construct Cr-smooth basis functions over the domain, and establish a rational Triangular B ezier Spline (rTBS) -based geometric mapping that Cr smoothly maps the parametric domain onto the physical domain and exactly recovers NURBS boundaries. As a result, this approach can achieve automated meshing of objects with complex topologies and allows highly localized re nement. Isogeometric analysis of problems from linear elasticity and advectiondi usion analysis are demonstrated.
M.S. in in Mechanical Engineering, May 2013
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Title: STRUCTURAL SEISMIC PERFORMANCE EVALUATION WITH CONSIDERATION OF ECONOMIC VULNERABILITY
Creator: Romero, Daniela Zuloaga
Date: 2014, 2014-05
Description: Performance evaluation of structures has until now been based on evaluation of maximum displacements, interstory drifts, deformation patterns,...
Show morePerformance evaluation of structures has until now been based on evaluation of maximum displacements, interstory drifts, deformation patterns, ductility and other similar parameters; a relative economic loss estimation as a performance measure for the structure is the next step that follows, and is what has been investigated in this work. For this study a steel mid-rise structure was designed according to code provisions using modal spectral analysis, after which it was subjected to an Incremental Dynamic Analysis (IDA) procedure to evaluate the capacity curve of the building. The capacity analysis was then used to determine damage states and compute fragility curves. Finally, economic relative loss values were assigned to represent each designated damage state, for which the mean damage ratio was computed (in terms of economic loss relative to total replacement cost) as a function of spectral displacement.
M.S. in Civil Engineering, May 2014
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Title: COORDINATE-EXCHANGE ALGORITHM CONSTRUCTION OF UNIFORM SPACE FILLING DESIGN
Creator: Han, Shipeng
Date: 2014, 2014-05
Description: Many scientific phenomena are now investigated by complex computer models. A computer experiment is a sequence of runs with various inputs....
Show moreMany scientific phenomena are now investigated by complex computer models. A computer experiment is a sequence of runs with various inputs. The uniform experimental design seeks its design points to be uniformly scattered on the experimental domain and is one kind of a space-filling design that can be used for computer experiments and OK for industrial experiments. The coordinate-exchange method we use is one-dimensional constrained optimization, searching for the optimal coordinate to make the points filling the space uniformly. This method saves large amounts of calculation compared to the multivariate optimization problems. In this thesis we provide the coordinate-exchange algorithm and demonstrate our methodology with numerical examples. Key words: Coordinate-exchange, Uniform design, Computer experiment, Space-filling design, optimal design.
M.S. in Applied Mathematics, May 2014
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Title: Track Elevation
Creator: Badger, Le Roy, Walbridge, John T.
Date: 2009, 1907
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/trackelevation00badg
Thesis (B.S.)--Armour Institute of Technology; Bibliography: leaves 34-36

Title: Zinc nitride, its formation, properties and alloys
Creator: Savoye, W. J., Edwards, A. R.
Date: 2009, 1921
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/zincnitrideitsfo00savo
Thesis (B.S.)--Armour Institute of Technology; Bibliography: leaves 25-28

Title: Informal Learning with Twitter
Creator: Wilhelm, Eva C.
Date: 2011-04-25, 2011-05
Description: Twitter use has evolved from status updates to a broad range of uses from personal broadcasting to information sharing and conversations. A...
Show moreTwitter use has evolved from status updates to a broad range of uses from personal broadcasting to information sharing and conversations. A study was conducted to determine how Twitter is used for informal learning purposes. It was examined what kind of questions with a learning objective are asked, and under which circumstances these questions are answered. Questions were categorized according to question topic, type, structure and audience. According to the analysis, users most frequently asked for definitions and procedural information about technology, web, software and Twitter use. The questions with the highest answer rate were questions directed at individual users via @replies, and asked about definitions and other factual information.
M.S. in Technical Communication and Informational Design, May 2011
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Title: DETECTION OF SUPEROXIDE ANION RADICALS IN ANION EXCHANGE MEMBRANE FUEL CELLS USING IN-SITU FLUORESCENCE SPECTROSCOPY
Creator: Zhang, Yunzhu
Date: 2016, 2016-07
Description: Anion exchange membrane (AEM) stability is a long-standing challenge that has limited the widespread development and adoption of AEM fuel...
Show moreAnion exchange membrane (AEM) stability is a long-standing challenge that has limited the widespread development and adoption of AEM fuel cells. It is essential to understand the mechanism of AEM degradation during fuel cell operation. There are multiple modes of AEM degradation, broadly classified as chemical, mechanical and thermal degradation. Chemical degradation is among the most destructive modes, and can be further sub-divided into nucleophilic degradation (induced by the hydroxide ion), and oxidative degradation (induced by reactive oxygen species). While the former has been extensively studied, there is minimal work on oxidative AEM degradation. The reactive oxygen chemical species produced during the operation of an AEM fuel cell have hitherto not been detected during operation. Given the high pH, it is postulated that superoxide anion radicals (𝑂2∙−), as opposed to hydroxyl radicals, are primarily involved in the degradation progress. The objective of this study was to confirm the 𝑂2∙− formation during AEM fuel cell operation and to monitor in real-time the rate of 𝑂2∙− generation in an operating fuel cell using in-situ fluorescence spectroscopy. 1,3-diphenlisobenzofuran (DPBF) was chosen as the fluorescence probe, the sensitivity of which towards 𝑂2∙− was evaluated by performing ex-situ experiments in a semi-batch reactor. We demonstrate that the fluorescence intensity of this dye selectively decreased upon exposing 𝑂2∙−. DPBF was then incorporated into an AEM (membrane was solution cast after mixing the dye with the casting solution), which was assembled into a fuel cell. 𝑂2∙− generation in an operating AEM fuel cell was then monitored via in-situ fluorescence spectroscopy using a bifurcated optical probe, when the cell was operated in H2/O2 mode. To confirm the impact of 𝑂2∙− on AEM degradation, independent experiments (without dye) were performed under identical conditions, under both H2/O2 and N2/N2 modes, and the ionic conductivity and ion exchange capacity were monitored to estimate degradation extent. From our in-situ fluorescence studies, we were able to estimate the rate constants and activation energy for oxidative AEM degradation in an operating AEM fuel cell.
M.S. in Chemical Engineering, July 2016
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Title: EFFECT OF HIGH PRESSURE PROCESSING ON MIGRATION CHARACTERISTICS IN POLYETHYLENE TEREPHTHALATE FILM
Creator: Zhou, Yue
Date: 2015, 2015-12
Description: High pressure processing (HPP) is gaining prominence worldwide as an alternative method of food preservation due to its benefits of improved...
Show moreHigh pressure processing (HPP) is gaining prominence worldwide as an alternative method of food preservation due to its benefits of improved quality, freshness and nutrient retention. The use of polymer-based flexible packaging materials has allowed application of HPP to prepackaged food products, without significant loss of physical and mechanical properties. However, there is limited data existing on migration properties in the materials before and/or after HPP. Therefore, it is necessary to evaluate potential migration issues in pre-packed foods during HPP (Song 2014). This research was conducted to determine the migration properties in polyethylene terephthalate (PET) films during and after HPP (121°C and 700MPa) and a comparable thermal processing (TP, 121°C and 0.1MPa), using gas chromatography (GC) coupled with mass spectrometer (MS) technique to quantify four model surrogates in FDA-suggested food simulants (Miglyol). This research will help the U.S Food and Drug Administration (FDA) and food industries to identify whether any safety issue related to chemical migration should be addressed concerning the use of HPP in production of pre-packaged foods.
M.S. in Food Safety and Technology, December 2015
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Title: INVOLVEMENT OF MIR-182 IN THE ACTION OF ATORVASTATIN IN PROSTATE CANCER CELLS
Creator: Li, Wenping
Date: 2013-04-10, 2013-05
Description: Atorvastatin (ATO), a widely used statin for lowering cholesterol was examined for its chemopreventive/therapeutic activities in prostate...
Show moreAtorvastatin (ATO), a widely used statin for lowering cholesterol was examined for its chemopreventive/therapeutic activities in prostate cancer cells. We found that ATO inhibited cell proliferation and induced autophagy in PC3 prostate cancer cells, as marked by significant induction of an autophagy marker LC3-II. Using Taqman RT-PCR technique, we also found that ATO treatment for 24h and 48h consistently up-regulated miR-182 in PC3 cells. However, adding geranylgeraniol (GGOH) to the culture media reversed the effect of ATO in regulating miR-182, suggesting that ATO up-regulates miR-182 through inhibition of geranylgeranyl biosynthesis. Overexpression of miR-182 in PC3 cells significantly decreased cell proliferation by about 36% (MTT assay), while knock-down of miR-182 stimulated cell proliferation by about 43% (MTT assay). In screening for miR-182 target genes, we found that Bcl2 and p21 are potential miR-182 target genes; Bcl2 was significantly down-regulated by ATO at both mRNA and protein levels and miR-182 knock-down up-regulated Bcl2 protein; p21 protein expression was positively correlated with alteration of miR-182 expression levels in PC3 cells. Through screening database of miR-182 target genes from TargetScanHuman 6.2 and PicTar, we found that p21 is not the direct target gene of miR-182, so it could be regulated by miR-182 indirectly. It has recently been established that miR-182 regulation is p53-dependent, since PC3 cells are p53 negative, it is clear that ATO regulates miR-182 in a p53-independent manner. These data demonstrate that miR-182 up-regulation and Bcl2 down-regulation by ATO could be two independent events and both could be involved in ATO mediated cell proliferation and autophagy.
M.S. in Biology, May 2013
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Title: Study of automatic electric fire pumps
Creator: Ross, L. R., Ballard, L. E., Swearingen, R.e.
Date: 2009, 1906
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/studyofautomatic00ross
Thesis (B.S.)--Armour Institute of Technology

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