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Title: IMPACT OF DATA SHAPE, FIDELITY, AND INTER-OBSERVER REPRODUCIBILITY ON CARDIAC MAGNETIC RESONANCE IMAGE PIPELINES
Creator: Obioma, Blessing Ngozi
Date: 2020
Description: Artificial Intelligence (AI) holds a great promise in the healthcare. It provides a variety of advantages with its application in clinical...
Show moreArtificial Intelligence (AI) holds a great promise in the healthcare. It provides a variety of advantages with its application in clinical diagnosis, disease prediction, and treatment, with such interests intensifying in the medical image field. AI can automate various cumbersome data processing techniques in medical imaging such as segmentation of left ventricular chambers and image-based classification of diseases. However, full clinical implementation and adaptation of emerging AI-based tools face challenges due to the inherently opaque nature of such AI algorithms based on Deep Neural Networks (DNN), for which computer-trained bias is not only difficult to detect by physician users but is also difficult to safely design in software development. In this work, we examine AI application in Cardiac Magnetic Resonance (CMR) using an automated image classification task, and thereby propose an AI quality control framework design that differentially evaluates the black-box DNN via carefully prepared input data with shape and fidelity variations to probe system responses to these variations. Two variants of the Visual Geometric Graphics with 19 neural layers (VGG19) was used for classification, with a total of 60,000 CMR images. Findings from this work provides insights on the importance of quality training data preparation and demonstrates the importance of data shape variability. It also provides gateway for computation performance optimization in training and validation time.
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Title: REVEALING LINGUISTIC BIAS
Creator: Karmarkar, Sathyaveer S.
Date: 2021
Description: Readers currently face bias in articles written by writers who focus more on partiality towards any person or organization than showing the...
Show moreReaders currently face bias in articles written by writers who focus more on partiality towards any person or organization than showing the real facts. The study aims to detect and reveal such bias against them and try to portray real facts without any partiality against any person or organization. The data is fetched by selecting various articles from Google, especially those containing some bias in them. The bias was checked by measuring the subjectivity and polarity of the article using multiple libraries such as NLTK etc. We created a google form to take readers’ views showing them randomly either the biased article or the improved article after changing bias and getting their opinions.
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Title: Effects of the Silicon Content on the Dimensional Changes of Electrodes for Lithium-ion Cells: An Electrochemical Dilatometry Study
Creator: Rodrigues Prado, Andressa Yasmim
Date: 2021
Description: The continuous growth of the electric vehicle market has significantly increased the demand for Li-ion batteries (LIBs). However, state-of-the...
Show moreThe continuous growth of the electric vehicle market has significantly increased the demand for Li-ion batteries (LIBs). However, state-of-the-art LIBs are not yet able to meet the EV industry demand for high energy density and long cycle life rechargeable batteries, prompting efforts to improve the performance of Li-ion cells. In this context, silicon became the most promising next-generation active material for LIBs negative electrodes, especially because Si can significantly increase the lithium storage capacity of the commonly available anodes. Nonetheless, commercialization of Si-based electrodes has been hindered by the poor electrochemical performance of these electrodes, which is mainly attributed to the severe volumetric changes in the silicon particles related to the electrochemical reactions with Li. Since the electrodes are composites with a complex combination of various materials interspaced by pores, the electrode-level swelling may differ significantly from the particle-scale expansion. Furthermore, an increase in electrode thickness due to silicon expansion can have a direct effect on how Li-ion cells are designed, as the accommodation of electrode dilation requires additional cell space to prevent significant dynamic stresses. Thus, the actual volumetric energy density of a LIB cell depends on the electrode swelling, since the higher the magnitude of the electrode expansion, the lower the gains in energy density. Monitoring the electrode dilation is just as important as the electrochemical evaluation when designing cells with Si-based anodes.In this work, we use high-resolution operando electrochemical dilatometry to quantify the (de)lithiation-induced expansion/contraction of silicon, blended silicon-graphite and graphite electrodes, upon electrochemical cycling. We evaluate the relationship between electrode capacity and dilation and observe that while the lithiation capacity improved with increasing the silicon content, the electrode swelling is highly aggravated. For silicon-rich anodes, the electrode dilation can be higher than 300%, and the expansion profile consists of a combination of slow swelling at low levels of lithiation followed by an accelerated increase at higher lithium contents. This non-linear dilation allows for narrowing the swelling by limiting the electrode capacity. In addition, we investigate how electrode properties, such as porosity, affect the dilation profile, and quantify the irreversible expansion of the electrodes. Finally, we discuss some of the challenges associated with the dilatometry technique and suggest experimental approaches for obtaining consistent and reliable data.
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Title: MITOCHONDRIA RELOCALIZATION IN CHLAMYDIA TRACHOMATIS INFECTED HFF-1 CELLS
Creator: Shuppara, Alexander Mitchell
Date: 2021
Description: Chlamydia trachomatis is an infectious, gram-negative, obligate intracellular human bacterial pathogen. With over eight hundred million cases...
Show moreChlamydia trachomatis is an infectious, gram-negative, obligate intracellular human bacterial pathogen. With over eight hundred million cases worldwide, C. trachomatis is the most prevalent sexually transmitted infection. It manifests as either trachoma, lymphogranuloma venereum, or other urogenital tract sequelae. As an intracellular pathogen, Chlamydia must scavenge for essential metabolites from establishing networks with its host’s organelles including Golgi apparatus, endoplasmic reticulum, endocytic vesicles, mitochondria, and the cytoskeleton. C. trachomatis was considered an “energy parasite” that is entirely dependent on their host’s ATP production. Yet, recent mitochondrial inhibitor-based evidence suggests that C. trachomatis possess a sodium-based energy gradient for ATP production. Despite this finding, literature on specific interactions between host cell mitochondria and C. trachomatis requires further definition. This project evaluates mitochondrial dynamics changes from C. trachomatis infection in the human foreskin fibroblast cell line, HFF-1. We first defined C. trachomatis growth characteristics in HFF-1 over 36 hours-post infection. Next, we determined changes in mitochondrial dynamics and content throughout infection using immunofluorescent and immunoblotting techniques. observations on infected cells show mitochondrial morphology changes from an elongated appearance at the early stages of infection to fragmented in the late infection stages. Unlike in HeLa cells, HFF-1 remains in a normal distribution throughout the cell and we do not observe mitochondria relocalizing toward the inclusion. By studying mitochondrial relocalization dynamics, new insights into the dynamic and parasitic relationship of Chlamydia and its host can be discovered.
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Title: Understanding the effect of temperature, strain and grain size on the stress relaxation behavior of Ni-base and steel alloys
Creator: Reny, Julia
Date: 2021
Description: Stress relaxation research is very valuable as it provides information on how materials relieve stress under a constant strain. In...
Show moreStress relaxation research is very valuable as it provides information on how materials relieve stress under a constant strain. In applications where parts are submitted to a constant deformation, it is important to know that regions containing notches or stress concentrations will be able to relax enough to avoid the formation of cracks during operations. In this study, the stress relaxation behaviors of experimental Ni-base superalloy RRHT5 and Pyrowear 53 steel alloy were investigated. Tests were conducted under different conditions, varying temperature, initial strain, and grain size to explore the influence of each of these factors. The stress relaxation test data was used to calculate apparent activation volumes which can be correlated with plastic deformation mechanisms governing the stress relaxation. Understanding these mechanisms and identifying how specific factors influence them is essential to further control and optimize the design and processing of materials to obtain the best properties. Depending on the test conditions, the stress relaxation underwent one or two stages dominated by different mechanisms. These governing mechanisms were considered to be either dislocation-dislocation interactions, dislocation rearrangement, dislocations spreading from localized slip bands or dislocation-precipitate interactions.
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Title: HERBS AND SPICES ON ENDOTHELIAL FUNCTION OVER 24 HOURS: A RANDOMIZED, CONTROLLED TRIAL
Creator: Thorat, Rajrajeshwari Sunil
Date: 2021
Description: Modern-day eating patterns are characterized by readily available carbohydrates and/or fats and have consistently been shown to disturb...
Show moreModern-day eating patterns are characterized by readily available carbohydrates and/or fats and have consistently been shown to disturb endothelial function. Recent investigations suggest herb and spice blends have beneficial effects in reducing inflammation and increasing endothelial function in humans. This study was designed to characterize the effect of herbs and spices on endothelial function as measured by flow-mediated dilation (FMD) over 24 h using a challenge meal paradigm. In a randomized, single-blinded, 4-arm, crossover trial, sixteen overweight/obese adults (BMI = 28.4 ± 2.5 kg/m2; age = 39 ± 15 years) consumed a high carbohydrate high-fat meal (≈ 41% Fat and ≈46% Carbohydrate of total Kcal) with or without the spices combinations, including Italian herbs (rosemary, basil, thyme, oregano, and parsley), cinnamon, and pumpkin pie spice (cinnamon, ginger, nutmeg, and allspice) on four separate days at least three days apart. Meals provided to subjects were customized according to the individual's energy needs to maintain the body weight. The meal was composed of 35% of the daily estimated energy requirement. FMD was performed at 0, 1, 2, 4, 5.5, 7, and 24h. A pressure cuff was positioned below the elbow, artery diameter was measured before the pressure is applied and then inflated to 220 mmHg systolic pressure for 5 minutes. Immediately after cuff deflation, brachial artery vessel diameter was measured to obtain peak vessel relaxation. FMD was calculated as a percentage change in artery diameter before and after the release of the pressure. Baseline (t= 0 h) %FMD change was not significantly different between the treatments (p>0.05). There was no significant increase in the %FMD after consuming the control meal at all time points (p>0.05). Consumption of meals with Italian herb mix, cinnamon, and pumpkin pie spice significantly increased %FMD at 24 h compared to the control meal (mean ± standard error at 24 h, 7.83 ±0.89%, 7.98±0.95% and 8.44±0.70% vs 6.03±0.79%, respectively, p˂0.05). Furthermore, % FMD was significantly increased at t= 24h in Italian herb mix and cinnamon compared to their respective baselines 5.68 ± 0.37% to 7.83 ± 0.89% (p=0.01) and 6.43 ± 0.89% to 7.89 ± 0.95% (p=0.03), respectively. The results of this research indicate that spices may be beneficial for improving endothelial function after 24 h consumption, suggesting bioactivity of herbs and spices on endothelial function will be related to their time course of bioavailability of bioactive components. This was the first study that assessed the effect of herbs and spices over 24 hours using FMD. Understanding the mechanism of how these herbs and spices improve endothelial function will be the subject of future research.
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Title: Eating Pathology Among Ethnic Subgroups of Latinas: An Examination of Acculturative Stress and Ethnic Identity
Creator: Quinones, Isabel Cristina
Date: 2021
Description: Latin women (Latinas) in the U.S may experience acculturative stress if ethnic group pressures regarding body ideals differ from the U.S. body...
Show moreLatin women (Latinas) in the U.S may experience acculturative stress if ethnic group pressures regarding body ideals differ from the U.S. body ideal. As a population consisting of multiple countries, the distinct cultures and customs among subgroups may impact how women from heterogeneous Latino countries/cultures perceive acceptable body weight and shape, as body ideals are culturally constructed. Furthermore, an individual’s ethnic identity level may impact the way acculturative stress relates to eating pathology. This study investigated 1) acculturative stress as a mediator of the relationbetween ethnic group and eating pathology among specific Latina subgroups, and 2) ethnic identity as a moderator of the association between ethnic group and acculturative stress, acculturative stress and eating pathology, and ethnic group and eating pathology. Mexican (n=30), Puerto Rican (n=31), Cuban (n=29), and non-Hispanic, White (n=30) women living in the U.S. were recruited via Prolific Academic to complete self-report questionnaires regarding ethnic group, ethnic identity level, acculturative stress, and eating pathology. Moderated mediation analyses supported a significant indirect effect of ethnic group on body dissatisfaction, binge eating, purging, restricting, excessive exercise, and negative attitudes towards obesity through acculturative stress, such that group differences were mediated by acculturative stress levels. Further, the association between acculturative stress and body dissatisfaction was dependent on strength of ethnic identity; there was a positive simple slope for women with low and moderate levels of ethnic identification (low b = 2.30, moderate b = 1.36, both p <0.001) but not for those with high ethnic identity (b = 0.52, p = 0.22), suggesting that a higher ethnic identification may be protective against the development of body dissatisfaction in Latinas experiencing acculturative stress. Findings support the importance of separating heterogeneous subgroups of Latinas and explicitly assessing acculturative stress. Assessment and preventive action should include addressing increased acculturative stress and the risk it may pose for Latinas endorsing eating pathology given that the combination of ethnic group, acculturative stress, and ethnic identity may pose an increased risk for Latina individuals vulnerable to eating pathology.
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Title: Learning Stochastic Governing Laws from Noisy Data Using Normalizing Flows
Creator: McClure, William Jacob
Date: 2021
Description: With the increasing availability of massive collections of data, researchers in all sciences need tools to synthesize useful and pertinent...
Show moreWith the increasing availability of massive collections of data, researchers in all sciences need tools to synthesize useful and pertinent descriptors of the systems they study. Perhaps the most fundamental knowledge of a dynamical system is its governing laws, which describe its evolution through time and can be lever-aged for a number of analyses about its behavior. We present a novel technique for learning the infinitesimal generator of a Markovian stochastic process from large, noisy datasets generated by a stochastic system. Knowledge of the generator in turn allows us to find the governing laws for the process. This technique relies on normalizing flows, neural networks that estimate probability densities, to learn the density of time-dependent stochastic processes. We establish the efficacy of this technique on multiple systems with Brownian noise, and use our learned governing laws to perform analysis on one system by solving for its mean exit time. Our approach also allows us to learn other dynamical behaviors such as escape probability and most probable pathways in a system. The potential impact of this technique is far-reaching, since most stochastic processes in various fields are assumed to be Markovian, and the only restriction for applying our method is available data from a time near the beginning of an experiment or recording.
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Title: POTENTIAL EXPOSURE TO SUBSTANCES IN POLYMER COMPOSITES USED AS FOOD PACKAGING MATERIALS
Creator: Shah, Saloni S.
Date: 2021
Description: In the food manufacturing, preservation, supply, and distribution chain, packaging plays a critical role. The fundamental goal of any...
Show moreIn the food manufacturing, preservation, supply, and distribution chain, packaging plays a critical role. The fundamental goal of any packaging method is to keep food contained and protected. There is an increasing demand for natural and "fresh-like" foods that are less processed and have a longer shelf life, necessitating a variety of packing strategies. With increasing demand, the biggest developments in the field of packaging technology have been innovative food packaging approaches, such as active packaging, intelligent packaging, and bioactive packaging, which include deliberate contact with the food or its surroundings and its effect on consumer health. Several research studies in the past few years have shown that nanocomposite materials have significant improvement in the strength, barrier characteristics, antimicrobial capabilities, and heat and cold stability of food packaging materials, but various studies have reported that these composites might be a source of engineered nanomaterials in the human diet or environment. It has also been reported in numerous studies that nanocomposites can migrate into the food during long-term storage. These studies use food simulants like acetic acid and water to mimic the food matrix. However, they raise issues regarding how ingredients in real foods could affect exposure. This research focuses on the migration of silver (Ag) ions into food matrix-like commercial beverages and demonstrating if the ingredients present in commercial food and beverages influence the migration process. For the study, polymer composites films and dogbones were made. Polymer composite films with 0.2%, 1%, and 5% of silver zeolite concentration in polylactic acid (PLA) were produced, and different media like water, Domino sugar, and Squirt were stored in packages manufactured from this material under accelerated room-temperature conditions. Polymer composite dogbones were made with low-density polyethylene (LDPE) and polypropylene (PP) with 1.25% and 2.51% of graphene and graphite. Further, these materials were characterized with the help of Thermogravimetric analysis (TGA), Fourier Transform Infrared Spectroscopy-Attenuated Total Reflection (FTIR-ATR), and inductively coupled plasma mass spectrometry (ICPMS). This hypothesis of this study was that, when polymer composites are employed in packaging applications, food and beverage components may impact dietary exposure to these particles, and the use of food simulants may underpredict the quantity of the migration in some cases
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Title: HIGH SURFACE AREA CARBONS FOR ENERGY STORAGE TECHNOLOGIES
Creator: Lee, Youngjin
Date: 2021
Description: Energy storage systems play a pivotal role in harvesting energy from various sources and converting it to the energy forms required for...
Show moreEnergy storage systems play a pivotal role in harvesting energy from various sources and converting it to the energy forms required for applications in several sectors, such as utility, industry, building and transportation. The outstanding growth of portable electronic devices and electric vehicle/hybrid electric vehicles (EVs/HEVs) has promoted the urgent and increasing demand for high‐power energy resources. The most common electrical energy‐storage device is the battery due to the large amount of energy stored in a relatively small volume and weight while providing suitable levels of power for many applications and requirements of everyday life. These days, lithium-sulfur batteries (LSBs) have been drawing attention with their potential to provide 3-5 times more energy than that of current lithium-ion batteries (LIBs) at lower cost. Thus, realization of a practical Li-S technology can move the U.S. rapidly toward a more sustainable transportation future. The electrochemical double-layer capacitor (EDLC) is also an emerging technology, which really plays a key part in fulfilling the demands of electronic devices and systems, for present and future. The EDLC technology strongly depends on the properties of electrode materials. Activated carbons play an important role in developing new electrodes for both LSB and supercapacitor technologies. For example, carbon electrode-based supercapacitors require very high specific surface area and superior pore size distribution for easy accessibility of ions. Thus, the primary objective of this study is to develop a new high surface area carbon material and assess its applicability for both LSB and supercapacitor technologies. In this thesis work, we have designed and synthesized several active carbon materials. One of them displayed very high surface area (1,832 m2/g) and excellent pore diameter (3.6 nm). We investigated the applicability of this carbon material for supercapacitor electrodes. We have also modified this carbon material with a nickel-rich phosphide in order to make it suitable for LSB cathode applications.
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Title: ENERGY METABOLISM OF CHLAMYDIA PNEUMONIAE
Creator: McMillan, B. Julia
Date: 2021
Description: Chlamydia pneumoniae is a gram-negative bacterium that infects the humanrespiratory tract. It causes acute pneumonia and has been linked to...
Show moreChlamydia pneumoniae is a gram-negative bacterium that infects the humanrespiratory tract. It causes acute pneumonia and has been linked to several chronic diseases including cardiovascular disease, asthma, and some neurological diseases. C. pneumoniae primarily exists in two forms, the elementary body (EB) and the reticulate body (RB). The EB infects host cells and the RB replicates inside them. In order to survive in and out of the host, it was thought that C. pneumoniae RBs obtain host ATP to use for energy, making it an “energy parasite.” However, genomic analysis indicated that it was also possible for C. pneumoniae to create ATP from its own respiratory chain using the Na + pump NADH Ubiquinone Oxidoreductase (Na + -NQR). Neither the details of the energy parasite theory nor the possibility of C. pneumoniae creating its own energy had been experimentally explored. This project used a pharmacological approach to explore C. pneumoniae host energy consumption at various developmental stages, examine a mechanism that the bacterium could use to produce its own energy, and assess the importance of a balanced Na + /H + gradient for energy production and maintaining homeostasis. Based on the genomic analysis, it was thought that C. pneumoniae would rely heavily on host ATP in the EB form but not the RB form, that inhibiting Na + -NQR would slow bacterial growth, particularly in RBs, and that disrupting the Na + /H + gradient would significantly reduce RB infection. The results indicate that in the EB form, C. pneumoniae relies on host ATP and requires a balanced Na + /H + gradient, but disrupting Na + -NQR does not hinder its growth. In the RB form, C. pneumoniae is not dependent on host ATP, nor on its own respiratory chain ATP, and is not impacted by an unbalanced Na + /H + gradient. Therefore, the energy parasite hypothesis appears to apply to C. pneumoniae EBs but not RBs. Furthermore, established C. pneumoniae infections are excellent at compensating for various environmental conditions and sources of energy, which proves challenging for drug design against C. pneumoniae.
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Title: The Public Stigma of Tourette Syndrome
Creator: Tooley, Anastasia Cherise
Date: 2021
Description: There is a dearth of quantitative research examining the public stigma of Tourette syndrome (TS), and no known studies assessing public...
Show moreThere is a dearth of quantitative research examining the public stigma of Tourette syndrome (TS), and no known studies assessing public perceptions of difference (how similar they are), disdain (how bad they are), and blame (how responsible they are) toward individuals with TS. The current study sought to understand the public stigma of TS as a visible and unconcealable condition. An internet sample of 450 adults were recruited through MTurk. Participants read four brief vignettes, each describing an adolescent with TS, obsessive-compulsive disorder (OCD), autism spectrum disorder (ASD), or a history of juvenile detention. Results showed TS to be associated with neutral or negative public perceptions across stigma facets. When compared to OCD and ASD, vignettes describing TS were viewed with similar difference, disdain, and blame. TS was least familiar to participants. Findings highlight differences in stigma for concealable versus visible stigmatized conditions which has implications for future research and anti-stigma interventions.
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Title: ELECTROCHEMICAL BEHAVIOR OF ADDITIVELY MANUFACTURED NON-SPHERICAL TI-6AL-4V POWDER IN 3.5 WT. % NACL SOLUTION
Creator: Bagi, Sourabh Dilip
Date: 2021
Description: In laser powder bed fusion (LPBF), also known as selective laser melting (SLM), the feedstock powder and processing parameters affect the...
Show moreIn laser powder bed fusion (LPBF), also known as selective laser melting (SLM), the feedstock powder and processing parameters affect the properties of additively manufactured parts. Limited research has been conducted on non-spherical Ti6Al4V feedstock powder prepared by Hydride-Dehydride process. Significant progress in metal powder additive manufacturing (AM) requires the inter-linking of multiple variables, which includes starting materials, process settings, and post-treatment to achieve desired resultant properties. Owing to the rapid emergence of metal 3D-printing, process-property relationships, and appropriate post-treatment conditions have not been as extensively characterized as for conventional materials, thus requiring significant attention. Over the years, spherical powders were used in powder bed AM machines and there have been various concerns related to powder as well as processing parameters leading to defects formation, poor part quality, and unsatisfactory performance. It is critical to keep the cost of manufacturing low for large-scale production which results in significant interest in low-cost powder, making it vital to understand the effect of microstructural defects on corrosion behavior. Recently, economical powder attracted attention in AM, thus, making it is necessary to understand the role of possible microstructural defects on corrosion behavior. In powder bed additive manufacturing, feedstock and processing affect final microstructure and properties of the 3D printed parts. While numerous studies have evaluated 3D-printing of spherical powder, very limited research has examined the processing of the non-spherical feedstock. In this research, parts are manufactured by SLM of hydride-dehydride (HDH) Ti6Al4V powder. heat treatment and hot isostatic pressing are applied on SLM parts. The microstructures, potentiodynamic curves, and electrochemical impedance spectroscopy are characterized for SLM processed, heat treated, and hot isostatically pressed HDH Ti6Al4V specimens. Results indicate although the as-built specimen has anisotropic microstructure (i.e., lamellar α + acicular α’ + β phases), the heat treatment and hot isostatic pressing result in homogenized grain structures and enhanced corrosion behavior. Results indicate that type of constituent phase, grain size, and morphology directly determine corrosion resistance. This research is beneficial for the manufacturing of low-cost titanium alloys. In the current research, we evaluate non-spherical powder processing by hydride-dehydride (HDH) method and selective laser melted in powder bed AM machine followed by heat treatment and hot isostatic pressing to alter microstructure and electrochemical behavior. If successful, the usage of non-spherical morphology in conjunction with the newer powder dispensing method of double smoothing will enable remarkable improvements in the quality and performance of additively manufactured products. This method will also cut down costs associated with a greener powder production method and enhance the fabrication rate. It is a well-established fact that corrosion behavior is drastically affected by heterogeneous microstructure and defects. Thus, it is paramount to conduct a systematic study on the role of processing parameters and post process heat treatment, which can enhance our understanding of possible defect formation in micro and macro scale and their impact on electrochemical behavior.
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Title: BURNOUT AMONG SEXUAL MINORITIES: THE ROLE OF CONCEALMENT, RUMINATION, AND ORGANIZATIONAL NON-DISCRIMINATION POLICIES
Creator: Burke, Margaret
Date: 2021
Description: Employee burnout is detrimental to individuals (e.g., physical and mental health concerns), as well as to organizations (e.g., diminished...
Show moreEmployee burnout is detrimental to individuals (e.g., physical and mental health concerns), as well as to organizations (e.g., diminished performance). Although numerous studies have examined burnout across a variety of industries and populations, there are limited studies that have examined burnout specifically among sexual minority employees, referring to lesbian, gay, bisexual, transgender, and queer (LGBTQ) workers. This study integrated Meyer’s (2003) Minority Stress Model and Hatzenbuehler’s (2009) Psychological Mediation Framework to investigate the role of concealment, rumination, and non-discrimination organizational policies on burnout among 406 sexual minority employees working in a variety of industries (e.g., healthcare, retail, education, etc.). To test the relationships between these variables, a mediation model and a mediation with moderation model was tested using Hayes’ (2018) Process macro. Results indicated that concealing one’s sexual orientation at work was positively related to rumination, and in turn, was positively related to burnout. Contrary to one of the hypotheses, organizational non-discrimination policies that were inclusive of sexual minorities did not moderate the relationship between concealment and burnout. Previous research, implications, and limitations to this study are discussed in detail.
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Title: IDEOLOGICALLY MOTIVATED INTENTIONAL ADULTERATION: THEORY INTO INDUSTRIAL APPLICATION
Creator: DeVuyst, Adrian Jeffrey
Date: 2021
Description: Ideologically motivated intentional adulteration is an attempt to cause harm to consumers of food. Within the context of the United States of...
Show moreIdeologically motivated intentional adulteration is an attempt to cause harm to consumers of food. Within the context of the United States of America (US), the current methods of addressing this risk are evolving in the modern post-Food Safety Modernization Act (FSMA) era. Currently, the US has the Food and Drug Administration (FDA), which requires companies to have a food defense plan with a risk assessment, mitigation strategies, and recordkeeping. Additional options from Global Food Safety Initiatives (GFSI) benchmarked standards offer additional options for a company. However, even with these standards companies are still being impacted by intentional adulteration. Historical examples from the poisoning of bread in Hong Kong during British occupation and spreading of bacteria on salad bars by the followers of Rajneesh, to more modern examples of putting needles in strawberries and urinating on production equipment show a food defense system that is not always able to address intentional adulteration. The question of why companies are still having intentional adulteration comes up. The lack of food defense events and primary research on the topic creates a system where individual companies must gather data. Evaluations and surveys at a manufacturing site, N=11, indicates that there is high confidence among front line workers about their level of knowledge, but workers are unable to articulate the basic principles of food defense. Each individual company is required to create a personalized food defense system in the status quo, but the results of the survey given suggests that the data they could gather may be insufficient to create an effective food defense system.
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Title: Computationally Efficient Predictive Control Strategies for Autonomous Vehicles
Creator: Bhattacharyya, Viranjan
Date: 2021
Description: This thesis aims at developing computationally efficient (hence real-time applicable) control strategies for autonomous vehicles in the...
Show moreThis thesis aims at developing computationally efficient (hence real-time applicable) control strategies for autonomous vehicles in the presence of uncertainty, while incorporating high fidelity vehicle dynamics. The motivation for the control strategies is to ensure safety and improve energy efficiency of the vehicles. In this research, an effort has been made to develop control strategies to strike a balance between these competing factors. The specific contributions are: development of a new hierarchical control framework that can guarantee avoidance of red-light idling in the presence of uncertainty in preceding vehicle information/prediction in connected environment (hence improves system mobility); exploitation of a data-driven modeling approach for identifying a linear predictor for the nonlinear vehicle dynamics, which facilitates formulation of a convex equivalent problem of the original non-convex problem (hence facilitates computational tractability); introduction of a novel vehicle dynamics-aware fast game-theoretic planner for behavior and motion planning of vehicles in uncertain and unconnected environments. This thesis explores both the possible directions of future autonomous vehicles: connected and unconnected autonomous vehicles. In particular, the first problem relates to longitudinal fuel efficient driving (eco-driving) in a connected urban environment, where the connected and automated vehicles (CAVs) aim at the improvement of fuel efficiency and reduction of red-light idling (stop and go motion). The CAVs also focus on ensuring collision avoidance with the preceding vehicles despite the prediction uncertainty in future trajectory of preceding vehicles. This problem assumes vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communication, and is a longitudinal control problem. The next problem considers the uncertainty in prediction of future states of neighbouring vehicles in an unconnected environment and involves both lateral and longitudinal control. Following previous research, the interactive nature of driving is modeled using game-theory and a computationally efficient game-theoretic planner is introduced. Simulation results show the efficacy of the proposed methods in terms of computational tractability and fuel-efficiency.
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Title: Evaluation of Bax∆2 Positive-Staining in Skin Samples Using Two Immunohistochemical Methods
Creator: Basheer, Sana
Date: 2021
Description: BaxΔ2 is a pro-death and tumor suppressor protein that sensitizes cells to certain chemotherapies. Previous diaminobenzidine (DAB)-based...
Show moreBaxΔ2 is a pro-death and tumor suppressor protein that sensitizes cells to certain chemotherapies. Previous diaminobenzidine (DAB)-based staining revealed that Bax∆2 is found in all organs, including breast, colon, and skin tissues. In the skin, the Bax∆2 positive cells were mainly found in the basal cell layer of the epidermis with a few Bax∆2 positive cells in the connective tissue of the dermis, although their cellular identity was unknown. Previous literature has shown that melanin, which is found throughout the cells of the epidermis, is a brown color that provides no visual contrast to the DAB staining. While the DAB-based immunostaining showed cells that appeared to be Bax∆2 positive, this result needed to be confirmed. For this, a set of human skin samples from normal and cancerous tissue of various patients was examined. The co-staining of these samples for Bax∆2 and basal cells using immunofluorescence revealed that the apparent Bax∆2-positve DAB staining in epidermal basal cells and squamous cell carcinoma as false-positive, but the Bax∆2 positive cells found in the dermal connective tissue were not false positive—which is consistent with both previous DAB-based and fluorescence-based immunostaining. Using co-immunostaining for Bax∆2 with different cellular markers, the Bax2-positive cells in the connective tissue were identified potentially as macrophages and fibroblasts. Further studies are required to confirm the identity of the Bax∆2 positive cells in the connective tissue.
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Title: Modeling and Control Methods for Boundary Constrained Soft Robots
Creator: Zhou, Qiyuan
Date: 2021
Description: Soft and deformable robots have been an active field of research in the past few years. However, they are limited in that they cannot apply...
Show moreSoft and deformable robots have been an active field of research in the past few years. However, they are limited in that they cannot apply much force to an environment due to the limitations of the flexible materials from which they are made of. To help overcome this limitation, a new architecture named the Jamming and Morphing Enabled Bot Array (JAMoEBA) system was conceived. This system consists of a flexible outer membrane which encloses an interior composed of a granular medium. Active sub-units along the flexible outer membrane allow for actuation and locomotion of the system. The granular material coupled with the flexible outer membrane allows the robot to maintain the characteristics typically associated with soft robots (continuum, compliant, configurable). At the same time, the granular material is also able to undergo a solid phase transition with the application of pressure to the flexible outer membrane and allow the system to behave more like a rigid robot if needed. This allows for the robot system to exploit the desirable characteristics of both soft and rigid robots in its tasks.The purpose of this thesis is to offer a discussion and demonstration of various simulation methods for the physically accurate modeling of the JAMoEBA constrained boundary robotic system and to show some of the control methods which have been investigated within the selected modeling framework. Simulation methods based on Lennard-Jones (L-J) potentials, non-smooth contact dynamics (NSCD), as well as the discrete element methods based on complementarity (DEM-C) and penalty (DEM-P) conditions as implemented in the open source physics library Project Chrono are considered. Comparisons are made in the areas of physical accuracy, computational efficiency, and feature availability in the consideration of the best simulation method for the JAMoEBA system. Investigations of control strategies such as leader-follower and heuristics based approaches are carried out using the selected simulation method. Finally, a framework for self contained localization which relies on measurements from onboard sensors and linear Kalman filtering is tested within the simulation framework, and the effectiveness of approximating the shape of the JAMoEBA system using elliptical Fourier descriptors is shown.The main contributions made in this thesis are in the areas of suitable modeling methods, controls strategies, and localization techniques for the novel boundary constrained JAMoEBA soft robot architecture. The work done serves as a solid foundation for the future study of this novel soft robotic architecture due to the demonstration of successful methods for modeling, control, and localization of the system. The work presented is not meant to be a comprehensive or deep dive into any one specific area, but rather a jumping off point for future areas of research.
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Title: EFFECTIVENESS OF CLEANING STRATEGIES FOR REMOVING MILK CHOCOLATE FROM PILOT-SCALE PIPE/VALVE ASSEMBLY AND CHOCOLATE PROCESSING EQUIPMENT
Creator: Zhang, Liyun
Date: 2019
Description: Dark chocolate manufactured on shared processing lines with milk chocolate is a high-risk food for consumers with milk allergy. Inadequate...
Show moreDark chocolate manufactured on shared processing lines with milk chocolate is a high-risk food for consumers with milk allergy. Inadequate cleaning of shared chocolate manufacturing equipment can result in milk contamination of subsequent products, and product recalls. Limited information is available on the effectiveness of different cleaning procedures for preventing the transfer of milk to dark chocolate processed on shared equipment. Pilot-scale experiments investigated the effectiveness of three dry cleaning methods: 1) no cleaning, 2) pig purging, and 3) a cocoa butter flush (40°C, 1 hour) for removing milk chocolate residue from a heated (40ºC) standard (1.5” OD) sanitary stainless steel pipe (30.5 cm length) and attached butterfly or ball valve. After cleaning, milk-free dark chocolate (~27 kg, 40°C) was pumped through the pipe/valve combination. Dark chocolate push-through samples were collected and analyzed for milk concentrations with a Neogen Veratox total milk ELISA kit. Experiments with no cleaning resulted in initial milk concentrations up to 6,070 (9.6% CV) ppm milk and up to 14,900 (0.3% CV) ppm milk for the pipe/butterfly valve and the pipe/ball valve, respectively. Cocoa butter recirculation through the pipe/butterfly valve decreased initial milk concentrations to 680 (10.3% CV) – 2720 (2.6% CV) ppm milk. Use of a pig purging dramatically reduced milk levels to 45 (4.3% CV) – 180 (15.7% CV) for the pipe/butterfly valve and below limit of quantification of ELISA (LOQ, 2.5 ppm milk) for the pipe/ball valve. After most cleaning treatments, > 14 kg of dark chocolate push-through was required to obtain milk levels < LOQ.A second set of pilot-scale experiments determined the efficacy of cleaning procedures for removing milk chocolate from selected chocolate processing equipment. Three cleaning methods explored removal of milk chocolate from a ball mill and conche: 1) no cleaning, 2) a cocoa butter flush (40°C, 5 min), and 3) wet cleaning (detergent-rinse-air dry). After cleaning, three batches of milk-free dark chocolate (40°C) were processed in the ball mill (~0.35 kg) and conche (2.5 kg), and each batch was collected and analyzed for milk. Milk chocolate (1.5 kg) was processed on a 3-roll refiner, followed by push-through with dark chocolate (~8 kg), with 0.3 kg samples collected at 5-min intervals. Milk was not detected (Show less

Title: Towards Assisting Human-Human Conversations
Creator: Nanaware, Tejas Suryakant
Date: 2021
Description: The idea of the research is to understand the open-topic conversations and ways to provide assistance to humans who face difficulties in...
Show moreThe idea of the research is to understand the open-topic conversations and ways to provide assistance to humans who face difficulties in initiating conversations and overcome social anxiety so as to be able to talk and have successful conversations. By providing humans with assistive conversational support, we can augment the conversation that can be carried out. The AdvisorBot can also help to reduce the time taken to type and convey the message if the AdvisorBot is context aware and capable of providing good responses.There has been a significant research for creating conversational chatbots in open-domain conversations that have claimed to have passed the Turing Test and can converse with humans while not seeming like a bot. However, if these chatbots can converse like humans, can they provide actual assistance in human conversations? This research study observes and improves the advanced open-domain conversational chatbots that are put in practice for providing conversational assistance.While performing this thesis research, the chatbots were deployed to provide conversational assistance and a human study was performed to identify and improve the ways to tackle social anxiety by connecting strangers to perform conversations that would be aided by AdvisorBot. Through the questionnaires that the research subjects filled during their participation, and by performing linguistic analysis, the quality of the AdvisorBot can be improved so that humans can achieve better conversational skills and are able to clearly convey their message while conversing. The results were further enhanced by using transfer learning techniques and quickly improve the quality of the AdvisorBot.
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