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Title: Automated Successive Baseline Schedule Model
Creator: Patel, Mihir Prakashbhai
Date: 2021
Description: The construction project involves many stakeholders and diverse phases. Usually, a construction schedule is initially set up as a simple ideal...
Show moreThe construction project involves many stakeholders and diverse phases. Usually, a construction schedule is initially set up as a simple ideal case scenario, but then, during construction, the project faces modifications such as delay, acceleration, and change in logic caused by the project’s complexity and inherent risk. To recover the damage(s) caused by these modifications, the parties responsible for them should be identified accurately. Researchers and practitioners developed and used various delay analysis models to quantify delays, but the selection of the model depends on the time of analysis, available information, and expertise of the analyst. So, the results can be biased. The general problem is that most delay analysis models consider only delays in quantifying impacts rather than every type of modification that impacted the project, including CPM logic changes and adding/removing activities during construction. This study proposes a new successive baseline model to enable the precise analysis of the impacts of all sorts of modifications that occur during construction. This model can achieve unbiased and accurate results. The analysis process can also be computerized into a web application to improve efficiency and productivity. The fundamental concepts of the various modifications that can occur in the work schedule during construction and the analysis of the modifications’ impacts are presented in this study. Issues related to concurrency, float ownership, type of modification, selection of delay analysis model, and challenges with automation are also highlighted to broaden the understanding disagreements of the parties to a construction contract. A case example is presented to prove the accuracy and usefulness of the proposed model and web application.
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Title: SAFETY AND MOBILITY IMPACTS ASSESSMENT OF THE CHICAGO BIKE LANE PROGRAM
Creator: Zhao, Yu
Date: 2021
Description: In recent years, bike as a travel mode is getting increasingly popular among large cities in the U.S. These cities also found promoting bike...
Show moreIn recent years, bike as a travel mode is getting increasingly popular among large cities in the U.S. These cities also found promoting bike mode can potentially mitigate traffic congestion issues, reduce carbon emission and improve the quality of life for residents. Therefore, many cities-initiated bike-related programs promote the bike mode from all aspects, such as establishing a shared bike system and developing bike-related facilities. Specifically, bike lane installation is widely seen in large cities as a pivot component of bike promotion programs. Due to the installation of bike lanes on the existing network, vehicles’ safety and mobility performance may be affected due to the variation of facilities. This study attempts to propose a methodology to quantify the safety and mobility impacts on vehicles brought by bike lane installation. The proposed method accounts for safety impact by using predicted crashes in conjunction with field observed crash data for empirical Bayes (EB) before-after comparison group analysis. The mobility impact is captured by comparing the segment average travel time before and after the bike lane installation. Further, vehicle volume information is involved in the consumer surplus computation to quantify the variation in vehicle safety, and mobility performance resulting from the bike lane installation. A case study is conducted using a real data set from the city of Chicago bike lane program. The results reveal that the safety and mobility impacts vary mainly depending on the type of bike lane installed and location.
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Title: Carrier phase multipath characterization and frequency-domain bounding
Creator: Benz, Chloe
Date: 2022
Description: Safely relying on Global Navigation Satellite Systems (GNSS) measurements for position estimation using multi-sensor navigation algorithms,...
Show moreSafely relying on Global Navigation Satellite Systems (GNSS) measurements for position estimation using multi-sensor navigation algorithms, especially in critical phases of flight – such as takeoff or landing – requires precise knowledge of the errors affecting position estimates and their extrema values at any time. This work investigates a method for characterization and power-spectral density (PSD) bounding of GNSS carrier phase multipath error intended for use in sensor fusion for aircraft navigation. In this dissertation, two methods of GNSS carrier phase multipath characterization are explored: single frequency dual antenna (DA) and single antenna dual frequency (DF). However, since not all aircraft are equipped with multiple GNSS antennas, because the DA method entails a meticulous tracking of the lever arm between the two antennas, and as multipath seen by two antennas in a short baseline configuration may cancel out, the DF method is preferred and is the main emphasis of this work. By subtracting carrier phase measurements collected by a receiver overtwo distinct frequencies, a composite measurement containing ionospheric delay and carrier phase multipath is obtained. The ionospheric delay has slower dynamics than multipath, so it is removed using a high pass filter. The filter cutoff frequency is carefully picked based on a study of ionospheric delay dynamics. The DF method is validated on a rooftop GPS carrier phase dataset, and finally, directions and considerations for its ultimate intended use on airborne collected GNSS carrier phase data are provided.
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Title: ESTIMATES OF AIR EXCHANGE RATES THROUGH THE USE OF TOTAL VOLATILE ORGANIC COMPOUND DECAY MEASUREMENTS
Creator: Bradley, Christopher
Date: 2021
Description: Indoor air exchange rates are commonly used to assess the overall fitness of a building and assess its performance. More recently, air...
Show moreIndoor air exchange rates are commonly used to assess the overall fitness of a building and assess its performance. More recently, air exchange has become a concern due to the COVD-19 pandemic, requiring replacement air to ensure safety; especially so considering that humans spend much of their time indoors. Building science has focused on air exchange to quantify needs for thermal loads, balancing the overall tightness of a building with the amount of energy consumed. Moreover, guidelines have been created by several different organizations to maintain adequate ventilation to remove indoor air pollution, replacing it with clean outdoor air. Research focuses on how to maintain a comfortable and safe quality of indoor air while balancing the needs of the energy crisis.When installed with proper HVAC systems, air exchange rates can be set to a recommended value based upon the conditions of the environment. Buildings without mechanical ventilation face another issue, mainly that they only rely on natural ventilation and the infiltration rate. Temperature differences between the indoor and outdoor environment and the condition of wind speed and direction create pressure differences across the building envelope, influencing the infiltration rate, which can change the amount of air exchange in buildings with natural or mechanical ventilation. Currently, air exchange rates are commonly measured using tracer gases. More frequently used gases have included perfluorocarbon, sulfur hexafluoride, and carbon dioxide, though none of these have proven to be ideal tracers. Alongside this, cost and burden on the participants of these studies often limit the amount of measurements made. Numerous studies have been conducted on how to model the air exchange rate by the changes in concentrations, but accuracy depends on the amount of information available. Other attempts have been made to characterize buildings by their infiltration rate to make estimations, but other questions have arisen about the accuracy of these methods. Due to their ubiquity in indoor environments, volatile organic compounds have been suggested as a plausible tracer gas for measuring air exchange rates. The plausibility of this method raises questions, such as their behavior within the indoor environment, their ability to be measured and the cost to measure concentrations, and the analytical requirements to characterize the rates of removal as air exchange rates. However, due to the rapid increase of available technology in low cost, lightweight, high-resolution sensors, this novel method of using VOCs, especially indicators of total VOCs (TVOCs), may prove fruitful in measuring air exchange within specific microenvironments. Analysis of time-series TVOC concentration measurements taken from a study conducted in multiple residences was conducted to investigate the feasibility of using these measurements, and especially naturally occurring elevation and decay periods, as a proxy for calculating air exchange rates. Though the removal rates of these compounds fell within the range of typical air exchange rates for residential spaces, the results of this analysis suggest the method has potential but with limitations, including the unknown behavior of the individual compounds comprising TVOC measurements within the space, proximity and mixing effects, and potentially invalid comparisons to air exchange rates given from a LBLX model rather than simultaneous tracer gas tests. Future work should explore simultaneous use of TVOC measurements alongside conventional tracer gas testing to further explore the potential utility of such methods.
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Title: INTELLIGENT STREET LIGHTING AND REMOTE POWER UNITS AS CASE STUDIES FOR CITIES TO DECARBONIZE
Creator: Burgess, Patrick G.
Date: 2022
Description: There is a scientific consensus that atmospheric warming caused by the release of emissions will reach critical levels in our lifetime if...
Show moreThere is a scientific consensus that atmospheric warming caused by the release of emissions will reach critical levels in our lifetime if significant efforts are not made to decarbonize our buildings and power grid. The City of Los Angeles is a prime example of the challenges of decarbonizing, balancing global, federal, and state policies and issues and addressing environmental justice. The first research case studies of the details and challenges of decarbonization efforts include the implementation of the first networked light-emitting diode (LED) streetlights in the city of Chicago on IIT’s campus to improve the reliability and economics of its main campus, 2.5 mi south of downtown Chicago. Research shows that these networked LED streetlights greatly reduce a city's rising energy costs, but the CSMART project team has set out to prove the benefits of integrating an intelligent communications and control system with an existing smart grid infrastructure, such as an existing network and supervisory control and data acquisition (SCADA) systems. In addition to assessing the economic and environmental drivers for the intelligent streetlight solution, the project team is dedicated to assessing the potential cybersecurity vulnerabilities of such a system and working to mitigate or eliminate them. The second research case study covers off-grid remote power units providing continuous illumination for safer streets and safer driving that is unaffected by power outages. Thanks to individual lighting control potentially allowing for dimming, blinking, and even color changing, streetlights powered by RPUs can be used as emergency signaling devices, directing traffic during a city evacuation or other emergency. The RPU control and monitoring can be accessed through the cloud, thereby avoiding reliance on local servers.
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Title: Examining Associations Between Discrimination, Social Cohesion, and Health among White and POC LGBT Chicagoans
Creator: Kannout, Lynn
Date: 2022
Description: Consistent with the minority stress perspective, lesbian/gay, bisexual, and transgender (LGBT) individuals on average report worse health than...
Show moreConsistent with the minority stress perspective, lesbian/gay, bisexual, and transgender (LGBT) individuals on average report worse health than heterosexual individuals in several domains, e.g., general health, mental health, physical health, and health care access. Intersectionality-based research shows that LGBT-POC are, on average, at even greater risk for adverse health outcomes compared to their White LGBT counterparts. Discrimination and social cohesion may be two mechanisms underlying these between- and within-group disparities, given their broader relations to health and their relatively high frequency within marginalized populations. This study used data from the Chicago Department of Public Health to examine broad health differences between LGBT White and LGBT-POC individuals, and to test specific mediations models in which social cohesion mediated links between discrimination and health. LGBT-POC reported experiencing worse general health, lower access to health care, more experiences of discrimination, and lower feelings of social cohesion than did White LGBT individuals. No mediation effects emerged, however there was a direct effect of experiencing discrimination on mental health distress. Further, discrimination exposure related inversely to feelings of social cohesion. Study strengths, limitations, and implications are discussed.
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Title: SYSTEMATIC ANALYSIS OF THE MCENTER BEAMLINE AT THE FERMILAB TEST BEAM FACILITY FOR THE NOVA TEST BEAM EXPERIMENT
Creator: Temizel, Buse Naz
Date: 2021
Description: This thesis presents a systematic analysis of the MCenter beamline at the Fermilab Test Beam Facility to help to generate improved beam...
Show moreThis thesis presents a systematic analysis of the MCenter beamline at the Fermilab Test Beam Facility to help to generate improved beam profiles for the NOvA Test Beam Experiment. Several studies were carried out to understand beam transport to the experiment, including optics calculations and computer simulations using a novel procedure for incorporating the acceptance of the channel. Data from beam profile monitors was used to trace the beam phase space and compared to simulation results. Detailed analysis revealed that the beam sizes on the NOvA target were large compared to its transverse size. New tunes were proposed for a detailed beam optics study. Analysis of the new tunes shows that the new optics produce two components corresponding to two different peaks at different energies in the horizontal profile at the NOvA target.
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Title: Health Information Seeking, Depression, and Satisfaction with Life in Racial/ethnic Minority vs. White individuals with Spinal Cord Injuries
Creator: Stipp, Kelsey
Date: 2022
Description: Health information is available both traditionally by conversations with health care professionals, and non-traditionally via use of the...
Show moreHealth information is available both traditionally by conversations with health care professionals, and non-traditionally via use of the Internet and other media sources. Health information is crucial to individuals with chronic health conditions and/or disabilities, such as spinal cord injury (SCI), to promote health, minimize comorbidities, and improve quality of life (QOL). Methods of health information seeking have been shown to differ between individuals who are racial/ethnic minority individuals and individuals who are White. Existing research appears to show health information seeking may increase QOL in populations with chronic health conditions and/or disabilities. However, it is unclear how aspects of QOL differ between individuals within the SCI population by race/ethnicity. The present study used Chi Square analyses to test racial/ethnic group differences in health information seeking and multiple analysis of covariance (MANCOVA) to test whether method of health information seeking and aspects of QOL, specifically depression and satisfaction with life, were moderated by race/ethnicity. An adult sample of 9,403 individuals with SCI who completed a survey on their injury, health, and QOL between 2011 and 2016 was used. Participants identified their source of health information as traditional (i.e., conversations with health care professionals) or non-traditional (e.g., newspaper, television, radio, etc.). Results indicated non-traditional sources of health information were utilized more frequently regardless of race/ethnicity. Unexpectedly, moderation results suggested that associations between source of health information and depression and satisfaction with life did not differ by race/ethnicity. However, source of health information was associated with satisfaction with life and depression for the entire sample. Study findings demonstrate the shift towards non-traditional (e.g., newspaper, television, radio, etc.) health information seeking within the SCI population. Further, findings support previous empirical work demonstrating the association between method of health information seeking and depression and satisfaction with life. These findings can be used to improve dissemination of accurate health information to the SCI population via non-traditional sources. Further research should include more diverse samples of individuals to better understand health information seeking as well as depression and satisfaction with life within the SCI population.
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Title: A Functionalized 2D Boron Nitride Electrode for Rechargeable Batteries
Creator: Tatagari, Vignyatha Reddy
Date: 2021
Description: Motivated by the great performance of the graphene oxide battery and its poor safety, in the present work, an attempt is made to fabricate an...
Show moreMotivated by the great performance of the graphene oxide battery and its poor safety, in the present work, an attempt is made to fabricate an alternative battery from functionalized 2-dimensional (2D) boron nitride. The expectation is that functionalized boron nitride can exhibit the same great electrochemical performance as graphene oxide while it would be much more thermally stable. Toward this goal, synthetic opportunities were explored to realize -OBF3 functionalized hexagonal boron nitride. Both top-down and bottom-up synthetic approaches were considered and implemented. In the top-down methods, commercially available bulk hexagonal boron nitride (h-BN) is reacted with functionalization agents such as LiOBF3 and LiOH.BF3. Synthesis of these functionalization agents and their reactions with h-BN were carried out in several different ways. Bottom-up synthetic approach using Boric Acid and Urea was utilized to synthesize turbostratic boron nitride (t-BN), which is an intermedier in the commercial synthesis of hexagonal boron nitride. Turbostratic boron nitride contains exfoliated and -OH functionalized monolayers of boron nitride. An attempt is made to esterify the -OH groups of turbostratic boron nitride to obtain the desired -OBF3 functionalized monolayers of h-BN. Initial electrochemical tests on turbostratic boron nitride and its esterified form are carried out along with ionic conductivity measurements. Only a very limited electrochemical activity was observed due to a low degree of functionalization in these materials, indicating the need for improved synthetic procedures to achieve the desired target materials.
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Title: PIMMINER: A HIGH-PERFORMANCE PIM ARCHITECTURE-AWARE GRAPH MINING FRAMEWORK
Creator: Su, Jiya
Date: 2022
Description: Graph mining applications, such as subgraph pattern matching and mining, are widely used in real-world domains such as bioinformatics, social...
Show moreGraph mining applications, such as subgraph pattern matching and mining, are widely used in real-world domains such as bioinformatics, social network analysis, and computer vision. Such applications are considered as a new class of data-intensive applications that generate massive irregular computation workloads and memory accesses, which degrade the performance and scalability significantly. Leveraging emerging hardware, such as process-in-memory (PIM) technology, could potentially accelerate such applications. In this paper, we propose PIMMiner, a high-performance PIM architecture graph mining framework. We first identify that current PIM architecture cannot be fully utilized by graph mining applications. Next, we propose a set of optimizations that enhance the locality, and internal bandwidth utilization and reduce remote bank accesses and load imbalance through cohesive algorithm and architecture co-designs. We compare PIMMiner with several state-of-the-art graph mining frameworks and show that PIMMiner is able to outperform all of them significantly.
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Title: SEPARATING NOBLE GASES SUCH AS KRYPTON AND XENON FROM NUCLEAR POWER PLANTS OFF-GAS USING DD3R ZEOLITIC MEMBRANES: A COMPUTATIONAL MOLECULAR DYNAMICS STUDY
Creator: BASHMMAKH, BANDAR JAMAL S.
Date: 2021
Description: Noble gas fission products generated within nuclear power reactors, such as Kr and Xe, are currently discharged into the atmosphere. This...
Show moreNoble gas fission products generated within nuclear power reactors, such as Kr and Xe, are currently discharged into the atmosphere. This practice has a major economic drawback because of the high value associated with some of these gases. Zeolites, nanoporous materials suitable for gas separation processes, have become of major interest due to the potentially high selectivity for such separations. We have used nonequilibrium molecular dynamics to investigate the separation performance of DD3R framework zeolitic membranes (using LAMMPS software package) for such separations. Our studies have shown that the DD3R membrane shows promise for high selectivity ratios of Kr over Xe. The effects of pressure, temperature and pure vs. mixture gas feed conditions are studied in this work to understand at the molecular level the mechanisms of these (Kr/Xe) separations. MD runs show an agreement with most experimental trends in the permeation of Kr/Xe pure and mixed gases using DD3R zeolite with high separation factor, despite the absence of Xe complete permeation through the membrane because of MD timescale limitation, signaling much slower diffusion in comparison to Kr which is a desired trend in looking for high separation factors.
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Title: CHARACTERIZATION OF HERBS AND SPICES PHYTOCHEMICALS AND PHARMACOKINETIC PROFILE OVER 24-HOUR AFTER CONSUMPTION IN OVERWEIGHT/OBESE ADULTS
Creator: Huang, Yudai
Date: 2022
Description: The health benefits of herbs and spices (H/S) have been known since ancient times. They are a rich source of phytochemicals, such as phenolic...
Show moreThe health benefits of herbs and spices (H/S) have been known since ancient times. They are a rich source of phytochemicals, such as phenolic compounds and terpenoids. However, there is limited information on their absorption and metabolism in humans. Therefore, the primary objective of this study is to identify and characterize phytochemical compounds in H/S mixtures and their absorption and metabolism in the human body over 24 h. H/S and plasma samples used in this study were from a randomized, single-blinded, 4-arm, 24 h, multi-sampling, single-center crossover clinical trial (Clincaltrials.gov NCT03926442) conducted in obese or overweight adults (n=24, aged 37 ± 3 years, BMI=28.4 ± 0.6 kg/m2). Plasma samples were collected at baseline (t=0 h), 0.5, 1, 2, 4, 5.5, 7, and 24 h after consuming a high-fat high-carbohydrate (HFHC) meal with salt and pepper (control) or the control meal with 6 g of three different H/S mixtures (Italian herb: rosemary, basil, thyme, oregano, and parsley in the same ratio; cinnamon; and pumpkin pie spice containing cinnamon, ginger, nutmeg and allspice, the ratio unknown). The phytochemical compounds in the H/S mixtures and their metabolites in human plasma were tentatively identified and quantified by dynamic multiple reaction monitoring transitions on UHPLC-QQQ-MS/MS. Statistical analysis was conducted on SAS-PC 9.4 using non-parametric test via NPAR1WAY procedure. A total of 79 phytochemical compounds were quantified from samples of three H/S mixtures and pepper, of which 36 were flavonoids conpounds, 8 were terpenoids, 27 phenolic acids, and 9 were identified as other compounds. Acetone showed the highest extraction ability for both (poly)phenols and terpenoids in H/S compared to other organic solvents (50% and 80% methanol, ethyl acetate and chloroform). Italian herb contains 763.1 mg/100 g flavonoids, 879 mg/100 g phenolic acids, and 498.6 mg/100g terpenoids; cinnamon contains 981 mg/100 g flavonoids, 11.2 mg/100g phenolic acids, 292.3 mg/100g coumarin, and 1977.1 mg/100 g cinnamaldehyde; pumpkin pie spice contains 655.8 mg/100 g flavonoids, 17.1 mg/100 g phenolic acids, 226.5 mg/100 g coumarin, and 1633 mg/100 g cinnamaldehyde. A total of 47 metabolites were tentatively identified and quantified in plasma samples after H/S consumption over 24 h. Plasma concentrations of carnosic acid derivatives and the glucuronidation products increased after intake of Italian herb, and the Area under the curve (AUC0-24h) was significantly different from control (all P < 0.05) except carnosol glucuronide. Carnosic acid and carnosol had Tmax at 3.4±1.1 and 1.8±0.3 h, respectively, while both of their conjugated glucuronides kept increasing until 24 h. Coumarin glucuronide was increased by cinnamon and pumpkin pie spice consumption with peak concentrations reached at between 1.5-1.6 h. The AUC0-24h after both meals were significantly different from control meal, both P < 0.05. Our results suggest that H/S contain diverse categories of phytochemical compounds that are absorbed and metabolized in the human body into various metabolites in response to 3 different H/S test meals and their appearance in the blood starts as early as around 0.5 h and extends to as long as 24 h for select metabolites.
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Title: High Energy High Power Primary Lithium Batteries with Graphite Fluoride and Functionalized Boron Nitride Cathodes
Creator: Huo, Haobin
Date: 2022
Description: The present Thesis concerns with the creation of high energy and high power batteries through the utilization of functionalized 2D materials...
Show moreThe present Thesis concerns with the creation of high energy and high power batteries through the utilization of functionalized 2D materials such as graphite fluoride (CFx) and functionalized boron nitride (FBN). The recent literature of Li-CFx batteries brings forward several methods to fabricate high energy and high power batteries. These methods include nano-architecture and porosity design, boron doping, electrolyte additives etc. The resulting batteries are capable to achieve 800-1000 Wh/kg energy density at a power density of 60-70 kW/kg. Our method is capable to achieve the same performance in a much simpler way by the application of a binder that also functions as an effective inhibitor of the growth of LiF crystals. Since LiF is the discharge product of Li-CFx batteries, it typically clogs the pores of the cathode and avoids fast discharge. Methods that increase the power density of Li-CFx batteries typically focus on the amorphization/dissolution of LiF to allow for a fast Li ion diffusion. Our solution using the effective binder appears to be well suited for a scalable production of high energy and high power Li-CFx batteries through a very small modification of existing production lines. Such high energy and high power batteries are needed for the electrification of aircraft such as unmanned aerial vehicles (UAVs), vertical take-off and landing planes (VTOLs), passenger airplanes and pulsed power sources. While Li-CFx batteries are not rechargeable this is not a problem for the above mentioned applications as current rechargeable batteries cannot provide the required energy and power densities.Li-FBN batteries may provide a rechargeable alternative to Li-CFx when fully developed. In the present thesis, we have demonstrated Li-FBN batteries with similar discharge plateaus and approximately half the capacity of Li-CFx batteries. Our Li-FBN batteries are also rechargeable to a much greater extent than Li-CFx.
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Title: Implicit Theory of Willpower and Life Satisfaction Among Persons with Spinal Cord Injury
Creator: Cerny, Brian M.
Date: 2022
Description: Spinal cord injury (SCI) is a leading cause of physical disability and physical, functional, and psychosocial outcomes vary among persons with...
Show moreSpinal cord injury (SCI) is a leading cause of physical disability and physical, functional, and psychosocial outcomes vary among persons with SCI. Persons with SCI are at risk for poor psychosocial adjustment, evidenced by higher rates of mood disorders and lower reported life satisfaction (LS) when compared to the general population. LS among persons with SCI is influenced by sociodemographic, injury-related, and psychosocial factors. Implicit theory of willpower (TOW) refers to individuals’ beliefs about their capacity for self-regulation; specifically, whether or not self-regulatory capacity (i.e., willpower) is depleted with use. TOW has previously been associated with LS and other aspects of subjective well-being. This is the first study to assess TOW among persons with SCI, and aims to investigate the association between TOW and LS among persons with SCI. The study sample consisted of 156 adults with SCI who completed an anonymous online questionnaire. Associations between demographic- and disability-related factors, global perceived stress, TOW, engagement coping, disengagement coping, and LS were assessed via bivariate Pearson correlations and a 3-block hierarchical multiple linear regression with LS as the primary outcome. LS was significantly correlated with age, perceived physical health, self-reported participation, and perceived stress. After controlling for the influence of other variables, age, perceived physical health, and perceived stress were significantly associated with LS, consistent with prior work. Neither TOW nor the interaction between perceived stress and TOW were significantly associated with LS. Post hoc analyses suggest a chronic disability population may have different interpretations of the TOW construct or measure items than populations previously investigated. Clinical implications and future directions for research are discussed.
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Title: Factors Influencing the Level of Detection of Testing Listeria monocytogenes in Ice Cream
Creator: Chen, Bairu
Date: 2022
Description: The increasing evidence has shown that having a sensitive detection method for Listeria monocytogenes in food products is critical for public...
Show moreThe increasing evidence has shown that having a sensitive detection method for Listeria monocytogenes in food products is critical for public health as well as industrial economics. L. monocytogenes was associated with foodborne illness outbreaks linked to ice cream in the United States from 2010 to 2015, with another recent outbreak under investigation. The FDA Bacteriological Analytical Manual (BAM) method was commonly used for L. monocytogenes detection. However, the performance characteristics of the chromogenic methods (MOX, RLM, and R&F agars) remain to be elucidated. The factorial effect on Level of Detection (LOD) as an essential element of the International Organization for Standardization (ISO) approach for qualitative method validation was investigated in this study.For examining the LOD of L. monocytogenes in ice cream, fractional contaminated samples were prepared with the ice cream obtained from the 2015 outbreak and enumerated using the FDA BAM Most Probable Number (MPN) method for Listeria. The effect of test portion size was determined by comparing 10g and 25g using the BAM method with chromogenic agars (MOX, RLM, and R&F). The ISO single-lab validation requirement was followed for the factorial effect study, including four different factors: sample size (10g and 25g), ice cream types (commercially available regular vanilla ice cream and vanilla ice cream with low fat and no added sugar), re-freezing process (with re-freezing and without re-freezing process), and thawing process (slow thaw and fast thaw). LOD and relative LOD (RLOD) were computed using MiBiVal software to compare the sensitivity of the three chromogenic agars and the different factors. For all of the detection experiments, presumptive colonies were identified using the API listeria kit. The 2015 naturally contaminated ice cream was enumerated and resulted in an average contamination level of 2.15 MPN/g. At fractional levels of 0.25 MPN/10g and 0.75 MPN/10g, the positive rates of L. monocytogenes detected from 10g and 25g of sample portions were consistent with the statistically theoretical positive rates. The RLOD values for the reference method (MOX) and the alternative methods (RLM, R&F) were above 1 in both portion sizes, which suggested that MOX was slightly more sensitive than RLM and R&F. The factorial effect study indicated that the four factors have no significant influence on the LOD of L. monocytogenes detection at the fractional contamination levels. However, the test portion size of 25g provided more consistent results among the chromogenic media than the 10g portion size. Fat content was shown to have an effect on L. monocytogenes detection in a large test portion. The information from this study will be useful for the improvement of the reproducibility of a qualitative detection method and can also be used for data analysis standards such as ISO 16140 in method validation studies.
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Title: Mothers’ Vaccination Decision: The Relation Between Science Skepticism, Social Networks, Vaccination Beliefs, and Fear of ASD
Creator: Lockwood, Maria Izabel Kugelmas Guarita
Date: 2021
Description: Vaccines are instrumental in stopping the spread of disease, yet some parents choose to not vaccinate their children. Despite scientific...
Show moreVaccines are instrumental in stopping the spread of disease, yet some parents choose to not vaccinate their children. Despite scientific evidence that childhood vaccines are safe, there is an increasing number of children in the United States and the United Kingdom who are not getting vaccinated. The current study investigates different factors that may be associated with mothers’ decision to vaccinate their children. This study examines the relations between skepticism in science, vaccination beliefs, fear of having a child with Autism Spectrum Disorder (ASD), social network recommendations, and maternal decision to vaccinate. Participants included 293 expectant mothers in the United States and the United Kingdom. Results indicated that mothers who are pro-vaccine and mothers who are vaccine-hesitant have different score profiles across scales that measure skepticism in science, vaccination beliefs, and fear of having a child with ASD. Specifically, we found that relative to mothers who are vaccine-hesitant, mothers who are pro-vaccine: (1) indicated less skepticism in science; (2) had fewer anti-vaccination beliefs; (3) did not statistically differ on their fear of having a child with ASD; and (4) had a smaller percentage of their social network advocating against vaccination. Thus, the study adds to the research literature, as it illustrates that mothers who are vaccine-hesitant differ from mothers who are pro-vaccine on key factors.
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Title: Data-Driven Methods for Soft Robot Control and Turbulent Flow Models
Creator: Lopez, Esteban Fernando
Date: 2022
Description: The world today has seen an exponential increase in its usage of computers for communication and measurement. Thanks to recent technologies,...
Show moreThe world today has seen an exponential increase in its usage of computers for communication and measurement. Thanks to recent technologies, we are now able to collect more data than ever before. This has dawned a new age of data-driven methods which can describe systems and behaviors with increasing accuracy. Whereas before we relied on the expertise of a few professionals with domain-specific knowledge developed over years of rigorous study, we are now able to rely on collected data to reveal patterns, develop novel ideas, and offer solutions to the world’s engineering problems. No domain is safe. Within the engineering realm, data-driven methods have seen vast usage in the areas of control and system identification. In this thesis we explore two areas of data-driven methods, namely reinforcement learning and data-driven causality. Reinforcement learning is a method by which an agent learns to increase its selection of ideal actions and behaviors which result in an increasing reward. This method was applied to a soft-robotic concept called the JAMoEBA to solve various tasks of interest in the robotics community, specifically tunnel navigation, obstacle field navigation, and object manipulation. A validation study was conducted to show the complications that arise when applying reinforcement learning to such a complex system. Nevertheless, it was shown that reinforcement learning is capable of solving three key tasks (static tunnel navigation, obstacle field navigation, and object manipulation) using specific simulation and learning hyperparameters. Data-driven causality encompasses a range of metrics and methods which attempt to uncover causal relationships between variables in a system. Several information theoretic causal metrics were developed and applied to nine mode turbulent flow data set which represents the Moehlis model. It was shown that careful consideration into the method used was required to identify significant causal relationships. Causal relationships were shown to converge over several hundred realizations of the turbulent model. Furthermore, these results match the expected causal relationships given known information of self-sustaining processes in turbulence, validating the method’s ability to identify causal relationships in turbulence.
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Title: Synthesis and Photophysical Characterization of Novel Aromatic Triplet Dyes for Photodynamic Therapy Applications
Creator: Morgan, Jayla A
Date: 2022
Description: Photodynamic therapy is a biomedical approach to treating specific types of cancerous tumor cells and harmful bacteria. The core principle of...
Show morePhotodynamic therapy is a biomedical approach to treating specific types of cancerous tumor cells and harmful bacteria. The core principle of photodynamic therapy involves the usage of a photosensitizer, which is an agent with the capability of transforming molecular, triplet state oxygen, into a reactive oxygen species upon a reaction with near-infrared (NIR) light. The reactive oxygen species has been demonstrated to cause apoptosis among harmful cells without damaging cancer free cells. The effectiveness of photodynamic is highly dependent upon the identity of the photosensitizer; a powerful and efficient photosensitizer should be non-toxic, exhibit high light absorption capabilities, and should produce large amounts of the reactive oxygen species. A novel chromophore bis-iodo-dipyrrolonaphthyridine-dione was demonstrated to have all vital characteristics of an ideal photosensitizer, however produced low amounts of the reactive oxygen species of interest due to the chemical instability of a carbon-halogen bond present in the molecule. Various subsequent halogenations (bis-bromo and bis-chloro) completed in order to remedy this instability revealed specific regioselectivity in regards to the dipyrrolonaphthyridinedione parent that are exhibited upon substituents effects by the substrate, electronic effects exhibited by the reagents of interest, and overall photophysical characterization of the molecules.
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Title: Video Object Detection using CenterNet
Creator: Mondal, Madhusree
Date: 2021
Description: This thesis investigates the options of video object detection with key-point-based approaches. The problem of recognizing, locating, and...
Show moreThis thesis investigates the options of video object detection with key-point-based approaches. The problem of recognizing, locating, and tracking objects in videos has been a challenging task in the computer vision area. There are few applications on key-point-based object detectors like CornerNet and CenterNet. At the first stage, this work involves the use of the previously proposed CenterNet module as a baseline detector on each frame of the Imagenet Video dataset. Then we apply an RNN module to exploit the temporal information from the past frames for better results.There are challenges in video object detection compared to still image-based object detection. It is not efficient to apply a still-image-based detector on each frame independently because we cannot exploit the temporal contextual information in videos since neighboring frames in a video are highly correlated. Object detection from videos suffers from motion blur, video focus, rare poses, etc. To overcome these issues one way of improving CenterNet for video object detection is to propagate the previous reliable detection results to boost the detection performance.
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Title: REDUCED-ORDER MODELING OF UNSTEADY FLOW OVER TWO COLLINEAR PLATES AT LOW REYNOLDS NUMBERS
Creator: Almashjary, Abdulrahman N
Date: 2021
Description: Wakes of bluff bodies that exhibit unsteady behavior are a topic of great interest in the study of fluid dynamics. Vortex formation in these...
Show moreWakes of bluff bodies that exhibit unsteady behavior are a topic of great interest in the study of fluid dynamics. Vortex formation in these wakes depends significantly on the Reynolds number and the arrangement of the bluff bodies in the computation domain. To attain a comprehensive understanding of the unsteady wakes of adjacent bodies, we examine the emerged flow patterns in the wake of two bodies when subjected to different flow regimes and geometric configurations. This work aims to develop a reduced-order model that can capture the dynamics and predict the time evolution of specific parameters in the flowfield. Investigations including direct numerical simulations of two collinear plates normal to the flow were performed. Flowfield data and forces exerted on the plates were collected using a numerical code of an immersed boundary projection method (IBPM). The conducted numerical simulations pursued classifying the flow patterns by systematically varying the Reynolds number and the gap between the two plates. It was found that at small gap spacings, a typical von Karman vortex street is observed. Whereas at larger gap spacings, both a biased and a flip-flopping gap flow are detected. Prevalent coherent structures present in various flow regimes can be extracted via data-driven modeling techniques. The proper orthogonal decomposition (POD) method is used in this framework, from which projection-based reduced-order models are developed utilizing the governing equations of fluid flows. Single and broadband spectra are observed in the unsteady wake of the two-plate configuration. The amplitude and frequency of the time-evolution of the true POD modes and the predicted models are assessed using the spectral proper orthogonal decomposition (SPOD), an empirical method to extract coherent structures one frequency at a time from fluid flows. It was found that these reduced-order models are able to recover the frequency content from non-time resolved data.
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