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Title: EMPIRICALLY KEYING PERSONALITY MEASURES TO MITIGATE FAKING EFFECTS AND IMPROVE VALIDITY: A MONTE CARLO INVESTIGATION
Creator: Tawney, Mark Ward
Date: 2012-12-05, 2012-12
Description: Personality-type measures should be viable tools to use for selection. They have incremental validity over cognitive measures and they add...
Show morePersonality-type measures should be viable tools to use for selection. They have incremental validity over cognitive measures and they add this incremental validity while decreasing adverse impact (Hough, 1998; Ones, Viswesvaran & Schmidt, 1993; Ones & Viswesvaran, 1998a). However, personality measures are susceptible to faking; individual’s instructed to fake on personality measures are able to increase their scores (Barrick & Mount, 1996; Ellingson, Sackett & Hough, 1999; Hough, Eaton, Dunnette, Kamp, & McCloy, 1990). Further, personality measures often reveal less than optimal validity estimates as research continually finds meta-analytic coefficients near .2 (e.g., Morgeson, Campion, Dipboye, Hollenbeck, Murphy, & Schmitt, 2007). Some researchers have suggested that these two problems are linked as faking on personality measure may reduce their ability to predict job performance (e.g., Tett & Christansen, 2007). Empirically keyed instruments traditionally enhance prediction and have been found to mitigate the effects of faking (Kluger, Reilly & Russell, 1991; Scott & Sinar, 2011). Recently suggested as a means to key to personality measures (e.g., Tawney & Mead, In Prep), this dissertation further investigates empirical keying methods as a means to both mitigate faking effects and as a means to increase validity of personality-type measures. A Monte Carlo methodology is used due to the difficulties in obtaining accurate measures of faking. As such, this dissertation investigates faking issues under controlled and known parameters, allowing for more robust conclusions as compared to prior faking research.
PH.D in Psychology, December 2012
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Title: Hybrid Living Space in the Context of Balat, Istanbul: Unal_Nezihe_Final Presantation
Creator: Unal, Nezihe Merve
Date: 2010-05
Publisher
Description

Title: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry (sequence unknown), IPRO 333 - Deliverables: IPRO 333 Brochure F09
Creator: Bonesz, Andrew, Clark, Howard, Douglas, Carlie, Gajdorus, Michael, Gottschall, Keenan, Hendricks, Rachel, Kimball, Clayton, Linares, Jared, Marks, Paul, Mellom, James, Oblenida, Cindy, Pop, Sabina, Stelcel, Carl, Young, Jeremy, Zhou, Raymond
Date: 2009-12
Description: The primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the...
Show moreThe primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the resources of the Museum of Science and Industry (MSI) in Chicago. This partnership endeavors to help the museum's Fabrication Laboratory (Fab Lab) maximize its potential as a resource for museum guests, young and old, as well as for IIT students, staff, and faculty.
Sponsorship: Museum of Science and Industry. Steven Willis- Director, Fabrication Lab
Deliverables for IPRO 333: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry for the fall 2009 semester
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Title: A study of the effect of momentary external fields on the retentivity of the permanent magnets of recording wattmeters
Creator: Simmons, Leslie E.
Date: 2009, 1909
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/studyofeffectofm00simm
Thesis (B.S.)--Armour Institute of Technology

Title: DETECTING A SPIT CALLER USING UN-SUPERVISED MACHINE LEARNING
Creator: Opara, Stanley
Date: 2013-05-02, 2013-05
Description: Spam over Internet Telephony (SPIT) is a form of un-solicited communication whereby an attacker sends automatically pre-recorded phone calls...
Show moreSpam over Internet Telephony (SPIT) is a form of un-solicited communication whereby an attacker sends automatically pre-recorded phone calls to several subscribers for purposes such as advertisements of product and services etc. In the near future, SPIT is expected to become a threat inhibiting the delivery of voice services over INTERNET because of its technical and economic characteristics. In this report, we purpose a detection mechanism to identify SPIT callers. This mechanism transforms the problem of identification of SPIT callers to a data clustering one by mapping callers to data points based on some characteristics. These characteristics (features) are gathered based on signaling characteristics, caller reputation and call metrics. These features include modified SymRank, termination coefficient, strong tie coefficient and average call duration. These features distinguish between a normal caller and SPIT caller but cannot stand alone as shown in the Results section. The data clustering was done by an un-supervised learning algorithm known as k-means which clusters closely related data points. To test our model, we simulated a testbed since we could not obtain real traffic. The testbed was generated in java, while the actual clustering algorithms were written Octave. The results gathered clearly showcased the high efficacy of our model, as it had accuracy (>95%) in all tests. After comparing our model with other models proposed by fellow researchers, we realized that our model either surpassed or was comparable to the other models considered.
M.S. in Electrical Engineering, May 2013
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Title: The variation of iron loss in transformers with shape of applied emf wave
Creator: Strong, Arthur Poole
Date: 2009, 1909
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/variationofironl00stro
Thesis (B.S.)--Armour Institute of Technology; Bibliography: leaf 1

Title: TOWARDS THE EXACT CALCULATIONS OF THE FREE ENERGY FOR ENTANGLED SEMIFLEXIBLE POLYMER CHAIN
Creator: Pilyugina, Ekaterina
Date: 2015, 2015-05
Description: This work consists of two separate projects unified by the idea to extend the Discrete Slip-Link Model, which has been being successfully...
Show moreThis work consists of two separate projects unified by the idea to extend the Discrete Slip-Link Model, which has been being successfully developed in this group to predict rheological behavior of entangled flexible polymers, to new applications. The first project was dedicated to application of the Discrete Slip-Link Model to dielectric relaxation in order to simultaneously predict linear rheology and dielectric relaxation experiments of entangled polyisoprenes. Linear monodisperse, linear bidisperse and star-branched monodisperse systems were studied. It was found that all circumstances save one are well described. Namely, dilute long chains in a sea of short chains can be predicted rheologically, but dielectric relaxation data show a reduction in the relaxation time of long chains greater than that predicted by either the DSM or the expected Rouse motion. The second project was focused on the derivation of the exact free energy expression for semiflexible chains in the presence of entanglements in order to implement the DSM for semiflexible polymers. The special cases of chains with one, two and three strands are examined. An additional implementation of obtained results for one and two strands to buckling instability was performed. It is believed that in two dimensional case the critical buckling force is increased by thermal fluctuations in comparison to classical Euler buckling. However, how the critical buckling force is influenced by thermal fluctuations in three dimensions remains unclear. Some research groups calculate the critical buckling force approximately and conclude that, in opposite to 2D case, in 3D the force is decreased by thermal fluctuations. In this work the critical buckling force for semiflexible chain under compression was calculated exactly. It was shown that thermal fluctuations significantly increase the critical force over classical Euler buckling force in both two and three dimensions.
Ph.D. in Chemical Engineering, May 2015
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Title: Powered Resonance Tubes: Resonance Characteristics and Actuation Signal Directivity
Creator: Sarpotdar, S., Raman, G., Cain, A. B.
Date: 2005-12
Publisher: Springer
Description: The powered resonance tube (PRT) actuator and its variants are new developments in active flow control (AFC) technology. The PRT is attractive...
Show moreThe powered resonance tube (PRT) actuator and its variants are new developments in active flow control (AFC) technology. The PRT is attractive because it has no moving parts and can produce acoustic tones that have amplitudes greater than 150 dB over a large frequency bandwidth. The first part of this paper deals with the resonance characteristics of the PRT as a function of the operating parameters such as jet-to-tube spacing (Sp), tube depth (d), and nozzle pressure ratio (NPR). It was found that: (1) at low NPR (3.33), the PRT resonates at discrete combinations of spacing and depth. (2) Using theoretical estimates for predicting shock cell lengths, one could observe a correlation between the theoretical prediction for shock cell length and the spacing at which the PRT resonates. (3) At high NPR (4.29), for a fixed depth, the PRT resonates at virtually all spacings. (4) The frequency at which the PRT resonates remains approximately constant, regardless of spacing. The second part of the study focused on examining the directivity of the acoustic radiation from the PRT-significant for developing orientation strategies of the PRT with respect to the target flow in the end application. The directivity of the fundamental PRT tone and that of its harmonics were studied for a variety of resonance frequencies, both separately as well as cumulatively. It was found that the fundamental part of the actuation signal radiated predominantly in the downstream direction of the jet for low resonance frequencies. As the resonance frequency was increased from 3 to 12 kHz, the directivity changed from downstream of the jet to vertically upward, and finally upstream of the jet at the higher frequencies.
http://dx.doi.org/10.1007/s00348-005-0041-5
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Title: Intelligent real-time performance monitoring and quality prediction for batch/fed-batch cultivations
Creator: Undey, C., Tatara, E., Cinar, A.
Date: 2004-02-19
Publisher: ELSEVIER SCIENCE BV
Description: Supervision of batch bioprocess operations in real-time during the progress of a batch run offers many advantages over end-of-batch quality...
Show moreSupervision of batch bioprocess operations in real-time during the progress of a batch run offers many advantages over end-of-batch quality control. Multivariate statistical techniques such as multiway partial least squares (MPLS) provide an efficient modeling and supervision framework. A new type of MPLS modeling technique that is especially suitable for online real-time process monitoring and the multivariate monitoring charts are presented. This online process monitoring technique is also extended to include predictions of end-of-batch quality measurements during the progress of a batch run. Process monitoring, quality estimation and fault diagnosis activities are automated and supervised by embedding them into a real-time knowledge-based system (RTKBS). Interpretation of multivariate charts is also automated through a generic rule-base for efficient alarm handling. The integrated RTKBS and the implementation of MPLS-based process monitoring and quality control are illustrated using a fed-batch penicillin production benchmark process simulator.
Endnote format citation for DOI:10.1016/j.jbiotec.2003.10.004
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Title: PARAMETRIC COST ESTIMATION MODEL OF INTEGRATED REACTOR VESSEL UNDER MODULAR CONSTRUCTION WITHIN A FACTORY ENVIRONMENT
Creator: Chen, Xuan
Date: 2013, 2013-12
Description: High initial cost is one of the major barriers for the nuclear power industry. Small modular reactors (SMR) may be a solution to this problem...
Show moreHigh initial cost is one of the major barriers for the nuclear power industry. Small modular reactors (SMR) may be a solution to this problem because they have a much smaller financial barrier. In this thesis, parametric cost estimation modeling studies have been performed for the SMR integrated reactor vessel (IRV) under a factory environment. Based on different prior fabrication experiences, three scenarios have been studied, and the corresponding possible manufacturing costs of the entire IRV and its subcomponents have been estimated. To explore the cost allocation, the total cost has been divided into five cost contributors: labor, material, tooling labor, tooling replacement, and other. The results have been analyzed and discussed.
M.S. in in Mechanical, Material and Aerospace Engineering, December 2013
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Title: MODELING AND SIMULATION OF DYNAMIC VOLTAGE CONTROLS AND PROTECTION IN 3 PHASES TRANSIENT STABILITY ANALYSIS
Creator: Zhang, Qiaoyu
Date: 2016, 2016-12
Description: The main object of this research is to build up a comprehensive 3-phases transient stability simulator(TS3ph) and use it to analyze the...
Show moreThe main object of this research is to build up a comprehensive 3-phases transient stability simulator(TS3ph) and use it to analyze the transient stability with dynamic voltage control and protection. Detailed exciter models, SVC model and protection model are needed in this research. We have implemented detailed exciter model. We chose several exciter models which are frequently used in power system to built. These exciters can control generator terminal voltage by changing current and voltage to generator field winding. It is critical for improving the dynamic voltage performance in power system. We also built up detailed SVC model. The SVC is an important device for dynamic voltage control. It is a power electronics-based equipment containing both reactors and capacitor banks which have the capability of dynamic voltage and reactive power control. When doing the dynamic voltage control simulation, it is meaningful to have a detailed SVC model in the transient simulator. The another mission of this research is to study the protection of power system with unbalance fault or unbalance network using 3-Phase Transient Stability Simulator. In order to obtain the relay operation, we need to set up the interface between protection simulator Electrocon CAPE and transient simulator TS3ph. As unbalance fault sometimes can cause serious voltage problem during the transient, simulating the unbalance fault with realistic relay operation is important for transient stability analysis.
M.S. in Electrical Engineering, December 2016
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Title: Product and Market Development for an Industrial Tool Product (sequence unknown), IPRO 341 - Project Plan
Creator: Bart, Jeffrey, Cantonwine, Sara, Ende, Mark, Gowe, Arence, Hotz, Thomas, Khaliqdina, Shahmeer, Lee, Jae, Ostasz, Raluca, Park:, Hyejin, Pauley, Erica, Rahman, Raihan, Sarvana:, Saad
Date: 2009-12
Description: Our mission is to build a modern, functional, and longstanding toolbox with the cooperation of Versatility Tool Works that fits the needs of...
Show moreOur mission is to build a modern, functional, and longstanding toolbox with the cooperation of Versatility Tool Works that fits the needs of the employees at Amada. This will be done through progressive prototyping and testing that will lead to innovative designs. We will mind expenses to make critical selections that have the highest cost effectiveness. Additionally, we will exercise cooperation amongst the whole team by utilizing the assets each person brings.
Sponsorship: Versatility Tool Works
Project plan for IPRO 341: Product and Market Development for an Industrial Tool Product for the fall 2009 semester
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Title: Laboratory Notebook 1
Creator: Koutchma, Tatiana
Date: 2010-03-04T20:50:48Z
Description: This laboratory notebook relates to the Combat Ration Network (Coranet) project which is connected with Shelf Stable Egg-Based Products...
Show moreThis laboratory notebook relates to the Combat Ration Network (Coranet) project which is connected with Shelf Stable Egg-Based Products Processed by Ultra High Pressure Technology
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Title: Innovative Mapping (sequence unknown), IPRO 303 - Deliverables: IPRO 303 Midterm Presentation F09
Creator: Komoroski, Aaron, Mora, Andres, Sarraf, Basel, Kemp, Brandon, Duong, Cindy, Woodward, Frank, Suwada, Jerry, Michael, Mark, Sinha, Piyush, Glover, Richard, Mandrekar, Urba
Date: 2009-12
Description: The team worked to target the majority of mobile device users and give them an outlet to report any changes, mistakes or developments that...
Show moreThe team worked to target the majority of mobile device users and give them an outlet to report any changes, mistakes or developments that have been overlooked by NAVTEQ in the company's mobile mapping solutions. The team also worked to develop a solution that enables the average map user – men and women ages 18-35, students and tourists – to address these alterations in a simple, hassle-free way.
Sponsorship: NAVTEQ
Deliverables for IPRO 303: Innovative Mapping for the fall 2009 semester.
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Title: INJECTION LOCKING BASED ULTRA LOW POWER RADIO FREQUENCY INTEGRATED CIRCUITS
Creator: Zhu, Qiang
Date: 2012-05-31, 2012-07
Description: Recent advances in radio frequency integrated circuit (RFIC) technology enable various innovative and versatile applications through ultra-low...
Show moreRecent advances in radio frequency integrated circuit (RFIC) technology enable various innovative and versatile applications through ultra-low-power wireless link such as mesh sensor network, personal area network (PAN) and semi-active RFID. This thesis introduces energy efficient demodulator and transceiver design for wireless communications. At the receiver front end, an ultra-low-power BPSK demodulator based on injection locked oscillators (ILOs) is introduced. Two second harmonic ILOs are employed to convert BPSK signals to ASK signals, which are then demodulated by an envelope detector to baseband. For sub-GHz applications, the ILOs are implemented using ring oscillators to allow compact chip area and ultra-low power dissipation. Bit error rate (BER) analysis of this demodulator indicates erroneous polarity flipping of demodulated bits due to phase noise of the ILO. The prototype chip is fabricated in a 65nm CMOS technology that consumes 228μW of power and occupies 0.014mm2 of die area. Measurement results reveal the demodulation of 750MHz 5Mb/s differential BPSK signal with a sensitivity of -43dBm. Theoretical BER analysis has been verified with erroneous flipping observed in the measurement and its probability close to the prediction. Then, an innovative injecting locking based transceiver architecture for ultra low power operation is proposed. It applied the ILO based BPSK demodulator at the receiver side. The oscillating signal at one receiver ILO also injects to another transmitter ILO for accurate carrier generation. Thus local frequency synthesis circuit which consumes considerable portion of power in traditional transceiver is not required. This design is implemented in a 45nm CMOS SOI technology. Measurement results indicate that the transceiver achieves downlink demodulation of -35dBm BPSK signal at 5Mb/s data rate and uplink transmission of -23dBm ASK signal at 1Mb/s data rate with 0.93mA current consumption from 1V power supply.
Ph.D. in Electrical Engineering, July 2012
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Title: A MULTI-CURVE LIBOR MARKET MODEL WITH UNCERTAINTIES DESCRIBED BY RANDOM FIELDS
Creator: Xu, Shengqiang
Date: 2012-12-19, 2012-12
Description: The LIBOR (London Interbank Offered Rate) market model has been widely used as an industry standard model for interest rates modeling and...
Show moreThe LIBOR (London Interbank Offered Rate) market model has been widely used as an industry standard model for interest rates modeling and interest rate derivatives pricing. In this thesis, a multi-curve LIBOR market model, with uncertainty described by random fields, is proposed and investigated. This new model is thus called a multi-curve random fields LIBOR market model (MRFLMM). First, the LIBOR market model is reviewed and the closed-form formulas for pricing caplets and swaptions are provided. It is extended to the case when the uncertainty terms are modeled as random fields and consequently the closed-form formulas for pricing caplets and swaptions are derived. This is a new model called the random fields LIBOR market model (RFLMM). Second, local volatility models and stochastic volatility models are combined with the RFLMM to explain the volatility skews or smiles observed in market. Closedform volatility formulas are derived via the lognormal mixture model in local volatility case, while the approximation scheme for the stochastic volatility case is obtained by a stochastic Taylor expansion method. Moreover, the above work is further extended to a multi-curve framework, where the curves for generating future forward rates and the curve for discounting cash flows are modeled distinctly but jointly. This multi-curve methodology is recently introduced lately by some pioneers to explain the inconsistency of interest rates after the 2008 credit crunch. Both LIBOR market model and RFLMM mentioned above can be categorized as models in singe-curve framework. Third, analogous to the single-curve framework, the multi-curve random fields LIBOR market model is derived and caplets and swaptions are priced with closedform formulas that can be reduced to exactly the Black’s formulas. This model is called a multi-curve random fields LIBOR market model (MRFLMM). Meanwhile, xii local volatility and stochastic volatility models are also combined with the multi-curve LIBOR market model to explain the volatility skews and smiles in the market. Fourth, the calibration of the above models is considered. Taking two-curve setting as an example, four different models, single-curve LIBOR market model, single-curve RFLMM, two-curve LIBOR market model and two-curve RFLMM are compared. The calibration is based on the spot market data on one trading day. The four models are calibrated to European cap volatility surface and swaption volatilities, given the specified parameterized form of correlation and instantaneous volatility. The calibration results show that the random fields models capture the volatility smiles better than non-random fields models and has less pricing error. Moreover, multi-curve models perform better than single-curve models, especially during/after credit crunch. Finally, the estimation of these four models, including pricing and hedging performance, is considered. The estimation uses time series of forward rates in market. Given a time series of term structure, the parameters of the four models are estimated using unscented Kalman filter (UKF). The results show that the random fields models have better estimation results than non-random fields models, with more accurate in-sample and out-sample pricing and better hedging performance. The multi-curve models also over-perform the single-curve models. In addition, it is shown theoretically and empirically that the random fields models have advantages that it is unnecessary to determine the number of factors in advance and not needed to re-calibrate. The multi-curve random fields LIBOR market model has the advantages of both multi-curve framework and random fields setting.
PH.D in Applied Mathematics, December 2012
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Title: CHARACTERIZATION OF WILD BLUEBERRY POLYPHENOLS BIOAVAILABILITY AND KINETIC PROFILE OVER 24-HOUR PERIOD IN HUMAN SUBJECTS
Creator: Zhong, Siqiong
Date: 2016, 2016-12
Description: Diets abundant in phenolic compounds have been linked to decreased risk of cardiovascular disease, obesity and diabetes. Wild blueberries (WBB...
Show moreDiets abundant in phenolic compounds have been linked to decreased risk of cardiovascular disease, obesity and diabetes. Wild blueberries (WBB) are one of the richest sources of dietary phenolic compounds, particularly anthocyanin compounds. They also contain hydroxycinnamic acids, namely chlorogenic acids (CGA). Understanding their metabolic fate may provide insight to their health benefits and protection against chronic disease development. The purpose of this study was to (1) identify WBB anthocyanin and CGA metabolites in human plasma (2) assess bioavailability and biotransformation of WBB anthocyanin and CGA in human (3) measure the acute e↵ects of WBB consumption on glucose homeostasis and lipid metabolism. This was a pilot study with healthy male and female volunteers (n=12). Plasma samples were collected at baseline (t=0h), 0.25h, 0.5h, 1h, 2h, 4h, 6h, 8h, 10h and 24h after consuming a WBB drink (25 g freeze dried WBB powder) with a standard polyphenol free breakfast. The anthocyanins in the WBB drink and their metabolites in human plasma were identified using HPLC-ESI-Q-TOF and quantified by dynamic MRM transitions on HPLC-ESI-QQQ. A total of 30 anthocyanins were identified in the WBB drink. These included glycosides of cyanidin, delphinidin, malvidin, petunidin and peonidin, which were detected in positive mode. Glucose was the most abundant glycoside attachment followed by galactose, arabinose, acetylated glucose, acetylated galactose and xylose. CGAs were also found in the WBB drink in negative mode and confirmed with standards. All the anthocyanins in the WBB drink were found in plasma as well as 3-CGA. The bioavailability for delphinidin, cyandin, malvidin, peonidin, and petunidin were each less than 1% and total bioavailability of WBB anthocyanins was 1.09%. The bioavailability for 3-CGA was 0.22% after consuming 25g WBB powder. The Tmax (time of maximum concentration was achieved) of anthocyanins and 3-CGA was ⇠2h post ingestion. Tmax of phase II metabolites, including petunidin- glucuronide, peonidin-glucuronide, delphinidin-glucuronide and cyanidin-glucuronide was 8.8, 2.6, 6.3 and 7h, respectively. Phenolic acids metabolites, including vanillic acids, ferulic acids, 2,3-dihydroxybenzoic acid, phloroglucinaldehyde, syringic acid were also detected in human plasma during the 24 h period. These results suggest that anthocyanins and CGAs from a WBB drink can be partly absorbed in their intact form in humans and partly transformed to conjugated and degraded metabolites. The data also indicate that there are early phase and late phase appearing metabolites in the blood of humans, which could have important health promoting implications. Future studies will need to be conducted to determine how these pools of metabolites impact physiology and the most sensitive systems to their e↵ect. In the present study, no significant di↵erences on glucose homeostasis and lipid metabolism were apparent. This study provides a foundation for further understanding on health benefits of dietary anthocyanins and their metabolites.
M.S. in Food Safety and Technology, December 2016
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Title: REPRODUCIBLE NETWORK RESEARCH WITH A HIGH-FIDELITY SOFTWARE-DEFINED NETWORK TESTBED
Creator: Wu, Xiaoliang
Date: 2017, 2017-05
Description: Network research, as an experimental science, ought to be reproducible. However, it is not a standard practice to share models, methods or...
Show moreNetwork research, as an experimental science, ought to be reproducible. However, it is not a standard practice to share models, methods or software code to support experimental evaluation and reproducibility when publishing a network research paper. In this work, we advocate reproducible networking experiments by building a unique testbed consisting of container-based network emulation and physical devices. The testbed provides a realistic and scalable platform for reproducing network research. The testbed supports large-scale network experiments using lightweight virtualization techniques and capable of running across distributed physical machines. We utilize the testbed to reproduce network experiments, and demonstrate the e↵ectiveness by comparing the results with the original published network experiments, such as Hedera, a scalable and adaptive traffic flow scheduling system in data center networks.
M.S. in Computer Science, May 2017
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Title: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry (sequence unknown), IPRO 333 - Deliverables: IPRO 333 Poster F09
Creator: Bonesz, Andrew, Clark, Howard, Douglas, Carlie, Gajdorus, Michael, Gottschall, Keenan, Hendricks, Rachel, Kimball, Clayton, Linares, Jared, Marks, Paul, Mellom, James, Oblenida, Cindy, Pop, Sabina, Stelcel, Carl, Young, Jeremy, Zhou, Raymond
Date: 2009-12
Description: The primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the...
Show moreThe primary objective of IPRO 333 is to partner the knowledge and ideas of young engineers, architects, and scientists at IIT with the resources of the Museum of Science and Industry (MSI) in Chicago. This partnership endeavors to help the museum's Fabrication Laboratory (Fab Lab) maximize its potential as a resource for museum guests, young and old, as well as for IIT students, staff, and faculty.
Sponsorship: Museum of Science and Industry. Steven Willis- Director, Fabrication Lab
Deliverables for IPRO 333: Fab Lab: Creating Design-to-Prototype Learning Modules at the Museum of Science and Industry for the fall 2009 semester
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Title: ELECTROSPUN COLLAGEN/SILK TISSUE ENGINEERING SCAFFOLDS: FIBER FABRICATION, POST-TREATMENT OPTIMIZATION, AND APPLICATION IN NEURAL DIFFERENTIATION OF STEM CELLS
Creator: Zhu, Bofan
Date: 2017, 2017-05
Description: Biocompatible scaffolds mimicking the locally aligned fibrous structure of native extracellular matrix (ECM) are in high demand in tissue...
Show moreBiocompatible scaffolds mimicking the locally aligned fibrous structure of native extracellular matrix (ECM) are in high demand in tissue engineering. In this thesis research, unidirectionally aligned fibers were generated via a home-built electrospinning system. Collagen type I, as a major ECM component, was chosen in this study due to its support of cell proliferation and promotion of neuroectodermal commitment in stem cell differentiation. Synthetic dragline silk proteins, as biopolymers with remarkable tensile strength and superior elasticity, were also used as a model material. Good alignment, controllable fiber size and morphology, as well as a desirable deposition density of fibers were achieved via the optimization of solution and electrospinning parameters. The incorporation of silk proteins into collagen was found to significantly enhance mechanical properties and stability of electrospun fibers. Glutaraldehyde (GA) vapor post-treatment was demonstrated as a simple and effective way to tune the properties of collagen/silk fibers without changing their chemical composition. With 6-12 hours GA treatment, electrospun collagen/silk fibers were not only biocompatible, but could also effectively induce the polarization and neural commitment of stem cells, which were optimized on collagen rich fibers due to the unique combination of biochemical and biophysical cues imposed to cells. Taken together, electrospun collagen rich composite fibers are mechanically strong, stable and provide excellent cell adhesion. The unidirectionally aligned fibers can accelerate neural differentiation of stem cells, representing a promising therapy for neural tissue degenerative diseases and nerve injuries.
Ph.D. in Chemistry, May 2017
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