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Title: IN VITRO ASSAYS FOR ASSESSING THE IMPACT OF PROCESSING ON THE ALLERGENIC POTENTIAL OF MILK ALLERGENS
Creator: Zhao, Yuhui
Date: 2014, 2014-07
Description: A better understanding of how processing may affect the allergenicity of proteins will allow a more accurate allergen risk assessment and...
Show moreA better understanding of how processing may affect the allergenicity of proteins will allow a more accurate allergen risk assessment and achieve a greater success in food allergy management. To determine whether food processing can affect the allergenic potential of proteins, immunochemical methods are commonly used, however, these methods are not able to determine changes in the proteins’ ability to elicit allergic reactions. Although food challenge studies are the gold standard for determining the allergenicity of proteins, such studies are seldom performed due to ethical reasons and the difficulty in recruiting a sufficient number of study participants. In recent years, a number of mediator release assays have been developed to measure the allergenic potential of food proteins in vitro. How these cell-based assays can be used to assess the impact of thermal or other processing conditions on the allergenic potential of proteins remains to be determined. This study evaluated the use of sensitized rat basophilic leukemia (RBL) cells for assessing the impact of boiling on the allergenic potential of milk allergens by measuring changes in the proteins’ ability to induce cell degranulation and the release of β-hexosaminidase. RBL-2H3 cells sensitized with rat IgEs that were specifically raised against NIST non-fat milk standard reference material, β-lactoglobulin (BLG), α-lactalbumin (ALA) and α-casein (αCAS) were challenged with various concentrations of each allergen in its native and processed (boiled in PBS for 10 min) forms. Cell degranulation caused by the allergen was monitored by measuring the release of β-hexosaminidase. All allergens (NIST milk, BLG, ALA, and αCAS) were able to induce the release of β-hexosaminidase, up to 43.1%. A decrease in % release of β-hexosaminidase was observed when cells were challenged with a decreasing concenration xi of the ALA and milk allergens. Boiling of nonfat milk, ALA, BLG and αCAS caused an increase in the % release of β-hexosaminidase from sensitized cells across antigen concentrations from 10-6 mg/mL to 1 mg/mL. In conclusion, this study demonstrated that the in vitro mediator release assay method may serve as a useful model to evaluate the impact of thermal processing on the allergenic potential of milk allergens.
M.S. in Food Safety and Technology, July 2014
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Title: BIOLOGICAL STRATEGIES FOR ENHANCEMENT OF LIQUID FUELS: SULFUR REMOVAL FROM PETROLEUM AND BIOETHANOL PRODUCTION
Creator: Wang, Jia
Date: 2013, 2013-12
Description: Rhodococcus baikonurensis CW25 was transformed with the Rhodococcus erythropolis strain IGTS8 desulfurization operon (dszABC, which encodes...
Show moreRhodococcus baikonurensis CW25 was transformed with the Rhodococcus erythropolis strain IGTS8 desulfurization operon (dszABC, which encodes the enzymes of the “4S” desulfurization pathway) or this operon modified to contain a synthetic cysteine-methionine rich “sulpeptide” gene (S1) (dszAS1BC). The two CW25 derivatives were subjected to directed evolution to select faster growing cells using the key 4S pathway substrate dibenzothiophene (DBT) as the sole source of sulfur. Data of cell doubling times verified the success of selection of cultures with increasingly rapid growth. The desulfurization activities of resting cells of early passages demonstrated improvements, and the highest activity of the dszAS1BC-bearing CW25 derivative was 115% higher than that of the CW25 derivative without S1. In addition, a trend of initial high activity was followed by a decrease in subsequent passages. Rates of DBT metabolism of growing cells demonstrated a different trend, probably because the activity of growing cells concurrently reflects the activity of DszABC enzymes and the growth rates of the recombinants. Dry cell weights fluctuated during the evolution process, probably because of variations in the efficiency of the conversion of the sulfur in DBT into sulfite, then into sulfate or biomass, or, for the S1-bearing cells, because the secretion of the S1 peptide from cells might have variable efficiency. A mixed culture of two Paenibacillus species (“W” and “Y”) was isolated that can metabolize DBT at temperatures up to 54 ºC. Strain Y is the only one of the two with desulfurization activity, while strain W enhances the desulfurization ability of Y. The W-Y culture may be a useful starting point for selection of desulfurization cultures with even greater thermal stability. xiii Ethanologenic Escherichia coli strain FBR5 was compared with Vitreoscilla hemoglobin (VHb)-expressing FBR5 (TS3) regarding the concentrations of ATP, NAD+, NADH, NAD+/NADH ratio; and growth and ethanol production at various points during growth. The significant finding was that the NAD+/NADH ratio for TS3 was lower in early growth, but higher in later growth compared to that for FBR5. This is probably because more NADH was required by TS3 for its enhanced ethanol production and VHb-related increased respiration under microaeration conditions.
PH.D in Biology, December 2013
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Title: Gerry-meandering: An Assessment of the Congressional District Model of Depository Allocation (preprint)
Creator: Ahrens, Aric G., Griffin, Luke A.
Date: 2003-06
Description: The preprint of a published article dealing with the effect of allocating Federal Depositories by Congressional district. Conclusions drawn...
Show moreThe preprint of a published article dealing with the effect of allocating Federal Depositories by Congressional district. Conclusions drawn include the fact that due to redistricting that occurs after each decennial census, over time some districts may have within their boundaries a greater number than the two depositories that Congressional district allocation was intended to produce. Likewise, over time shifting boundaries of districts have created districts that have no depositories whatsoever.
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Title: MATHEMATICAL MODELING OF POLY(ETHYLENE GLYCOL) DIACRYLATE HYDROGEL SYNTHESIS VIA VISIBLE LIGHT FREE-RADICAL PHOTOPOLYMERIZATION FOR TISSUE ENGINEERING APPLICATIONS
Creator: Lee, Chu-yi
Date: 2013, 2013-05
Description: Crosslinked hydrogels of poly(ethylene glycol) diacrylate (PEGDA) have been extensively used as scaffolds for applications in tissue...
Show moreCrosslinked hydrogels of poly(ethylene glycol) diacrylate (PEGDA) have been extensively used as scaffolds for applications in tissue engineering. In this thesis, PEGDA hydrogels are synthesized using visible light free-radical photopolymeriza- tion (λ = 514 nm) in the presence of the visible light photosensitive dye, EosinY, the co-initiator, triethanolamine (TEA), a comonomer, N-vinyl pyrrolidone (NVP), a crosslinking agent, PEGDA, and an optional PEG monoacrylate monomer that contains the cell adhesive ligand YRGDS. The incorporation level of the YRGDS lig- and as well as the physical and mechanical properties of these hydrogels dictate cell behavior and tissue regeneration. These hydrogel properties may be tuned through variations in polymerization conditions. The goal of this thesis was to develop a math- ematical model for PEGDA hydrogel formation which predicts the incorporation level of YRGDS and the crosslink density of hydrogel as a variety of polymerization con- ditions. This model provides insight into the process of hydrogel crosslinking and in effectively guiding the experimental design of these scaffolds for tissue engineering applications. To accomplish this task two major components comprised the studies of this thesis. The first component involved an investigation of the visible light photo- initiation mechanism of EosinY and TEA, and the second component involved the develop of a hydrogel synthesis model and its validation. Experiments and modeling were used to determine an expression for the rate of initiation of the EosinY/TEA initiation system and to propose a photoinitiation mechanism. In Chapter 2, exper- imental data and parameter fitting were utilized to obtain an empirical expression for the rate of initiation. However, this empirical expression did not consider the ef- fect of inhomogeneous light distribution which is present in this experimental system. The dynamics of light absorption during polymerization were measured under differ- xiv ent conditions in order to gain insight into the kinetic photoinitiation mechanism as well as the rate of initiation. In Chapter 3, a mechanism for this photo-initiation was proposed. Using this mechanism the light absorption dynamics accounting for inhomogeneous light distribution were simulated which were found to be in an agree- ment with the light absorption measurements shown in Chapter 2. Further validation of this proposed mechanism was achieved from polyNVP conversion measurements. This photo-initiation mechanism was implemented in the hydrogel model. In Chapter 4, the hydrogel synthesis model was developed based on the kinetic approach of the method of moments combined with the Numerical Fractionation technique. The model was used to predict the dynamics of hydrogel properties such as gel fraction, crosslink density, and RGD incorporation under various polymerization conditions. Model predictions were compared with experimental data. Three sets of experiments were conducted. In the first set of experiments where hydrogels were formed in the absence of Acryl-PEG-RGD, the total double bond concentration was kept constant while varying the compositions of NVP and PEGDA. The model and the experiments showed a maximum crosslink density for an acrylate to double bond ratio of 0.5 to 0.6. This is related to the synergistic cross-propagation between NVP and PEGDA, which results in an increase in the rate of polymerization leading to higher crosslink density. In the second set of experiments, hydrogels were formed in the presence of Acryl-PEG-RGD to investigate its incorporation as well as the hydrogel crosslink density. The model showed reasonable agreement with the experimental data and in some cases the predicted RGD deviated from the experimental measurements due to changes in volume upon swelling. The effect of swelling was not considered by the model. The calculated crosslink densities were compared with the inverse swelling ratios from the experiments. The reduction of free volume due to the space occupied xv by the unreacted pendant double bonds was not considered by the model. This reduc- tion of free volume affected the apparent swelling ratio obtained from experiments thus resulting in the observed mismatch between the experimental trends and the predicted crosslink density by the model. In the third set of experiments, additional crosslink density measurements were conducted using a PEGDA macromer of lower molecular weight (MW = 575 Da.). The experiments were performed in the absence of Acryl-PEG-RGD. Few cases were not accurately predicted since the model did not consider the reduction in the concentration of available pendant double bonds when gelation occurs. Among the three set of experiments, the hydrogel synthesis model offers reasonable predictions for most of the experimental cases. This model can be used as a guide for experimen- tally designing PEGDA hydrogels with the desired properties for tissue engineering applications.
PH.D in Chemical and Biological Engineering, May 2013
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Title: FINFET BASED STANDARD CELL LIBRARY CHARACTERIZATION
Creator: Yuan, Yu
Date: 2015, 2015-07
Description: In this work, four standard cell libraries based on FinFET technology have been characterized and implemented. The first library uses the BSIM...
Show moreIn this work, four standard cell libraries based on FinFET technology have been characterized and implemented. The first library uses the BSIM-CMG and PTM-MG models, which represents the common multi-gate devices. Two libraries are based on the BSIM-IMG model, operating in short-gate (corresponding to low-Vt) mode and lowpower (corresponding to high-Vt) mode separately. Synthesis and simulation of BSIMCMG based library is presented and compared to the conventional 45nm CMOS library, FreePDK45. The results show acceptable accuracy of the library based on BSIM-CMG model. For the libraries based on BSIM-IMG model, Short-Gate (SG) mode, Low-Power (LP) mode and the mixed-mode (combining both SG and LP modes) have been analyzed. The results proved that the low-power independent multi-gate FinFET can be used for leakage power reduction, just like the bulk CMOS high-Vt devices. At the end of this work, another library based on CCS model was characterized and verified, which show far better accuracy in terms of both timing and power modeling.
M.S. in Electrical Engineering, July 2015
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Title: PREPARATION FOR IMPLANTATION OF AN INTRACORTICAL VISUAL PROSTTIESIS IN A HUMAN: WORKING TOWARDS SATURATION
Creator: Troyk, Melissa J
Date: 2017, 2017-07
Description: The research focused on restoring visual perception via a vision prosthetic is progressing at a rapidly advancing rate. Previous research on...
Show moreThe research focused on restoring visual perception via a vision prosthetic is progressing at a rapidly advancing rate. Previous research on the experiences and perspectives of past, current, and potential vision prosthesis users has demonstrated that the decision to obtain a vision prosthetic is driven by a variety of unique factors and variables that merge with one another during the process of deciding to participate in clinical vision prosthesis research (Lane, Huyck, Troyk, & Schug, 2012; Lane, Nitsch, Huyck, Troyk, & Schug, 2014; Lane, Nitsch, & Troyk, 2015). The purpose of the current study was twofold: 1) to determine if our understanding of the experiences and perspectives of potential vision prosthesis users was nearing saturation, and 2) to understand the perspectives of potential vision prosthesis users who are veterans. Data were analyzed in accordance with qualitative analysis procedures. Results identified several new themes and subthemes that were determined to be important to our understanding of potential users’ perspectives of an intracortical vision prosthesis device. A preliminary framework is proposed for understanding how the identified themes and subthemes merge during the process of deciding to participate in an experimental vision prosthesis human clinical trial. The results demonstrated that while progress has been made, there is still more to learn about blind individuals’ perspectives of vision prostheses and how they would decide to participate in vision prosthesis research.
M.S. in Psychology, July 2017
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Title: PROPOSITION AND EVALUATION OF A NEW DAMPER, CALLED ROTATIONAL CYLINDRICAL FRICTION DAMPER (RCFD)
Creator: Divani, Abbass
Date: 2013, 2013-12
Description: The objective of this study is to propose and evaluate an innovative frictional damper for structural systems, called Rotational Cylindrical...
Show moreThe objective of this study is to propose and evaluate an innovative frictional damper for structural systems, called Rotational Cylindrical Friction Damper (RCFD), which does not bear limitation of previously proposed systems and yet maintains their advantages. Different kinds of energy dissipaters have been studied and used in structural systems in recent years. They perform more effectively compared to structures without any energy dissipater. Each of previously employed devices has its advantages and limitations. In this report, applicability of previous energy dissipaters will be investigated; then the proposed damper, RCFD, will be introduced, and the performance of RCFD will be evaluated under lateral load using ABAQUS software. RCFD consists of a shaft, a cylinder and proper assembly of braces so that the bracing members make the cylinder and shaft move in opposite circular directions under defined load. The assemblage of braces depends on type of bracing system that is employed. When load in bracing member exceeds the buckling load of the member, it overcomes the friction between the shaft and inner surface of the cylinder and while providing the ductility demand of the structure, it absorbs the energy of the seismic load, and it will work like a safety valve to protect main structural members from inelastic deformation. In spite of other types of frictional dampers, RCFD does not use and reduces the construction cost of high strength bolts. There is no limitation for the size and fitness of the bracing members more than that is for conventional design of braced frames. When we prove the performance of RCFD, some of the requirements of conventional design such as requirement of section F2 of Seismic Provisions for Structural Steel Buildings, AISC 341-10, will be eliminated. The pressure needed for developing friction is provided by heating the shaft and placing it into the cylinder with slightly smaller xiii diameter. It is simple to design and construct and does not have the limitation of other kinds of frictional damper systems. It can also be installed with little or no modification on any kind of Braced Frames or to retrofit Moment Frames. In this study, RCFD will be installed and evaluated on an Inverted V Concentrically Braced Frame, although installation of the RCFD on X Braced frame will be illustrated.
M.S. in Civil Engineering, December 2013
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Title: DEGRADATION RATE MODEL TO ESTIMATE SOIL CARBON SEQUESTRATION
Creator: Zhai, Wenjuan
Date: 2016, 2016-05
Description: Concern over climate change as a consequence of carbon dioxide (CO2) emissions from human activities has resulted in efforts to better...
Show moreConcern over climate change as a consequence of carbon dioxide (CO2) emissions from human activities has resulted in efforts to better understand potential mitigation measures such as carbon sequestration in soils. Processes shaping natural carbon sequestration may be used to remove excess CO2 from combustion and other anthropogenic sources of carbon, and, alleviate concerns over climate change. Land application of biosolids is a process that increases the amount of soil carbon sequestration and may produce carbon credits in accordance with the definition of UN Climate Change Convention. A dynamic degradation rate model (DRM) has been developed based on a mass balance and first order kinetics to describe the soil organic carbon (SOC) decomposition process, which provides insights on carbon sequestration due to microbial biomass, SOC, CO2 emission rates, residence time of sequestered carbon, and biomass to biosolids ratios. A curve fitting approach was used to produce a best fit average degradation rate for biosolids degradation and microbial biomass yield. This study employed a 34-year biosolids application database from the literature to determine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory resultsdetermine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory resultsdetermine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory resultsdetermine the amount of carbon sequestered in 41 strip-mined Illinois fields. The DRM application identifies two SOC phases in soil. Soil organic carbon gain in phase one (first 10 yrs) is primarily due to biosolids C application remaining and accumulation while in phase two, SOC gain is due to biomass or C sequestration. Carbon sequestration changes with time relate to variations in biosolids application amounts (10 and 18 Mg ha-1 yr-1), different degradation rate constants (0.04yr-1 to 0.16yr-1), and biomass yields (35 to 40%). Additionally, comparison between model simulation results and laboratory results provided by a yearlong study indicates that higher temperatures and moisture content and finer soils are related to larger degradation rates. To summarize, this study has the following contributions: (1) developed a degradation rate model which simulates the biosolids degradation process in soil and identifies two SOC phases in soil, and quantifies the biosolids degradation rate constant, biomass yield, and the C sequestered amount for multiple and long term soil application; (2) assessed the effect of changes in the amount of biosolids applied, soil type, and weather conditions on the C degradation rate by comparing model results to laboratory data; and (3) provides an easy quantitative method for predicting C sequestration from biosolids added to soil.
Ph.D. in Environmental Engineering, May 2016
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Title: SURFACE CHARACTERIZATION OF NIOBIUM FOR SUPERCONDUCTING RF CAVITIES
Creator: Cao, Chaoyue
Date: 2014, 2014-07
Description: Surface characterization techniques including point contact tunneling (PCT) spectroscopy and Raman spectroscopy have been employed to study...
Show moreSurface characterization techniques including point contact tunneling (PCT) spectroscopy and Raman spectroscopy have been employed to study the surface of niobium (Nb) superconducting radio frequency (SRF) cavities. PCT spectroscopy provides a direct means of measuring the surface superconductivity, which is closely correlated with the cavity’s performance characterized by the quality factor Q. Cavities with remarkably high Q show near ideal tunneling spectra with sharp coherent peaks and low zero bias conductance, consistent with the Bardeen-Cooper-Schrie↵er (BCS) density of states (DOS), and bulk gap parameter, " = 1.55 -1.6 meV. Cavities with Q-drop often exhibit strong non-uniform heating during RF operations, with high loss regions identified as hot spots. PCT spectra on hot spots reveal suppressed superconductivity, broadened DOS and Kondo tunneling, consistent with magnetic impurities on the surface. Raman spectra on hot spots indicate the presence of various impurities on the surface including amorphous carbon, C-H chain compounds and NbC, providing insights into the formation of hot spots. The origin of the impurities is unclear at present but it is suggested that particular processing steps in SRF cavity fabrication may be responsible.
Ph.D. in Physics, July 2014
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Title: Functionalized Polyoxovanadates: Synthesis, Characterization and Properties
Creator: Zheng, Yujuan
Date: 2012-04-30, 2011-12
Description: The compound [NaVIV6O6{(OCH2CH2)2NCH2CH2OH}6]Cl.H20, designated C0 in this report, an Anderson type structure, contains a single nitrogen atom...
Show moreThe compound [NaVIV6O6{(OCH2CH2)2NCH2CH2OH}6]Cl.H20, designated C0 in this report, an Anderson type structure, contains a single nitrogen atom in place of a single oxygen atom in each of the six vanadium-oxygen octahedra. Attached to each nitrogen are two alkoxide arms (-O-C-C-) which terminate on separate oxygen atoms of the octahedra. A third ethoxy group (-CH2-CH2-OH) dangles freely from each nitrogen atom. The functionalized cationic core [NaVIV6O6{(OCH2CH2)2NCH2CH2OH}6]+ is generated in situ and is cationic with a charge of +1. Chloride is the counteranion. Each vanadium addenda atom is the +4 oxidation state, and the six unpaired electrons result in interesting magnetic properties. C0 is obtained by reaction of a vanadium oxide source triethanolamine. The purpose of the research described here was to adapt the synthetic protocol associated with triethanolamine to other similar ligands. Ligand choice was motivated by the broader goal of this research group to form (extended) hybrid electronic and magnetic materials by chemically bonding POM cores to chemically interesting ligands, such as dyes or other POM cores. In this regard, the original triethanolamine derivative has a number of shortcomings; chief among them is the inaccessibility of the alcoholic functional group chemistry---due to its low pH---that otherwise might have been used to form linkages through the dangling alkoxy arms. Additionally, linkages containing paraffinic carbon (-C-C-), which is not a good conduit of electronic interaction, are chemically undesirable where the synthetic goal is hybrid structures with interesting electronic and magnetic properties. The results associated with the three ligands, diethanolamine, N,N'-Bis(2-hydroxyethyl)ethylenediamine, and N,N-Bis(2-hydroxyethy) ethylenediamine, are described herein. Diethanolamine was chosen because---based on a structural comparison to triethanolamine---it was expected to produce a structure having a hydrogen atom in place of the dangling ethoxy arms, which was indeed the result. We considered this structure highly desirable becasue of the potential lability of the hydrogen atom (-N-H), which would allow us to functionalist the core directly. The resulting compounds are characterized by single-crystal X-ray diffraction, elemental analysis, mass spectroscopy, thermogravimetric analysis, FT-IR and UV-Vis spectroscopy, maganometric titration, temperature-dependent magnetic susceptibility measurements, and cyclic voltammetry. The results of the cyclicvoltammetric investigation are consistent with the labile hydrogen atom (-N-H).
M.S. in Chemistry, December 2011
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Title: MULTIPLE-INPUT MULTIPLE-OUTPUT NONLINEAR CONTROL OF SELECTIVE CATALYTIC REDUCTION SYSTEMS
Creator: Dong, Siwei
Date: 2015, 2015-05
Description: Selective catalytic reduction (SCR) is one of the most promising solutions to meet the future nitrogen oxides (NOx) emissions regulations for...
Show moreSelective catalytic reduction (SCR) is one of the most promising solutions to meet the future nitrogen oxides (NOx) emissions regulations for heavy-duty diesel vehicles. However, such vehicles often operate in highly transient operations in which mobile selective catalytic reduction systems encounter significant efficiency challenges, especially when the engine is under a low load. A detailed simulation model of the SCR system was developed in the Gamma Technologies simulation suite and a baseline model of feedback control on SCR was constructed. Experiment data for the exhaust gas composition and conditions from a Cummins ISB engine was used to provide the input parameters for the SCR model. The results reveal that in the low-load conditions, the efficiency of NOx reduction in the SCR system is very low, and the level NOx concentration exiting the vehicle could be over 5 times than the limitation set by the US Environmental Protection Agency (EPA). However, these issues are encountered in part due to the fact that current SCR controls focus solely on the aftertreatment components and treat the incoming engine output conditions as system disturbances. To address the low NOx conversion problems encountered in low load conditions, a new integrated engine and aftertreatment control model was designed. This integrated approach improves the SCR system efficiency by using available feedback and modulating the upstream air/fuel ratio to provide more favorable SCR inlet conditions. From experiment data analysis, the engine’s air/fuel ratio is shown to have a critical impact on exhaust gas temperature and exhaust oxygen fraction, which highly affect the SCR reactions. In order to integrate the engine and aftertreatment system, a model of the SCR dynamics was created and validated and a simple model of the relationship between the engine’s air/fuel ratio and resulting exhaust temperature and composition is leveraged. The new model-based control strategy is proven to be effective to improve SCR system performance at low-load operations. With a small value shift in air/fuel ratio, the efficiency of low-load SCR system can increase from 40% to 85% at low load operating conditions.
M.S. in Mechanical and Aerospace Engineering, May 2015
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Title: LINEAR AND NONLINEAR BEHAVIOR OF TRANSIENT LIFT RESPONSE TO PULSE-ACTUATION
Creator: An, Xuanhong
Date: 2014, 2014-07
Description: The transient lift coe cient for a NACA0009 airfoil with pulsed jet actuation type of active ow control at stall conditions is investigated....
Show moreThe transient lift coe cient for a NACA0009 airfoil with pulsed jet actuation type of active ow control at stall conditions is investigated. The experimental mea- surements show the lift coe cient dependence to a single-pulse with di erent pulse widths and amplitudes. Based on the single-pulse with optimal parameters, multi- pulse and continuous pulse actuation cases are studied, which indicate that the pulse interval is the major factor of the active ow control system capability. Linear and nonlinear model are used to predict the lift coe cient variation for di erent input signals to the actuators. A combined nonlinear model is introduced to predict lift coe cient change due to arbitrary unsteady pitching motion with active ow control.
M.S. in Mechanical and Aerospace Engineering, July 2014
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Title: BIG DATA SYSTEM INFRASTRUCTURE AT EXTREME SCALES
Creator: Zhao, Dongfang
Date: 2015, 2015-07
Description: Rapid advances in digital sensors, networks, storage, and computation along with their availability at low cost is leading to the creation of...
Show moreRapid advances in digital sensors, networks, storage, and computation along with their availability at low cost is leading to the creation of huge collections of data { dubbed as Big Data. This data has the potential for enabling new insights that can change the way business, science, and governments deliver services to their consumers and can impact society as a whole. This has led to the emergence of the Big Data Computing paradigm focusing on sensing, collection, storage, management and analysis of data from variety of sources to enable new value and insights. To realize the full potential of Big Data Computing, we need to address several challenges and develop suitable conceptual and technological solutions for dealing them. Today's and tomorrow's extreme-scale computing systems, such as the world's fastest supercomputers, are generating orders of magnitude more data by a variety of scienti c computing applications from all disciplines. This dissertation addresses several big data challenges at extreme scales. First, we quantitatively studied through simulations the predicted performance of existing systems at future scales (for example, exascale 1018 ops). Simulation results suggested that current systems would likely fail to deliver the needed performance at exascale. Then, we proposed a new system architecture and implemented a prototype that was evaluated on tens of thousands nodes on par with the scale of today's largest supercomputers. Micro benchmarks and real-world applications demonstrated the e ectiveness of the proposed architecture: the prototype achieved up to two orders of magnitude higher data movement rate than existing approaches. Moreover, the system prototype was incorporated with features that were not well supported in conventional systems, such as distributed metadata management, distributed caching, lightweight provenance, transparent compression, acceleration through GPU encoding, and parallel serialization. Towards exploring the proposed architecture at millions of node scales, simulations were conducted and evaluated with a variety of workloads, showing near linear scalability and orders of magnitude better performance than today's state-of-the-art storage systems.
Ph.D. in Computer Science, July 2015
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Title: Some commutation phenomena of direct current machinery
Creator: Clark, F. C.
Date: 2009, 1905
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/somecommutationp00clar
Thesis (B.S.)--Armour Institute of Technology

Title: DESIGN OF RESILIENT CONTROLLABLE CHEMICAL PROCESSES - AN AUTOTHERMAL REACTOR CASE-STUDY
Creator: Chylla, R. W., Cinar, A.
Date: 1990-07
Publisher: AMER CHEMICAL SOC
Description: A technique for the analysis of state-space linear systems is applied to the problem of selection of resilient chemical process designs....
Show moreA technique for the analysis of state-space linear systems is applied to the problem of selection of resilient chemical process designs. Structural Dominance Analysis affords the evaluation of many process design and control configurations and assessment of the effects of potential manipulated variables and disturbances. After a brief presentation of the analysis method, a complex multibed tubular autothermal reactor system is examined. Resilient process configurations, ease of control, and effects of various inputs on reactor state variables and outputs are considered, and effective control configurations are selected.
Endnote format citation
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Title: OPTIMIZATION OF POWER TRENCH MOSFETS FOR HIGH EFFICIENCY SYNCHRONOUS BUCK CONVERTERS
Creator: Wang, Wendi
Date: 2016, 2016-05
Description: Synchronous buck converter might be one of the most widely used and fabricated circuitry in the world for its favorable trade-off on many...
Show moreSynchronous buck converter might be one of the most widely used and fabricated circuitry in the world for its favorable trade-off on many subjects. However, the ever higher operation frequency has lead to increasing power loss in power switches and imposed new challenge to MOSFET engineering. One promising alternative for the traditionally used trench MOSFET is the shield gate MOSFET. Shield gate MOSFET has superior conduction performance as well as fast switching transient response due to its Reduced Surface Electric Field (RESURF) effect. In recent years, characterization of power MOSFET has developed along with MOSFET technology itself. New Figure of Merits (FOMs) have come into people's sight as they serve as better standards to fully describe MOSFET's overall performance. Being the same case for many other device structures, this new characterizing system also puts advanced requirements to shield gate MOSFET. And one of the most crucial problems is the rather large output capacitance this structure is having. To improve the property of shield gate MOSFET and meet the requirements of new standards, several ways of structure refinement have been proposed in this work. Both shield gate MOSFET and conventional MOSFET rated at 40V have been designed and simulated in the second chapter. The outcome shows that shield gate MOSFET has superior performance in almost every respect except for its large output charge. Then new structure for COSS reduction has been introduced in the following section, with decrement of about 50% in QQS-1 being achieved. Finally, another issue that has been tackled with is the shoot through of synchronous buck converter. Equivalent circuit model for shoot through analysis is built in this section to study the effect of each parasitic element. And a p type pillar added structure has been verified as an effective way to suppress shoot through gate bounce.
M.S. in Electrical Engineering, May 2016
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Title: Searching for W' bosons at LHC with single top production, Proceedings of the XLIII International Symposium on Multiparticle Dynamics
Creator: Duffty, Daniel, Sullivan, Zack
Date: 2013-09-15, 2013-09-15
Publisher: IIT Press
Description: One of the strengths of the LHC is its capacity for the discovery of new physics. As a consequence of many BSM theories, W′ bosons make an...
Show moreOne of the strengths of the LHC is its capacity for the discovery of new physics. As a consequence of many BSM theories, W′ bosons make an ideal particle to search for to constrain many models. One mode in particular has relatively low background: Single top quark production mediated by a W′ boson. For W′ masses less than 1500 GeV, all the decay products of the top quark are visible, and the strongest channel is the top’s decay into an electron or muon, with the associated neutrino and a bottom jet. As the W′ mass increases, the decay products from the highly boosted top and bottom quarks from the W′ appear as fat jets; boosted top tagging algorithms abound, and we propose a boosted bottom tag to set an exclusion limit of 2750 GeV for standard model-like couplings with existing 8 TeV data.
Sponsorship: IIT College of Science, High Energy Physics Division of Argonne National Laboratory
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Title: BIO-COMPOSITE NANOMATERIALS; CHARACTERIZATION, MANIPULATION AND APPLICATION
Creator: Kim, Taeyoung
Date: 2013, 2013-05
Description: Biomaterials are any matter or material which interacts with biological system which were present on natural or synthetic nonviable materials....
Show moreBiomaterials are any matter or material which interacts with biological system which were present on natural or synthetic nonviable materials. An ideal biomaterial must physically and chemically compatible for biological applications to avoid toxicity and immune reaction. Collagen is a widely abundant, robust biopolymer that is found in the extracellular matrix (ECM) of many tissues. In terms of its structure and organization, collagen is a bio-nano material. The use of collagen in stem cell differentiation is particularly enticing since it is now evident that the extracellular matrix (ECM) proteins can regulate the cell’s fate and growth by their molecular and physical properties. In this thesis research, we have characterized the physical and structural properties of collagen and its composite materials. We found collagen interacts with NaCl and other nano-materials, such as carbon nanotube (CNT) and TiO2 nanotube, resulting in the modification of collagen structure and increase of its stiffness. In particular, CNT has changed collagen structure at both the molecular level and the higher organizational level. The effects of the matrices on cell growth and development were studied. It was found that collagen/CNT matrix specify and accelerate the stem cell differentiation toward neural cells. Since neurons form the foundation of biological circuit, manipulation of neurons in growth has the potential to form desired biological circuit. We also examined collagen in vaginal wall connective tissues, and found that alteration of collagen properties in clinical tissues is correlated to the onset of pelvic organ prolapse.
PH.D in Chemistry, May 2013
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Title: Feedback control of a continuous-flow stirred tank reactor with competing autocatalators
Creator: Chaivorapoj, W., Birol, I., Cinar, A., Teymour, F.
Date: 2003-08-06
Publisher: AMER CHEMICAL SOC
Description: Two types of nonlinear feedback control schemes are introduced and analyzed for their capability of recovering the original state of an...
Show moreTwo types of nonlinear feedback control schemes are introduced and analyzed for their capability of recovering the original state of an isothermal continuous-flow stirred tank reactor with one robust cubic autocatalytic species, perturbed by a temporary disturbance of an invading cubic autocatalytic species in the inflow. The control objectives are to eliminate the invading species from the system and to restore the original state of the host species. The extent of applicability of the control design to different nonrobust invading species is studied, when the controller is tuned for a specific invader. Moreover, a time-delay feature is suggested in one of the control schemes developed to achieve the control objectives in systems with poor detection of invading species.
Endnote format citation for DOI:10.1021/ie020427+
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Title: Some features of a modern overhead distributing system
Creator: Redman, A. R.
Date: 2009, 1916
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/somefeaturesofmo00redm
Thesis (B.S.)--Armour Institute of Technology

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