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Title: Incorporation of non-standard amino acids into proteins: challenges, recent achievements, and emerging applications
Creator: Jin, Xing, Park Oh-Jin, Hong, Seok Hoon
Date: 2019
Description: The natural genetic code only allows for 20 standard amino acids in protein translation, but genetic code reprogramming enables the...
Show moreThe natural genetic code only allows for 20 standard amino acids in protein translation, but genetic code reprogramming enables the incorporation of non-standard amino acids (NSAAs). Proteins containing NSAAs provide enhanced or novel properties and open diverse applications. With increased attention to the recent advancements in synthetic biology, various improved and novel methods have been developed to incorporate single and multiple distinct NSAAs into proteins. However, various challenges remain in regard to NSAA incorporation, such as low yield and misincorporation. In this review, we summarize the recent efforts to improve NSAA incorporation by utilizing orthogonal translational system optimization, cell-free protein synthesis, genomically recoded organisms, artificial codon boxes, quadruplet codons, and orthogonal ribosomes, before closing with a discussion of the emerging applications of NSAA incorporation.
Sponsorship: NIH R15AI130988
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Title: Undecanoic Acid, Lauric Acid, and N-Tridecanoic Acid Inhibit Escherichia coli Persistence and Biofilm Formation
Creator: Jin, Xing, Zhou, Jiacheng, Richey, Gabriella, Wang, Mengya, Hong, Sung Min Choi, Hong, Seok Hoon
Date: 2021
Description: Persister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating...
Show morePersister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating persister cells is challenging, owing to their tolerance to conventional antibiotics, which cannot kill cells in a metabolically dormant state. A high frequency of persisters in biofilms makes inactivating biofilm cells more difficult, because the biofilm matrix inhibits antibiotic penetration. Fatty acids may be promising candidates as antipersister or antibiofilm agents, because some fatty acids exhibit antimicrobial effects. We previously reported that fatty acid ethyl esters effectively inhibit Escherichia coli persister formation by regulating an antitoxin. In this study, we screened a fatty acid library consisting of 65 different fatty acid molecules for altered persister formation. We found that undecanoic acid, lauric acid, and N-tridecanoic acid inhibited E. coli BW25113 persister cell formation by 25-, 58-, and 44-fold, respectively. Similarly, these fatty acids repressed persisters of enterohemorrhagic E. coli EDL933. These fatty acids were all medium-chain saturated forms. Furthermore, the fatty acids repressed Enterohemorrhagic E. coli (EHEC) biofilm formation (for example, by 8-fold for lauric acid) without having antimicrobial activity. This study demonstrates that medium-chain saturated fatty acids can serve as antipersister and antibiofilm agents that may be applied to treat bacterial infections.
Sponsorship: NIH-R15AI130988; NSF REU-1757989
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Title: Priming Movie Product Placements: New Insights from a Cross-National Case Study
Creator: Balasubramanian,Siva K, Gistri, Giacomo
Date: 44354, 44327
Publisher: Taylor & Francis
Description: The paucity of research on priming product placements and insights from practitioners (Study 1) motivated our investigation into how and when...
Show moreThe paucity of research on priming product placements and insights from practitioners (Study 1) motivated our investigation into how and when priming works in movie placements. Study 2 explores the impact of media priming (a media story announcing a movie placement before the movie’s release) and ad priming (a similar ad announcement) on recall through contrasts with no priming (control). US students watched a movie in a theatre after such priming for a subtle or a prominent placement. When compared to no priming, both media priming and ad priming enhanced recall for the subtle placement; no difference in recall performance emerged between no priming and either type of priming for the prominent placement. Contrast tests comparing media priming and ad priming indicated no differences in recall for either subtle or prominent placement. Study 3 replicated these recall findings with Italian moviegoers, and supported additional hypotheses and propositions for brand attitude. For the subtle (prominent) placement, attitude did not change (decreased) when comparing either media priming or ad priming with no priming. Contrast tests comparing media priming and ad priming indicated no differences in attitude outcomes, for either subtle or prominent placement. Using no priming as a baseline for comparison, the converging conclusion is that any type of priming improves (does not change) recall and does not change (worsens) attitude for subtle (prominent) placements. Overall, results do not support priming for prominent placements; selective use of any type of priming for subtle placements appears appropriate to improve recall outcomes.
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Collection: International Journal of Advertising

Title: Abraham Lincoln School Art Classes leaflet, 1945-1946
Creator: Abraham Lincoln School
Date: 1945-1946
Description: Course catalog for evening classes in art and design at Abraham Lincoln School (30 West Washington Street, Chicago, Illinois). Class topics...
Show moreCourse catalog for evening classes in art and design at Abraham Lincoln School (30 West Washington Street, Chicago, Illinois). Class topics were layout and typography, basic design, home planning, and photography, and the classes were taught, at least in part, by students from the Institute of Design, including Mary Henry, Morton Goldsholl, and Jack Waldheim. This catalog is Mary Henry's personal copy, and her inscription on the rear cover reads "While I was a student at the Institute of Design I taught one semester at the Abraham Lincoln School - no salary involved! This is my only copy. M.H." Date of leaflet is unknown, date range indicated is inferred from Mary Henry's dates of attendance at the Institute of Design.
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Collection: Mary Dill Henry Papers, 1913-2021

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of Illinois Institute of Technology faculty and students attending an open meeting with President John T. Rettaliata regarding...
Show morePhotograph of Illinois Institute of Technology faculty and students attending an open meeting with President John T. Rettaliata regarding student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of student protests outside of Perlstein Hall on Illinois Institute of Technology's campus following the fatal shooting of four...
Show morePhotograph of student protests outside of Perlstein Hall on Illinois Institute of Technology's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of student protests outside of Perlstein Hall on Illinois Institute of Technology's campus following the fatal shooting of four...
Show morePhotograph of student protests outside of Perlstein Hall on Illinois Institute of Technology's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of student protesters gathered outside of President John T. Rettaliata's office in Perlstein Hall on Illinois Institute of...
Show morePhotograph of student protesters gathered outside of President John T. Rettaliata's office in Perlstein Hall on Illinois Institute of Technology's campus. Student protests took place following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of student protesters gathered outside of President John T. Rettaliata's office in Perlstein Hall on Illinois Institute of...
Show morePhotograph of student protesters gathered outside of President John T. Rettaliata's office in Perlstein Hall on Illinois Institute of Technology's campus. Student protests took place following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of student protests outside of Perlstein Hall on Illinois Institute of Technology's campus following the fatal shooting of four...
Show morePhotograph of student protests outside of Perlstein Hall on Illinois Institute of Technology's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding...
Show morePhotograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding...
Show morePhotograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: School of Architecture and Planning Faculty Meeting, April 10 and 16, 1970
Creator: Illinois Institute of Technology, Illinois Institute of Technology. College of Architecture
Date: 1970-04
Description: Digitized 7" open reel-to-reel tape recording of the Illinois Institute of Technology's School of Architecture and Planning faculty meeting,...
Show moreDigitized 7" open reel-to-reel tape recording of the Illinois Institute of Technology's School of Architecture and Planning faculty meeting, 1970. The meeting was opened with an unidentified person (possibly George Danforth, chairman of Architecture or Dr. Antonis Tritsis) reading the statement by Ludwig Mies van der Rohe (as director of the Armour Institute of Technology department of architecture) published in the 1939-1940 AIT Bulletin (academic catalog) identifying the philosophy and content of the 5-year architecture course. The IIT architecture curriculum is discussed before meeting begins.
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Collection: Ludwig Mies van der Rohe Memorial collection, 1969-1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of student protesters gathered outside of President John T. Rettaliata's office in Perlstein Hall on Illinois Institute of...
Show morePhotograph of student protesters gathered outside of President John T. Rettaliata's office in Perlstein Hall on Illinois Institute of Technology's campus. Student protests took place following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding...
Show morePhotograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
Show less
Collection: John T. Rettaliata student protest photographs, 1970

Title: Student protest at Illinois Institute of Technology, 1970
Creator: Illinois Institute of Technology
Date: 1970
Description: Photograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding...
Show morePhotograph of Illinois Institute of Technology faculty and students attending an open meeting with IIT President John Rettaliata regarding student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970.
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Collection: John T. Rettaliata student protest photographs, 1970

Title: Robert Gordon, ca. 1980s
Date: 1980-1989
Description: Photograph of architect Robert Gordon with mounted images of some of his commercial and residential architectural projects (left to right:...
Show morePhotograph of architect Robert Gordon with mounted images of some of his commercial and residential architectural projects (left to right: Icosahedron Guest House on Indiana Dunes, Mermel House, Walton Carpets), possibly taken in Gordon's studio. Photographer unknown. Date of photograph unknown. Date listed is approximate.
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Collection: Robert Philip Gordon papers, 1963-2010

Title: Buckminster Fuller, 1948
Date: 1948
Description: Photomontage portrait of Buckminster Fuller, 1948. Fuller, then an instructor at Black Mountain College, spent the winter of 1948 teaching at...
Show morePhotomontage portrait of Buckminster Fuller, 1948. Fuller, then an instructor at Black Mountain College, spent the winter of 1948 teaching at the Institute of Design, when this portrait was likely produced. Photographer/creator unknown.
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Collection: Institute of Design records, 1937-ca. 1962

Title: La Jolla - Peaceful Promenade
Creator: Gordon, Robert Philip
Date: 1991
Description: Watercolor painting of the coast of La Jolla in San Diego, California.
Collection: Robert Philip Gordon papers, 1963-2010

Title: Some Paradoxes of Whistleblowing
Creator: Davis, Michael
Date: 2006, 1996
Publisher: Philosophy Documentation Center
Description: By "paradox" I mean an apparent- and in this case, real-inconsistency between theory (our systematic understanding of whistleblowing) and the...
Show moreBy "paradox" I mean an apparent- and in this case, real-inconsistency between theory (our systematic understanding of whistleblowing) and the facts (what we actually know, or think we know, about whistleblowing). What concerns me is not a few anomalies, the exceptions that test a rule, but a flood of exceptions that seem to swamp the rule. This paper has four parts. The first states the standard theory of whistleblowing. The second argues that the standard theory is paradoxical, that it is inconsistent with what we know about whistleblowers. The third part sketches what seems to me a less paradoxical theory of whistleblowing. The fourth tests this new theory against one classic case of whistleblowing, Roger Boisjoly's testimony before the presidential commission investigating the Challenger disaster (the "Rogers Commission"). I use that case because the chief facts are both uncontroversial enough and well-known enough to make detailed exposition unnecessary. For the same reasons, I also use that case to illustrate various claims about whistleblowing throughout the paper.
Business and Professional Ethics Journal, Vo. 15, No.1. pp.3-19.
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