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Title: COMPUTER MODELING OF BREAST LESIONS AND STUDIES OF ANALYZER-BASED X-RAY IMAGING
Creator: Garcia, Luis De Sisternes
Date: 2011-11, 2011-12
Description: Phase-contrast x-ray imaging is an emerging technique that promises to yield highly sensitive medical images of soft tissue, which is...
Show morePhase-contrast x-ray imaging is an emerging technique that promises to yield highly sensitive medical images of soft tissue, which is difficult to observe via conventional radiography given its low X-ray attenuation differences. One of these phase-contrast techniques, known as analyzer-based imaging, has demonstrated that highly detailed breast tissue images can be obtained using synchrotron radiation. However, synchrotron facilities are impractical for clinical use. This thesis introduces studies and exposure consideration towards the application of analyzer-based imaging in a clinical environment, particularly in the context of breast imaging. It also introduces a computational breast lesion model that generates randomized three-dimensional phantoms which follow realistically the characteristics observed in real lesions. Moving analyzer-based imaging to clinical application requires the consideration of photon noise, inherent from the use of a photon-limited conventional source. We summarize the statistical properties in the presence of photon noise of two popular analyzer-based imaging techniques, known as diffraction-enhanced imaging (DEI) and multiple-image radiography (MIR). The statistics for MIR have not been previously derived and are introduced in this thesis. Comparison of the resulting statistical predictions with results obtained by Monte Carlo simulation validated the analysis. An expression for the maximum-likelihood (ML) solution for analyzer-based imaging is presented as a way of minimizing the effects of photon noise in the reconstruction of the object’s absorption, refraction and ultra-small angle scattering properties, and more practical maximum-likelihood expectation-maximization (ML-EM) and maximum-a-posteriori expectation-maximization (MAP-EM) solutions are also introduced. The behavior of the ML-EM and MAP-EM solutions was compared to the results produced by the five best-known analyzer-based reconstruction methods using computer simulations. The ML-EM and MAP-EM reconstructions proved closer to the theoretical values as they do not rely on commonly known limitations and approximations introduced by the other techniques. We introduce the development and evaluation of a new computational breast lesion phantom model that can simulate either massess or microcalcifications. The proposed tool allows the generation of a large number of randomized three-dimensional breast lesion simulations following desired characteristics normally used to describe breast lesions in clinical practice. The initial motivation for the development of this new phantom model was to enable the proposed evaluations of analyzer-based imaging to be achieved. However, the model became a major focus of this thesis because it improves significantly upon those that can be found in previous literature. The proposed lesion model can be used for evaluation studies across different breast imaging techniques, as well as for training purposes, so it is our hope that it could become an important resource for the broader mammography research community. As part of the lesion modeling research, we also introduce methods to computationally modify experimental mammography and analyzer-based images of breast tissue so that they present the generated tumor simulations embedded within their parenchyma realistically. The realism of the simulated lesion images was evaluated by comparison of 83 real tumor cases observed in mammograms with 83 constructed hybrid images in which simulated tumors matching the characteristics observed in the real cases were embedded, with healthy tissue acting as background. As a quantitative comparison, extracted features describing tumor shape and density showed no statistically significant differences between real and simulated tumors. A known computational tumor classification technique based on their shape observed in mammography was implemented and showed no significant performance differences between real and simulated cases, as well as showing good correlation with previously published performance results in real tumors. To measure the realism for use in human observer studies, we conducted a reader study in which 5 experienced radiologists were asked to judge whether each of the 166 images was real or simulated by assigning a score on a 7-point scale. The results were analyzed in a multiple-reader multiple-case statistical framework. The conclusion of the study was that the readers’ accuracy in assessing whether the lesions were real or simulated was not significantly better than random chance. This thesis also incorporates a reader study to evaluate the degree to which photon-limited analyzer-based images may be effective for visualization of breast cancer features. Our motivation was to establish the x-ray intensity that would be required to make these methods feasible, the purpose being to serve as a guide in parameter selection for future design of imaging hardware. We conducted a series of observer studies that quantify the performance of analyzer-based refraction images at different noise levels for the task of identifying subtle details present in breast tumors which are relevant to clinical diagnosis. The cases shown to the readers consisted of hybrid images where simulated lesions of known characteristics were computationally embedded in real breast analyzer-based background images. The original phase-contrast data was obtained using synchrotron radiation and was later modified to simulate the noise and blurring effects produced from a photon-limited source with a 300μm aperture size, similar to those used in a laboratory environment. Results showed that the analyzer-based imaging techniques statistically outperformed conventional mammography for the given task with an average of just 128 recorded photons per pixel in background image regions
Ph.D. in Electrical Engineering, December 2011
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Title: FEASIBILITY OF INDICATOR MICROORGANISMS IN ASSESSING THE EFFICACY OF SANITIZERS IN FRESH PRODUCE WASHING
Creator: Zhong, Zeyan
Date: 2016, 2016-05
Description: Sanitizers have been widely used in controlling cross-contamination during fresh produce washing processes. It is important to identify...
Show moreSanitizers have been widely used in controlling cross-contamination during fresh produce washing processes. It is important to identify different approaches for monitoring the efficacy of sanitizer washing. In this study, our objective was to determine the feasibility of indicator microorganisms in assessing the efficacy of chlorine and peroxyacetic acid (PAA) in fresh-cut produce washing. In inactivation experiments, the survivals of inoculated indicator microorganisms [total viable count (TVC), Enterobacteriaceae and total coliforms] and E. coli O157:H7 were determined after exposure to different concentrations of chlorine or PAA in water with added organic load (TOC~200 mg/l). In small-scale washing experiments, bacterial transfer from lettuce leaves inoculated with indicators or E. coli O157:H7 to wash water containing chlorine or PAA with/without organic matters was evaluated. In the inactivation study, higher log reduction was observed for Enterobacteriaceae and total coliforms than for E. coli O157:H7 after chlorine treatment at an initial concentration of 30 ppm. In the bacterial transfer study [a inoculated leaf (~5 log CFU) in 30 ml of wash water], without additional organic matter, approximately 3.5 log total CFU of all bacteria groups was transferred into wash water. Less than 1.5 log total CFU were detected for Enterobacteriaceae, total coliforms and E. coli O157:H7 in 1 ppm chlorine washing. With introduced organic matter, similar microbial loads of Enterobacteriaceae, total coliforms and E. coli O157:H7 were detected on washed leaves and in wash water with initial chlorine concentration of 1 ppm; when initial chlorine level increased to 10 ppm, less than 2 log total CFU of Enterobacteriaceae and total coliforms was detected while about 3 log total CFU of E. coli O157:H7 transferred to wash water, suggesting that chlorine at an initial concentration of 10 ppm could not prevent cross-contamination in the presence of organic load. The indicators showed different levels of survival and transfer from E. coli O157:H7 in this study and were unreliable to effectively monitor the behavior of the pathogen during chlorine wash in fresh produce processes. Enterobacteriaceae and total coliforms were more vulnerable to 40 ppm PAA treatment than E. coli O157:H7 in PAA inactivation experiments. No survival, except for TVC, was observed after 80 ppm of PAA inactivation. In the bacterial transfer study, 40 ppm PAA in wash water was found unable to prevent cross-contamination of indicators and E. coli O157:H7 from leaves to water. Further investigation is needed to compare the bacterial transfer levels of E. coli O157:H7 and the indicators at higher PAA levels.
M.S. in Food Safety and Technology, May 2016
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Title: Nutrition and Diabetes: Pathophysiology and Management
Creator: Opara, Emmanuel C.
Date: 2006
Publisher: CRC, Taylor & Francis

Title: COOPERATIVE BATCH SCHEDULING FOR HPC SYSTEMS
Creator: Yang, Xu
Date: 2017, 2017-05
Description: The batch scheduler is an important system software serving as the interface between users and HPC systems. Users submit their jobs via batch...
Show moreThe batch scheduler is an important system software serving as the interface between users and HPC systems. Users submit their jobs via batch scheduling portal and the batch scheduler makes scheduling decision for each job based on its request for system resources and system availability. Jobs submitted to HPC systems are usually parallel applications and their lifecycle consists of multiple running phases, such as computation, communication and input/output data. Thus, the running of such parallel applications could involve various system resources, such as power, network bandwidth, I/O bandwidth, storage, etc. And most of these system resources are shared among concurrently running jobs. However, Today's batch schedulers do not take the contention and interference between jobs over these resources into consideration for making scheduling decisions, which has been identified as one of the major culprits for both the system and application performance variability. In this work, we propose a cooperative batch scheduling framework for HPC systems. The motivation of our work is to take important factors about jobs and the system, such as job power, job communication characteristics and network topology, for making orchestrated scheduling decisions to reduce the contention between concurrently running jobs and to alleviate the performance variability. Our contributions are the design and implementation of several coordinated scheduling models and algorithms for addressing some chronic issues in HPC systems. The proposed models and algorithms in this work have been evaluated by the means of simulation using workload traces and application communication traces collected from production HPC systems. Preliminary experimental results show that our models and algorithms can effectively improve the application and the system overall performance, HPC facilities' operation cost, and alleviate the performance variability caused by job interference.
Ph.D. in Computer Science, May 2017
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Title: APPLICABILITY OF THE INTERVAL ANALYSIS METHOD TO RELIABILITY ASSESSMENT OF STRUCTURES
Creator: Taha, Raguez A.
Date: 2012-11-26, 2012-12
Description: The scope of this study is focused on the applicability of the interval method to the reliability analysis of structures. The study includes...
Show moreThe scope of this study is focused on the applicability of the interval method to the reliability analysis of structures. The study includes using the traditional probability methods in several applications and comparing the results with the interval analysis. Accordingly, the interval arithmetic rules are applied in several examples and the results are compared with those from the traditional probability theory concepts. Specifically, the procedure for using the interval methods was applied to the development of the probability of failure for a simple structural member; and for a link in a network system. Through three simple examples, the research shows that the interval method offers comparable results with those from the traditional first-order reliability method. The procedure based on the interval method, however, may offer advantages, especially in cases where the uncertainties in various parameters describing the reliability of a system are large. In the presence of large uncertainties, the traditional methods of reliability analysis, based on the first order approximation, may lose their accuracy. In these cases, the interval method may offer a simple method yet with more accurate results.
M.S. in Civil Engineering, December 2012
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Title: Cobalt Alloys
Creator: Levinson, David W., Mcandrew, Joseph B., Metcalfe, Arthur G.
Date: 1961-05-09
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

Title: Magazine for Magnetic Recording Apparatus
Creator: Greenleaf, Leland B.
Date: 1950-08-15
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

Title: Magnetic Pick-up Head
Creator: Wiegand, David E.
Date: 1959-12-22
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

Title: Integrator and Hysteresis Loop Tracer
Creator: Wiegand, David E.
Date: 1952-09-09
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

Title: A FAT home: Boards_aFAThome_01
Creator: Szajna, Conrad
Date: 2012, 2012-05
Description: The aim of this thesis is to revitalize suburban subdivisions not by destroying existing typology but by using the typical cookie cutter homes...
Show moreThe aim of this thesis is to revitalize suburban subdivisions not by destroying existing typology but by using the typical cookie cutter homes as a basis for re-envisioning subdivisions. By creating key room components, existing homes can expand outward to provide additional rooms for current family members, for older generations moving back home and/or for additional rental spaces as a way to supplement income. The end result creates unique spaces and courtyards that places the resident much closer to nature.
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Title: STUDY OF VITREOSCILLA HEMOGLOBIN VARIANTS PRODUCED BY RANDOM MUTAGENESIS
Creator: Lin, Xiaodan
Date: 2015, 2015-05
Description: This study is focused on comparing the wild type and mutated versions of the Vitreoscilla hemoglobin gene (vgb). The purpose of this focus is...
Show moreThis study is focused on comparing the wild type and mutated versions of the Vitreoscilla hemoglobin gene (vgb). The purpose of this focus is to find out whether any of the vgb mutations provides an advantage regarding cell growth rate, as well as on the expression level of Vitreoscilla hemoglobin protein (VHb). A negative control Escherichia coli DH5α (E. coli DH5α) bearing no pUC plasmid, as well as seven E. coli DH5α strains bearing different pUC-based plasmids were tested in the experiments. Among these were one vector-only negative control (pUC18), one wild type positive control (pUC8:16, which carries wild type vgb) and five different types of pUC-bearing vgb mutants (pUC-vgb M1, M2, M3, M4 and pUC18-vgb M3). In order to compare cell growth rate among these strains, the growth rate assay was carried out under three different conditions: (1) Luria-Bertani (LB) medium, aerobic conditions; (2) Terrific Broth (TB) medium, low oxygen conditions; and (3) TB medium, microaerobic conditions. In addition, the carbon monoxide (CO) difference spectra assay was conducted to measure functioning VHb protein expression levels for the strains grown under aerobic conditions. In contrast to the results obtained by our Australian collaborators, our growth rate assay and CO difference spectra assay showed no growth advantage or higher expression level of functioning VHb protein due to any of the vgb mutations. For the further study of the vgb mutants, four different recombinant plasmids were constructed by cloning three types of mutated vgb (vgb M1, M3 and M4) as well as wild type vgb into the prokaryotic expression vector pUC8 with ampicillin (Amp) resistance. After being transformed into competent E. coli DH5α cell, these resulting xii strains, as well as the plasmid-free negative control (E. coli DH5α) and vector-only negative control (E. coli DH5α bearing plasmid pUC8) were tested by the CO difference spectra assay. Except strain E. coli DH5α [pUC8-vgb M3], which showed a slight increase in the VHb expression level, the strain bearing other mutated vgbs did not demonstrate any elevation in VHb protein expression level, compared to the positive control containing wild type vgb.
M.S. in Biology, May 2015
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Title: Design of Kranti Home and School (Mumbai) for Sexually Trafficked Girls (sequence unknown), IPRO 343 - Project Plan
Creator: Arastu, Insiyah, Choe, Jonathan, Davis, Elena, Enriquez, Sheena, Kimball, Mark, Kleehammer, Christopher, Klimek, Joseph, Marcheva, Boryana, Martin, Amy, Patel, Hamida, Patel, Avni, Semerdjiev, Ivo, Sturrup, Terez
Date: 2009-12
Description: To develop and design a home and center of education for girls who have been previously trafficked.
Project Plan for IPRO 343: Design of Kranti...
Show moreTo develop and design a home and center of education for girls who have been previously trafficked.
Project Plan for IPRO 343: Design of Kranti Home and School (Mumbai) for Sexually Trafficked Girls for the fall 2009 semester
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Title: FUNCTIONAL ANALYSIS OF POTENTIAL PHOSPHORYLATION SITES IN BAXΔ2 UNIQUE OLIGOPEPTIDE
Creator: Tsai, Yu-tseng
Date: 2014, 2014-07
Description: The tumor suppressor gene, Bax, plays a critical role in tumor progression through regulating cell apoptosis. Mutations on the BAX gene often...
Show moreThe tumor suppressor gene, Bax, plays a critical role in tumor progression through regulating cell apoptosis. Mutations on the BAX gene often result in silencing its expression and the loss of pro-death ability. However, there is a unique Bax isoform, BaxΔ2, recently discovered in these Bax mutated cancer cells. BaxΔ2 isoform shows higher pro-apoptotic activity than Baxα. Unlike the parental Baxα, BaxΔ2 does not target mitochondria and forms aggregates in cytosol. There is a unique 10-amino-acid peptide in the N-terminus of BaxΔ2 protein possible function as a special signal. Two serines in this region are predicted as potential phosphorylation sites for regulation of the protein activity. To test this hypothesis, we mutated both serines (SS) into non-phosphorylatable alanines (AA) by site-directed mutagenesis approach. Both BaxΔ2 wild type (BaxΔ2-SS) and mutants (BaxΔ2-AA) were tagged with GFP, which allows us to monitor the protein expression and cellular localization in live cells. Here, we found that the distribution patterns of BaxΔ2-AA and BaxΔ2-SS were similar and appeared as aggregates in cytosol. BaxΔ2-AA mutant also possessed the similar pro-apoptotic activity with BaxΔ2-SS wild type. These results suggested that the two serines in BaxΔ2 unique oligopeptide might not play a critical role in BaxΔ2 localization and pro-death activity under the current ectopic expression conditions. Further study is needed to have better understanding of phosphorylation in contribution to unique behavior of BaxΔ2.
M.S. in Biology, July 2014
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Title: Synthesis of Therapeutic and Diagnostic Drugs Centered on Regioselective and Stereoselective Ring Opening of Aziridinium Ions
Creator: Chong, Hyun-soon
Date: 2016-09-21, 2016-09-20
Description: Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in...
Show moreStereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in steroselective and regioselective synthesis of therapeutic and diagnostic compounds
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: The utilization of sunflower stalks in paper manufacture
Creator: Zavertnik, J.
Date: 2009, 1914
Publisher: Armour Institute of Technology
Description: http://www.archive.org/details/utilizationofsun00zave
Thesis (B.S.)--Armour Institute of Technology

Title: POINT CLOUD FUSION BETWEEEN AERIAL AND VEHICLE LIDAR
Creator: Guangyao, Ma
Date: 2015, 2015-05
Description: Because of the increasing requirement of precision in region of 3-D map, we began to use LiDAR to establish a more accurate map. There still...
Show moreBecause of the increasing requirement of precision in region of 3-D map, we began to use LiDAR to establish a more accurate map. There still exist some problems although we have already made a great progress in this area. One of them, which I tried to process during my thesis study, is that we have two points source - Aerial LiDAR Data( Points gotten by Airplane ) and Vehicle LiDAR Data( Points gotten by Vehicle ) - while both of them have a different density and cannot be merged well. This process - Fusion-is kindly similar to registration, the difference is that the points we would like to merge are generated from different devices and have only few points pairs in the same region. For example, the Aerial LiDAR data has a higher points density in the roofs and ground, but lower in the walls. In the meanwhile, the Vehicle LiDAR data has a lot of points in the walls and ground region. It is beneficial to minimize the difference between these two point sets since the process is necessary for modeling, registration and so on. Therefore, my thesis is to minimize the difference between these two data sources, a procedure of Fusion. The main idea is to read the LiDAR data into data structure of Point Cloud, sample their density to the similar level, and select several corresponding special region pairs( we named these regions -chunks, e.g. Median strip and boundaries of road ) with sufficient interesting points to do fusion. Interesting points indicate the points with one and more special features among all points. And, the algorithm we used to implement the fusion is ICP( Iterative Closet Point Algorithm). Not similar to Registration of Point Cloud, research in the Fusion area is rare. Therefore, the existing algorithms are not well suitable in this project. I deduce some new algorithms during my research since the original ICP Algorithm cannot work well. Both Update Equation and Objective Function are modified. In this thesis, PCL( Point Cloud Library ) is mainly used to implement the basic function, such as nding the nearest points and sampling point cloud, and Eigen library to write the core functions( e.g. Modified Iterative Closest Point Alg ). I also use libLAS library to implement the IO operations and MeshLab to visualize the point cloud after modification.
M.S. in Computer Science, May 2015
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Title: SPEECH INTELLIGIBILITY AND ACCENTS IN SPEECH-MEDIATED INTERFACES: RESULTS AND RECOMMENDATIONS
Creator: Lawrence, Halcyon M.
Date: 2013, 2013-07
Description: There continues to be significant growth in the development and use of speech–mediated devices and technology products; however, there is no...
Show moreThere continues to be significant growth in the development and use of speech–mediated devices and technology products; however, there is no evidence that non-native English speech is used in these devices, despite the fact that English is now spoken by more non-native speakers than native speakers, worldwide. This relative absence of non-native English speech in devices may be due in part to the costs associated with localizing speech devices, but it may also be attributable to the fact that not enough is known about user performance with accented speech in speech–mediated environments. In the absence of targeted research, developers may be relying on existing studies which focus on perception (impression) of accented speech, as a basis of decision-making. However, perception paints only part of the picture when it comes to understanding how and why people perform in certain ways and in certain environments. Three studies were conducted to answer the following questions: (1) What are the acoustic-phonetic characteristics of negatively- and positively-perceived accented speech? And how are these characteristics related to markers of intelligible speech? (2) How do participants perform on different types of accented-speech tasks? (3) What is the relationship between user perception of accented speech and user performance in response to accented speech? and; (4) How do participants perform on accented speech tasks of varying complexity? Arising out of this research, there are six recommendations for the use of accented speech in speech-mediated devices. Also, the findings of this study raise questions about inherent linguistic stereotypes which impact both our perceptions and our choices about xvi the accents we want to hear on our speech devices. A discussion about if and how these stereotypes can be altered and measured are included. Future research should examine the role of experienced non-native talkers in speech devices. Results of study one demonstrated that some experienced non-native talkers were positively-perceived by raters and may be good candidates for talkers in speech devices. A study like this would explicitly establish if listeners consistently make native vs. non-native distinctions in their preferences or if a prestige continuum emerges.
PH.D in Technical Communication, July 2013
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Title: Remote Home: a handcrafted, component-based solution for southwest living: cordell_masters_boards_2012
Creator: Cordell, Christopher
Date: 2012-05-01, 2012-05
Description: A prefabricated home with componentry optimized for simple fabrication and human-scale labor. This project explores the benefits of linking...
Show moreA prefabricated home with componentry optimized for simple fabrication and human-scale labor. This project explores the benefits of linking digital design and prefabrication to maximize construction efficiency and minimize on-site delays. Its physically remote location also necessitates a highly light and mobile solution that is simple in construction.
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$Imaging Method Based on Attenuation, Refraction and Ultra-Small-Angle-Scattering of X-Rays$

Title: Imaging Method Based on Attenuation, Refraction and Ultra-Small-Angle-Scattering of X-Rays
Creator: Wernick, Miles N., Chapman, Leroy Dean, Oltulu, Oral, Zhong, Zhong
Date: 2009-05-19, 2005-09-20
Description: A method for detecting an image of an object by measuring the intensity at a plurality of positions of a transmitted beam of x-ray radiation...
Show moreA method for detecting an image of an object by measuring the intensity at a plurality of positions of a transmitted beam of x-ray radiation emitted from the object as a function of angle within the transmitted beam. The intensity measurements of the transmitted beam are obtained by a crystal analyzer positioned at a plurality of angular positions. The plurality of intensity measurements are used to determine the angular intensity spectrum of the transmitted beam. One or more parameters, such as an attenuation property, a refraction property and a scatter property, can be obtained from the angular intensity spectrum and used to display an image of the object.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Coil-Less Playback Head
Creator: Wiegand, David E.
Date: 1959-12-22
Description: Sponsorship: Armour Research Foundation of Illinois Institute of Technology
United States Patent

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