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Title: EXPERIMENTAL AND STRUCTURAL STUDIES OF FDA APPROVED EXON SKIPPING TREATMENT DRUGS
Creator: Zhang, Jingwen
Date: 2021
Description: DMD is an X-chromosome related genetic disease caused by loss of dystrophin protein expression, and which impacts 1 in 5000 boys born in the...
Show moreDMD is an X-chromosome related genetic disease caused by loss of dystrophin protein expression, and which impacts 1 in 5000 boys born in the world. The usual cause of this at the genetic level is a frame shift due to internal deletions of one or more exons that results in a change of the reading frame. This results in loss of expression of the protein encoded by this gene, dystrophin, which in turn leads to the disease phenotype. Exon skipping is a therapy for DMD which restores dystrophin pre-mRNA reading frame to produce a modified dystrophin. This is done by antisense oligonucleotides, AONs, which disturb the process of exon splicing and exclude targeted exons near the patient’s defect which restore the correct reading frame in the pre-mRNA transcript. In 2016, the first AON was approved for clinical use targeting exon 51, called eteplirsen. This provided the first disease modifying therapy for DMD, but it was only relevant to ~6% of patients who had defects that were correctable by skipping this specific exon. In 2020 two more AONs targeting exon 53 were developed, viltolarsen and golodirsen, providing benefit to an additional 5% of patients, and in 2021 casimersen targeting exon 45 was approved.However, this raises an interesting issue, in that for some patients, with an exon 52 deletion, skipping exon 51 or skipping exon 53 could both restore the reading frame. Which approved exon skipping treatment is better and the differences between them are still unknown. This is the aim of this study: to help patients figure out which AON can have a consequence of less long-term health problems like cardiomyopathy and longer life and get more precise treatment. We selected three exon skipped edits – two that represent exon 53 skipping repair of an underlying Δe52 defect and one targeting exon 51 skipping repair of a Δe52 defect. We then used a panel of biophysical and biochemical including dynamic light scattering, circular dichroism Spectroscopy, thermal denaturation, and protease K challenge to investigate the biophysical characteristics of these different exon skipped edits. From our results we found that Δe51-52 has the more structure (i.e., is less perturbed), compared to e52-53, as assessed by CD or by proteinase K challenge, but it also has lower thermal stability, with a low Tm=48C transition that begins to unfold at the physiological relevant temperature of 37C. On the other hand, e52-53 has less helical structure, but what structure did form had unfolding transitions in the normal range for wild type STRs, Tm> 60C; but this edit also had more non-helical structure. So, the total experimental results of these three edits are very complex, which may be due to the fact that these edits span the normally unfolded H3 region.
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Title: Two Essays on Corporate Finance
Creator: Wang, Bo
Date: 2021
Description: This dissertation is comprised of two essays on finance. In the first chapter, I investigate whether and to what extent unionization would...
Show moreThis dissertation is comprised of two essays on finance. In the first chapter, I investigate whether and to what extent unionization would influence the compensation to the non-executive employees. In the second chapter, I explore how social capital would impact regional innovation performance by private firms.In the first chapter, I examine the effects of unionization on stock options granted to non-executive employees. Adopting a regression discontinuity design, I find that employees receive more stock options after the union election wins. The positive association is more pronounced when unions have more bargaining power and when free-riding problems are less severe. Further, I provide evidence that employees receive more stock options when CEOs are entrenched. Finally, I show that stock options provide risk-taking incentives to non-executive employees. This work provides a potential explanation to the union wage premium puzzle that unions utilize stock options to increase non-executive employees’ total compensation. In the second chapter, I investigate whether and to what extent social capital may affect regional innovation by private firms in the U.S. I document that regional social capital is positively associated with the quantity, quality, and novelty of county-level innovation by private firms. This effect is more prominent in regions with a lower supply of financial capital. My findings further suggest that social capital is complementary to investment in research and development. Using a Spatial Durbin Model, I report that regional social capital has significant spillover effects in boosting the innovation of neighboring counties.
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Title: Testing a pilot intervention aiming to increase transgender allyship among future healthcare providers
Creator: Yoder, Wren
Date: 2021
Description: Transgender individuals often experience poor health outcomes related to a lack of provider knowledge and comfort around transgender issues. ...
Show moreTransgender individuals often experience poor health outcomes related to a lack of provider knowledge and comfort around transgender issues. Ally identity development and cultural humility theories have been used to develop interventions shown to improve attitudes, knowledge, and skills related to being an ally to the transgender community. Additionally, healthcare providers have reported a desire for online tools related to transgender healthcare, and online interventions can be more cost effective than traditional in-person trainings. The current study developed an hour-long online intervention composed of six activities aiming to increase attitudes, knowledge, skills, and identification as an ally to the transgender community. Tests were conducted to assess whether these domains increased significantly from baseline to post in the intervention condition compared to the control condition and whether the increase was maintained at 2-week follow up. The sample included cisgender (i.e., male or female) students studying a subject related to healthcare recruited online through Prolific (N = 78). Results indicated that knowledge and skills increased significantly from baseline to post in the intervention condition compared to the control condition, and increases were maintained at 2-week follow up. However, this was not the case for attitudes and identity. These findings largely replicate existing research on knowledge about transgender individuals and provide new insights into skills, attitudes, and identity related to transgender allyship. Findings can inform future research on transgender allyship intervention design and allyship theory as well as support improvements in clinical practice and policy related to transgender healthcare services.
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Title: HIGH-THROUGHPUT FIRST-PRINCIPLES STUDY ON HIGH-ENTROPY ALLOYS
Creator: Zhang, Jie
Date: 2021
Description: This research thesis discusses the current ecosystem surrounding a new type of alloy: high entropy alloys (HEA) or multi-element crystalline...
Show moreThis research thesis discusses the current ecosystem surrounding a new type of alloy: high entropy alloys (HEA) or multi-element crystalline materials and lays out the high-throughput first-principles calculation as a valuable approach to study these materials. The density function theory (DFT) from computational material science prospect was implemented to investigate the HEAs. Using EMTO-CPA algorithm, high-throughput DFT calculations were conducted. A total of 1958 HEA systems including equimolar and non-equimolar systems were studied with respect to the varies properties, including lattice parameters, bulk moduli, elastic constants, and elastic anisotropy. The first-principles HEA dataset was employed as the training set for the DeepSets a machine learning model. DeepSets, in combination with EMTO-CPA high-throughput calculation, successfully predicted the mechanical properties of specific HEA composition. This paves a promising new path of designing, investigating, and validating the HEA system compared to the time-consuming conventional HEA design method. The doping effect of Vanadium (V) and Titanium (Ti) to NbMoTaW HEA, as well as V or Ti as the fifth element with different molar fraction to the NbMoTaW HEA system, were studied. The phase stability of the new systems was discussed and concluded that all proposed systems tend to form single-phase solid solution. Though the addiction of V only slightly enhances the system’s ductility, the addition of Ti not only enhances the quinary system NbMoTaWTiX (X =0.25, 0.5,0.75, 1.0) ductility, but enables the system to be closer to fully isotropic.
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Title: Drawing on Darwinism: Rewriting the Origin of Louis Sullivan's Idea
Creator: Frey, Syan
Date: 2021
Description: To observe that the unique architectural ornaments that make up the body of work of Louis Henri Sullivan (1856-1924) emulate nature is to...
Show moreTo observe that the unique architectural ornaments that make up the body of work of Louis Henri Sullivan (1856-1924) emulate nature is to state a reality so obvious that it is both pedantic and droll. To use the double entendre that those natural forms drew on Darwinism, however, is to make several more specific claims. First, it can be credibly established that the system of architectural ornament that was the primary contribution of Louis Sullivan to the discipline of architecture was directly inspired by Sullivan’s synthesis of the thesis of natural selection contained within the pages of Asa Gray’s botanical manual. Second, the circumstances of that moment of synthesis reveal that the reason for Sullivan’s Darwinism was not merely the desire to emulate nature, but rather to signify the end of faith. Finally, Sullivan’s synthesis of various Darwinisms drew not only on the thesis for his own artistic inspiration, he drew on the substance of Darwin’s arguments to formulate a secular theory of the nature of inspiration and the technique of design. In the years following, this theory has become the primary technique by which design is taught.Louis’ unique education, which was tied to Darwinism from the very beginning, gave him an unusual perspective on the challenges of architectural design in the industrial age. The economic circumstances of his life as a first-generation immigrant exposed him to just the right education to lead him to explore evolutionary science as the inspiration for design. To be clear, the content of the thesis of natural selection was entirely irrelevant to the theory and practice of architecture in the nineteenth century. Yet by the end of the century the broad consensus among architects, historians, and theorists alike was that there was a, “close and causal relationship,” between Darwinism and modern architecture. Sullivan’s theory drew on Darwinian ideas to dismiss theological styles as empty formalisms, reveal the racism of ethnographic accounts for architectural forms, and argue for the evolution of an American Architecture, liberated from its colonialist origins. The context within which that shift occurred is significant. The justification for nearly every work of architecture in human history prior to the middle of the nineteenth century was some form of god. Mid-nineteenth century architecture in the United States was composed of a variety of regional ethnic styles intended to represent the ethnic origins, religious affiliations, moral inclinations, and nationalist allegiances of an array of displaced immigrant communities. The Civil War laid bare the reality that such ethnic styles represented a segregationist and racialized idea of the modern world. Over the course of the late nineteenth century, the profession of architecture was forced to abandon theological justifications for the practice of architecture as scientifically invalid, morally corrupt, and motivated by racism. This was Sullivan’s full idea: Put instinct before reason in priority, and engage in the iterative analysis of various instincts about the situation. Observe the patterns that emerge. Explore those instincts, until you find that your patterns merge with universal patterns. Do not fear error, as it makes the work alive. The capacity to capture that living essence is in all of us, individually and collectively, not some external force. The most-right instincts are ones in which the resulting form is a demonstration of its function. To understand what Sullivan meant with this we must see it as a Darwinian idea. Instinct is an animal property, a capacity which we share with other species. For Darwin, this sharing of instinct is essential for interspecies empathy. The antithesis of instinct is reason, which Sullivan describes as secondary. Reason is cold and lifeless, but also correct. True reason, Sullivan claims, is learned by experiment, and example. The greatest art speaks not just to our reason, but to our instinct. This, then is the task of the designer – to temper instinct with reasoned evaluation. Sullivan argues that it begins with an intuition, an idea he drew from Darwin’s Descent of Man.
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Title: Sex Differences in a Network Model of Depressive Symptoms
Creator: Ginger, Emily J
Date: 2021
Description: Major Depressive Disorder (MDD) is one of the most prevalent mental health disorders, with a lifetime prevalence rate of 13-16% and 12-month...
Show moreMajor Depressive Disorder (MDD) is one of the most prevalent mental health disorders, with a lifetime prevalence rate of 13-16% and 12-month prevalence rates of 5-7%. It has long been established that the rates of MDD in females is two to three times that of males. Previous research has examined sex differences in the occurrence and severity of MDD symptoms, primarily indicating greater severity of appetite increase and weight gain in females compared to males. The majority of previous research has been conducted assuming the latent factor model that MDD accounts for the symptoms of depression, and sex operates as a mediator or moderator between the latent variable and MDD, or between MDD and its symptoms. The present study used network analysis to examine whether there are sex differences in the relations between symptoms of depression, which might be an important factor for understanding sex differences in prevalence rates of MDD. The present study compared networks of DSM MDD symptoms between currently depressed females and males, and separate networks that also included other symptoms commonly associated with depression (e.g., anxiety, anger). Sex differences were examined using jointly estimated networks, and a Network Comparison Test (NCT) for the independently estimated networks. Results indicated no sex differences in depression symptom networks. These results indicate that depressive symptom networks, or the relations between symptoms are not an important factor for understanding the disparity in sex differences in MDD prevalence rates. Interestingly, non-DSM symptoms were among the strongest and most important symptoms within the network, suggesting future research and diagnostic criteria should consider inclusion of non-DSM symptoms associated with MDD.
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Title: Child Temperament, Attachment, and Loneliness: The Mediating Effects of Social Competence
Creator: Evans, Lindsey M
Date: 2021
Description: Chronic loneliness is a risk factor associated with adverse psychological, physical, and academic outcomes. Converging evidence suggests that...
Show moreChronic loneliness is a risk factor associated with adverse psychological, physical, and academic outcomes. Converging evidence suggests that young children experience and can reliably report on their own loneliness. Due to the significant negative sequalae associated with childhood loneliness, it is critically important to examine risk factors for child loneliness. The aims of this study were two-fold: (a) to examine if temperament (i.e., negative affect, effortful control, and inhibitory control) and attachment security assessed at 4 years of age predict loneliness at age 6; and (b) to determine if social competence at age 5 mediates the relation between temperament and attachment security at age 4 and loneliness at age 6. Participants included a diverse sample of 796 4-year old children, about half of whom were male. At age 4, temperament was assessed with the Rothbart Child Behavior Questionnaire and three inhibitory control tasks, and attachment security was assessed with the Attachment Q-Sort. At age 5, the Social Skills Rating Scale was used to assess social competence, and, at age 6, loneliness was assessed with the Loneliness and Social Dissatisfaction Questionnaire. Results of hierarchical regression analyses indicated that lower levels of effortful control and inhibitory control at age 4 significantly predicted higher levels of loneliness at age 6. Also, lower levels of negative affect and higher levels of effortful control and attachment security at age 4 significantly predicted higher levels of social competence at age 5. However, social competence at age 5 did not predict loneliness at age 6. There was no evidence that social competence at age 5 mediated the relation between age 4 temperament, attachment security and age 6 loneliness. These findings reveal that early self-regulation is associated with later child-reported loneliness and that intervention for children who struggle with cognitive regulation may be effective in decreasing risk for later loneliness.
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Title: Inviscid Shock Propagation within a Variable-Geometry Scramjet Inlet
Creator: Grybko, Maciej
Date: 2021
Description: The study concerns the propagation of shockwaves within an inlet of a scramjet engine and effect of inlet geometry variation on performance. A...
Show moreThe study concerns the propagation of shockwaves within an inlet of a scramjet engine and effect of inlet geometry variation on performance. A Python code was developed to simulate and visualize a flowfield within a scramjet inlet, based on inviscid oblique shock theory. The program was validated against NASA Shock software, and the results differed only by round-off error (0.05%). Subsequently a geometric sensitivity study was conducted, showing that throughout acceleration from Mach 5 to Mach 20 parameters like inlet height could be varied to ensure constant number of shocks within an inlet (preventing discontinuous changes of flowfield), whereas lower wedge angle could control compression required for optimal combustion. Correspondingly, a trajectory was determined with a constraint on static pressure entering combustion chamber (100 kPa). For an arbitrary baseline inlet geometry, it was established that beyond Mach 10 the scramjet would exceed structural load limit, despite delivering sufficient conditions for rapid combustion. Nevertheless, below Mach 10 it would operate efficiently, proving that hydrocarbon-fueled scramjets can have a fixed geometry. For higher speeds, a variable geometry is a necessity.
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Title: ARE SUPPORTIVE FOSTER CAREGIVERS ASSOCIATED WITH IMPROVED FOSTER CARE ALUMNI OUTCOMES? A LONGITUDINAL EXAMINATION OF THE EFFECT OF SUPPORTIVE FOSTER CAREGIVERS ON MENTAL HEALTH OUTCOMES IN A NATIONALLY REPRESENTATIVE SAMPLE
Creator: Dunn, Megan Reeves
Date: 2021
Description: Foster youth are a vulnerable population associated with poor health outcomes, but relatively little research has identified factors that may...
Show moreFoster youth are a vulnerable population associated with poor health outcomes, but relatively little research has identified factors that may mitigate adverse outcomes for these youth. The present study augments previous research by utilizing a nationally representative, longitudinal study (The National Longitudinal Study of Adolescent to Adult Health or Add Health) to investigate whether foster youth in the United States face significantly different mental and behavioral health outcomes compared with same-age peers, and second, whether presence of a supportive foster caregiver may predict better mental and behavioral health outcomes in the foster youth subsample. Using data from Waves III and IV of the Add Health study (N = 12,288 participants, of which n = 282 were foster youth), analyses examined whether foster status and higher caregiver support was related to rates of depression symptoms, suicidal ideation, marijuana use, and alcohol use. Surprisingly, there were few differences between those with and without a foster history; higher frequency of marijuana use among foster youth was the only significant difference. However, analyses in the foster youth subsample indicated that the presence of a supportive caregiver was associated with lower rates of depression symptoms and lower endorsement of suicidal ideation, demonstrating caregiver support as a possible protective factor for foster youth. Future research must continue to explore potential benefits of caregiver support, as it may inform policy that can improve long-term outcomes for foster youth.
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Title: THE EFFECTS OF MODIFIED SURFACES ON INSULIN CRYSTALLIZATION
Creator: Hammadi, Okba Tahar
Date: 2021
Description: Engineered nucleation features (ENFs) were designed with the hope to improve the efficiency of protein crystallization and increase...
Show moreEngineered nucleation features (ENFs) were designed with the hope to improve the efficiency of protein crystallization and increase reproducibility both in quality and quantity. These ENFs were tested with human insulin as the protein of choice since it has flexible parameters, only one cofactor, and a large amount of commercially available crystal ready protein. Insulin crystallization on the ENFs will produce more crystals while also having a reduced crystallization on-set time compared to the control glass surface. The ENFs were compared to control surfaces under similar conditions and observed over time to record both onset-times and end times. The ENFs performed markedly better in on-set times, having an overall 87%-time reduction when compared to the control drops. The drops placed on the ENF produced more than 2.5x the number of crystals in the control drops.
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Title: THE EFFECTS OF COMMUNICATION MODALITY ON PRESENCE, COGNITIVE LOAD AND RETENTION IN SECOND LIFE
Creator: WILKES, STEPHANY FILIMON
Date: 2009-12
Description: This thesis reports findings from a study (N = 60) of the impact of three communication modalities (voice only, text only, and voice and text...
Show moreThis thesis reports findings from a study (N = 60) of the impact of three communication modalities (voice only, text only, and voice and text simultaneously) on cognitive load, as measured by subjective reports of mental effort; on learning, as measured by tests of recall and retention; and on perceptions of presence as measured by a Presence Questionnaire (Witmer & Singer, 2005). Based on the results of prior empirical research, it is hypothesized that retention scores will be higher for voice participants and voice-and-text participants than for text-only participants; that cognitive load will be lower for voice participants and higher for text conditions; that voice will contribute to greater perceptions to presence; and that higher perceptions of presence will not correlate with deeper learning. Study results indicate that communication modality significantly effected cognitive load (F(2, 54) = 4.58, p = .01) and retention (F(2, 54) = 3.53, p = .04), and that experience with and time spent in the virtual environment had significant effects on measures of cognitive load, retention, and presence: Significant between-subjects effects were found for cognitive load and time (p = .23), for retention and time (p = .21), and for retention and experience (p — .03).
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Title: Basketball in Keating Hall, Illinois Institute of Technology, Chicago, Illinois, 1980s
Date: 1980-1989
Description: Photograph of students playing basketball in the Keating Sports Center gymnasium. Photographer unknown. Date of photograph unknown. Date range...
Show morePhotograph of students playing basketball in the Keating Sports Center gymnasium. Photographer unknown. Date of photograph unknown. Date range listed is approximate.
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Collection: Office of Communications and Marketing photographs, 1905-1999

Title: Basketball in Keating Hall, Chicago, Illinois, 1970s
Date: 1970-1979
Description: Photograph of Illinois Institute of Technology's basketball team practicing in the Keating Sports Center gymnasium. Photographer unknown. Date...
Show morePhotograph of Illinois Institute of Technology's basketball team practicing in the Keating Sports Center gymnasium. Photographer unknown. Date of photograph unknown. Date range listed is approximate.
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Collection: Office of Communications and Marketing photographs, 1905-1999

Title: Harold Leonard Stuart Building, Illinois Institute of Technology
Creator: Strohm, Adam
Date: 2015
Description: 10 West 31st Street, Chicago, Illinois
Collection: Building History project (buildinghistory.iit.edu)

Title: Arthur Keating Hall, Illinois Institute of Technology
Creator: Strohm, Adam
Date: 2015
Description: 3040 South Wabash Avenue, Chicago, Illinois
Collection: Building History project (buildinghistory.iit.edu)

Title: Arthur Keating Hall, Illinois Institute of Technology
Creator: Strohm, Adam
Date: 2015
Description: 3040 South Wabash Avenue, Chicago, Illinois
Collection: Building History project (buildinghistory.iit.edu)

Title: Graduate Hall, Illinois Institute of Technology
Creator: Strohm, Adam
Date: 2015
Description: 70 East 33rd Street, Chicago, Illinois
Collection: Building History project (buildinghistory.iit.edu)

Title: Cunningham Hall, Illinois Institute of Technology
Creator: Strohm, Adam
Date: 2015
Description: 3100 South Michigan Avenue, Chicago, Illinois
Collection: Building History project (buildinghistory.iit.edu)

Title: Basketball game in Keating Hall, Illinois Institute of Technology, Chicago, Illinois, ca. 1970s
Creator: Illinois Institute of Technology
Date: 1970-1979
Description: Photograph of tip-off at a basketball game between Illinois Tech and Roosevelt University in Keating Hall. Date of photograph is unknown. Date...
Show morePhotograph of tip-off at a basketball game between Illinois Tech and Roosevelt University in Keating Hall. Date of photograph is unknown. Date range listed is approximate.
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Collection: Office of Communications and Marketing photographs, 1905-1999

Title: Ecko Pool, Illinois Institute of Technology, Chicago, Illinois, ca. 1970s
Creator: Illinois Institute of Technology
Date: 1970-1979
Description: Photograph of students in Ecko Pool on the lower level of Keating Hall. Date of photograph is unknown. Date range listed is approximate.
Collection: Office of Communications and Marketing photographs, 1905-1999

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