Search results

(1 - 1 of 1)
HERBS AND SPICES ON ENDOTHELIAL FUNCTION OVER 24 HOURS: A RANDOMIZED, CONTROLLED TRIAL
Title
HERBS AND SPICES ON ENDOTHELIAL FUNCTION OVER 24 HOURS: A RANDOMIZED, CONTROLLED TRIAL
Creator
Thorat, Rajrajeshwari Sunil
Date
2021
Description
Modern-day eating patterns are characterized by readily available carbohydrates and/or fats and have consistently been shown to disturb...
Show moreModern-day eating patterns are characterized by readily available carbohydrates and/or fats and have consistently been shown to disturb endothelial function. Recent investigations suggest herb and spice blends have beneficial effects in reducing inflammation and increasing endothelial function in humans. This study was designed to characterize the effect of herbs and spices on endothelial function as measured by flow-mediated dilation (FMD) over 24 h using a challenge meal paradigm. In a randomized, single-blinded, 4-arm, crossover trial, sixteen overweight/obese adults (BMI = 28.4 ± 2.5 kg/m2; age = 39 ± 15 years) consumed a high carbohydrate high-fat meal (≈ 41% Fat and ≈46% Carbohydrate of total Kcal) with or without the spices combinations, including Italian herbs (rosemary, basil, thyme, oregano, and parsley), cinnamon, and pumpkin pie spice (cinnamon, ginger, nutmeg, and allspice) on four separate days at least three days apart. Meals provided to subjects were customized according to the individual's energy needs to maintain the body weight. The meal was composed of 35% of the daily estimated energy requirement. FMD was performed at 0, 1, 2, 4, 5.5, 7, and 24h. A pressure cuff was positioned below the elbow, artery diameter was measured before the pressure is applied and then inflated to 220 mmHg systolic pressure for 5 minutes. Immediately after cuff deflation, brachial artery vessel diameter was measured to obtain peak vessel relaxation. FMD was calculated as a percentage change in artery diameter before and after the release of the pressure. Baseline (t= 0 h) %FMD change was not significantly different between the treatments (p>0.05). There was no significant increase in the %FMD after consuming the control meal at all time points (p>0.05). Consumption of meals with Italian herb mix, cinnamon, and pumpkin pie spice significantly increased %FMD at 24 h compared to the control meal (mean ± standard error at 24 h, 7.83 ±0.89%, 7.98±0.95% and 8.44±0.70% vs 6.03±0.79%, respectively, p˂0.05). Furthermore, % FMD was significantly increased at t= 24h in Italian herb mix and cinnamon compared to their respective baselines 5.68 ± 0.37% to 7.83 ± 0.89% (p=0.01) and 6.43 ± 0.89% to 7.89 ± 0.95% (p=0.03), respectively. The results of this research indicate that spices may be beneficial for improving endothelial function after 24 h consumption, suggesting bioactivity of herbs and spices on endothelial function will be related to their time course of bioavailability of bioactive components. This was the first study that assessed the effect of herbs and spices over 24 hours using FMD. Understanding the mechanism of how these herbs and spices improve endothelial function will be the subject of future research.
Show less