Search results

(1 - 2 of 2)
CYCLIC THERMAL TREATMENT
Title
CYCLIC THERMAL TREATMENT
Creator
Gu, Sijie
Date
2015, 2015-12
Description
Cyclic thermal treatment has the potential to improve energy efficiency of thermal processing. It has been shown that in some cases, the...
Show moreCyclic thermal treatment has the potential to improve energy efficiency of thermal processing. It has been shown that in some cases, the productivity was enhanced by the cyclic thermal treatment operation. In order to investigate the cyclic thermal treatment effect, Copper-Nickel interdiffusion couples were investigated. When the Cu-Ni interdiffusion couple showed positive results, the cyclic thermal treatment was applied to pack carburization and gas carburization of steel. The Cu-Ni interdiffusion couples were annealed with different time-temperature profiles for 5 days. There are three types of time-temperature profile; isothermal, symmetric, and asymmetric cyclic thermal treatment. After thermal treatment, concentration-distance profiles were. Based on the concentration-distance profile, the interdiffusion coefficients of different time-temperature profiles were calculated. The interdiffusion coefficient of the diffusion couple with a ramp rate of 1°C/min had a higher diffusion coefficient than that of the diffusion couple annealed isothermally at the equivalent temperature, 863°C, which means that cyclic thermal treatment has the effect of accelerating diffusion. When the ramp rate was 5ºC/min interdiffusion coefficients were higher than that of the diffusion couple annealed isothermally at the maximum temperature. However, when the ramp rate was increased to 10°C/min, the diffusion coefficient decreased to almost the same as the interdiffusion coefficient of the diffusion couple at the equivalent temperature. After achieving a promising result for the Cu-Ni diffusion couples, we expanded the cyclic thermal treatment to carburizing. The temperature range for cyclic pack carburization was 850° to 950°C. Increasing the cyclic ramp rate resulted in an increase in the case depth. Due to the setup of the pack carburization, the maximum cooling rate achievable is 5°C/min. In order to reach a higher ramp rate, an induction heating gas carburization system was setup. The temperature range for the cyclic induction heat gas carburization was 850°C to 950°C. For the cyclic induction heat gas carburization with increase in ramp rate, the case depth increased. The sample induction gas carburized at a ramp rate of 20°C/min had a deeper case depth than the sample induction gas carburized isothermally at 904.4°C, the equivalent temperature. The first test showed the sample induction gas carburized with a ramp rate of 20°C/min had a deeper case depth than the sample induction gas carburized isothermally at 950° C. With this we draw the conclusion that the cyclic induction gas carburization can achieve a deeper case depth than the isothermal at equivalent temperature induction gas carburization.
Ph.D. in Materials Science and Engineering, December 2015
Show less
BIOMATERIAL SYSTEMS WITH PERSISTENT GROWTH FACTOR GRADIENTS IN VIVO FOR TISSUE ENGINEERING APPLICATIONS
Title
BIOMATERIAL SYSTEMS WITH PERSISTENT GROWTH FACTOR GRADIENTS IN VIVO FOR TISSUE ENGINEERING APPLICATIONS
Creator
Akar, Banu
Date
2016, 2016-12
Description
Tissue engineering aims to develop strategies for the replacement of damaged, injured or missing tissues with biologically compatible...
Show moreTissue engineering aims to develop strategies for the replacement of damaged, injured or missing tissues with biologically compatible substitutes such as bioengineered tissues. However, generating tissues of su cient volume for clinical application requires the formation of stable and extensive vasculature within the tissue constructs. The overall goal of this work is to enhance vascularization using a gradient biomaterial system and apply this research to engineering vascularized bone of clinical size. First, a method was developed to create persistent growth factor gradients with an adjustable gradient magnitude in vivo. This method generated persistent gradients of platelet-derived growth factor (PDGF-BB) within brin/poly (ethylene glycol) (PEG) sca olds. The presence of a growth factor gradient within the system was veri ed in vivo using near-infrared imaging. Also, a computational model was developed to investigate gradient characteristics within the system. Gradient properties can be controlled by varying the degradation rate of the gradient layer components or dose of PDGF-BB delivered. The angiogenic potential of gradient sca olds was tested in rodents using a subcutaneous implantation model. The depth of tissue invasion and density of blood vessels formed in response to the biomaterial increased with dose of the growth factor. The gradient biomaterial system allows formation of persistent gradients that can be in uenced by biomaterial characteristics, and enhances vascularization. Therefore, this biomaterial system can be used for tissue engineering applications. Second, the brin/PEG-based sca olds were modi ed to be degradable via hydrolysis and to include bioactive ceramic particles (hydroxyapatite and -tri-calcium phosphate). Characteristics of the hydrogel ceramic composites were investigated in vitro and in vivo. The presence of ceramic particles extended degradation time of thehydrogels in vitro and in vivo. Hydrogel ceramic composites were tested in a rodent cranial defect model and enhanced bone tissue regeneration. Third, strategies developed from the previous studies were combined to prepare ceramic supplemented gradient sca olds for bone tissue engineering applications. A gradient layer was applied to the hydrogel-ceramic composites and bone tissue response was evaluated in a periosteum guided large animal model. Ceramic supplemented gradient sca olds augmented vascularization and bone regeneration in vivo. In conclusion, a biomaterial system with persistent growth factor gradients was developed and enhanced vascularization and bone regeneration in vivo. This system holds a great potential for tissue engineering applications.
Ph.D. in Biomedical Engineering, December 2016
Show less