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Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314: Kolff Rotating Drum Artificial Kidney IPRO 314 Final Report Sp06
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
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Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314: Kolff Rotating Drum Artificial Kidney IPRO 314 Poster Sp06
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
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Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314: Kolff Rotating Drum Artificial Kidney IPRO 314 Midterm Report Sp06
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
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Title: QUANTITATIVE ANALYSIS OF THE EFFECTS OF BIOFUNCTIONAL AND PHYSICAL GRADIENTS ON CELL BEHAVIOR IN POLY (ETHYLENE GLYCOL) DIACRYLATE HYDROGELS
Creator: Turturro, Michael
Date: 2012-10-29, 2012-12
Description: The continued enhancement of tissue engineered scaffolds relies on their ability to stimulate the formation of a stable microvascular network...
Show moreThe continued enhancement of tissue engineered scaffolds relies on their ability to stimulate the formation of a stable microvascular network within the biomaterial. In vivo, the spatial presentation of immobilized extracellular matrix cues and matrix mechanical properties play an important role in directed and guided cell behavior and neovascularization. The overall goals of this thesis are to develop a technique for the generation of gradients of physical properties and incorporated biofunctionality within poly(ethylene glycol) diacrylate (PEGDA) scaffolds and to investigate the effects of these gradients on 3D cell invasion and neovascularization. To this end, a novel photopolymerization technique for generating spatial variations in matrix properties and incorporated biofunctionality within synthetic PEGDA hydrogels, perfusion-based frontal polymerization (PBFP), was developed. This technique relies on the controlled perfusion of a photoinitiator to a reaction chamber containing a precursor solution and results in the propagation of a polymer reaction front that travels through the monomer solution creating a gradient in hydrogel crosslinking. Manipulation of the magnitude of the gradient can be achieved through alterations in the polymerization conditions. Scaffolds with embedded gradients were designed and optimized based on a range of properties shown to support 2D cell adhesion, proliferation, and 3D vascular cell invasion in bulk photopolymerized hydrogels with homogeneous properties. An in vitro model of neovascularization was used to evaluate the effect of these gradients on vascular sprout formation. Sprout invasion in gradient hydrogels occurred bi-directionally with sprout alignment observed in the direction parallel to the gradient while control hydrogels with homogeneous properties resulted in uniform invasion. In PBFP gradient hydrogels, sprout xvi length was found to be twice as long in the direction parallel to the gradient as compared to the perpendicular direction after three weeks in culture. This directionality was found to be more prominent in gradient regions of increased stiffness, crosslinked matrix metalloproteinase (MMP)-sensitive peptide presentation, and immobilized YRGDS concentration. In vivo tissue invasion was shown to be directly related to gradient properties and orientation. Alterations in the magnitude of the gradient in elastic modulus enhanced the directionality of invading vascular sprouts while restricting in vivo tissue invasion.
PH.D in Biomedical Engineering, December 2012
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Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
Show less

Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314: Kolff Rotating Drum Artificial Kidney IPRO 314 Project Plan Sp06
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
Show less

Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
Show less

Title: Building a Working Replica of Kolff's Rotating Drum (Spring 2004), IPRO 314: Kolff Rotating Drum Artificial Kidney IPRO 314 IPRO Day Presentation Sp06
Creator: Abbasian, Niekoo, Antoniou, Antonis, Barta, Jennifer, Britt, Tim, Crendall, Dan, Das, Abhishek, Dawe, Robert, George, Ryan, Hannah, Rebecca, Hannink, Mary, Higashi, Andrew, Inouye, Brendan, Jungels, Ryan, Lin, Grace, Ram, Justin, Shrivastava, Archita, Stumph, Shawn, Sutalo, Joseph, Turturro, Michael, Tuthill, Chris, Vasu, Kedari, Vasquez, Sam, Whiting, Aaron
Date: 2006-05, 2006-05
Description: This IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful...
Show moreThis IPRO team has the unique opportunity to recreate, from the original plans, a working replica of the first clinically successful artificial kidney. Designed, built, and implemented in 1942, Willem Kolff’s rotating drum was the first successful extra-corporeal medical technological device. It provided a successful technological reference point for subsequent development of dialysis devices. This device literally established the field of artificial organs. There are no working models in the Western Hemisphere. Two exist in Europe both in the Netherlands.
Sponsorship: Museum of science and Industry; Paticia ward, PhD, Dept. of Science and Technology
Deliverables for IPRO 314: Building a Working Replica of Kolff's Rotating Drum for the Spring 2006 semester
Show less

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