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POSTPRANDIAL PLASMA POLYPHENOL PROFILE AND BIOAVAILABILITY OF ANTHOCYANINS IN INSULIN RESISTANT HUMANS AFTER CONSUMING MULTIPLE DOSES OF STRAWBERRIES BEVERAGE WITH A MEAL
Title
POSTPRANDIAL PLASMA POLYPHENOL PROFILE AND BIOAVAILABILITY OF ANTHOCYANINS IN INSULIN RESISTANT HUMANS AFTER CONSUMING MULTIPLE DOSES OF STRAWBERRIES BEVERAGE WITH A MEAL
Creator
Wei, Hequn
Date
2014, 2014-05
Description
Strawberries represent a rich source of polyphenolic compounds that are purported to be important for human health. However, data on their...
Show moreStrawberries represent a rich source of polyphenolic compounds that are purported to be important for human health. However, data on their bioavailability are limited. Therefore, the objective of the present study was to assess the absorption and metabolism of strawberry polyphenols in the postprandial phase using LC-MS/MS. Plasma was collected from humans (n=17) every 30-60 min over 6 h after ingestion of a 650 kcal standard meal accompanied with a beverage containing 0, 10, 20 or 40 g freeze dried strawberry powder. Pelargonidin-O-glucuronide (PG) was the most abundant strawberry metabolite in plasma. Maximum concentrations (Cmax) of PG were achieved at 188 ± 44 min and the levels were significantly different among beverages containing 0, 10, 20, 40 g strawberry powder: 0, 66.0±4.15, 113.64±10.11 and 202.1±15.18 nmol/L, respectively (P<0.05). Area under the concentration curve (AUC) over 6 h also increased with increasing doses (P<0.05); Cmax and AUC of PG was reduced as a percent of pelargonidin-3-O-glucoside (P3G) delivered in the 4 strawberry beverages (P<0.05). The 3 major anthocyanin polyphenols (PG, Pelagonidin-3-Glucoside (P3G) and Cyanidin-3-O-glucoside (CG)) found in plasma increased significantly after consumption of all strawberry-containing beverages compared to placebo (p<0,05). Bioavailability of PG from P3G among beverages containing 10, 20, 40 g strawberry powder were 1.76%, 1.40%, 1.30%, respectively. While higher concentrations of key strawberry compounds and metabolites were achieved with consumption of more strawberry powder, adjusting for dose suggested possible saturation of absorptive capacity of pelargonidin-based anthocyanins. These data provide the basis for understanding the relationship between dose, kinetic profile and efficacy outcomes for making recommendations to deliver optimal health benefits of strawberries; and moreover, serve as a model of the type of data required for understanding the relationship between dietary phytochemical intake and their biological effects.
M.S. in Food Processing Engineering, May 2014
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