(9,641 - 9,660 of 10,078)
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Title
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Hyde Park Theater
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Date
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1985-02
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Description
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Sketch for a proposed renovation of the Hyde Park Theater (built in 1913, designed by Horatio Wilson) for Robert Gordon's City Facade Project ...
Show moreSketch for a proposed renovation of the Hyde Park Theater (built in 1913, designed by Horatio Wilson) for Robert Gordon's City Facade Project (1984-1985). The completed renovation restored the facade and created a new overhang for the theater.
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Collection
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Robert Philip Gordon papers, 1963-2010
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Title
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Technology Center Today and Tomorrow
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Date
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1947
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Description
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Fundraising booklet for distribution to businesses and entrepreneurs soliciting funds for the development of the new campus buildings and...
Show moreFundraising booklet for distribution to businesses and entrepreneurs soliciting funds for the development of the new campus buildings and academic programs of Illinois Institute of Technology. At the time of the booklet's publication, the earliest of Mies van der Rohe's buildings on the Illinois Tech campus had been completed, with others under construction. The booklet includes a plan of the proposed Mies campus as well as drawings and descriptions of the buildings yet to be built. Some extant copies of the booklet include Technology Center of Tomorrow in the Making Today (see http://hdl.handle.net/10560/islandora:1011682), an insert with an update on campus construction.
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Collection
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Fund Raising Brochures collection, 1941-1950
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Title
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Nate Thomas, Illinois Institute of Technology, Chicago, IL, 1968-1973
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Date
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1968-1973
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Description
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Photograph of Nate Thomas. Thomas worked at Illinois Tech in various positions, first as part of the Computing Center in 1965. Thomas later...
Show morePhotograph of Nate Thomas. Thomas worked at Illinois Tech in various positions, first as part of the Computing Center in 1965. Thomas later served as Assistant Director of Co-Op Education , Director of Admission, head of Minority Affairs, and Vice President for External Affairs. Thomas was instrumental in recruiting students from underserved communities into STEM programs at Illinois Tech, and founded the Early Identification program in 1974 in order to attract and support diverse students interested in STEM, architecture, and other programs at Illinois Tech. Photographer unknown. Date of photograph is unknown. Date range listed is approximate.
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Collection
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Office of Communications and Marketing photographs, 1905-1999
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Title
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Nate Thomas, Illinois Institute of Technology, Chicago, IL, 1968-1973
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Date
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1968-1973
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Description
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Photograph of Nate Thomas. Thomas worked at Illinois Tech in various positions, first as part of the Computing Center in 1965. Thomas later...
Show morePhotograph of Nate Thomas. Thomas worked at Illinois Tech in various positions, first as part of the Computing Center in 1965. Thomas later served as Assistant Director of Co-Op Education , Director of Admission, head of Minority Affairs, and Vice President for External Affairs. Thomas was instrumental in recruiting students from underserved communities into STEM programs at Illinois Tech, and founded the Early Identification program in 1974 in order to attract and support diverse students interested in STEM, architecture, and other programs at Illinois Tech. Photographer unknown. Date of photograph is unknown. Date range listed is approximate.
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Collection
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Office of Communications and Marketing photographs, 1905-1999
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Title
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Quantification of Vascular Permeability in the Retina Using Fluorescein Videoangiography Data as a Biomarker for Early Diabetic Retinopathy
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Creator
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Kayaalp Nalbant, Elif
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Date
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2023
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Description
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Diabetic retinopathy, which is the most common reason for blindness in the working-age population, affects over one-third of those who have...
Show moreDiabetic retinopathy, which is the most common reason for blindness in the working-age population, affects over one-third of those who have had diabetes for over ten years. High blood sugar level (hyperglycemia) in the blood damages blood vessels and tight junction at the blood-retinal barrier (BRB). Chronic inflammation leads to changes in vascular health, and over time blood vessels tend to get damaged and exhibit higher “leakage” or permeability. In the late stage of DR, hemorrhages can occur, leading to irreversible damage of neuronal tissue in the retina and vision loss. In the clinic, there are some biomarkers and imaging modalities used to diagnose DR based on some of the more severe products of DR (e.g., hemorrhage), but there is no non-invasive, highly sensitive method to detect diabetic retinopathy before clinical signs occur, when mitigating therapies could be more effective. In this thesis, indicator dilution theory was explored to modeling the temporal dynamics of fluorescein in the retina after intravenous injection, with an aim to quantitatively map subtle changes in retinal blood flow and vascular permeability that could preempt subsequent irreversible damage. Specifically, a simplified version of indicator dilution theory—namely the “adiabatic approximation in tissue homogeneity” (AATH) model—was used to estimate physiological parameters such as the blood flow (F) and the extraction fraction (E: a parameter coupled with vascular permeability) from retinal fluorescein videoangiography data. The AATH fitting protocol was optimized through simulations using a more complex model (the AATH-vascular heterogeneity model, AATH-VH). It was determined that a two-step least square fitting method was more sensitive than a single-step least square fitting of AATH to simulated data to evaluate vascular permeability in early diabetic retinopathy.
The optimized data analysis protocol was then evaluated in an initial clinical study comparing healthy control subjects to those with moderate non-proliferative DR. Volumetric blood flow and retinal vascular permeability maps were compared between patient groups with clear increases in extraction fraction observed in the mild NPDR patients compared to control. These promising early data have been the foundation to an ongoing 5 year study tracking 100 Diabetic patients with no DR so see if early changes in vascular permeability can predict which patients are more likely to progress to DR.
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