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Title: LARGE-SCALE SIMULATION OF ELECTRIC POWER SYSTEMS FOR WIND
Creator: Wei, Tian
Date: 2011-08, 2011-07
Description: The utilization of wind energy will pose great socioeconomic benefits with reductions in power plant emissions and the supply of zero cost...
Show moreThe utilization of wind energy will pose great socioeconomic benefits with reductions in power plant emissions and the supply of zero cost energy; however, largescale wind energy integration could introduce inevitable challenges to regional transmission systems and hourly system operations. This thesis addresses the congestion identification, simulation and analysis of large-scale electric power systems in different scenarios, large-scale wind energy integration and related transmission expansion issues. A methodology based on the security-constrained unit commitment (SCUC) is applied to analyze the transmission congestions in the Eastern Interconnection of the United States. The identified congestions are visualized along with the Geographical Information System (GIS) data and compared with the results in National Electric Transmission Congestion Study (NETCS) published by the Department of Energy of the United States in 2006. The study also provides the locational marginal price (LMP) information in the Eastern Interconnection, which is not available in the NETCS report. This thesis implements a comprehensive simulation and scenario analysis of the Illinois electric power system for the year 2011. Possible scenarios representing electrical load sensitivities to economic growth, fuel price variations, and the impact of carbon cost, are studied. This thesis presents the hourly simulation results for the large-scale wind energy integration in the Eastern Interconnection of the United States. An hourly unit commitment is applied for the simulation of the economics of wind energy integration in the year 2030. The energy portfolio for supplying the hourly load in 2030 is developed based on wind integration levels. The sensitivities of fuel price, wind energy quantity, xvii load forecast, carbon cost, and load management to the proposed 2030 wind integration are studied. This thesis identifies transmission congestions and expands the existing transmission system in the Eastern Interconnection of the United States for accommodating a large-scale integration of wind energy. Violated transmission flows which would cause the infeasibility of hourly SCUC are identified. An iterative transmission expansion analysis is implemented to identify the minimum required additions to the Eastern Interconnection for mitigating hourly transmission congestions.
Ph.D. in Electrical Engineering, July 2011
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Title: POLARIZATION INDUCED BY A TERAHERTZ ELECTRIC FIELD ON A CONDUCTIVE PARTICLE
Creator: Shen, Tao
Date: 2013, 2013-05
Description: Interactions of an electromagnetic wave with an object of dimensions small compared to the wavelength can often be accounted for by...
Show moreInteractions of an electromagnetic wave with an object of dimensions small compared to the wavelength can often be accounted for by considering the dipole moments, which are effective in explaining the scattering characteristics in the frequency range referred to as the Rayleigh region. Dielectric functions derived from polarization processes due to molecular orientation or bound charge displacements have been employed over the years to account for the scattering properties of particles. In the presence of mobile charges, bulk conductivity may be incorporated with a complex dielectric function to explain the peak in absorption near the plasma frequency exhibited by metallic particles in the optical region. With the current interest in nanostructures, an investigation of the electromagnetic properties of a conductive particle with attention given to space-charge effects would appear timely. This can be accomplished by coupling the transport equations of the charge carriers to the Maxwell’s equations. Results of computations performed for elementary structures such as plates and particles revealed the screening of the internal field while dispersion and absorptions effects are shown by the complex dipole moments. To gain insight into the nature of charge-wave interactions, results based on quasi-static formulation for the electric field will be compared with those based on full-wave analysis, with special attention given to the charge and current distributions within the structure. By consideration of the physical process of charge carrier motion and lattice polarization, the equivalent circuit model for a conductive nanoparticle in the terahertz frequency range is developed. All circuit elements are of electrical nature and can be directly expressed in terms of material parameters. The equivalent circuit can serve as the basis of analysis for composite structures and aggregates of which the conductive nanoparticle is a constituent.
PH.D in Electrical Engineering, May 2013
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Title: MODEL-BASED EXPLORATION OF THE FEASIBILITY OF CREATING MULTIPLE PROPERTY GRADIENT IN CROSSLINKED POLYMER FILMS IN CONTROLLED LIVING POLYMERIZATION
Creator: Qin, Zikai
Date: 2014, 2014-05
Description: The functional gradient materials have been widely used in chemical engineering, biomedical engineering and tissue engineering since they have...
Show moreThe functional gradient materials have been widely used in chemical engineering, biomedical engineering and tissue engineering since they have been reported because of their admirable mechanical, physical and chemical properties. Several traditional methods of synthesis gradient materials are known to all. Here we introduced a new mathematical model of designing and producing crosslinked polymeric films with target multiple gradients. We derive our model from batch reactor system and explore how each condition of the system affects the gradient of the polymer film. Then we extend to semi-batch reactor to control the gradient in crosslink density and set up different strategies to make the target multiple gradient crosslink density accomplish. With any given target gradient crosslinked polymer film, we can make an exact similar film in our model.
M.S. in Chemical Engineering, May 2014
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Title: PARADIGM SHIFT IN REMOTE EDUCATION FOR THE LABORATORY: A SOCIAL APPROACH TO DISTANCE LEARNING
Creator: Hanley, Richard
Date: 2011-12, 2011-12
Description: With modern telecommunication tools the ability for two individuals to work together remotely has greatly improved. Moreover, there have been...
Show moreWith modern telecommunication tools the ability for two individuals to work together remotely has greatly improved. Moreover, there have been great strides made to improve handling medium to large groups of people in real time in remote settings, viz. the teleconference and webinar. However, the status of remote tools for laboratory environments where there is significant hardware and the individuals are more likely to talk amongst themselves in irregular patterns is not nearly as well studied. This thesis examines the way most laboratories in electrical engineering are setup, and creates a model for how to create a remote environment for distance learning. It then discusses the current state of the art, and how such an implementation of the model can be made with such tools. Finally a usability study of the implementation is examined. The primary result of the usability study is that when moving to a remote environment the social paradigm that students and instructors use is likely to change, and simply working on creating a virtual mirror to the laboratory may not work in the future.
M.S. in Electrical Engineering, December 2011
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Title: IMPROVED DYNAMIC CONTRAST ENHANCED MR IMAGING WITH AN APPLICATION TO PROSTATE CANCER LOCALIZATION
Creator: Afshar, Niloufar Totonchi
Date: 2011-07, 2011-07
Description: Prostate cancer is one of the most frequently detected cancers and a leading cause of death for men in the United States. Fortunately, chances...
Show moreProstate cancer is one of the most frequently detected cancers and a leading cause of death for men in the United States. Fortunately, chances of successful treatment significantly improve when prostate cancer is diagnosed at an early stage. An accurate and reliable imaging technique that can localize tumors is very valuable for example in guiding needle biopsy, therapy, as well as surgery. Current imaging techniques such as ultrasound provide unsatisfactory result for tumor localization. Therefore, Multispectral Magnetic Resonance Imaging (MRI) emerged as an alternative method of imaging for prostate cancer. An important part of multispectral MRI is Dynamic contrast enhanced MRI (DCE-MRI). Traditionally, a compartmental model is used with DCE-MRI to estimate parametric images. However these images are usually very noisy. Therefore, we propose to use directly the series of DCE-MRI for tumor localization instead of the pharmacokinetic parameters which are derived from DCE MR images through a compartmental model. As a second contribution, we have developed new features in addition to traditional parameters based on different characteristic of tumor and normal pixels. These new features are standard deviation and the energy of the first half of the spectrum divided by the energy of the second half of the spectrum based on an analysis of TACs for tumor and normal pixels. We use quantitative and qualitative evaluation methods to demonstrate that employing DCE-MRI directly as features and our proposed features result in an improvement in terms of tumor localization performance.
M.S. in Electrical Engineering, July 2011
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Title: THE EFFECT OF FLOW ON MICROPARTICLE TRANSPORT AND THE ROLE OF MICROPARTICLES IN THROMBOSIS
Creator: Lee, Ying-hui
Date: 2012-11-27, 2012-12
Description: Elevated monocyte/macrophage-derived microparticles (MPs) have been found to correlate with thrombotic complications. These MPs carry tissue...
Show moreElevated monocyte/macrophage-derived microparticles (MPs) have been found to correlate with thrombotic complications. These MPs carry tissue factor (TF), the principal coagulation pathway initiator, as their parental cells and expose anionic phospholipid phosphatidylserine (PS), which can promote thrombin generation and fibrin formation. During thrombus development, MPs may be delivered to the injured/dysfunctional vascular endothelium or biomaterial surfaces and influence the process of thrombosis. MPs are submicron membrane vesicles that may have increased transport and/or binding capabilities compared to platelets or other cell types due to their decreased size and their higher Brownian diffusion. MPs and their surface molecules can be delivered to surfaces, either biological or prosthetic, and alter the local environment. Little is known of the mechanisms by which MPs are transported to and impart their biological activity on surfaces, especially in blood. Such a transfer of activity will depend on the ability of MPs to be transported to the surface, the strength of adhesion of the MPs on the surface and the nature of the activity/host interaction. In the present study, physical and biological properties of MPs generated from macrophage-like cell lines by endotoxin stimulation were characterized, the transport of MPs to surface by flow was investigated, and the import biological activity on surfaces was elucidated. We observed that the deposition of MPs suspended in buffer on glass surfaces was strongly shear-dependent using a well-defined parallel plate flow chamber. The diffusivity coefficients of MPs at shear rate ranges ranging from 100 to 3200 s-1 were determined from the classical mass transport equation proposed by Leveque and the values were found to be of the same order of magnitude as predicted by Brownian xi diffusion. MPs non-specific attachment to glass was dominated by electrostatic interactions; this was verified by changing the surrounding ionic strength of the suspending solution. In addition to shear rate, red blood cells (RBCs) also influenced MP adhesion due to the complex movement of RBCs. Such movement has been shown to enhance the adhesion of platelets (1-2 micron size cells) to surfaces in flowing blood. MP lateral transport was enhanced at low concentrations of RBCs and reduced at higher concentration of RBCs. The reduction of MP deposition was due to the competition for surface binding sites between the two populations of MPs. The two types of MPs studied here, those produced by macrophages after endotoxin stimulation and those produced by RBCs during experimental preparation (repeated centrifugal washing) have the capability of nonspecific binding to artificial surfaces in a competitive manner. Finally, we demonstrated that the amount of adherent MPs on surfaces influenced fibrin formation via both a TF-dependent and a negatively charged phospholipid pathway. These findings suggest that procoagulant MPs may modulate thrombotic events under certain conditions, especially in MP-associated diseases. The knowledge of the effects of flow on MP transport and the influence of increased MPs on thrombosis may provide novel insights for the transfer of biological activity to relatively passive surfaces.
PH.D in in Biomedical Engineering, December 2012
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Title: Framework For Cloud-Based BIM Governance
Creator: Mehraj, Isma
Date: 2020
Description: Due to the rapid adoption of building information modeling (BIM) in the architecture, engineering, and construction (AEC) every building can...
Show moreDue to the rapid adoption of building information modeling (BIM) in the architecture, engineering, and construction (AEC) every building can be visualized and interpreted even before its foundation touches the ground. BIM methods are expanding and have entered mainstream use that requires immediate consideration. BIM is new and difficult to operate as mostly due to the enormous amount of data that causes improper data management. The objective of this study is to formulate a cloud-based BIM governance framework with a focus on practical issues for its implementation in the construction organizations. A framework was developed to study Data Management, Team Collaboration, Data Organization, and Legal Assurance as major constructs. It is expected that the constructs will provide a benchmark for BIM cloud governance implementation for BIM /VDC engineers to follow. The incorporation of this framework in BIM practices would produce new opportunities for the AEC community to work in collaboration and increase efficiency in data sharing. A survey among a wide spectrum of BIM/VDC practitioners from major construction organizations in the United States was conducted to explore and find evidence of the strength of the constructs. We anticipate that this framework will provide a basis for assessment and recognition of pivoting, driving factors for practical and effective BIM implementation.
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Title: A Risk-Based Approach in Selecting Design Natural Hazard Loads for Temporary Structures
Creator: Saleh, Eman
Date: 2020
Description: Temporary structures are systems that are used for short period applications such as in maintenance and retrofit applications or for staged...
Show moreTemporary structures are systems that are used for short period applications such as in maintenance and retrofit applications or for staged performances. Examples of its applications are tents, scaffoldings, and other facilities that have a short service life. Structures under construction and structures under serviceability conditions also fall under this category of structures; because their service time period is only limited to the duration of the construction, which is much shorter than the lifetime of the finished structure. One of the main characteristics of these types of structures is their high vulnerability to stability. Most specifications rarely cover temporary structures. Designing these structures to appropriate levels of the dead and live load does not impose an issue, in which using the same load factors as in permanent structures is considered a reasonable choice. However, an issue is raised when choosing the appropriate wind, seismic and snow load levels, where using the same exposure levels as in permanent structures may not be a desirable economic decision. Thus, for temporary structures, it makes sense to reduce the extreme event design loads proportional to the intended design life. In this manner, it is imperative to have specific rules or guidelines that would address the design aspects and reliability of these structures especially against lateral loads such as wind and earthquakes. This study aims at establishing several decision-making processes that could help contractors, designers, and erectors of temporary works to decide upon safety factors and/or return periods for environmental loads, with emphasis on the wind load. This decision-making process can be used in temporary projects (e.g., bridge erecting) to establish a design criterion based on the nature of the project. The study shows that the optimal decision-making process depends on the willingness to take advantage of wind locality characteristics (e.g., seasonality factor) in certain construction period or region, type of information available for the decision-maker (i.e., precise or imprecise), the risk associated with the constructed facility or the temporary structure itself, a potential for recourse actions, and the decision-maker’s attitude toward the trade-off between losses and gains with respect to uncertainty. The suggested decision-making process proposed is Bayesian decision process, the fuzzy decision process; (3) a two-stage stochastic programming solution; and (4) case-based decision theory. Several practical examples are presented in this thesis to show how different situations may require varying decision-making processes in order to reach the optimal decision. The design of temporary structures can be altered in response to a forecasted hurricane; thus, we propose a three-stage stochastic programming solution to decide upon their optimal wind design load. In addition, we extend the hurricane catastrophe models for application in temporary structures. This enables contractors to forecast the hurricane losses as a basis for estimating the adequate catastrophe cover such as insurance premiums and reinsurance for temporary structures. This scheme is then illustrated in an example for deciding the required temporary bracings for a steel frame under construction during the hurricane season.To prevent temporary structures from collapse, it is important to investigate the performance quality of previous projects and remove any causes for potential mishaps. This can be done by continuous monitoring of different projects and an investigation of accidents, if any, to help prevent future failures. In this study, we use an audit evidence scheme based on commonly available evidence theories used in the construction industry. In one such theory, the evidence is represented via a tree structure, in which the propagation is toward the variables that represent the project as a whole and separate work packages within a project. For simplicity, we only consider the binary case of variables i.e. whether or not a project conforms to the quality standards. The formulation of the auditing tool relates belief functions to the assertion of the quality assurance and quality control (QA/QC) measures and provides formulas for human error risk. These formulas provide plausibilities of human error in a belief-function format. An auditor may use the belief values to assess the degree of quality performance and to identify the sources of the problem in temporary work. We further illustrate the method in a practical application to evaluate the shoring/reshoring operations for estimating the construction risk in a multistory concrete structure. This evaluation may be used to decide on an appropriate time for formwork removal, shoring/reshoring schedule, casting cycles, post-tensioning sequence, and the required number of reshoring levels given the available evidence. To reduce the computational burden, we describe the shoring/reshoring system as a multi-state system (MSS) where the universal generating function (UGF) was used to estimate the reliability of the system.
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Title: Gradient Hydrogels for Neovascularization of Engineered Tissues
Creator: He, Yusheng Jason
Date: 2020
Description: The inability to induce extensive and perfusable microvasculature within complex engineered tissues that possess spatial variations in...
Show moreThe inability to induce extensive and perfusable microvasculature within complex engineered tissues that possess spatial variations in mechanical properties, physical architecture and biochemical composition remains as a major hurdle to their clinical translation. Biomaterial strategies focused on designing scaffolds with physiologically relevant gradients provide a promising means for elucidating 3D vascular cell responses to spatial and temporal variations in matrix properties. This work developed a cell-laden hydrogel platform with tunable decoupled and combined gradients of multiple matrix properties critical for maintenance of long term-vascular cell viability, adhesion, migration and invasion outgrowth to elucidate the impact of gradient matrix cues on 3D neovascularization in culture. This was achieved through the completion of three specific aims. First, a novel ascending frontal polymerization (AFP) technique was developed to generate gradient-based PEG hydrogel scaffolds with tunable individual and combined matrix gradients. Using programmable syringe pumps to control the delivery of precursors with distinct composition during crosslinking, we were able to generate gradient scaffolds with decoupled spatial variations in the immobilized concentration of the RGD cell adhesion peptide ligand and elastic modulus. Using this approach, the slope and magnitude of the imposed RGD gradients were readily manipulated without inducing variations in elastic modulus. Vascular spheroids inserted into gradient hydrogel scaffolds supported 3D vascular sprout formation, while the immobilized RGD gradient promoted an increase in sprout length towards the imposed gradient. Next, to create cell-laden scaffolds photopolymerization conditions were optimized to enable viable cell encapsulation during scaffold fabrication. To achieve this, an experimental sensitivity analysis combined with the design of experiments (DOE) was implemented to design isotropic hydrogel scaffolds with a broad range of matrix properties (elastic modulus, immobilized RGD and proteolytic degradation) that supported vascular sprouting in 3D culture. We examined the individual and interaction effects of each matrix property and demonstrated that an optimal combination associated with increases in immobilized RGD and proteolytic degradation of mediate synergistic enhancements in 3D vascular sprouting. Based on the findings from this in vitro study with isotropic hydrogel scaffolds, we designed scaffolds with 5 types of gradient combinations in immobilized RGD, stiffness and protease-sensitivity and explored the impact of spatial variations these matrix cues on vascular sprouting within the constructs in 3D culture. Specifically, we created hydrogel scaffolds with gradients in immobilized RGD with (1) steep and (2) shallow slopes, (3) gradients in elastic modulus, (4) gradients in protease-sensitivityand and (5) opposing gradients of RGD and modulus and concurrent gradients of protease sensitivity and RGD. By encapsulating vascular spheroids in different regions of each gradient scaffold, we observed spatial variations in total sprout length within all gradient scaffolds. We also found that RGD gradient and combined gradient scaffolds induced biased vascular sprouting toward increased RGD concentration and that biased sprouting was enhanced by gradient magnitude and slopes of immobilized RGD concentration. Conversely, directional sprouting responses diminished in scaffolds possessing opposing gradients in RGD (with concurrent gradients of degradation) and modulus. The presented work is the first to demonstrate the use of a cell-laden biomaterial platform to explore the impact of gradients in RGD, proteolytic degradation, and stiffness on vascular sprouting responses in 3D culture. The presented platform and findings of this thesis work hold great potential in the fields of tissue engineering specifically for prevascularization of complex tissues that possess spatial variations in mechanical properties, degradation rate and adhesion ligand composition to facilitate their regeneration.
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Title: Mixed-use High-rise
Creator: Lei, Lei
Date: 2012-05-02, 2012-05
Description: Located in an area that is multi-functionally operated, where old meet new, the tower is not to be a stand-alone artiface, but a new comer who...
Show moreLocated in an area that is multi-functionally operated, where old meet new, the tower is not to be a stand-alone artiface, but a new comer who can naturally fit in the existing surroundings. The curved outline of the building undoubtedly radiating the style of new, facing old low-rises near by. However, conflict is reduced to a minimum level, by its softed surfaces and transparent material, as well as the recesses on the surfaces of the building.
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Title: Physics at the MeV-Scale in Liquid Argon Time Projection Chambers
Creator: Lepetic, Ivan Thomas
Date: 2020
Description: The liquid argon time projection chamber (LArTPC) is the detection technology chosen for several Fermilab-based neutrino experiments. This...
Show moreThe liquid argon time projection chamber (LArTPC) is the detection technology chosen for several Fermilab-based neutrino experiments. This technology will be used in studies of neutrino cross-sections and oscillations, neutrinos from supernovae as well as a variety of studies of beyond the Standard Model physics. This thesis explores the use of these detectors to study MeV-scale activity. MeV-scale electrons arising from Compton scatters of deexcitation photons and photons from inelastic neutron scattering in neutrino-nucleus interactions are reconstructed using novel methods presented here. This work represents the first demonstration of MeV-scale physics capabilities in a LArTPC neutrino experiment as well as the first observation of neutrino-produced photons from nuclear de-excitation and inelastic neutron scattering. A search for millicharged particles, postulated by theories of beyond the standard model physics, is also performed using data from a LArTPC and the low-energy reconstruction techniques developed. The results set world-leading bounds on the parameter space of millicharged particles. The work in this thesis demonstrates that studies of MeV-scale activity and new physics are possible with LArTPC technology and provides the foundation for future LArTPC studies of low energy neutrinos and new physics.
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Title: A MULTIPLE CASE STUDY OF COLLEGE MATHEMATICS INSTRUCTORS’ TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE (TPACK) AND ITS RELATIONSHIP TO THE INTEGRATION OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (ICT) IN THEIR TEACHING PRACTICES AND STUDENTS’ LEARNING
Creator: Alhejoj, Kawkab
Date: 2020
Description: This multiple-case study aimed to investigate the following essential aspects of instructors’ ICT integration in higher education: self...
Show moreThis multiple-case study aimed to investigate the following essential aspects of instructors’ ICT integration in higher education: self-reported technological pedagogical content knowledge (TPACK), level of ICT integration, and motivations-challenges to integrate specific ICT tools to teach particular mathematics concepts. Four college math instructors were selected purposefully from four community colleges. The TPACK conceptual framework was adopted through the use of the TPACK-M self-assessment survey to understand the perceived TPACK knowledge of the instructors. The model of Niess et al (2009), which describes the teacher’s level of practical ICT integration in the light of their TPACK, assisted in exploring the way college math instructors used ICT. Data collection involved surveys, semi-structured interviews, and direct classroom observations. Quantitative data was analyzed using descriptive statistics, while Atlas.ti software was applied for qualitative data. The findings showed that the total TPACK-M was rated high, with TPK the lowest among all the constructs. In terms of the ICT integration model, one instructor fitted into the recognizing level, another into the adapting level, and two others into the accepting level. There was a misalignment between the self-reported TPACK knowledge and the in-class level of ICT integration. Instructors need more support in developing practical TPACK abilities via effective PD and activating the “teacher model” to help college math instructors integrate ICT in creative and successful practice. Also, more research in higher education is recommended using a larger sample in the area of designing a TPACK instrument for college math instructors to help capture their perceptions and recognize any gap between what they know and what they do in higher education contexts.
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Title: Implementation of a multisensor wearable artificial pancreas platform: ensuring safety with communication robustness and cyber security
Creator: Lazaro Martinez, Carmen Caterina
Date: 2019
Description: Advances in IoT technologies and new sensor capabilities contributed to the rapid growth of wearable medical devices. Today, mobile sensor...
Show moreAdvances in IoT technologies and new sensor capabilities contributed to the rapid growth of wearable medical devices. Today, mobile sensor platforms can be effectively, cost efficiently integrated in healthcare applications. However, the increased risks of these devices, inherent vulnerabilities of mobile operating systems and open nature of the wireless protocols call for improved safety and security measures to prioritize patient's well-being. In the field of type 1 diabetes, blood glucose level management with insulin control algorithms are available in diabetes therapy systems, though none are fully automated and require extra announcements (such as meal and exercise) to operate. A mobile artificial pancreas (AP), based on Android smartphone, is developed: such a platform relies on off-the-shelf components and receives in real-time the physiological measurements from the wrist worn physical activity tracker and the glucose measurements, then used in a predictive control algorithm (originally developed and tested on a laptop), to compute the optimal amount of insulin to administer via an insulin pump. A dedicated remote server provides additional support for registration, authentication and data backup.The nature of the algorithm required a fast, reliable method to translate its inherent functions. Therefore, we implement a new semi-automatic conversion mechanism which ports MATLAB to Android as native C code. Validation tests of the mobile version confirm there are no deviations in the results.Moreover, in order to enhance safety guarantees for the patient, this cyber-physical system needs a robust implementation also resilient to attacks and failures. A central monitor module is introduced, wherein wireless devices and communications channels are integrated with complementary alarm and safety subsystems. The parameterization of the AP as a state machine demonstrates the efficiency to detect and react to possible errors, since any state change triggers the appropriate correcting response. The result is a protected and fail-safe environment, further expanded with security modules enforcing encryption, authenticated access and data-flow rules for intrusion detection.Overall, this research demonstrates, in the case of an AP, how challenges in diverse fields such as sensor fusion, control systems, wireless communications and cybersecurity can be addressed with a holistic approach for mobile health (mHealth).
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Title: USING COMPUTATIONAL MOLECULAR MODELING TO STUDY TRANSPORT PROCESSES OF INTEREST IN SEPARATIONS
Creator: Wang, Xiaoyu
Date: 2020
Description: Separation processes are widely used in chemical productions. The further development of membrane-based separation processes, compared with...
Show moreSeparation processes are widely used in chemical productions. The further development of membrane-based separation processes, compared with thermal separations, can lead to significant energy savings in chemical process industries. However, the main obstacle of experiments is that many separation processes are not well understood at the fundamental molecular level. In this dissertation, we use computational molecular modeling tools, mainly classical molecular dynamics (MD), to clarify molecular forces and provide detail at a molecular level, which can aid in the understanding of transport process and designing materials for a proposed application.In the first study, we investigated separation of water/alcohol vapor using zeolite membranes. Experimentally, the separation of water/isopropanol (IPA) mixtures shows a dramatic decrease in selectivity due to increase of IPA flux as the feed water concentration decrease when using the sodium A zeolite membrane. We used molecular dynamics simulations to help our experimental collaborators understand these puzzling results. The MD results reveal that the water molecules gather around the defect pores on the zeolite membrane, which stops the IPA from going through the membrane and has a positive effect on separation.Then, we studied the HPLC used to separate chiral drug mixtures. One popular chiral stationary phase, amylose tris(3,5-dimethylphenyl carbamate) (ADMPC), has been investigated using both experimental and computational methods; however, the dynamic nature of the interaction between enantiomers and ADMPC, as well as the solvent effects on the ADMPC-enantiomer interaction, are currently absent from the chiral recognition mechanism. We used MD simulations to model the ADMPC in different solvents to elucidate the chiral recognition mechanism from a new dynamic perspective. The ADMPC is found to hold the left-handed helical structure in both methanol and heptane/IPA (90/10); however, the ADMPC has a more extended average structure in heptane/IPA. We developed a model where the ADMPC atoms were restricted in the MD simulation. To better understand the molecular dynamic chiral recognition that provides the retention factor and the elution order in HPLC, we examined hydrogen bonding lifetimes, and mapped out ring-ring interactions between the drugs and the ADMPC. We discover several MD metrics related to hydrogen-bonding lifetimes and correlate them with HPLC results. One metric provides a prediction of the correct elution order 90%, and the ratios of these quantities for the enantiomers provide linear correlation (0.85 coefficient) with experimental retention factors.In the following study, we presented an improved model wherein multiple ADMPC polymer strands are coated on an amorphous silica slab. Using various MD techniques, we successfully coated ADMPCs onto the surface without losing the structural character of the backbone in the solvent. This model provides more opportunities for chiral molecules interacting with ADMPC, resulting in a better agreement compared with experiment when using the overall average metric. The new model also provides the possibility for drug molecules to interact with two polymer strands simultaneously, which is not possible in the previous single-strand model. For a better understanding of why some metrics are better predictors than others, we used charts of the distribution of hydrogen bonding lifetimes to display the information for various donor-acceptor pairs. The results are more consistent than the previous models and resolves the problematic cases of thalidomide and valsartan.Besides the membrane-based separations, immiscible liquid-liquid equilibrium states were also studied. We successfully predicted results based on MD simulations and showed comparable accuracy with experimental data. This method has applications in liquid-liquid extraction which is widely used in industrial separation process.
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Title: A FRAMEWORK FOR MANAGING UNSPECIFIED ASSUMPTIONS IN SAFETY-CRITICAL CYBER-PHYSICAL SYSTEMS
Creator: Fu, Zhicheng
Date: 2020
Description: For a cyber-physical system, its execution behaviors are often impacted by its operating environment. However, the assumptions about a cyber...
Show moreFor a cyber-physical system, its execution behaviors are often impacted by its operating environment. However, the assumptions about a cyber-physical system’s expected environment are often informally documented, or even left unspecified during the system development process. Unfortunately, such unspecified assumptions made in cyber-physical systems, such as medical cyber-physical systems, can result in patients’ injures and loss of lives. Based on the U.S. Food and Drug Administration (FDA) data, from 2006 to 2011, there were 5,294 recalls and 1,154,451 adverse events resulting in 92,600 patient injuries and 25,800 deaths. One of the most critical reasons for these medical device recalls is the violations of unspecified assumptions. These compelling data motivated us to research unspecified assumptions issues in safety-critical cyber-physical systems, and develop approaches to reduce the failures caused by unspecified assumptions.In particular, this thesis is to study the issues of unspecified assumptions in cyber-physical system design process, and to develop an unspecified assumption management framework to (1) identify unspecified assumptions in system design models; (2) facilitate domain experts to perform impact analysis on the failures caused by violating unspecified assumptions; and (3) explicitly model unspecified assumptions in system design models for system safety validation and verification.Before starting to develop the unspecified assumption management framework, we first need to study how unspecified assumptions may be introduced into cyber- physical systems. We took cases from the FDA medical device recall database to analyze the root causes of medical device failures. By analyzing these cases, we found two important facts: (1) one of the major reasons that causes medical device recalls is violation of some unspecified assumptions; and (2) unspecified assumptions are often introduced into the system design models through syntactic carriers. Based on the two findings, we propose a framework for managing unspecified assumption in cyber- physical system development process. The framework has three components. The first component is called the Unspecified Assumption Carrier Finder (UACFinder), which is to identify unspecified assumptions in system design models through automatically extracting syntactic carriers associated with unspecified assumptions. However, as the number of unspecified assumptions identified from system design models can be large, and it may not be always feasible for domain experts to validate and address the most safety-critical assumptions at different system development phases. Therefore, the second component of the framework is a methodology that uses the Failure Mode and Effects Analysis (FMEA) based prioritization approach to facilitate domain experts to perform impact analysis on unspecified assumptions identified by the UACFinder and asses their safety-critical level. The third component of the framework describes a model architecture and corresponding algorithms to model and integrate assumptions into system design models, so that system safety associated with these unspecified assumptions can be validated and formally verified by existing tools.We also have conducted case-studies on representative system models to demonstrate how UACFinder can identify unspecified assumptions from system design mod- els, and how the FMEA based prioritizing approach can facilitate domain experts to verify the appropriateness of identified assumptions. In addition, case studies are also conducted to demonstrate how system safety properties can be improved by modeling and integrating unspecified assumptions into system models. The results of case-studies indicate that the unspecified assumption management framework can identify unspecified assumptions, facilitate domain experts to validate and verify the appropriateness of identified assumptions, and explicitly specify assumptions that would cause defects in these systems.
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Title: Regenerating the Jordan River: Through Ecological and Sociocultural Interventions
Creator: Shadid, Rula
Date: 2019
Description: The Jordan River is often described as one of the world’s most unique eco-systems and is attributed to serving as a cradle of history, culture...
Show moreThe Jordan River is often described as one of the world’s most unique eco-systems and is attributed to serving as a cradle of history, culture, and spirituality in the ancient and modern times. Archaeological evidence on its banks reveal signs of some of the world’s earliest existences of civilization. Its history as a meeting place for the crossing and exchange between plants, animals, and human societies, along with its strong association to three of the world’s great religions – Christianity, Islam, and Judaism – has made it a world known and important site. Being located in the Middle East, in the heart of a complex political conflict that has been ongoing since the middle of the last century, years of war, political clashes, and water and resource exploitation has reduced the river from a once lush and bio-diverse ecosystem to nothing but a polluted stream. Today the river is a “hydro-border” that divides the competing nations around it and segregates the people of the Jordan Valley in which the river runs via militarized security efforts. The conflict has left the region politically and socially segregated and has eliminated the productive exchange which once allowed the valley to thrive while efforts to protect, preserve, or rehabilitate the river are given little chance to succeed. The thesis addresses river degradation and social segregation as two interdependent issues in the Jordan Valley. It highlights saving the Jordan River as a driver for integration between the conflicting society and points to the Jordan Valley river border as a site for regenerative interventions that suggest an alternative and productive way of life in an area filled with conflict, economic distress, and spatial divide through the collaboration and exchange of efforts, ideas, and resources.
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Title: FABRICATION, CHARACTERIZATION AND RELEASE STUDIES OF LOW DENSITY POLYETHYLENE/CLAY NANOCOMPOSITES
Creator: Zhao, Ziqian
Date: 2015, 2015-07
Description: Nanocomposites exhibit enhanced physical properties including mechanical strength, thermal stability, and gas barrier properties. The...
Show moreNanocomposites exhibit enhanced physical properties including mechanical strength, thermal stability, and gas barrier properties. The development of nanocomposites has led to applications in food industry, mostly in food packaging. The application of nanocomposites in food packaging may extend the shelf life of a food, thus increasing the market value for manufactures. However, there is limited data and research to assess the risk of exposure of nanomaterials to consumers. This project aims at evaluating the factors that can influence the release of nanomateirals in low density polyethylene/clay nanocomposites films. Nanocomposites based on low density polyethylene (LDPE), containing 1, 3, 5 and 7 wt.% of Cloisite 20A and maleic anhydride-grafted polyethylene (MAPE) as a compatibilizer were prepared by melt compounding and characterized in this thesis project. Cloisite 20A is mostly composed of montmorillonite (MMT), which is commonly used as a nanoscale size filler. LDPE/Clay nanocomposite films containing MMT and three mass equivalents of MAPE were successfully extruded into thin films with good optical clarity. The materials were characterized by using transmission electron microscope (TEM), thermogravimetric analysis (TGA), oxygen permeation analysis and a material testing machine. Important properties such as tensile modulus, oxygen transmission rate, thermal resistance and glass transition temperature were measured. Nanocomposite films were immersed in three kinds of food simulants (absolute ethanol, 3% acetic acid and deionized water). Storage time, storage temperature and percent fill of clay were evaluated as the factors that can influence the release of nanomaterials. The content of released of Al, Mg, and Si was quantified using inductively coupled plasma mass spectrometry (ICP-MS). Mg, Al and Si were continuously released from nanocomposite films in duration of 30 days. Fastest releasing speed was found in 3% aqueous acid at 75 °C, and lower temperature can largely decrease the release of nanoparticles. This project is an initial attempt to assess the risks from the use of nanocomposites as food packaging.
M.S. in Food Safety and Technology, July 2015
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Title: COMPUTATION AND ANALYSIS OF TUMOR GROWTH
Creator: Turian, Emma
Date: 2016, 2016-05
Description: The ability of tumors to metastasize is preceded by morphological instabilities such as chains or fingers that invade the host environment....
Show moreThe ability of tumors to metastasize is preceded by morphological instabilities such as chains or fingers that invade the host environment. Parameters that control tumor morphology may also contribute to its invasive ability. In this thesis, we investigate tumor growth using a two-phase Stokes model. We first examine the morphological changes using the surface energy of the tumor-host interface and investigate its nonlinear dynamics using a boundary integral method. In an effort to understand the interface stiffness, we then model the tumor-host interface as an elastic membrane governed by the Helfrich bending energy. Using an energy variation approach, we derive a modified Young-Laplace condition for the stress jump across the interface, and perform a linear stability analysis to evaluate the effects of viscosity, bending rigidity, and apoptosis on tumor morphology. Results show that increased bending rigidity versus mitosis rate contributes to a more stable growth. On the other hand, increased tumor viscosity or apoptosis may lead to an invasive fingering morphology. Comparison with experimental data on glioblastoma spheroids shows good agreement especially for tumors with high adhesion and low proliferation. Next, we evaluate tumor regression during cancer therapy by a combined modality involving chemotherapy and radiotherapy. The goal is to address the complexities of a vascular tumor (e.g. apoptosis and vascularization) during treatment. We introduce an apoptotic time delay and study its impact on tumor regression using numerical and asymptotic techniques. In particular, we implement the linear-quadratic model and identify two extreme sets of parameter data, namely the slow, and fast tumor response to therapy. Numerical simulations for the slow response set show good agreements with data representing non-small cell lung carcinoma. Using the evolution equation for tumor radius with time delay, we find that tumors with shorter time interval to the onset of apoptosis shrink faster.
Ph.D. in Applied Mathematics, May 2016
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Title: DEVELOPMENT OF AN EMBEDDED CONTROLLER FOR TWO QUADRANT OPERATION OF BLDC MOTORS IN AUTOMOTIVE APPLICATIONS
Creator: Liu, Yizhe
Date: 2011-07-06, 2011-07
Description: Due to growing concerns over the availability of non-renewable petroleum products and the increasing emphasis on protecting our environment...
Show moreDue to growing concerns over the availability of non-renewable petroleum products and the increasing emphasis on protecting our environment from green house gas emissions, plug-in hybrid electric vehicle and hybrid electric vehicles have been gaining increasing popularity over recent years. This has led to the design of advanced drive systems using different electric motors such as BLDC, PMSM, IM and SRM. An electric motor/generator requires controller that not only has a strong I/O control function, but also high speed signal processing ability for realizing real time control. Therefore, a DSP (Digital Signal Processors), which integrates flexible multiple PWM signal generator, high speed high precision ADC and encoder interface for motor speed and position feedback, is considered as one of the strongest controllers for electric motor control. Owing to a growing emphasis on identification, interference, and communication of security services of drive train in intelligent PHEVs and HEVs, a DSP can also be used to identify and isolate security issues in the integrity of the drive train in PHEVs and EVs. This thesis has two main contributions: a) it focuses on the development of an embedded controller using TMS320LF2812 DSP to realize two quadrant control of the BLDC; and b) it develops an automotive test bench to identify and investigate some potential security issues using the embedded controller’s eCAN communication function.
M.S. in Electrical Engineering, May 2011
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Title: AN EVALUATION OF THE FEASIBILITY OF AN ONLINE FAMILY-BASED INDICATED PREVENTION PROGRAM FOR ADOLESCENT EATING DISORDERS
Creator: Lebow, Jocelyn R.
Date: 2011-10, 2011-12
Description: Adolescent eating disorders are highly impairing class of mental illness, marked by chronicity and recurrence. Data indicate that early...
Show moreAdolescent eating disorders are highly impairing class of mental illness, marked by chronicity and recurrence. Data indicate that early intervention, before anorexia nervosa (AN) or bulimia nervosa (BN) symptoms become entrenched, leads to an increased likelihood of positive outcomes (Fisher, Schneider, Burns, Symons & Mandel 2001; Le Grange, Loeb, Van Orman & Jellar, 2004). As such, numerous prevention programs have been developed for adolescent eating disorders, with mixed success (Shaw, 2008, Stice, Shaw & Marti, 2007). Most recently, programs have utilized the technology of the Internet to make prevention and early intervention more accessible and cost effective for affected teens and families. The current study assessed the feasibility of an original Internet-based indicated prevention program for families of adolescents with subsyndromal eating disorders. The program was based on the empirically-supported Family Based Treatment (FBT) for adolescent AN and BN. Seven families (comprised of 7 caregivers and 7 adolescents with subthreshold levels of eating disorder symptoms) were enrolled in the study, and 4 families successfully completed all program requirements. Four separate aims were assessed including: evaluation of program acceptability, identification of recruitment and retention patterns, assessment of program compliance and dosage received, and analysis of preliminary outcomes. Results suggested that the program was acceptable to all participants, and that the program format and content were positively received. Preliminary outcome data was limited due to the small sample size, however, descriptive analyses showed that the program had a significant effect on the reduction of all cognitive and behavioral eating disorder symptoms, as well as on the reduction of adolescent depressive symptoms. Adolescent ix self esteem was not significantly impacted by program participation. Compliance results were less straightforward. Program adherence was mixed, and further investigation is needed to clarify patterns of compliance and retention. Finally, the recruitment strategies used were found to not be feasible. Despite a wide-ranging and multi-faceted recruitment strategy, rates were very slow. Further, a large percentage of interested potential participants had to be excluded, calling into question the appropriateness of the applicant pool that was accessed through the implemented program of recruitment. Implications of these findings, possible explanations and suggestions for future research are discussed.
Ph.D. in Psychology, December 2011
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