(9,221 - 9,240 of 10,079)
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Title
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Intraoperative tumor margin detection using nanoparticles: protocol optimization through kinetic modeling
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Creator
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Xu, Xiaochun
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Date
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2018
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Description
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Clear margins (no tumor on the surface of the resected tissues) is essential to minimize tumor recurrence and prolong survival for wide local...
Show moreClear margins (no tumor on the surface of the resected tissues) is essential to minimize tumor recurrence and prolong survival for wide local excision cancer surgeries. However, standard methods of margin assessment cannot be carried out within the time frame of surgery (meaning patients with positive margins are suggested to undergo call-back surgeries). Intraoperative molecular imaging of cell surface receptors can offer a solution; however, substantial nonspecific diffusion and retention of imaging agents in resected tissues remains a significant challenge to identifying cancer reliably. Recently, “paired-agent” methods—which employ co-administration of a control-imaging agent with a targeting agent—have been applied to thick-sample staining and rinsing applications to account for background staining. This dissertation aimed to optimize paired-agent molecular imaging tumor-to-healthy tissue discrimination through mathematical modeling.Two simplified mathematical models—the rinsing paired-agent model (RPAM) and the serial staining model (SSM)—were derived and tested in accurate simulation models (also developed as a component of this dissertation,) and in preclinical cancer models. More specifically, RPAM was demonstrated to be capable of providing more accurate estimates of receptor concentration than more standard “ratiometric” methods (essentially dividing the targeted agent signal by the control agent signal), and the model was insensitive to the variability of rinsing time from one image to the next. Though it was noted in experiments, that regardless of the approach taken, a very large fraction of signal was removed upon the first rinse, leading to large “gaps” in the data that would be available to RPAM. The SSM, on the other hand, provided a model that could be applied to serial staining data, which yielded a more gradual change in signal between imaging.Considering the multidimensional complexity of paired-agent topical tissue molecular imaging (with diffusion, imaging agent chemical/binding properties, tissue staining, rinsing, imaging, and data analysis protocols all being subject to alteration), thorough optimization margin analysis imaging protocols is untractable using experiments alone. Therefore, a salient feature of this dissertation was the development and validation of a “forward” mathematical diffusion and binding model for in silico testing of proposed paired-agent staining and rinsing protocols in thick tissue.
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Title
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Integral, 1910
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Date
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1910
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Description
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Volume 12 of Integral, the 1910 yearbook for the Armour Institute of Technology. The Armour Institute of Technology yearbooks was known by...
Show moreVolume 12 of Integral, the 1910 yearbook for the Armour Institute of Technology. The Armour Institute of Technology yearbooks was known by three different titles: Integral (1898-1910), Senior Class Book (1911-1912), and The Cycle (1913-1940). A 1902 volume of Integral is not a part of Galvin Library collections; it is uncertain of a yearbook was published that year. Publication of the Armour Institute ceased in 1941, when the Armour Institute of Technology merged with the Lewis Institute to form Illinois Institute of Technology.
Sponsorship: Scanning of the Armour Institute of Technology yearbooks was supported in part by an award from the Illinois State Historical Records Advisory Board, through funding from the National Historical Publications and Records Commission, National Archives and Records Administration.
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Collection
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Armour Institute of Technology yearbooks, 1898-1940
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Title
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Picasso statue
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Date
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1970-1978
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Description
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Photograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date...
Show morePhotograph of the sculpture Chicago Picasso and Daley Plaza, taken from a vantage point above the plaza. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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Nuns picnicking
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Date
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1967-1969
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Description
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Photograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title...
Show morePhotograph of nuns having a picnic on the banks of a body of water. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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Norwegian Landscape
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Date
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1986
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Description
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Digitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title...
Show moreDigitally modified photograph of a Norwegian landscape taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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English Hill Street
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Date
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1976
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Description
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Digitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title...
Show moreDigitally modified photograph of an England street corner taken by photographer Howard LeVant as part of his Painting Technique series. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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Kaplan's Junkyard, Chicago, Illinois, 1959
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Date
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1959
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Description
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Two photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of...
Show moreTwo photographs scanned from negatives, presumed to depict the demolition of Kaplan's Junkyard, once adjacent to the Illinois Institute of Technology Campus. The Chicago Land Clearance Commission acquired the land on which the junkyard stood in 1958, and demolition occurred in 1959, after which the land was sold to Illinois Tech. Photographer unknown.
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Collection
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Office of Communications and Marketing photographs, 1905-1999
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Title
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Mecca Flats, Chicago, Illinois, ca. 1951
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Date
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1951
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Description
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Photograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham,...
Show morePhotograph of the Mecca Flats, located at 3360 South State Street and constructed in 1891. The apartments were designed by Edbrooke & Burnham, and were demolished in 1952. Originally constructed as a hotel for the World's Columbian Exposition of 1893, the 96-unit Mecca building became an apartment building after the fair. The building was acquired by Illinois Tech around 1941, and was demolished in 1952 to make way for the construction of S.R. Crown Hall. The building was also known as Mecca Apartments, and The Mecca.
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Collection
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Office of Communications and Marketing photographs, 1905-1999
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Title
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Blue skyline ad
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Date
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1969-1978
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Description
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"New Priorities|New Directions" Print advertisement created by photographer Howard LeVant/LeVant Photography (other contributors unknown) for...
Show more"New Priorities|New Directions" Print advertisement created by photographer Howard LeVant/LeVant Photography (other contributors unknown) for Amoco Chemicals Corporation, featuring fiberglass windmills created to look like Chicago buildings. Date of advertisement is unknown. Date range listed (1969-1968) is approximate. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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Armour Engineer, Index 1-8, 1909-1916
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Date
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1916
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Description
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General index for volumes 1-8 of the Armour Engineer, a serial publication for Armour Institute alumni with school, research, and engineering...
Show moreGeneral index for volumes 1-8 of the Armour Engineer, a serial publication for Armour Institute alumni with school, research, and engineering news. Index compiled by Ellyn C. Broomell, Assistant Librarian, Armour Institute of Technology.
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Collection
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Armour Engineer alumni magazine, 1909-1935
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Title
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Trapeze artist, Barnum and Bailey Circus
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Date
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1950-1953
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Description
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Photograph of a trapeze artist performing at an unknown venue in Chicago as part of the Ringling Bros. and Barnum & Bailey Circus. Date of...
Show morePhotograph of a trapeze artist performing at an unknown venue in Chicago as part of the Ringling Bros. and Barnum & Bailey Circus. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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Chicago River, Marina City
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Date
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1963-1966
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Description
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Photograph of Bertrand Goldberg's Marina City complex and the Chicago River. Date of photograph is unknown. Date range listed is approximate....
Show morePhotograph of Bertrand Goldberg's Marina City complex and the Chicago River. Date of photograph is unknown. Date range listed is approximate. Title supplied by Howard LeVant.
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Collection
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Howard LeVant papers, 1950-2020
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Title
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Conflicts of Interest in Engineering
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Creator
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Davis, Michael, Wells, Paula, Jones, Hardy
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Date
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2009, 1986
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Publisher
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Kendalll/Hunt Publishing Company
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Description
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This module begins by examining the Hydrolevel case, and uses this as a way to highlight relevant principles regarding conflict of interest in...
Show moreThis module begins by examining the Hydrolevel case, and uses this as a way to highlight relevant principles regarding conflict of interest in engineering, and to discuss the importance of these principles for engineers as professionals and moral agents. The module then considers four applications of these principles drawn from the “Opinions” of the Board of Ethical Review of the National Society of Professional Engineers. The module also includes ten short cases to be used in classroom discussion. It also includes professional codes from the National Society of Professional Engineers and the American Society of Mechanical Engineers.
Sponsorship: Exxon Education Foundation
The Module Series in Applied Ethics was produced by the Center for the Study of Ethics in the Professions in under a grant from the Exxon Education Foundation. This series is intended for use in a wide range of undergraduate, graduate, and continuing education programs in such areas as science and/or technology public policy, and professional ethics courses in engineering, business, and computer science.
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