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Title: Using Computational Approaches to Investigate Streptococcal Species from the Food Industry
Creator: Sun, Yukun
Date: 2020
Description: Streptococcal species are a major cause of concern in the Food industry. In the swine industry, Streptococcus suis is not only a major...
Show moreStreptococcal species are a major cause of concern in the Food industry. In the swine industry, Streptococcus suis is not only a major pathogen that can cause several systemic issues in pigs, but also an emergent zoonotic agent that can infect workers and consumers alike. However, not all S. suis strains are pathogenic and strain 90-1330, an avirulent Canadian serotype 2/sequence type 28 isolate, was previously found to produce a lantibiotic bacteriocin that kills several pathogenic Streptococcus species. This finding led to the suggestion that S. suis 90-1330 could be used as a probiotic in the swine industry for prophylactic purposes.As part of my thesis (Chapter 2), I sequenced the complete genome of S. suis 90-1330 and used comparative genomic approaches to predict if this strain is indeed avirulent and suitable for probiotic purposes. Results from our comparative analyses suggested that this strain may not be as harmless as initially thought, as its genome was found to code for several virulence factors including a hemolysin that lyses blood cells. The bacteriocin it produces and the products that confer resistance to its effect were found encoded in a functional, mobile integrative and conjugative element (ICE), suggesting that use of this strain as probiotic without further engineering would facilitate the spread of resistance to this bacteriocin. Furthermore, the bacteriocin was found widely distributed across several streptococcal species, indicating that the use of this strain as a probiotic might provide fewer health benefits than originally thought.In Chapter 3, I used the approaches and tools we developed as part of our work on S. suis strains to investigate the genetic diversity pertaining to Streptococcus parasuis and Streptococcus ruminantium. These two streptococcal species were recently removed taxonomically from S. suis based on phenotype assays and on limited genotype data, and the extent of their intra- and interspecific diversity as well as their potential for virulence were unknown. The two novel species were found to be genetically distinct from S. suis in our comparative analyses, as expected from previous studies, but the genetic differences responsible for their phenotypic differences could not be ascertained in large part due to the presence of many unique proteins of unknown functions, highlighting a need for improved methods to infer functions computationally.In Chapter 4, I describe the computer pipeline that we built to facilitate and automate genetic diversity analyses between bacterial species, and which was used extensively for Chapters 2 and 3. Notably, to palliate for data missing from sequencing archives, we implemented a simple solution that generates in silico sequencing datasets from complete and/or draft genomes. I tested and validated our pipeline extensively and describe in this chapter its pros and cons and current limitations.
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Title: High Frequency Trading and Its Impact on Market Quality in U.S. Futures Market
Creator: Wang, Chao
Date: 2020
Description: This research focuses on the effects of high frequency trading (HFT) on market liquidity in US futures market. This research utilizes a unique...
Show moreThis research focuses on the effects of high frequency trading (HFT) on market liquidity in US futures market. This research utilizes a unique data set consisting of all book events for multiple underlying assets and contracts during calendar year 2018, covering all trading days information of E-mini S&P 500, Gold, Eurodollar, Crude Oil, Corn and Soybean futures with their nearby and deferred contract data each day. This study extends findings from existing HFT equity research (e.g. Brocher et al., 2016; Frino et al., 2019, etc.) that HFT promotes market liquidity, into the commodity market. It also addresses HFT’s contributions to price discovery, and find it varies by types of commodities. Furthermore, the research identifies how an HFT phenomenon, the Cancel Cluster, impacts the futures market. Also, this research verifies and extends the models in Frino et al. (2019) to multiple commodities. Finally, a series of promising future analyses are suggested.
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Title: FINANCIAL BURDEN AND COPING IN HEAD AND NECK CANCER PATIENTS
Creator: Yap, Bonnie Joyce
Date: 2020
Description: In order to contribute to knowledge about how treatment impacts the financial well-being of patients diagnosed with head and neck cancer, this...
Show moreIn order to contribute to knowledge about how treatment impacts the financial well-being of patients diagnosed with head and neck cancer, this study examined the relationship between patient characteristics, financial burden, and financial coping over the treatment period among patients receiving treatment for locally advanced head and neck cancer at a major midwestern medical center. A sample of 65 participants completed self-report questionnaires on out-of-pocket costs, use of financial coping strategies, healthcare utilization, and personal and medical characteristics. Participant disease-specific information was obtained from their medical charts. Age, illness intrusiveness, and distance significantly predicted use of lifestyle-altering financial coping strategies. In addition, human papillomavirus (HPV) status significantly predicted use of care-altering financial coping strategies. Results of hierarchical linear regression analyses found significant main effects of financial burden, loneliness, and social support as predictors of the use of financial coping strategies. Moderation effects of loneliness and social support were not found. Trajectories of out-of-pocket costs indicated that costs are highest at the beginning of treatment and decrease over time. The results highlight the non-disease characteristics of patients diagnosed with head and neck cancer that may make them more vulnerable to financial distress and financial burden. Future studies with larger and more representative sample sizes could further add to information about the impact of cancer treatment on patient financial wellbeing.
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Title: Technology News, April 09, 1946
Date: 1946-04-09, 1946-04-09
Collection: Technology News Microfilm collection, 1928-1981

Title: Armour Institute of Technology campus, Chicago, Illinois, ca. 1901
Date: 1901
Description: Photograph of the Armour Institute of Technology campus, including the Armour Mission, Main Building, and Machinery Hall, taken from Ogden...
Show morePhotograph of the Armour Institute of Technology campus, including the Armour Mission, Main Building, and Machinery Hall, taken from Ogden Field. Photographer unknown, possibly C.V. Smith. Date of photograph unknown. Date indicated is an estimate.
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Collection: C.V. Smith photographs, circa 1900-1929

Title: Technology News, September 23, 1946
Date: 1946-09-23, 1946-09-23
Collection: Technology News Microfilm collection, 1928-1981

Title: The effect of information overload on knowledge recall and related cognitions for an educational program based on the Mental Health First Aid Model
Creator: Bink, Andrea B.
Date: 2020
Description: Early-intervention public health education programs have been effective at teaching a skillset to help others. However, some of these programs...
Show moreEarly-intervention public health education programs have been effective at teaching a skillset to help others. However, some of these programs have also been criticized for delivering more information than is necessary to learn the skill. Receiving too much information could cause information overload and interfere with program goals. The current study investigated the differential effect on outcomes of two trainings: (i) a standard training with lecture material about depression and anxiety (illness-information), and a skillset to guide interpersonal support for someone with depression and anxiety (skill-information); and (ii) a targeted training that omitted the lecture material and only presented the skillset. Predicted outcomes were that the combination of illness-information and skill-information in the standard training would result in information overload and would interfere with skill-information recall and attitude change. The current study also investigated two variables that could influence outcomes: general information overload about mental health (MHIO) and interest in the topic of mental health. Results were that participants in the standard training endorsed significantly more information overload and performed significantly better on recall measures than participants in the targeted training. Both trainings were effective at attitude change. Finally, preexisting MHIO was associated with training information overload, care seeking, and skill-information recall. Preexisting topic interest was associated with skill-information recall. Results suggest that some background lecture material might be necessary to learn how to support someone with depression and anxiety. Also, programs that promote interpersonal support are effective at attitude change no matter how much information they provide.
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Title: Small Molecule Ligands and Antibody Drug Conjugates for Potential Application in Targeted Cancer Therapy and PET Imaging
Creator: Ren, Siyuan
Date: 2020
Description: Cancer has been a deadly disease threatening humans. Traditional treatment methods such as chemotherapy with non-specific targeting may cause...
Show moreCancer has been a deadly disease threatening humans. Traditional treatment methods such as chemotherapy with non-specific targeting may cause severe side effects to normal cells and tissues. Novel and better methods for treatment and imaging of cancer has been eagerly sought. We wanted to develop new small molecule inhibitors and antibody drug conjugates for targeted cancer therapy and imaging. Theranostic conjugates combining therapeutic entity and imaging agent are useful in treatment and diagnosis of cancer. We designed a theranostic conjugate containing iron chelating anti-tumor agent and optical imaging probe. Novel iron chelator CAB-NE3TA displayed significant anti-proliferation activity against several cancer cell lines and was conjugated to targeting antibody panitumumab (PAN). The therapeutic conjugate exhibited excellent anti-tumor efficacy and targeting ability to EGFR overexpressed on cancer cells such as skin cancer (A431). The theranostic conjugate CAB-NE3TA-PAN loaded with a near IR fluorescent dye provided promising anti-tumor efficacy and optical imaging in tumor-bearing mice. Tetrahydroisoquinoline (THIQ) analogues were synthesized and evaluated for cytotoxicity against different cancer cell lines. Our in vitro studies showed that the THIQ analogues exhibited anti-proliferative activities against multiple cancer cell lines. Cytotoxicity study revealed that anti-tumor activity of THIQ analogues are structure-dependent. Binding affinity between THIQ analogues and a potential target Tdp1 was determined. Positron emission tomography (PET) has been used in diagnosis of cancer. In this study, small molecules and chelators with potential donor groups were evaluated systematically for complexation with 89Zr for PET imaging. New ligands with different donors were evaluated for radiolabeling efficiency and complex stability with 89Zr. The theranostic conjugate (CAB-NE3TA-PAN-IR800) and small molecule THIQs and 89Zr-chelators showed encouraging results for potential applications in for therapy and imaging of cancer.
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Title: The Differential Influence of Computerized Neuropsychological Assessment Across Psychopathology
Creator: Singh, Shifali
Date: 2020
Description: The method of administering neuropsychological assessments has transformed with the advent of novel technologies. The present study examined...
Show moreThe method of administering neuropsychological assessments has transformed with the advent of novel technologies. The present study examined how the manual versus computerized administration of the Wisconsin Card Sorting Test (WCST) influenced the relation between psychological symptom severity and performance on the WCST, using perseverative responses and failures to maintain set (FMS) subscales. The Dot Counting Test, Depression Anxiety Stress Scales, and SUPPS-P Impulsive Behavior Scale were used to measure performance validity, depression and anxiety, and impulsivity. Eighty-five participants were recruited from the Chicagoland area. Participants reported their age, gender, handedness, education, ethnicity, computer and smartphone familiarity, and medication use. Age ranged from 18 to 66 years (mean (SD) = 34.3 (15.8)), and 49.4% were recruited from an outpatient facility. For perseverative responses, both method of administration of the WCST were equivalent regardless of psychological symptom severity. For FMS, method of administration itself influenced performance, and particularly the impact of impulsivity symptom severity on FMS. Specifically, method of administration significantly moderated the relationship between FMS and Lack of Perseverance, Sensation Seeking, and Positive Urgency. There were also significant main effects between FMS, Lack of Perseverance, and Positive Urgency. The findings from this study suggest that the equivalence between the manual and computerized versions of the WCST depends on the WCST subscale and the type of psychological symptom. New normative data need to be developed for the computerized WCST, along with a more consistent method of scoring and interpreting WCST subscales.
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Title: The Association Between Executive Functioning, Verbal Memory, and Internalized Stigma in Predicting Psychotropic Medication Adherence Behaviors Among People with Serious Mental Illness
Creator: Powell, Karina
Date: 2020
Description: Long-term symptom management is an important consideration for many individuals with serious mental illness to maintain recovery over time,...
Show moreLong-term symptom management is an important consideration for many individuals with serious mental illness to maintain recovery over time, prevent relapse and rehospitalization, and decrease symptom severity. Psychotropic medications can be an important aspect of treatment planning; however, many barriers exist that can impact medication adherence and treatment efficacy. Research suggests that internalized stigma and neurocognition may impact medication adherence, but research has yet to investigate the relationship between these three constructs in tandem. In this study, medication adherence was measured via medication possession ratio calculated from pharmacy records (objective) and self-reported medication use (subjective). Selection of neurocognitive domains and assessment measures was informed by MATRICS and ISBD-BANC consensus batteries. The primary expectations were that verbal memory and executive functioning would be related to medication adherence behaviors and that these domains would moderate the relationship between internalized stigma and medication adherence. A consistent association was seen between measures of self-reported medication use over time, suggesting participants were generally consistent in their reported use. While analyses testing the primary hypotheses were nonsignificant, in the context of limitations of statistical power, trends emerged that may be worthy of further investigation. Future research should continue to explore the potentially multifaceted relationships between factors contributing to adherence. A more comprehensive understanding these relationships has implications for clinicians and consumers in addressing treatment barriers and disengagement by developing more nuanced and targeted interventions.
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Title: The Impact of Depression and Cognitive Dietary Restraint on the Association between Obstructive Sleep Apnea and Disordered Eating Behaviors
Creator: Schwartz, Natalie
Date: 2020
Description: Obstructive sleep apnea (OSA) is characterized by loud snoring and repeated episodes of obstruction in the upper airway during sleep that...
Show moreObstructive sleep apnea (OSA) is characterized by loud snoring and repeated episodes of obstruction in the upper airway during sleep that cause partial or total stop in the airflow, often resulting in short, disruptive sleep. Sleep disruption as a result of OSA has been shown to result in reduced cognitive functioning and disordered eating behaviors, however, few studies to date have sought to determine whether OSA is associated with disordered eating behaviors. Bariatric patients are asked to restrict their food intake prior to surgery; however, restraint theory suggests that the eating behavior of those intending to restrict their intake can be disinhibited by a variety of conditions, which cause the restrained eater to engage in disinhibited and overeating behaviors. Depression has also demonstrated an association with disordered eating behaviors and cognitive dysfunction. Affect regulation theory is often cited as a possible explanation for this association, with the desire to avoid unpleasant affective states resulting in disordered eating behaviors. A sample of 93 bariatric surgery candidates were recruited from an academic medical center in a large metropolitan city to participate in the current study. Participants were recruited during their routine pre-surgical assessment for bariatric surgery and completed measures of disordered eating and depression. Both body mass index and diagnosis of OSA were obtained from patient medical chart. It was hypothesized that the presence of OSA would be related to higher levels of disordered eating behaviors, including disinhibited eating, frequency of loss of control and frequency of binge eating. Additionally, it was hypothesized that cognitive dietary restraint would moderate the association between OSA and disordered eating in bariatric patients, such that the greater the intent to strictly control food intake (i.e., greater cognitive dietary restraint), the more strongly sleep disturbance will be associated with disordered eating. Finally, it was hypothesized that depression would mediate the association between OSA and disordered eating in bariatric patients, such that depressive symptomatology accounts for the relation between OSA and disordered eating behaviors. Results indicated that the presence of OSA was not related to higher levels of disordered eating behaviors, nor did depression mediate the association between OSA and the disordered eating outcomes. Two of the moderation models were significant, including the disinhibited eating model and the frequency of loss of control over eating model. Although bariatric patients are encouraged to restrict their food intake, findings suggested that restraint does not appear to function as intended in reducing disinhibited eating behaviors in individuals with OSA. The findings for the loss of control model supported restraint theory and suggested that those with OSA who also endorse high restraint are at increased risk for experiencing loss of control over eating, whereas those who do not have cognitive dysfunction associated with OSA may or may not exhibit the same association. The current study highlights the impact of restraint on bariatric patients’ disordered eating behaviors, suggesting that restraint theory may not be entirely applicable to bariatric populations and may depend on the disordered eating behavior being examined. The current study also points to numerous gaps in the current literature and provides future directions for research on OSA and disordered eating in bariatric populations.
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Title: A Network Analysis to Examine the Construct of Acculturative Stress in Mexican Americans
Creator: Mosqueda, Andrea I
Date: 2020
Description: Acculturative stress (AS) is a negative consequence of acculturation and occurs when acculturation is problematic for the individual. There is...
Show moreAcculturative stress (AS) is a negative consequence of acculturation and occurs when acculturation is problematic for the individual. There is a substantial variation in AS phenomena across different cultural/ethnic groups, across individual variables (e.g., sex, age, education, attitude, cognitive style), and across social variables (e.g., contact, social support, status). There does not seem to be one specific way in which AS affects all groups or individuals. Elevated levels of AS are associated with multiple manifest difficulties, including family dysfunction, geographical separation from family, low-income levels, and non-positive expectations for the future. AS has been associated with outcomes such as anxiety, depression, suicidal ideation, and feelings of isolation and alienation. Using a network analysis approach, this exploratory study examined the structure of the construct of AS as represented in the Social, Attitudinal, Familial, and Environmental (SAFE) AS Scale, a measure used to assess the AS construct across four contexts. Results of the network analysis of AS aspects suggest that the AS construct is best understood as a latent variable rather than as a network of interacting AS aspects, and that distress is related to particular aspects of AS. The present study findings suggest a particular model of relations between latent AS, its manifest aspects, and clinical outcomes. Further research can help to better understand the relationship between individual AS aspects (i.e., treatment targets) and treatment goals of impacting AS-related outcomes (e.g., distress), as well as the mechanisms of change.
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