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PSECMAC Intelligent Insulin Schedule for Diabetic Blood Glucose Management Under Nonmeal Announcement
Title
PSECMAC Intelligent Insulin Schedule for Diabetic Blood Glucose Management Under Nonmeal Announcement
Creator
Teddy, S. D., Quek, C., Lai, E. M.-k., Cinar, A.
Date
2010-03
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Description
Therapeutically, the closed-loop blood glucose-insulin regulation paradigm via a controllable insulin pump offers a potential solution to the...
Show moreTherapeutically, the closed-loop blood glucose-insulin regulation paradigm via a controllable insulin pump offers a potential solution to the management of diabetes. However, the development of such a closed-loop regulatory system to date has been hampered by two main issues: 1) the limited knowledge on the complex human physiological process of glucose-insulin metabolism that prevents a precise modeling of the biological blood glucose control loop; and 2) the vast metabolic biodiversity of the diabetic population due to varying exogneous and endogenous disturbances such as food intake, exercise, stress, and hormonal factors, etc. In addition, current attempts of closed-loop glucose regulatory techniques generally require some form of prior meal announcement and this constitutes a severe limitation to the applicability of such systems. In this paper, we present a novel intelligent insulin schedule based on the pseudo self-evolving cerebellar model articulation controller (PSECMAC) associative learning memory model that emulates the healthy human insulin response to food ingestion. The proposed PSECMAC intelligent insulin schedule requires no prior meal announcement and delivers the necessary insulin dosage based only on the observed blood glucose fluctuations. Using a simulated healthy subject, the proposed PSECMAC insulin schedule is demonstrated to be able to accurately capture the complex human glucose-insulin dynamics and robustly addresses the intraperson metabolic variability. Subsequently, the PSECMAC intelligent insulin schedule is employed on a group of type-1 diabetic patients to regulate their impaired blood glucose levels. Preliminary simulation results are highly encouraging. The work reported in this paper represents a major paradigm shift in the management of diabetes where patient compliance is poor and the need for prior meal announcement under current treatment regimes poses a significant challenge to an active lifestyle.
Endnote format citation for DOI:10.1109/TNN.2009.2036726
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Urban Sanctuary: Life and Revitalization Center: Ellis Venia III - Final Boards
Title
Urban Sanctuary: Life and Revitalization Center: Ellis Venia III - Final Boards
Creator
Venia Iii, Ellis
Date
2012-04-29, 2012-05
Description
The project is a revitalization and life center for people and their families living with diabetes. The goal of the facility is to provide a...
Show moreThe project is a revitalization and life center for people and their families living with diabetes. The goal of the facility is to provide a place to escape from everyday living. Elements to improve the knowledge and livelihoods of individuals who have been diagnosed with the disease will be implemented allowing the project to become a central node. Creating an environment that promotes relaxation and revitalization within an urban context is of great importance to the project. Partnerships with relative medical facilities will establish a client base and ease the access to the facility. If used successfully, the project could be a cornerstone to multiple facilities across the country.
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Urban Sanctuary: Life and Revitalization Center
Title
Urban Sanctuary: Life and Revitalization Center
Creator
Venia Iii, Ellis
Date
2012-04-29, 2012-05
Description
The project is a revitalization and life center for people and their families living with diabetes. The goal of the facility is to provide a...
Show moreThe project is a revitalization and life center for people and their families living with diabetes. The goal of the facility is to provide a place to escape from everyday living. Elements to improve the knowledge and livelihoods of individuals who have been diagnosed with the disease will be implemented allowing the project to become a central node. Creating an environment that promotes relaxation and revitalization within an urban context is of great importance to the project. Partnerships with relative medical facilities will establish a client base and ease the access to the facility. If used successfully, the project could be a cornerstone to multiple facilities across the country.
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Urban Sanctuary: Life and Revitalization Center: Ellis Venia III - Graphic Argument + Presentations
Title
Urban Sanctuary: Life and Revitalization Center: Ellis Venia III - Graphic Argument + Presentations
Creator
Venia Iii, Ellis
Date
2012-04-29, 2012-05
Description
The project is a revitalization and life center for people and their families living with diabetes. The goal of the facility is to provide a...
Show moreThe project is a revitalization and life center for people and their families living with diabetes. The goal of the facility is to provide a place to escape from everyday living. Elements to improve the knowledge and livelihoods of individuals who have been diagnosed with the disease will be implemented allowing the project to become a central node. Creating an environment that promotes relaxation and revitalization within an urban context is of great importance to the project. Partnerships with relative medical facilities will establish a client base and ease the access to the facility. If used successfully, the project could be a cornerstone to multiple facilities across the country.
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Adaptive control strategy for regulation of blood glucose levels in patients with type 1 diabetes
Title
Adaptive control strategy for regulation of blood glucose levels in patients with type 1 diabetes
Creator
Eren-oruklu, Meriyan, Cinar, Ali, Quinn, Lauretta, Smith, Donald
Date
2009-09
Publisher
ELSEVIER SCI LTD
Description
Current insulin therapy for patients with type 1 diabetes often results in high variability in blood glucose concentrations and may cause hype...
Show moreCurrent insulin therapy for patients with type 1 diabetes often results in high variability in blood glucose concentrations and may cause hype rglycemic/hypoglycemic episodes. Closing the glucose control loop with a fully automated electro-mechanical pancreas will improve the quality of life for insulin-dependent patients. An adaptive control algorithm is proposed to keep glucose concentrations within normoglycemic range and dynamically respond to glycemic challenges. A model-based control strategy is used to calculate the required insulin infusion rate, while the model parameters are recursively tuned. The algorithm handles delays associated with insulin absorption, time-lag between subcutaneous and blood glucose concentrations, and variations in inter/intra-subject glucose-insulin dynamics. Simulation results for simultaneous meat and physiological disturbances are demonstrated for subcutaneous insulin infusion.
Endnote format citation for DOI:10.1016/j.jprocont.2009.04.004
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THE ASSOCIATION BETWEEN PSYCHOLOGICAL FACTORS AND GLYCEMIC CONTROL IN TYPE 2 DIABETIC PATIENTS ON INSULIN
Title
THE ASSOCIATION BETWEEN PSYCHOLOGICAL FACTORS AND GLYCEMIC CONTROL IN TYPE 2 DIABETIC PATIENTS ON INSULIN
Creator
AraÚjo, Fabiana Souza
Date
2016, 2016-12
Description
This study investigated the relationship among several psychological constructs and glycemic control in Type 2 diabetes patients on multiple...
Show moreThis study investigated the relationship among several psychological constructs and glycemic control in Type 2 diabetes patients on multiple daily doses of insulin. Participants were mostly impoverished and underserved minorities and were all patients of a diabetes specialty clinic in a county hospital of a metropolitan area in the Midwest of the U.S. Eighty-two participants completed self-reported questionnaires on diabetes, self-efficacy, psychological distress, diabetes-related distress, adherence to medication, diabetes knowledge, literacy, numeracy, health locus of control and had their HbA1c tested. Results of multiple regression analyses controlling for age, gender, and duration of diabetes indicted that higher self-efficacy (p = .005) was associated with better glycemic control. Mediation analyses did not yield significant results when testing whether self-efficacy mediated the relationship between some psychological constructs (i.e., diabetes knowledge, literacy, or numeracy) and glycemic control. Similarly, no significant results were found in mediation analyses neither when adherence to medication was tested as a mediator between diabetes knowledge and glycemic control nor when diabetes-related distress was tested as a mediator between psychological distress and glycemic control. These results emphasize the importance of self-efficacy among underserved minority patient in their abilities to perform all complex behaviors required to properly manage diabetes. Future studies with larger sample sizes should expand our findings and provide more information on some of our non-significant findings.
Ph.D. in Psychology, December 2016
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Development of Microfluidic Platform to Study Insulin Resistance
Title
Development of Microfluidic Platform to Study Insulin Resistance
Creator
Tanataweethum, Nida
Date
2020
Description
Insulin resistance, a precursor for the development of type 2 diabetes (T2D), propagates among heterologous tissues through dysregulated lipid...
Show moreInsulin resistance, a precursor for the development of type 2 diabetes (T2D), propagates among heterologous tissues through dysregulated lipid flux, as well as dysregulated glucose production, and secretion of cytokines, adipokines and hepatokines. Although T2D is characterized by systemic insulin resistance, disruption of insulin signaling in the liver and adipose tissue recapitulates many aspects of T2D, including enhance endogenous glucose production as well as defects of insulin action. Mechanistic studies often aim to provide fundamental understanding of the observations from human and animal studies. Due to the complexity of animal models and the multifactorial character of T2D, there is a strong need to develop advanced experimental systems such as in vitro models that can enable the recapitulation of the complex physiology of the in vivo system and enable investigation of the pathological pathways as well as identify novel treatment options. The overall goal of this study was to develop insulin resistant models of adipose tissue and liver to study the metabolic function of each organ as well as to the organ-organ crosstalk. To accomplish this goal, four specific aims were pursued: (1) Establish adipose tissue on-a-chip to study the metabolic function of the adipocytes in flow culture; (2) Develop towards an insulin resistant adipose on-a-chip to study the metabolic function of adipocytes in setting of insulin resistance; (3) Develop insulin resistant liver on-a-chip to investigate the metabolic function of hepatocytes in setting of insulin resistance; (4) Develop adipose-liver on-a-chip in setting of insulin resistance to identify the metabolic interaction between organs.
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