Organizations are organically grown, and it can be very satisfying to see them thrive under the right conditions and treatment just like their... Show moreOrganizations are organically grown, and it can be very satisfying to see them thrive under the right conditions and treatment just like their botanical equivalents. But, at some stage, if you're not cautious, they can uncontrollably sprout and spread out until one day they've begun strangling themselves and even others. Organizations are strangling by not responding to development. As new people enter, procedures that worked perfectly in the beginning with only one participant often get unsuccessful, sometimes painful. It's easy to spot the signs of stressful processes; increased stress, constant yet insufficient coordination, low levels of effort and resources, bottlenecks, e-mail congestion, repeated progress updates, expired tabs, dysfunctional rules, low productivity the list continues. With Business Improvement it becomes very critical on how we plan & what are the facts which we have derived from the initial analysis. In this article, we will try to cover different tools that can be used for analyzing & planning. Show less
Effective use of the Requirement gathering is our greatest and most critical role. We need to communicate with stakeholders to make the best... Show moreEffective use of the Requirement gathering is our greatest and most critical role. We need to communicate with stakeholders to make the best of it. The techniques mentioned here are mixed and for each project, the mix shall be different. This technique for gathering requirements is perhaps the most common way to obtain requirements from all the required techniques. This article also looks at how to run a Delphi session, Creating Affinity Diagram & Mind maps. Show less
As a futuristic approach in order to increase their productivity and efficiency while being agile and quick to adapt to the new dynamic... Show moreAs a futuristic approach in order to increase their productivity and efficiency while being agile and quick to adapt to the new dynamic environment, companies must undergo business process reengineering as a potential trend. The digitizing period is followed by an accelerating IT cycle, often linking reengineering with tech or IT revolution. The article discusses what is a Business Process, what are the opportunities for Improvements, how to measure the success criteria, what are different process flow & the value for an organization to achieve the objective of business process improvement Show less
A flowchart or Process Flow is a powerful business tool. With proper design and construction, it communicates the steps in a process very... Show moreA flowchart or Process Flow is a powerful business tool. With proper design and construction, it communicates the steps in a process very effectively and efficiently. There are a variety of ways to make a flowchart. Initially, flowcharts were made by hand using a pencil and paper. Until the advent of a personal computer, drawing models made of plastic flowchart form outlines helped flowchart designers work faster and gave their diagrams a more detailed look. Flowcharts were initially used by industrial engineers to organize work processes such as assembly line output. Today, flowcharts are used for several purposes in manufacturing, architecture, engineering, industry, technology, education, research, medicine, government, administration, and many other fields. In this article, we will be looking at different types of Flowchart & their usages Show less
Effective use of the Requirement gathering is our greatest and most critical role. We need to communicate with stakeholders to make the best... Show moreEffective use of the Requirement gathering is our greatest and most critical role. We need to communicate with stakeholders to make the best of it. The techniques mentioned here are mixed and for each project, the mix shall be different. This technique for gathering requirements is perhaps the most common way to obtain requirements from all the required techniques. This article also looks at how to run a Delphi session, Creating Affinity Diagram & Mind maps. Show less
The study of long-span structures developed from a design problem for an aircraft hangar. The problem of the aircraft hangar was concerned... Show moreThe study of long-span structures developed from a design problem for an aircraft hangar. The problem of the aircraft hangar was concerned with the development of a reasonable structurtal type into an architectural solution. Several types were considered; the truss, the arch, a rigid frame system in prestressed concrete. These were discarded in favor of a rigid frame system of steel that seemed to give the best visual solution. Show less
Automatic cubatures approximate multidimensional integrals to user-specified... Show moreAutomatic cubatures approximate multidimensional integrals to user-specified
error tolerances. In many real-world integration problems, the analytical solution is
either unavailable or difficult to compute. To overcome this, one can use numerical
algorithms that approximately estimate the value of the integral.
For high dimensional integrals, quasi-Monte Carlo (QMC) methods are very
popular. QMC methods are equal-weight quadrature rules where the quadrature
points are chosen deterministically, unlike Monte Carlo (MC) methods where the
points are chosen randomly. The families of integration lattice nodes and digital nets
are the most popular quadrature points used. These methods consider the integrand
to be a deterministic function. An alternate approach, called Bayesian cubature,
postulates the integrand to be an instance of a Gaussian stochastic process. Show less
This report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software... Show moreThis report provides supplementary technical details to the conference paper that introduced C-Saw, a language for expressing software architecture patterns. This report provides additional examples of using C-Saw, supplementary evaluation details, and it defines the formal semantics of the language. Show less
In the present study, we present a model to predict the chiral separation results for drug enantiomers by ADMPC chiral stationary phase in... Show moreIn the present study, we present a model to predict the chiral separation results for drug enantiomers by ADMPC chiral stationary phase in high performance liquid chromatography (HPLC) wherein multiple ADMPC polymer strands are coated on an amorphous silica slab. Both reactive and classical MD are used to prepare the surface. Using various MD techniques, we successfully coat ADMPCs onto the surface without losing the structural character of the backbone in the presence of the solvent system. Not only is this model more representative of the polymer surface on a solid support that is encountered by the enantiomers, it also provides more opportunities for chiral molecules interacting with ADMPC, resulting in a better agreement compared with experiment when we use overall average quantities as the metric. In our previous studies, we had used a single polymer strand of amylose tris(3,5-dimethylphenyl carbamate) (ADMPC) in the solvent system. The new model provides the possibility for large drug molecules to interact with two polymer strands at the same instant, which was not possible to model with only a single polymer strand in the solvent. For a better understanding of why some metrics are better predictors than others, we use charts of the distribution of hydrogen bonding lifetimes in this work to display the hydrogen-bonding information for various donor-acceptor pairs that contribute to the interaction events determining the relative retention times for the enantiomers. We also examine the contribution of the ring-ring interactions to the molecular recognition process and ultimately to differential retention of S and R enantiomers. The results using the new model are more consistent than the previous models and resolves the problematic case of two drugs, thalidomide and valsartan. Sponsorship: The National Science Foundation (CBET 1545560) Show less