An adaptive robust M-estimator for nonparametric nonlinear system identification is proposed. This M-estimator is optimal over a broad class... Show moreAn adaptive robust M-estimator for nonparametric nonlinear system identification is proposed. This M-estimator is optimal over a broad class of distributions in the sense of maximum likelihood estimation. The error distributions are described by the generalized exponential distribution family. It combines nonparametric regression techniques to form a powerful procedure for nonlinear system identification. The adaptive procedure's excellent performance characteristics are illustrated in a Monte Carlo study by comparing the results with previous methods. Endnote format citation Show less
Molecular imaging has revolutionized medical diagnostics by providing detailed insights into biological processes at the molecular level... Show moreMolecular imaging has revolutionized medical diagnostics by providing detailed insights into biological processes at the molecular level within the living subject. Ultrasound Molecular Imaging (USMI) has emerged as a promising diagnostic imaging modality by utilizing targeted contrast agents to unveil crucial molecular information, including vascular biomarkers associated with cancer and other diseases. Despite its potential, the transition of Ultrasound Contrast Agents (UCA) from preclinical evaluation to FDA-approved clinical use faces challenges due to the short in vivo half-life of Micro-Bubbles (MBs), necessitating repeated administrations for comprehensive assessments. Moreover, conventional ultrasound imaging methods suffer from limited scanning areas and single-target focus, leading to low throughput in preclinical evaluations.This thesis addresses these challenges by proposing a robot-assisted whole-body scanning pipeline for preclinical evaluations in Ultrasound Molecular Imaging. By integrating a robotic arm into the imaging setup, this approach enhances scanning flexibility and precision, enabling scans across the entire body of a mouse. This extension of the imaging time window allows for comprehensive assessments without the need for repeated contrast agent administrations. Additionally, the ability to simultaneously scan multiple targets within the same session significantly increases the throughput of preclinical assessments, thereby improving the efficiency and reliability of Ultrasound Molecular Imaging in clinical translation. Show less
