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(941 - 960 of 1,234)
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- Title
- ATTACHMENT, COGNITIVE STYLES, AND THEIR RELATIONSHIPS TO DEPRESSION
- Creator
- Beyderman, Irina
- Date
- 2014, 2014-07
- Description
-
From the developmental perspective, insecure attachment to people in one’s life predisposes a person to develop maladaptive affect regulation...
Show moreFrom the developmental perspective, insecure attachment to people in one’s life predisposes a person to develop maladaptive affect regulation strategies (Shaver & Mikulincer, 2007), which, when employed, result in suboptimal emotional states and increased risk for developing depression (Marganska, Gallagher, & Miranda, 2013). From the cognitive styles perspective, rumination and overgeneral autobiographical memory constitute risk factors for depression through various mechanisms, including impaired social problem-solving (Goddard, Dritschel, & Burton, 1996), intensification of dysphoric mood (Donaldson & Lam, 2004), difficulties with concentration (Lyubomirsky, Kasri, & Zehm, 2003) and memory (Hertel, 1998). This study examined the potential mediating roles of rumination and overgeneral memory in explaining the relationship between insecure attachments (anxious/avoidant and anxious/ambivalent) and depression. One hundred African American outpatient psychiatry patients at an urban county hospital participated in the study. Participants completed the Experiences in Close Relationships Scale, the Ruminative Response Scale, the Diagnostic Inventory for Depression, and the Autobiographical Memory Test. Results are presented from mediational analyses conducted using the PROCESS program and bootstrapped estimates of the indirect (mediated) effects (Hayes, 2012). In line with predictions, support for the mediating role of rumination was found. Results did not support the hypotheses regarding overgeneral memory as a mediating variable. Implications of the current findings for further research and clinical work are discussed.
M.S. in Psychology, July 2014
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- Title
- DESIGN OF A DYNAMIC MUSCULOSKELETAL MODEL OF THE HUMAN HAND FOCUSED ON FUNCTIONAL TASKS
- Creator
- Barry, Alexander
- Date
- 2016, 2016-05
- Description
-
This thesis explores the creation and validations of a simulated musculoskeletal model of the human hand with a focus on the aspects of...
Show moreThis thesis explores the creation and validations of a simulated musculoskeletal model of the human hand with a focus on the aspects of pinching. Specifically, the thumb, index finger, and wrist were represented in OpenSim 3.3, using anatomical definitions for increased accuracy. Specifically, the inclusion of physiological axes of rotation at all joints, anatomically accurate passive joint torques, and appropriate moment arms for each muscle. The model was subsequently validated against experimental results found in literature. First, the digit tip force directions produced by each of the 15 muscles were compared to those obtained by loading the corresponding tendons in cadaveric specimens and measuring three-dimensional force generation at the tip of the thumb or index finger. Second, isometric force generation by activation of multiple muscles were compared. Finally, dynamic simulations were run using electromyographic (EMG) recordings as inputs. The capabilities of the model were then explored by using it to predict activation patterns from imposed movement and to simulate extension deficits in a hand affected by stroke. The model generated isometric force in the correct directions for most individual muscles, with the extensor pollicis brevis (EPB) showing the largest directional differences between cadaveric and simulated results. With combined muscle activation patterns the model simulated force profiles accurately, showing only a 5.3% mean squared error (MSE) from the actual force profile. In terms of force magnitudes between the model and simulated results, the model produced significantly lower force magnitudes, especially in the thumb. This validation was also found to be reasonably accurate to the expected motions. With the model anatomically validated, two different simulations were run using the model. First, known kinematics were applied to the model and the muscle activations were simulated; the resultant joint angles were found to match the expected within 10% MSE. Second, a stroke affected hand was simulated, with activation deficits added to each of the muscles individually. It was found through this that, in the model, the intrinsic muscles played a larger role in force production and dynamic motion than the extrinsic muscles. In all, these validations and simulations produce a promising groundwork for the use of this model for further simulation.
M.S. in Biomedical Engineering, May 2016
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- Title
- Efforts to Obtain Desulfurization Competent Cultures from Environmental Samples with Increased Desulfurization Activity
- Creator
- Davaadelger, Batzaya
- Date
- 2011-04-18, 2011-05
- Description
-
In this study, environmental samples were collected from different places to obtain various desulfurization competent cultures with increased...
Show moreIn this study, environmental samples were collected from different places to obtain various desulfurization competent cultures with increased desulfurization activity. In order to obtain the cultures the soil samples were inoculated in enriched medium and minimal medium containing DBT as the sole source of sulfur. The cultures grown in minimal medium with DBT were transferred multiple times with increasing temperatures, where as the cultures grown in enriched media were grown only one cycle at 37 degrees. After a certain growth period the cells were isolated and DNA was extracted. Efforts to amplify dsz genes from the obtained cultures with universal dszABC primers were mostly unsuccessful. DNA from bacterial strains isolated from the environmental samples were amplified with universal primers and amplicons were cloned. Samples #2, #6, #17, #21, #32 were amplified successfully but sequencing analyses showed little homology with dszABC genes. DNA from samples #32*, 32*Y and 32*W was isolated with Power Soil kit and PCR analysis showed a 3 kb amplicon. Sequencing analyses, however, showed less homology with dszABC and revealed homology instead with proteins such as those involved in Fe/S biogenesis and thiol:disulphide interchange. In addition, alternate universal primers were designed and PCR analyses were made with R .erythropolis IGTS8 and sample #32*. Alternate primer combination #3 (A1 and C1) and combination #8 (B1 and C2) amplified expected bands with IGTS8 DNA. Combination #8 amplified a 1 kb band from sample #32* DNA. Cultures #32*, #32*Y and #32*W were selected due to their ability to grow in minimal medium with DBT as high as 55 ˚C for multiple transfers. These isolated cultures from a soil sample from the Chicago area are able to catabolize dibenzothiophene (DBT) to 2-hydroxybiphenyl (2-HBP), which was detected by the Gibbs assay.
M.S. in Biology, May 2011
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- Title
- RECRYSTALLIZATION MECHANISM FOR TWO NICKEL BASED SUPERALLOYS
- Creator
- Balandra, Ombeline
- Date
- 2016, 2016-05
- Description
-
The demand for enhanced structural performances materials is growing every year. A lot of technological advancements in the sector of...
Show moreThe demand for enhanced structural performances materials is growing every year. A lot of technological advancements in the sector of aerospace or nuclear are in constant need for materials with good mechanical properties and high temperature resistance. The alloys commonly used for these features are Nickel-based superalloys as they exhibit high strength and good resistance to corrosion and oxidation. To improve their mechanical behavior, recent studies have focused on grain refinement methods. Among these methods to obtain the finest grain size distribution, one is particularly advantageous for it low cost and feasibility: severe plastic deformation.In this study, the deformation mechanism of two high performance, low stacking fault energy nickel-based alloys are investigated. The first alloy, Monel 400, it is a single FCC phase material. The second one is Inconel 625 wich has a two-phase (γ and γ’) microstructure. During hot deformation, the γ’ precipitate may be present in the γ phase and above a certain solvus temperature, the γ phase exists in the material. The restoration mechanism for FCC crystals is well known, and particular attention was given in this report to the recrystallization response and flow behavior of Inconel 625 for sub-solvus temperatures. In the introduction a brief review of the current state of literature on the deformation response of Nickel-based superalloys is provided. Samples were compressed under various temperatures and strain rate conditions using a Gleeble-3500 thermo-mechanical simulator and flow stress curves were extracted. To characterize both qualitatively and quantitatively the deformation, samples were then analyzed using standard microscopy, scanning electron microscopy and electron backscatter diffraction analysis. The resulting images and maps combined with flow stress curves have lead to the formulation of constitutive models of the recrystallization process using three parameters, the stress, grain size and recrystallized volume fraction.The data shows that deformation is first accommodated through dynamic recovery with the formation of sub-grains structures. Then, after the experimental strain reaches a critical value, recrystallized grains form within the microstructure. EBSD analysis show a trend for new recrystallized grain to grow under certain conditions. Results show a trend of increasing the grain size with increasing the strain and decreasing the Zener-Hollomon parameter and an increasing recrystallized volume fraction with increasing the strain and Zener-Hollomon parameter.
M.S. in Material, Mechanical and Aerospace Engineering, May 2016
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- Title
- PHYSICAL ACTIVITY AND EMOTIONAL EATING AS POTENTIAL MEDIATORS OF THE RELATION BETWEEN MOTIVATION AND ADHERENCE TO POSTBARIATRIC SURGERY RECOMMENDATIONS
- Creator
- Bardsley, Leland Richard
- Date
- 2015, 2015-05
- Description
-
Obesity is a major public health concern throughout the world. 10-38% of those who receive the most effective treatment for obesity--bariatric...
Show moreObesity is a major public health concern throughout the world. 10-38% of those who receive the most effective treatment for obesity--bariatric surgery--fail to lose substantial weight at all or over time regain weight that was lost post-surgery. The current study tested a model of autonomous motivation for diet and exercise, physical activity, emotional eating, and adherence to post-surgery recommendations (e.g., eating behaviors, fluid intake, dietary supplement management, etc.) in post-bariatric surgery patients. It was hypothesized that autonomous motivation for diet and exercise post-surgery would predict adherence to post-bariatric surgery recommendations. Further, it was also hypothesized that physical activity and emotional eating would in serial partially mediate the relation between autonomous motivation for diet and exercise and adherence to postsurgery recommendations. Results found a positive relation between autonomous motivation for diet and exercise and adherence to post-bariatric surgery recommendations; however, there was no evidence to support mediation via a path from physical activity to emotional eating. Implications for treatment are discussed.
M.S. in Psychology, May 2015
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- Title
- THE ROLES OF SUPPORT AND SOCIAL PROBLEM SOLV ING IN SOCIAL INTEGRATION FOR INDIVIDUALS WITH BRAIN INJURY
- Creator
- Batchos, Elisabeth
- Date
- 2014, 2014-12
- Description
-
Individuals with acquired brain injury (ABI) may not only struggle with physical and cognitive impairments, but may also face challenges...
Show moreIndividuals with acquired brain injury (ABI) may not only struggle with physical and cognitive impairments, but may also face challenges reintegrating into the community socially. Research has demonstrated that following ABI, individuals’ social networks tend to dwindle, support may decline, and isolation increases. Social aspects of rehabilitation are often overlooked for more physical or cognitive symptom management. Social integration, however, may act as a protective factor for stress and has shown benefits for the rehabilitation process physically, cognitively, and psychosocially. Therefore, it may be vital to the rehabilitation process to examine factors promoting social integration. One important construct is that of social problem solving, which incorporates both the social and cognitive domains related to the rehabilitation of brain injury. Another such variable is social support, a factor previously shown to affect social outcomes. This study uses a sample of 102 individuals with ABI to examine factors impacting social integration. Predictors included emotional support, instrumental support, problem solving confidence, and approach-avoidance style of problem solving, while controlling for age, gender, education, and time since injury. Hierarchical regression was used to analyze whether these factors were predictive of social integration. Results demonstrated that emotional support was initially a significant predictor; however, when controlling for emotional support the variance in social integration was better accounted for by social problem solving—specifically, approachavoidance style. Given the results, a follow-up mediation analysis was conducted to look at social support as a mediator of the relationship between social problem solving (specifically, approach-avoidance style) on social integration. Findings indicated that the relationship between approach-avoidance style and social integration was indeed partially mediated by emotional support. This suggests that for individuals with ABI, their tendency to approach rather than avoid social problem solving issues is a significant predictor for social integration both directly and indirectly through its association with emotional social support.
M.S. in Psychology, December 2014
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- Title
- LISTERIA MONOCYTOGENES SURVIVAL AND GROWTH IN FLAVORED MILKSHAKES MADE FROM NATURALLY-AND ARTIFICIALLY-CONTAMINATED ICE CREAM
- Creator
- Bathija, Vriddi Mahesh
- Date
- 2016, 2016-12
- Description
-
Listeria monocytogenes is the causative agent of the disease listeriosis and was implicated in a multistate foodborne outbreak associated with...
Show moreListeria monocytogenes is the causative agent of the disease listeriosis and was implicated in a multistate foodborne outbreak associated with ice cream spread over four years from 2010 to 2014 in Kansas, Oklahoma, Texas and Arizona. Ten illnesses were reported during the course of this outbreak, resulting in 100% hospitalization and a mortality rate of 33%; the individuals who died in the outbreak had consumed milkshakes made with the contaminated ice cream. The ice cream was found to be contaminated uniformly at 10 MPN/g. This study assessed the growth kinetics of L. monocytogenes in milkshakes made with naturally- and artificially-contaminated ice cream, and with or without flavoring agents. Artificial-contamination of ice cream samples included inoculation with a cocktail of rifampicin-resistant L. monocytogenes into the middle of the product using a wide-orifice pipet tip. Milkshake were prepared with or without strawberry, chocolate, or mint flavoring, using the recipe associated with the healthcare facility where the illnesses occurred. Milkshakes were stored in sterile plastic cups at 10ºC and an asymmetric (3 tubes of 100ml, 5 tubes of 10 ml, 8 tubes of 1ml and 8 tubes of 0.1ml sampling scheme) most probable number (MPN) enumeration was conducted after 0, 12, 24, 48, 72, 96 and 144 h. The Baranyi model was used to model L. monocytogenes growth rates, maximum populations, and lag phases. Compared to milkshakes made with no flavoring agents, the milkshakes with flavoring resulted in decreased growth rates for L. monocytogenes for both contamination states; the lowest growth rate of the pathogen was observed in strawberry flavored milkshakes made from artificially-contaminated ice cream (0.029 log CFU/ml per hour). Chocolate and mint flavorings resulted in significantly (P < 0.05) longer lag phases for both natural (68.2 and 83.0 h) and artificial-contamination (47.7 and 54.2 h, respectively). The highest maximum population (5.79 log CFU/ml) was achieved by L. monocytogenes in naturallycontaminated milkshakes without any flavoring agent. Since challenge studies often depend on the artificial contamination of a food product, this study evaluated the differences between artificial and natural contamination of L. monocytogenes in milkshakes. The data obtained can be used for risk assessment purposes.
M.S. in Food Safety and Technology, December 2016
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- Title
- THE RELATION BETWEEN PSYCHOLOGICAL DISTRESS, TRAIT ANXIETY, AND MATERNAL BEHAVIORS DURING SONOGRAM PROCEDURES
- Creator
- Butler, Kristina
- Date
- 2016, 2016-12
- Description
-
The aim of this study was to examine whether psychological distress and trait anxiety were related to positive (i.e., smiling and surprised)...
Show moreThe aim of this study was to examine whether psychological distress and trait anxiety were related to positive (i.e., smiling and surprised) and negative (i.e., worried and sad) facial expressions and gaze towards the fetus during routine ultrasound procedures in the second trimester of pregnancy. Assessment of mood symptoms during the second trimester of pregnancy is important because it is when depression begins to have a negative impact biochemically, which may lead to adverse postnatal outcomes. Participants included a diverse group of 70 women in their second trimester of pregnancy. The Depression Anxiety Stress Scales (DASS-21) and the State Trait Anxiety Inventory (STAI), Trait Form were used to assess psychological distress and trait anxiety, respectively. Videos of participants’ faces during their ultrasound examination were coded to assess facial expressions and gaze towards the fetus. Results of regression analyses indicated that higher levels of distress and trait anxiety were related to fewer smiles. Higher levels of distress also were related to longer durations of sad expressions. There was not a relation between duration of gaze towards the fetus and levels of distress and trait anxiety. These findings suggest that women’s negative facial expressions during routine sonograms may show that they are feeling distressed, and could indicate the need for more formal screening for depression and anxiety symptoms.
M.S. in Psychology, December 2016
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- Title
- Calibration of the pitot steammeter
- Creator
- Carr, A. L, Strube, H. L
- Date
- 2009, 1906
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/calibrationofpit00carr
Thesis (B.S.)--Armour Institute of Technology, 1906 B.S. in Mechanical Engineering, 1906
- Title
- By-products from wool washing
- Creator
- Butterman, Samuel, Marx, Victor E
- Date
- 2009, 1916
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/byproductsfromwo00butt
Thesis (B.S.)--Armour Institute of Technology; Includes folded leaves in back pocket
- Title
- By-products from garbage
- Creator
- Mease, A. J., Goorskey, N. J., Botts, T. E.
- Date
- 2009, 1917
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/byproductsfromga00meas
Thesis (B.S.)--Armour Institute of Technology
- Title
- Calibration of the pitot tube
- Creator
- Dreffein, Henry A., Mcburney, Edward, Jr
- Date
- 2009, 1905
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/calibrationofpit00dref
Thesis (B.S.)--Armour Institute of Technology, 1905 B.S. in Mechanical Engineering, 1905
- Title
- Calibration test of electric water meter
- Creator
- Steward, W. H., Jr
- Date
- 2009, 1915
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/calibrationtesto00stew
Thesis (B.S.)--Armour Institute of Technology, 1915 Bibliography: leaves 19-27 B.S. in...
Show morehttp://www.archive.org/details/calibrationtesto00stew
Thesis (B.S.)--Armour Institute of Technology, 1915 Bibliography: leaves 19-27 B.S. in Mechanical Engineering, 1915
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- Title
- MULTIFUNCTIONAL ELECTROCATALYST SUPPORTS AND ELECTROCATALYSTS FOR ELECTROCHEMICAL ENERGY CONVERSION
- Creator
- Kumar, Amod
- Date
- 2014, 2014-07
- Description
-
Polymer electrolyte fuel cell (PEFC) technology has several underlying problems (lifetime, reliability and cost) that need to be resolved as a...
Show morePolymer electrolyte fuel cell (PEFC) technology has several underlying problems (lifetime, reliability and cost) that need to be resolved as a prerequisite for large-scale commercialization. Amongst these, the lifetime issue is regarded as critical. From the perspective of durability, the current state-of-the-art electrocatalyst, viz. platinum (Pt) supported on high surface area carbon, suffers substantial degradation during fuel cell operation. A key pathway for electrocatalyst degradation is the corrosion of the carbon support. During fuel cell startup and shutdown in automotive applications, the cathode potential undergoes excursions of up to 1.6 V. At these high potentials, the carbon corrosion reaction is significantly accelerated, leading to irreversible carbon loss at the electrode. The best way to eliminate the issue of support corrosion in PEFCs is to develop alternate corrosion-resistant catalyst supports. This dissertation investigates (i) mixed oxides of silica (SiO2) and ruthenia (RuO2) and (ii) tantalum modified titanium oxide (Ta0.3Ti0.7O2) for use as corrosion-resistant electrocatalyst supports in PEFCs, especially for the automotive sector, using detailed microstructure characterization and electrochemical evaluation, including two carefully chosen accelerated stress tests (startstop cycling to simulate fuel cell vehicle start-up and shut-down, and load cycling to simulate full-load to no-load transitions in the vehicle during operation). RuO2–SiO2 (0.5:0.5) displayed outstanding electrochemical stability upon exposure to rigorous accelerated potential cycling tests that mimic automotive drive cycles. The Pt/RuO2–SiO2 (0.5:0.5) electrocatalyst yielded a mass activity of 50 mA/mgPt and an area specific activity of 156.3 μA/cm2 at 0.9 V vs. RHE when tested in a fuel cell operating at 80 ºC and 75% RH. A 20 wt.% Pt/Ta0.3Ti0.7O2 catalyst was compared in terms of activity and stability against benchmark Pt/C catalysts. The importance of a corrosion resistant support in a PEFC was demonstrated by monitoring performance loss during start-stop cycling and load cycling; while load cycling did not cause a performance drop, the corrosion-resistant nature of the Ta0.3Ti0.7O2 support helped prevent catastrophic fuel cell failure observed in carbon-supported catalysts during start-stop cycling. Corrosion-resistant electrode materials can not only be applied to PEFCs but can also be extended to other electrochemical energy storage and conversion devices such as redox-flow batteries and electrolyzers. The results of this work also indicate suitable strategies for incorporation of other possible dopants (such as Nb, W and Zr) within TiO2, as well as the use of other metal oxides (such as SnO2 and HfO2) as alternative catalyst supports.
Ph.D. in Chemical Engineering, July 2014
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- Title
- VALIDATION AND CHARACTERIZATION OF TURBULENCE IN AN AORTIC COARCTATION
- Creator
- Arzani, Amirhossein
- Date
- 2012-04-25, 2012-05
- Description
-
Image based, patient speci c computational uid dynamics (CFD) modeling has gained dramatic attention in evaluation of health and disease...
Show moreImage based, patient speci c computational uid dynamics (CFD) modeling has gained dramatic attention in evaluation of health and disease progression. With the popularity of these techniques in clinical settings the need to address how these numerical predictions validate against the empirical data becomes more imperative. Validation studies have primarily been used in vitro models, since experiments are dif- cult to control in vivo, and in vivo conditions are challenging to replicate numerically. However, in vivo validations are essential for a more reliable assessment. Moreover, direct quanti cation of turbulence, necessary for diagnostic purposes, makes the validation process more challenging in turbulent ows. A phase-contrast magnetic resonance imaging (PCMRI) method was used to obtain turbulent kinetic energy (TKE) in an aortic coarctation, a congenital disease, where the aorta narrows blocking the passage of blood to a great portion of the body. A 3D patient-speci c computer model of the aortic coarctation was constructed from the MRI data. Direct numerical simulation was performed to solve the Navier-Stokes equations using a stabilized nite element method. Based on the PCMRI procedures, di erent methods were used to compute TKE from the CFD velocity data, and were compared to the PCMRI data. The velocity data obtained from CFD was also used to study the ow topology by computing the Finite-Time Lyapunov Exponent (FTLE) eld, and the Lagrangian coherent structures (LCS). The TKE results showed relative good agreement between the in vivo measurements and the CFD predictions of TKE. Observed di erences were within expectations due to modeling, measurement and numerical errors.
M.S. in Mechanical, Materials, and Aerospace Engineering, May 2012
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- Title
- DEGUELIN AS A THERAPEUTIC DRUG FOR TRIPLE NEGATIVE AND METASTATIC BREAST CANCER
- Creator
- Kalra, Amit
- Date
- 2011-12-13, 2011-12
- Description
-
Breast cancer is a second leading cause of cancer related deaths. 15-20 % of women with Breast cancer are diagnosed with Triple negative...
Show moreBreast cancer is a second leading cause of cancer related deaths. 15-20 % of women with Breast cancer are diagnosed with Triple negative breast cancer (ER, PR, and HER2 –ve) which is the most aggressive type showing higher incidence of recurrence at the local as well as distant sites. Conventional chemotherapy, which shows high levels of toxicity, is the only option available for triple negative breast cancer as hormonal therapy does not work. Thus new drugs which could successfully inhibit the growth of triple negative breast cancer along with the inhibition of metastasis are highly desired. Deguelin, originally isolated from an African plant Mundulea sericea is shown to be effective in skin, lung, breast and colon cancer, effect is thought to be mediated by downregulation of the PI3K/AKT pathway. However, its effect on triple negative breast cancer in vitro and in vivo has not been evaluated. There are few in vivo experimental models to study the effect of novel drugs for the therapy of TNBCs. Murine 4T1 mammary breast cancer cell model is so far the most appropriate experimental model to study efficacy of new drugs on not only tumor growth but also on metastasis to different visceral organs including lungs. This model is relevant and mimics stage IV breast cancer in women. We evaluated the effects of Deguelin on triple negative and highly metastatic breast cancer cell line MDA MB 231 and also In vivo in the 4T1 breast cancer model. We also evaluated effect of Deguelin in combination with low dose (IC30) Taxol. Deguelin treatment alone inhibited the growth of MDA MB 231 breast cancer cells in a time and dose dependent manner causing S-G2 arrest. Deguelin induced apoptosis and inhibited cell proliferation. Deguelin also induced changes in the cell shape and subcellular distribution of the cytoskeletal (F-actin and Tubulin) and cell-cell attachment protein beta-catenin. Growth inhibitory effect was enhanced when Deguelin was given along with low dose Taxol. In vivo, Deguelin (2 or 6mg/kg body weight) administered daily for 21 days significantly (P<0.05) inhibited growth of 4T1 cells transplanted s.c. in to 4-6 weeks old female BALB/c mice. Interestingly, as compared to vehicle only, Deguelin treatment also significantly (P<0.02) reduced the number of metastatic lesions from intravenously injected 4T1 cells. Western blot analysis of several key signaling proteins in MDA MB 231 cells suggested that Deguelin (250nM) reduces PI3K, pAKT, and NF-κB protein levels. Immunohistochemical studies in 4T1 xenografts and metastatic lung lesions obtained from vehicle and Deguelin treated animals suggested that Deguelin reduces pAKT, COX2 and HIF-1 alpha, major key players involved in angiogenesis, cell proliferation and metastasis. In conclusion, our results show that Deguelin has growth inhibitory effect on TNBC cell lines; it inhibits in vivo and in vitro growth of murine mammary cancer cell line. Deguelin has anti metastatic activity in 4T1 experimental model. Anti proliferative and anti metastatic effects of Deguelin are mediated through down regulation of pAKT, COX2 and HIF-1 alpha. Deguelin alone or in combination to Taxol showed promising results and could be further developed as potential drugs for the treatment of triple negative breast cancer.
M.S. in Biology, December 2011
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- Title
- THE GARDEN BLOCK: A NEW MODEL OF SUPERBLOCKS TOWARDS SOCIO-ECOLOGICAL COHESION
- Creator
- Sharari Alzraikat, Saly Azmi
- Date
- 2016, 2016-12
- Description
-
It is said that the contemporary Chinese city is a global model of future urban development, in terms of superblocks’ development, advanced...
Show moreIt is said that the contemporary Chinese city is a global model of future urban development, in terms of superblocks’ development, advanced technological applications and accelerated expansion. However, this model’s characteristics can be perceived as its own challenges; this mono-functional gated community is built on a blank slate without taking into consideration culture, transportation and socio-ecological infrastructure, creating bedroom communities that lack social cohesion, and ecological sensitivity and awareness. A hybrid typology is a potential adaptive prototype that generates community stability, public benefit and sustainable practices. Chinese authorities proposed the "Sponge City" initiative to ensure healthy urban expansion, control water flooding and diminish pollution. By proposing a “Garden System” as a solution that responds to the "Sponge City" objectives, quality of life of the block's users can be enhanced by juxtaposing contemporary garden applications that would directly target the current superblock conditions in China, and produce a superblock model that balances the socio-ecological infrastructure with density, culture, program and context.
M.S. in Architecture, December 2016
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- Title
- THE DEVELOPMENT OF A CRYOGENIC OVER-PRESSURE PUMP
- Creator
- Alvarez, Matthew L.
- Date
- 2001-07-17, 2012-07
- Description
-
The Dark Energy Survey (DES) project will study the accelerated expansion of the universe. In order to further study this phenomenon,...
Show moreThe Dark Energy Survey (DES) project will study the accelerated expansion of the universe. In order to further study this phenomenon, scientists have devised a method of creating an array of charged couple devices (CCD) to capture images that will be studied. These CCDs must be cooled and remain at 173K to eliminate thermal gradients and dark current. Therefore, a two-phase CCD liquid nitrogen (LN2) cooling system was designed to maintain the array of CCDs at a constant temperature. However, the centrifugal pump used to supply LN2 has a mean time between failure (MTBF) of approximately two thousand-eight hundred hours (116 days). Because of the low MTBF of the centrifugal pump, a new pump is being considered to replace the existing one. This positive displacement pump is a simpler design that is expected to have a MTBF that will exceed 116 days (2800hrs). This positive displacement reciprocating pump, also known as, the cryogenic over-pressure pump (OPP), was tested in February 2012 and successfully cooled the CCD array to 173K. Though un t for service for DES CCD cooling system, the overall concept of this pump has been proven. Typical ow rates, pressures, and temperatures trends have been captured via instrumentation and are speci c to the operation of future over-pressure pumps.
M.S. in Mechanical and Aerospace Engineering, July 2012
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- Title
- AN IMPROVED BACKGROUND SUBTRACTION ALGORITHM FOR INTELLIGENT VIDEO SURVEILLANCE
- Creator
- Xia, Zhengyu
- Date
- 2013, 2013-07
- Description
-
This thesis briefly introduces background subtraction which is one of the current advanced techniques for intelligent video surveillance. The...
Show moreThis thesis briefly introduces background subtraction which is one of the current advanced techniques for intelligent video surveillance. The paper also presents an improved background subtraction technique for motion detection in the area of intelligent video surveillance. The proposed technique is difference from the state-of-the-art background subtraction algorithms such as Gaussian Mixture Models or Behavior Subtraction, etc. The idea of this enhanced background subtraction is inspired by the ViBe algorithm. In the first step, which is the initialization of background subtraction, it takes samples only in its current location and 3x3 neighborhoods for each pixel. Then compare each pixel with the sampling set to determine whether this pixel belongs to background models or foreground objects. The next step is to update the sampling sets so that the algorithm can adapt to different scenarios. The final procedure is the post-processing method, which has better performance to overcome difficulties. This approach differs from those based upon the classical belief that the samples set of current pixels should be collected according to certain mathematic models. Experimental results of the proposed algorithm are better than earlier techniques that use the ViBe algorithm. Keywords: Background subtraction, computer vision, motion detection, real-time systems, intelligent video surveillance.
M.S. in Electrical Engineering, July 2013
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- Title
- Analysis and design of a power plant for a proposed department store and office building
- Creator
- Ratcliff, W. A.
- Date
- 2009, 1905
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/analysisdesignof00ratc
Thesis (B.S.)--Armour Institute of Technology