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- Title
- SYNTHESIS OF TETRAZINE-BASED COVALENT ORGANIC NETWORKS
- Creator
- Han, Songyang
- Date
- 2015, 2015-05
- Description
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After comparison of inorganic, hybrid and organic porous materials, tetrazine based organic porous material was chosen as a target material...
Show moreAfter comparison of inorganic, hybrid and organic porous materials, tetrazine based organic porous material was chosen as a target material since it was rigid material providing micro- to mesoscale pores and could do post-synthetic modifications through inverse electron demand Diels-Alder Reaction with different dienophiles. Such networks own the potential as catalysts after modifying with different metal chelation sites. Here, three strategies were provided to synthesize such materials. During of construction of building blocks through double Diels-Alder Reaction, reactivities of tetrazines and dienophiles were studied. The coupling study provided the information of which type of coupling reaction could be used as well as how it was proceeded. The Direct synthesis of tetrazine-based network through formation of tetrazines then broadened the variety materials that could be synthesized.
M.S. in Chemistry, May 2015
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- Title
- BLOCK COPOLYMER BASED MICELLE FOR EFFICIENT IMMUNOSENSING
- Creator
- Li, Ying
- Date
- 2012-11-26, 2012-12
- Description
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This thesis demonstrates the formation of micelles from a block copolymer and the application in establishing the micelle based immunosensing...
Show moreThis thesis demonstrates the formation of micelles from a block copolymer and the application in establishing the micelle based immunosensing system. The utilization of polymeric micelle as probe container and antibody carrier increases the probe to antibody ratio, which is expected to leads to better detection efficiency. The substrate used in the immunosensing is a porous 0.45 μm PVDF membrane which allows the stable immobilization of proteins. Tetraphenylporphyrin, a hydrophobic fluorescent dye, was chosen as the probe encapsulated in micelles. The block copolymer is a self synthesized α-carboxyl-ω-hydroxyl terminated Poly(ethylene oxide)-Polycaprolactone with carboxyl group on the hydrophilic end, permitting the conjugation of antibody to the micelle surface. We choose mouse IgG and its antibody anti-IgG as the pair of protein conjugates to demonstrate the immunoassay. So far, the detection limit of mouse IgG is 1.5 μg/ml (10-8 M) in this immunosensing system, which is expected to improve by modifying the system.
M.S. in Chemistry, December 2012
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- Title
- MAGNETIC RESONANCE IMAGING (MRI) OF CALIBRATION PHANTOMS AND MRI CONTRAST TRENDS IN POLYNUCLEAR CHROMIUM COMPOUNDS
- Creator
- Sun, Wanlin
- Date
- 2012-04-25, 2012-05
- Description
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This thesis is composed of two projects. The first project involves the investigation of a series of Cr+++ compounds as potential magnetic...
Show moreThis thesis is composed of two projects. The first project involves the investigation of a series of Cr+++ compounds as potential magnetic resonance imaging (MRI) contrast agents. The second part of the thesis involves collaborative work with the National Institute of Standards and Technology (NIST) in the development of an MRI calibration phantom designed to correlate data from different MRI institutions for long term studies of diseases such as Alzheimer’s. Data from the Cr+++ project indicated that these compounds show some promise for enhancement of MRI images. The second project resulted in a NIST phantom being built based partly upon data obtained here at IIT.
M.S. in Chemistry, May 2012
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- Title
- ENGINEERING 2D PHOTO-REACTING COF FOR PATTERNING AND DRUG DELIVERY
- Creator
- Chen, Kuo Hao
- Date
- 2017, 2017-07
- Description
-
Covalent Organic Frameworks (COFs) are 2-dimensional polymers that exhibit rigid and large surface area as well as porous architectures....
Show moreCovalent Organic Frameworks (COFs) are 2-dimensional polymers that exhibit rigid and large surface area as well as porous architectures. Currently, COFs are tailored for gas storage applications, drug delivery, catalysis and they are used as filtering membranes for water treatment. It is well documented that at the nano/micro scale, COFs can form multi-layered architecture with respect to the basic molecular building blocks. In this picture, it is possible that the 2D intra-layer and 3D inter-layer interactions of the basic molecular units COFs may dictate the overall efficiency of the aforementioned applications. To understand the dimensionality-function relationship of COFs, we are engineering hybrid 1D-2D organic polymers. This hybrid architecture will allow us to study the propagation of energy/exciton transfer within the resulting materials among other applications such as drug delivery and light-induced nano/micro-patterning. To achieve our objectives, I exploited the photo-reacting properties of two molecular systems: The first system is used to prepare the 2D COF of interest and the other system is used to engineer a 1D crystalline solid. Although I have not tested the energy/exciton propagation with the desired material, I have successfully engineered a 1D crystalline solid and synthesized the expected 2D COFs. Using a combination of synthetic strategies, I prepared and characterized photoreacting tetra-phenyl ketone building block that was used to form the desired polymer. I have also engineered 1D needle-like crystals of bisphenyl cyclopropenone compound. Moreover, the two materials were characterized by optical and electron microscopy methods. This thesis will detail the synthesis and characterization of all precursors of the basic molecular units that were used to engineer the 1D crystalline solid and 2D COF materials. Condignly, the optical and scanning electron microscopy images highlight the microscale features of the materials of interest. I am certain that this preliminary investigation will pave the way to study the dimensionality of energy/exciton transfer and reaction propagation in the many organic materials.
M.S. in Chemistry, July 2017
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- Title
- BIOREMEDIATION VIA SILICA ENCAPSULATION
- Creator
- Li, Xiaohui
- Date
- 2011-04-25, 2011-05
- Description
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In this thesis, a new bioremediation concept is designed and implemented. Using copper (II) as a model pollutant, the concept involves the use...
Show moreIn this thesis, a new bioremediation concept is designed and implemented. Using copper (II) as a model pollutant, the concept involves the use of green algae Chlamydomonas reinhardtii to efficiently collect copper ions from the environment, followed by encapsulating copper loaded algae with silica, thus reducing the bioavailability of copper ions in the environment. A proof-of-concept was established for this concept. In Chapter 1, a brief overview of bioremediation, current state-of–the-art bioremediation methods, and the mechanisms and applications of biosorption is introduced. In Chapter 2, the potential of Chlamydomonas reinhardtii as a copper (II) absorbent is demonstrated by quantifying the copper toxicity, copper uptake rate, copper uptake capacity, copper uptake conditions and effect factors, as well as copper release process from Chlamydomonas reinhardtii. In Chapter 3, a method of encapsulating Chlamydomonas reinhardtii with silica shell using the biomimetic silicification process is described. The silica shell formation is confirmed by both scanning electron microscope (SEM) images and the fluorescence images. Finally in Chapter 4, the work in this thesis is summarized and the future research direction is discussed.
M.S. in Chemistry, May 2011
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