In the present study, we present a model to predict the chiral separation results for drug enantiomers by ADMPC chiral stationary phase in... Show moreIn the present study, we present a model to predict the chiral separation results for drug enantiomers by ADMPC chiral stationary phase in high performance liquid chromatography (HPLC) wherein multiple ADMPC polymer strands are coated on an amorphous silica slab. Both reactive and classical MD are used to prepare the surface. Using various MD techniques, we successfully coat ADMPCs onto the surface without losing the structural character of the backbone in the presence of the solvent system. Not only is this model more representative of the polymer surface on a solid support that is encountered by the enantiomers, it also provides more opportunities for chiral molecules interacting with ADMPC, resulting in a better agreement compared with experiment when we use overall average quantities as the metric. In our previous studies, we had used a single polymer strand of amylose tris(3,5-dimethylphenyl carbamate) (ADMPC) in the solvent system. The new model provides the possibility for large drug molecules to interact with two polymer strands at the same instant, which was not possible to model with only a single polymer strand in the solvent. For a better understanding of why some metrics are better predictors than others, we use charts of the distribution of hydrogen bonding lifetimes in this work to display the hydrogen-bonding information for various donor-acceptor pairs that contribute to the interaction events determining the relative retention times for the enantiomers. We also examine the contribution of the ring-ring interactions to the molecular recognition process and ultimately to differential retention of S and R enantiomers. The results using the new model are more consistent than the previous models and resolves the problematic case of two drugs, thalidomide and valsartan. Sponsorship: The National Science Foundation (CBET 1545560) Show less
Photograph of Illinois Institute of Technology president John Rettaliata at an open meeting with students and faculty regarding the student... Show morePhotograph of Illinois Institute of Technology president John Rettaliata at an open meeting with students and faculty regarding the student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970. Show less
Photograph of State Street in Chicago's loop, looking north from Randolph Street. Date of photograph determined from the movie titles visible... Show morePhotograph of State Street in Chicago's loop, looking north from Randolph Street. Date of photograph determined from the movie titles visible on the theater marquees. Show less
This compressed collection of map files constitutes data used in "Analysis on the Persisting Effects of Redlining on Green Infrastructure in... Show moreThis compressed collection of map files constitutes data used in "Analysis on the Persisting Effects of Redlining on Green Infrastructure in Chicago Neighborhoods", published in SoReMo, March 2023 (DOI: https://doi.org/10.18409/soremojournal.v3i1.221). The report looks at “redlining” maps produced by the Home Owners’ Loan Corporation (HOLC) to analyze the current green infrastructure levels in various neighborhoods of Chicago. Show less
Photograph taken by Mary Henry in 1946 as part of a photography course taught by László Moholy-Nagy at the Institute of Design. Inscription on... Show morePhotograph taken by Mary Henry in 1946 as part of a photography course taught by László Moholy-Nagy at the Institute of Design. Inscription on verso: "Beginning photo lessons in Moholy-Nagy's class, learning to focus the camera, develop & print the negative. Chicago, 1946, Institute of Design." Show less
Photograph of Mary Henry surrounded by her paintings, Mendocino, California, 1966.This photograph was apparently distributed by Estelle... Show morePhotograph of Mary Henry surrounded by her paintings, Mendocino, California, 1966.This photograph was apparently distributed by Estelle Grunewald, founder of Art to Industry, a business that attempted to connect artists with corporate patrons. Inscription on verso: "Mary Henry 2222 East White Fir Place Freeland, WA 98249 206-331-3404 / Artist surrounded by her paintings, Mendocino, Calif. 1966." A small label is affixed to verso that reads "Please return: Estelle Grunewald Art-to-Industry 4621 Ruthelma Ave. P.A." Photographer unknown. Show less
Photograph taken by Mary Henry in 1946 as part of a photography course taught by László Moholy-Nagy at the Institute of Design. Inscription on... Show morePhotograph taken by Mary Henry in 1946 as part of a photography course taught by László Moholy-Nagy at the Institute of Design. Inscription on verso: "Photographed for Moholy-Nagy's class at the Institute of Design, 1946. A lesson in lighting the subject." Show less
Photograph of Mary Henry in her garden in Mendocino, California in the late 1960s. Inscription on verso: "Mary Henry looking at her 'Japanese'... Show morePhotograph of Mary Henry in her garden in Mendocino, California in the late 1960s. Inscription on verso: "Mary Henry looking at her 'Japanese' pond in the garden at Mendocino, late sixties." Photographer unknown. Date of photograph unknown. Date indicated is an estimate. Show less