In the present study, we present a model to predict the chiral separation results for drug enantiomers by ADMPC chiral stationary phase in... Show moreIn the present study, we present a model to predict the chiral separation results for drug enantiomers by ADMPC chiral stationary phase in high performance liquid chromatography (HPLC) wherein multiple ADMPC polymer strands are coated on an amorphous silica slab. Both reactive and classical MD are used to prepare the surface. Using various MD techniques, we successfully coat ADMPCs onto the surface without losing the structural character of the backbone in the presence of the solvent system. Not only is this model more representative of the polymer surface on a solid support that is encountered by the enantiomers, it also provides more opportunities for chiral molecules interacting with ADMPC, resulting in a better agreement compared with experiment when we use overall average quantities as the metric. In our previous studies, we had used a single polymer strand of amylose tris(3,5-dimethylphenyl carbamate) (ADMPC) in the solvent system. The new model provides the possibility for large drug molecules to interact with two polymer strands at the same instant, which was not possible to model with only a single polymer strand in the solvent. For a better understanding of why some metrics are better predictors than others, we use charts of the distribution of hydrogen bonding lifetimes in this work to display the hydrogen-bonding information for various donor-acceptor pairs that contribute to the interaction events determining the relative retention times for the enantiomers. We also examine the contribution of the ring-ring interactions to the molecular recognition process and ultimately to differential retention of S and R enantiomers. The results using the new model are more consistent than the previous models and resolves the problematic case of two drugs, thalidomide and valsartan. Sponsorship: The National Science Foundation (CBET 1545560) Show less
Photograph of Illinois Institute of Technology president John Rettaliata at an open meeting with students and faculty regarding the student... Show morePhotograph of Illinois Institute of Technology president John Rettaliata at an open meeting with students and faculty regarding the student protests that occurred on IIT's campus following the fatal shooting of four students at Kent State University by the Ohio National Guard on May 4, 1970. Show less
Fundraising booklet for distribution to businesses and entrepreneurs soliciting funds for the development of the new campus buildings and... Show moreFundraising booklet for distribution to businesses and entrepreneurs soliciting funds for the development of the new campus buildings and academic programs of Illinois Institute of Technology. At the time of the booklet's publication, the earliest of Mies van der Rohe's buildings on the Illinois Tech campus had been completed, with others under construction. The booklet includes a plan of the proposed Mies campus as well as drawings and descriptions of the buildings yet to be built. Some extant copies of the booklet include Technology Center of Tomorrow in the Making Today (see http://hdl.handle.net/10560/islandora:1011682), an insert with an update on campus construction. Show less
Photograph of State Street in Chicago's loop, looking north from Randolph Street. Date of photograph determined from the movie titles visible... Show morePhotograph of State Street in Chicago's loop, looking north from Randolph Street. Date of photograph determined from the movie titles visible on the theater marquees. Show less
Photograph of Civil Engineering professor Eben Vey with students. Vey was appointed an assistant professor of Mechanics at Illinois Tech in... Show morePhotograph of Civil Engineering professor Eben Vey with students. Vey was appointed an assistant professor of Mechanics at Illinois Tech in the fall of 1948. Vey later became a professor of Civil Engineering and chairman of the Department of Civil Engineering before taking leave of the university in 1977. Photographer unknown. Date of photograph is unknown. Date range listed is approximate. Show less
Photograph of Civil Engineering professor Eben Vey with students. Vey was appointed an assistant professor of Mechanics at Illinois Tech in... Show morePhotograph of Civil Engineering professor Eben Vey with students. Vey was appointed an assistant professor of Mechanics at Illinois Tech in the fall of 1948. Vey later became a professor of Civil Engineering and chairman of the Department of Civil Engineering before taking leave of the university in 1977. Photographer unknown. Date of photograph is unknown. Date range listed is approximate. Show less
This compressed collection of map files constitutes data used in "Analysis on the Persisting Effects of Redlining on Green Infrastructure in... Show moreThis compressed collection of map files constitutes data used in "Analysis on the Persisting Effects of Redlining on Green Infrastructure in Chicago Neighborhoods", published in SoReMo, March 2023 (DOI: https://doi.org/10.18409/soremojournal.v3i1.221). The report looks at “redlining” maps produced by the Home Owners’ Loan Corporation (HOLC) to analyze the current green infrastructure levels in various neighborhoods of Chicago. Show less
Photograph taken by Mary Henry in 1946 as part of a photography course taught by László Moholy-Nagy at the Institute of Design. Inscription on... Show morePhotograph taken by Mary Henry in 1946 as part of a photography course taught by László Moholy-Nagy at the Institute of Design. Inscription on verso: "Beginning photo lessons in Moholy-Nagy's class, learning to focus the camera, develop & print the negative. Chicago, 1946, Institute of Design." Show less