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- Title
- THE RECIPROCAL INTERACTIONS BETWEEN RED RASPBERRY POLYPHENOLS AND GUT MICROBIOME COMPOSITION: PRELIMINARY FINDINGS
- Creator
- Zhang, Xuhuiqun
- Date
- 2017, 2017-07
- Description
-
Red raspberry (Rubus idaeus L.) contains a variety of polyphenols including anthocyanins and ellagitannins. Red raspberry polyphenols absorbed...
Show moreRed raspberry (Rubus idaeus L.) contains a variety of polyphenols including anthocyanins and ellagitannins. Red raspberry polyphenols absorbed in different forms (parent compounds, degradant or microbial metabolite molecules) are subject to xenobiotic metabolism in the intestine, liver, and/or kidney, forming methylate, glucuronide, and sulfate conjugated metabolites. Consistent exposure of certain polyphenols to the gut microbiota may act as prebiotic-like substances feeding the beneficial gut bacteria and changing the gut microbiome composition and function. The dichotomy between the biotransformation of polyphenols into their metabolites by gut microbiota and the modulation of gut microbiome composition by polyphenols is hypothesized to contribute to positive health outcomes. The present study examined the regular consumption of red raspberry purée (RRB) and/or fructo-oligosaccharide (FOS) on gut microbiome composition and subsequent bioavailability of red raspberry polyphenols in healthy volunteers. An 8-week pilot study, including two 4-week chronic treatments and 3 postprandial days, served as a feasibility study and mechanism to collect multiple biological specimens for method development. An ultra high-performance liquid chromatography (HPLC) coupled with electrospray ionization quadrupole time of flight (QTOF) and triple quadrupole (QQQ) mass spectrometer were used to identify and quantify the phenolic compounds in red raspberry purée, plasma and urine samples. Fecal samples were used for the metagenomic study. The sequencing of the 16S ribosomal RNA gene was utilized to study the gut microbiome composition. The red raspberry purée contained 148.55 ± 5.43 mg/100 g fresh weight (FW) polyphenols. Chronic RRB and/or FOS exposure influenced gut microbiome composition: at the phylum level, 4-week FOS (8 g/d), RRB (125 g/d), or FOS plus RRB (8 and 125 g/d, respectively) exposures all decreased Firmicutes and increased Bacteroidetes; at the genus level, 4-week FOS, RRB, or FOS plus RRB exposures all boosted Bacteroides and diminished Blautia; and the increased Akkermansia was only observed after RRB exposure. Chronic RRB and/or FOS exposure also altered the observed RRB polyphenol metabolites: the parent anthocyanins, such as cyanidin 3-O-sophoroside, were lower in plasma and urine after adaptation to RRB, while the production of urolithin A glucuronide (the main microbial-derived metabolite of ellagitannins) increased after FOS, RRB and FOS plus RRB exposure; an effect hypothesized to be related to the altered composition and metabolic activity of the gut microbiota. Overall, these data suggest chronic RRB and/or FOS exposure influenced gut microbiome composition and subsequently increased gut microbial metabolites.
M.S. in Food Safety and Technology, July 2017
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- Title
- A test of a 2,500 KVA turbo-generator
- Creator
- Grabendike, C. A.
- Date
- 2009, 1921
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/testof2500kvatur00grab
Thesis (B.S.)--Armour Institute of Technology
- Title
- ASSESSMENT OF THE IPR ALGORITHM FOR THE DIFFERENTIAL FUNCTIONING OF ITEMS AND TESTS FRAMEWORK
- Creator
- Neuhengen, Jonas M.
- Date
- 2013, 2013-12
- Description
-
The Diferential Functioning of Items and Tests (DFIT) framework is a widely used test of di erential functioning. DFIT uses the Item Parameter...
Show moreThe Diferential Functioning of Items and Tests (DFIT) framework is a widely used test of di erential functioning. DFIT uses the Item Parameter Replication (IPR) algorithm to generate statistical cuto s, which relies on several simpli cations have not been formally tested. This study examines these assumptions by comparing the IPR algorithm with an extended, unsimpli ed procedure intended to represent results observed in practice. Monte Carlo simulation was used to compare cuto s between the two methods under a number of conditions. Di erences between the IPR and extended cuto s indicate that Type I error rates are conservative at the test level and in ated at the item level. Mean group di erences resulted in massive in ation. Sample size and test length had only minor inuences on error rates.
M.S. in Psychology, December 2013
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- Title
- Tests of a mechanical rectifier
- Creator
- Smith, Bernard M, Wolfson, William
- Date
- 2009, 1916
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/testsofmechanica00smit
Thesis (B.S.)--Armour Institute of Technology; Bibliography: leaf 50
- Title
- COMPUTER-BASED LEARNING ENVIRONMENTS IN ORGANIZATIONAL TRAINING: IMPACT OF LEARNING ENVIRONMENT AND PERSONALITY
- Creator
- Papaioannou, Georgia-niki
- Date
- 2015, 2015-05
- Description
-
The purpose of this study was to investigate the potential effects of technology and personality on training using a computer based learning...
Show moreThe purpose of this study was to investigate the potential effects of technology and personality on training using a computer based learning environment designed to improve learning through technology-delivered instruction. Data were collected from a sample of undergraduate students (N = 98), recruited from three universities (two in the US and one in Canada), who participated in both experimental days. Condition had no effect on learning outcomes, while Conscientiousness was found to be significantly correlated with academic performance. In further analyzing the relationship between personality and learning outcomes across time using a latent growth curve model results showed non-significant conclusions for the direction of the relationship for each of the Big Five. Discussion of the results and implications for practice and future research are provided. In conclusion, this study provides a basis for considering personality characteristics when designing computer-based training interventions in organizational settings.
M.S. in Psychology, May 2015
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- Title
- A study of resorcinol production
- Creator
- Bernstein, Joseph M., Vogt, Emil G.
- Date
- 2009, 1920
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/studyofresorcino00bern
Thesis (B.S.)--Armour Institute of Technology
- Title
- Study of the building problems of the Badger Basket Company of Burlington, Wisconsin
- Creator
- Chase, Derwood
- Date
- 2009, 1921
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/studyofbuildingp00chas
Thesis (B.S.)--Armour Institute of Technology
- Title
- Test of a 400 hp gas producer at Armour & Co., Chicago, Ill.
- Creator
- Boblett, K. M., Boughton, N. J.
- Date
- 2009, 1909
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/testof400hpgaspr00bobl
Thesis (B.S.)--Armour Institute of Technology; Includes bibliographical references(...
Show morehttp://www.archive.org/details/testof400hpgaspr00bobl
Thesis (B.S.)--Armour Institute of Technology; Includes bibliographical references( leaves 78-84) and index
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- Title
- Study of a selenium cell
- Creator
- Newlander, R. A.
- Date
- 2009, 1918
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/studyofseleniumc00newl
Thesis (B.S.)--Armour Institute of Technology; Bibliography : leaf 33
- Title
- INVESTIGATION AND CONTROL OF NOROVIRUS TRANSFER DURING PREPARATION OF FRESH PRODUCE IN A FOOD SERVICE SETTING
- Creator
- Zhao, Heng
- Date
- 2013-04-24, 2013-05
- Description
-
Outbreaks of human norovirus are commonly attributed to fresh produce and multi-ingredient foods that have received significant handling...
Show moreOutbreaks of human norovirus are commonly attributed to fresh produce and multi-ingredient foods that have received significant handling immediately prior to consumption. The objective of this study was to evaluate the effect of gloved and ungloved hands on norovirus transfer during fresh produce preparation. The palm and fingers of bare or gloved (polyvinyl, vinyl or nitrile) hands were inoculated with approximately 7-log PFU/hand murine norovirus (MNV-1). Freshly chopped Romaine lettuce was handled by the contaminated hands, and then sampled to determine the transfer coefficient. MNV-1 transfer was also measured from chopped contaminated lettuce to clean bare or gloved hands. In addition, pulsed light was investigated, in a preliminary study, for its ability to inactivate MNV-1 on the surface of food contact surfaces including the various glove types and Romaine lettuce, and thus prevent the spread of contamination. Transfer of MNV-1 occurred more readily to (up to 45%) Romaine lettuce than from (less than 12%) it. Transfer to Romaine lettuce was greater (p<0.05) from vinyl gloves than bare hands and the other glove types tested, while no significant difference (p>0.05) in transfer from lettuce to the different glove types was observed. The results indicate that norovirus transfer can occur readily in a food service setting, and that transfer coefficients are affected by the type of surfaces involved. MNV-1 was reduced by pulsed light by >4-log within 30 sec on all surfaces except nitrile gloves, indicating the potential for this technology to be employed in a food service setting to control the spread of noroviruses during food preparation.
M.S. in Food Safety and Technology, May 2013
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- Title
- Speed-time curve study of electric railway load conditions
- Creator
- Banning, Thomas A., Jr
- Date
- 2009, 1907
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/speedtimecurvest00bann
Thesis (B.S.)--Armour Institute of Technology
- Title
- MULTIPLE SIGNAL TRANSDUCTION EVENTS AND MODULATION OF OLFACTORY RESPONSES IN MOUSE OLFACTORY SENSORY NEURONS
- Creator
- Yu, Yiqun
- Date
- 2012-04-30, 2012-07
- Description
-
In the mammalian olfactory system, one olfactory sensory neuron (OSN) expresses a single olfactory receptor (OR) gene. I studied two subsets...
Show moreIn the mammalian olfactory system, one olfactory sensory neuron (OSN) expresses a single olfactory receptor (OR) gene. I studied two subsets of mouse OSNs, hereafter refered to as Ho-OSNs and AB-OSNs, in intact mouse olfactory turbinates using calcium imaging. Both of Ho-OSNs and AB-OSNs were located in the most ventral olfactory receptor zone. Ho-OSNs were specifically responsive to 2-heptanone (Ho), heptaldehyde (H) and cis-4-heptenal (cH). Dose-dependent analysis indicated that their responses to individual odorant was saturated within one logarithm unit of concentrations, a typical characteristic of isolated OSNs. Binary mixture and crossadpatation studies showed that these three odorants bound to the same binding sites in Ho-OSNs. However, these three structurally similar odorants activated distinct signaling pathways in Ho-OSNs. In detail, 2-heptanone-evoked intracellular calcium elevation was mediated by AC-cAMP signaling, while heptaldehyde triggered the PLC-DAG pathway. The cis-4-heptenal-evoked [Ca2+]i increases resulted from a combination of cAMP mediated activation and suppression involving PLC signaling. Furthermore, the PLCmediated intracellular calcium alteration was independent of IP3 signaling. A further complexity is that these olfactory receptors were able to interact with other types of Gprotein coupled receptors (GPCRs), such as purinergic receptors. I determined that both the P2X3 and P2Y2 receptor subtypes were expressed in Ho-OSNs. Application of purinergic agonists elevated [Ca2+]i increases in Ho-OSNs. It was discovered that the ATP-induced calcium response required either intracellular or extracellular calcium, while depletion of intracellular calcium stores blocked the UTP-evoked [Ca2+]i increases. Purinergic agonists were able to modulate the odor response in Ho-OSNs, and purinergic antagonist experiments showed that modulation of heptaldehyde-induced calcium responses was due to activation of P2X3 receptor subtypes while heptanone-induced calcium responses was not. Although AB-OSNs were found adjacent to Ho-OSNs, they had complete separate response profiles. AB-OSNs were sensitive to acetophenone (Ace) and benzaldehyde (Ben). In AB-OSNs, both acetophenone and benzaldehyde activated the PLC signaling pathway. Pharmacological characterization indicated that in AB-OSNs, P2X1 and P2Y2 receptors were present, which is different from that in Ho-OSNs. P2X and P2Y agonists modulated odorant responses in AB-OSNs. Purinergic signaling differentially regulated the various odorant responses in AB-OSNs. The acetophenoneevoked [Ca2+]i increases were negativly modulated through activation of the P2Y2 receptor, while the calcium response induced by benzaldehyde was modulated by P2X1 receptor activation. Collectively, these studies suggest that a complex signaling mechanism exists in OSNs, which has important implications for understanding the mechanism of information process in the olfactory system.
Ph.D. in Biology, July 2012
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- Title
- PAST- AND FUTURE- ORIENTED COGNITIONS IN PTSD: THE RELATIONSHIP BETWEEN RUMINATION AND WORRY IN DEPRESSION AND ANXIETY SYMPTOMS
- Creator
- Stickney, Laurie
- Date
- 2016, 2016-07
- Description
-
Post-Traumatic Stress Disorder (PTSD) is a complex disorder characterized by symptoms of both anxiety and depression. Likewise, individuals...
Show morePost-Traumatic Stress Disorder (PTSD) is a complex disorder characterized by symptoms of both anxiety and depression. Likewise, individuals with PTSD experience Repetitive Negative Cognitions in the form of rumination and worry that may be focused on the past, present, or future. Although cognitions in individuals with PTSD have been studied, there is some question as to what types of cognitions individuals with PTSD generally experience and to what extent different types of cognitions contribute to different PTSD symptomatology. Further, although worry and rumination in PTSD have been studied, the question of the importance of the time-focus of cognitions in PTSD has not been adequately addressed. Time-focused cognitions and the relationships among depression, anxiety, rumination and worry were examined in this study using experience sampling method. Participants were asked to fill out a short survey measuring depression, anxiety, rumination, worry and time-focus five times per day for seven days. Results indicated that the presence of Current-focused cognitions strengthened the relationship between worry and anxiety compared to Future-focused cognitions. These findings suggest that in terms of the relationship between anxiety and worry, it is current-focus that is important not future-focus. Additionally, worry partially mediated the relationship between rumination and anxiety, and rumination partially mediated the relationship between worry and depression. Overall, the results suggest that time-focus may be important in some areas of PTSD, and the study highlights the complex relationships among depression, anxiety, rumination, worry and time-focused cognitions.
Ph.D. in Psychology, July 2016
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- Title
- A technical study of the solids of skimmed milk
- Creator
- Whittington, J. A., Wilson, L. T., Yonkman, W.
- Date
- 2009, 1914
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/technicalstudyof00whit
Thesis (B.S.)--Armour Institute of Technology; Bibliography: leaf 25
- Title
- INTERNET-BASED CONTACT PROGRAMS TO FIGHT THE STIGMA OF SCHIZOPHRENIA
- Creator
- Wassel, Abigail K.
- Date
- 2014, 2014-07
- Description
-
Stigma is an insidious problem that has resulted in loss of opportunities for people with mental illness. Research suggests that contact...
Show moreStigma is an insidious problem that has resulted in loss of opportunities for people with mental illness. Research suggests that contact provided through a structured talk by a person with mental illness could serve as an effective tool in combating stigma and promoting attitude change. Additionally, research on imagined contact suggests this approach can also decrease negative stereotypes toward people with schizophrenia. The current study examined the effectiveness of these two approaches in changing attitudes toward people with mental illness when delivered via the Internet. It was hypothesized that both a videotaped contact and an imagined contact approach would increase positive attitudes and decrease negative attitudes toward people with mental illness when presented alone, and that efficacy would increase when combined. Findings showed no significant changes for any experimental condition from baseline attitudes or relative to a control condition, which suggests that interventions used in this study are not successful in creating sustainable attitude change over the Internet.
Ph.D. in Psychology, July 2014
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- Title
- A C-OMPARISON OF TWO ALGORITHMS FOR ADAPTING INTERVIEWS TO PERSONALITY SCORES
- Creator
- Van Overberghe, Courtney T.
- Date
- 2012-04-18, 2012-05
- Description
-
Two adaptive interviews – adding questions based on low or high scores from a personality assessment – were compared to a structured interview...
Show moreTwo adaptive interviews – adding questions based on low or high scores from a personality assessment – were compared to a structured interview. In a mock selection process, it was found that the adaptive and structured interviews had similar correlations with performance on a role play task. However, due to the added length of the adaptive interview, it had slightly less utility than a structured interview. A cognitive measure and the interview conditions were better predictors of performance than the personality questionnaire, which had no relationship with performance. A post-hoc analysis found that the social desirable scale from the personality instrument correlated negatively with the structured interview, the role play and the IQ test, and positively correlated with the personality composite score.
Ph.D. in Psychology, May 2012
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- Title
- Stresses in riveted joints
- Creator
- Rook, Henry A.
- Date
- 2009, 1916
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/stressesinrivete00rook
Thesis (B.S.)--Armour Institute of Technology, 1916 Bibliography: leaves 39-44 B.S. in...
Show morehttp://www.archive.org/details/stressesinrivete00rook
Thesis (B.S.)--Armour Institute of Technology, 1916 Bibliography: leaves 39-44 B.S. in Civil Engineering, 1916
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- Title
- The treatment of stock yard's sewage by the activated sludge process
- Creator
- Newman, Joseph Julius
- Date
- 2009, 1917
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/treatmentofstock00newm
Thesis (B.S.)--Armour Institute of Technology; Includes folded leaves in back pocket
- Title
- A study of neutral currents in star connected three-phase alternators and transformers
- Creator
- Kaiser, Everett Dee, Myers, Frank Edward
- Date
- 2009, 1911
- Publisher
- Armour Institute of Technology
- Description
-
http://www.archive.org/details/studyofneutralcu00kais
Thesis (B.S.)--Armour Institute of Technology; Includes bibliographical references and index
- Title
- Amorphous Solid Polymer Electrolytes for Lithium-Ion Batteries
- Creator
- Lee, Sooyun
- Date
- 2012-07-05, 2012-07
- Description
-
The rechargeable lithium-ion batteries that started in the early 1990’s, are extensively used in lots of electronic devices, including...
Show moreThe rechargeable lithium-ion batteries that started in the early 1990’s, are extensively used in lots of electronic devices, including cellular phones, laptop computers, camcorders, cameras and medical devices. Due to high energy and power density of lithium-ion batteries, they are one of the most useful batteries, and lots of researches and developments are still progressing, especially in electronic vehicle / hybrid electric vehicle (EV/HEV). However, current lithium-ion batteries have many problems, especially those related to its electrolyte system. Because this component contains flammable organic solvents, they have several disadvantages, such as leakage, instability, and difficulty in manufacture of large flat types of batteries. To eliminate these problems, the studies on Solid Polymer Electrolyte (SPE) system are now an active research area. In this thesis work, three different approaches have been executed to improve electrolyte properties of lithium-ion batteries. As a based material tosylate poly(ethylene glycol) was prepared, and a plasticizer was synthesized and incorporated into a conventional poly(ethylene oxide)-based Solid Polymer Electrolyte systems. First, to increase amorphousness in plasticizer, bisphenol-A was introduced, which has free rotating unit and only ionic conductivity was measured to verify. Secondly, hyperbranched poly(p-hydroxy styrene) derivatives were synthesized and used as the base matrix in SPEs. Polymers which have higher order of branching exhibited higher ionic conductivity, and it was assumed that branching structure lowered crystallinity. Finally, we synthesized 3-chloropropanesulfonyl-trifluoromethanesulfonylimide (LiCPSI) and attached to hyperbranched poly(p-hydroxy styrene) to verify that how hyperbranched structure would affect the ionic conductivity. Major characterization techniques include ionic conductivity, cyclic voltammetry (CV) and thermogravimetric analysis (TGA).
M.S. in Chemistry, July 2012
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