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Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
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Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Final Report F08
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
Deliverables
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Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Poster F08
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
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Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Ethics F08
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
Deliverables
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Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 MidTerm Presentation F08
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
Deliverables
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Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Brochure F08
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
Deliverables
Show less

Title: DEVELOPMENT OF AN ARTIFICIAL PANCREAS (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Final Presentation F08
Creator: Klug, Allen, Kuuspalu, Adam, Smith, Adam, Naveenan, Anju, Sin, In Seok, Sonoiki, Olufemi, Wakeman, William
Date: 2008, 2008-12
Description: Our team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as...
Show moreOur team was asked to come up with an innovative and non-invasive means of extracting and measuring glucose levels in the body as well as administering insulin back into the body, also by non-invasive means. Our research lead us to several reports on the effectiveness of ultrasound in expanding pore opening diameters. We decided to approach the problem with a device that would administer ultrasonic vibration to the surface of the skin thus expanding the pore openings. Once expanded a combination of vacuum and reverse iontophoresis would then extract a small amount of interstitial fluid. The fluid would be measured for glucose concentration using impedance spectroscopy. Once a glucose concentration was found, a proper amount of insulin would then be administered back through the skin by means of pressure and iontophoresis. Our experiments were conducted on harvested porcine skin. Sonic vibration at or around 10kHz served as a substitute for ultrasound. Vacuum was administered to the surface of the skin after a set amount of time of sonic vibration. Although results at first seemed promising, further investigation into the behavior of harvested skin yielded that our results were not as they seemed. Impedance spectroscopy was explored by first trying to find the resonant frequency of glucose. Earlier attempts at this were unsuccessful do to frequency limitations of measuring devices. Our team learned of a device that could measure 10 times higher frequencies than what had previously been recorded, but unfortunately was unable to solidify a concrete resonant frequency for glucose.
Deliverables
Show less

Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
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Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 MidTerm Report Sp08
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
Show less

Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Final Presentation Sp08
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
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Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Final Report Sp08_redacted
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
Show less

Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Poster Sp08
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
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Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Project Plan Sp08
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
Show less

Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Brochure Sp08
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
Show less

Title: Creating an Artificial Pancreas (Semester Unknown) IPRO 308: Creating an Artificial Pancreas IPRO 308 Ethics Sp08
Creator: Mathews, Rohan, Estrada, Zak, Hanley, Richard, Khalil, Shezami, Laster, Kyle, Mesquitta, Walatta, S. Park, Joon, Saseendran, Anju, Tishler, Michael, Wakeman, William
Date: 2008, 2008-05
Description: Insulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an...
Show moreInsulin is a hormone released by pancreatic islet cells that interacts with cells to increase their permeability to glucose. Diabetes is an illness that is becoming more prevalent around the world and is linked with either abnormal insulin production, or utilization or both in the body. Diabetes may be classified into two groups: Type 1 and Type 2 In an individual with Type 1 diabetes, the pancreatic ß cells that normally produce insulin are nonexistent as they have been destroyed due to autoimmune response. In an individual with Type 2 diabetes there is tissue-wide resistance to insulin and usually some impairment of ß cells as well. Therefore, although insulin production may be present its functionality is impaired. Type 1 diabetes is typically treated with frequent extraneous insulin injections, depending on the prevailing blood glucose levels of the individual; however, in order to determine the glucose levels individuals subject themselves to periodic finger pricks throughout the day which is often uncomfortable and stressful. Mechanical devices for insulin delivery, also known as “artificial pancreases”, are currently available in the marketplace. However, these devices are not only highly invasive and painful, but also must be sanitized frequently to prevent infections. As a result, they are inconvenient and many diabetic patients choose not to use them. The goal of IPRO 308 is to develop an automated, non-invasive artificial pancreas that will be capable of determining blood glucose levels and administering an appropriate amount of insulin into the blood stream while causing minimal discomfort to the individual.
Deliverables
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