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Title: High Throughput Non-Photochemical Laser Induced Nucleation
Creator: Myerson, Allan S.
Date: 2009-05-14, 2004-05-11
Description: A method for the high-throughput non-photochemical laser induced nucleation of crystals from aged supersaturated solutions in which short high...
Show moreA method for the high-throughput non-photochemical laser induced nucleation of crystals from aged supersaturated solutions in which short high-intensity laser pulses are used to induce nucleation in an array or sequence aged supersaturated solutions. The laser reduces nucleation time and induces nucleation only in the area where the beam is focused or passes through, resulting in fewer nuclei than would be achieved by spontaneous nucleation. The high-throughput methodologies allow more crystals to grow in a given amount of time.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Controlled Nucleation of Protein Crystals
Creator: Myerson, Allan S.
Date: 2009-05-14, 2003-07-22
Description: A method for the non-photochemical laser induced nucleation in which short high-intensity laser pulses are used to induce nucleation in...
Show moreA method for the non-photochemical laser induced nucleation in which short high-intensity laser pulses are used to induce nucleation in supersaturated solutions including protein solutions. The laser induces nucleation only in the area where the beam is focused or passes through, resulting in fewer nuclei than would be achieved by spontaneous nucleation. In addition, the laser reduces nucleation time significantly.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Molecular Crystals of Controlled Size
Creator: Myerson, Allan S.
Date: 2009-05-14, 2003-11-11
Description: Methods for the crystallization of nano-size crystals of molecular organic compounds while operating at a low supersaturation. The methods are...
Show moreMethods for the crystallization of nano-size crystals of molecular organic compounds while operating at a low supersaturation. The methods are based on controlling the domain size available during the crystallization process. In one exemplary method, microcontacted printed self-assembled monolayers (SAMs) with local domain area sizes ranging up to 2500 .mu.m.sup.2 and fabricated SAMs generated from electron beam lithography, are employed to control the size, orientation, phase, and morphology of the crystal. In another exemplary method, a continuous micro-crystallizer having a vessel diameter of 25 microns or less is used to ensure that that the maximum size of the crystals in at least one dimension, ad preferably two dimensions is constrained by the vessel itself. The methods allow control of supersaturation and growth conditions, as well as manageability over crystallinity and polymorphism, and each method's domain size has the potential for further reduction.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Methods for Producing Organic Nanocrystals
Creator: Myerson, Allan S., Lee, In Sung
Date: 2012-11-01, 2012-10-30
Description: Methods for producing small crystals on islands formed on specialized substrates by, inter alia, subjecting the substrate to a hydrophilic...
Show moreMethods for producing small crystals on islands formed on specialized substrates by, inter alia, subjecting the substrate to a hydrophilic SAMs solution for self-assembling hydrophilic SAMs on certain portions of the substrate surface and subjecting the substrate to a hydrophobic SAMs solution for self-assembling hydrophobic SAMs on certain other portions of the substrate surface.
Sponsorship: Illinois Institute of Technology
United States Patent
Primary US Patent Classification 430/324
International Patent Classification G03F 7/20
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Title: Continuous Antisolvent Crystallization Process and System Using Plug Flow Reactors
Creator: Myerson, Allan S., Alvarez, Alejandro
Date: 2012-07-12, 2012-07-10
Description: A process and system for continuous crystallization of a compound using antisolvent addition in which a solution is prepared with an organic...
Show moreA process and system for continuous crystallization of a compound using antisolvent addition in which a solution is prepared with an organic compound and a solvent. An antisolvent is added to the solution in a continuous plug flow system comprising at least one process module. The antisolvent can be added in multiple addition points such that the overall amount of antisolvent added to the continuous plug flow reactor remains fixed. The multiple addition point technique provides every process module with an equal volume of antisolvent. Finally, crystals are recovered from the slurry upon exiting the system. Preferably, the mean crystal size is less than 100 μm.
Sponsorship: Illinois Institute of Technology
United States Patent
Primary US Patent Classification 117/68
US Patent Classification 117/69
US Patent Classification 117/70
International Patent Classification C30B29/54
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Title: Method for Producing Crystals and Screening Crystallization Conditions
Creator: Myerson, Allan S., Lee, Alfred Y.
Date: 2009-05-19, 2008-02-12
Description: A method for producing crystals and for screening crystallization conditions of chemical materials on distinct metallic islands with specific...
Show moreA method for producing crystals and for screening crystallization conditions of chemical materials on distinct metallic islands with specific functional groups, for preparing and screening the conditions necessary to promote a specific polymorph of a crystal, and a means for testing and screening the more precise conditions suitable for achieving a desired size or form of a crystal.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Method for Screening Crystallization Conditions Using Multifunctional Substrates
Creator: Myerson, Allan S., Lee, Alfred Y.
Date: 2009-05-19, 2008-02-12
Description: A method for producing crystals and for screening crystallization conditions of chemical materials on distinct metallic islands with specific...
Show moreA method for producing crystals and for screening crystallization conditions of chemical materials on distinct metallic islands with specific functional groups by using multi-functional substrates comprising a plurality of self-assembled monolayers having at least two different functionalities, for preparing and screening conditions necessary to promote specific polymorphs of a crystal, and a means for testing and screening the more precise conditions suitable for achieving desired sizes or forms of a crystal.
Sponsorship: Illinois Institute of Technology
United States Patent
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Title: Hydrodynamic Cavitation Crystallization Device and Process
Creator: Kozyuk, Oleg V., Myerson, Allan S., Weinberg, Roger
Date: 2009-05-19, 2008-01-01
Description: A device and process for crystallizing a compound using hydrodynamic cavitation comprising the steps of mixing at least one stream of a feed...
Show moreA device and process for crystallizing a compound using hydrodynamic cavitation comprising the steps of mixing at least one stream of a feed solution of such compound to be crystallized with at least one stream of an anti-solvent in a nucleating section via collision of the feed solution and the anti-solvent, passing the mixed streams at an elevated pressure through at least one local constriction of flow to create hydrodynamic cavitation thereby causing nucleation and the production of seed crystals, passing the fluid stream containing the seed crystals through an intermediate section to a crystal growth section, passing the fluid stream containing the seed crystals through the crystal growth section at an elevated pressure through at least one local constriction of flow to create hydrodynamic cavitation thereby causing further crystallization of the compound contained in the solution.
Sponsorship: Five Star Technologies, Inc.
Sponsorship: Illinois Institute of Technology
United States Patent
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